Volume 15, Issue 21

November 15, 2023pp 11694—12698

About the Cover

The cover features Figure 3 "Golgi staining revealed morphological changes in pyramidal neurons of PFC and hippocampus from P301S Tau mice at different ages" from Cao et al.

Editorial

PME-1-regulated neural cell death: new therapeutic opportunities?

Liesbeth Guffens, Rita Derua, Veerle Janssens

https://doi.org/10.18632/aging.205303pp 11694—11696

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Research Papers

Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model

Qing Cao, Manasa Kumar, Allea Frazier, Jamal B. Williams, Shengkai Zhao, Zhen Yan

https://doi.org/10.18632/aging.205057pp 11697—11719

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Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans

Camille Lenzi, Alexis Piat, Pascal Schlich, Judith Ducau, Jean-Claude Bregliano, Hugo Aguilaniu, Anne Laurençon

https://doi.org/10.18632/aging.205098pp 11720—11739

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1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway

Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, Ikuro Maruyama

https://doi.org/10.18632/aging.205228pp 11740—11763

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Antibiotics that target mitochondria extend lifespan in C. elegans

Gloria Bonuccelli, Darren R. Brooks, Sally Shepherd, Federica Sotgia, Michael P. Lisanti

https://doi.org/10.18632/aging.205229pp 11764—11781

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Hub gene identification and molecular subtype construction for Helicobacter pylori in gastric cancer via machine learning methods and NMF algorithm

Lianghua Luo, Ahao Wu, Xufeng Shu, Li Liu, Zongfeng Feng, Qingwen Zeng, Zhonghao Wang, Tengcheng Hu, Yi Cao, Yi Tu, Zhengrong Li

https://doi.org/10.18632/aging.205053pp 11782—11810

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Systematic analysis of glutamine metabolism family genes and exploration of the biological role of GPT in colorectal cancer

Weiqi Dai, Wenhui Mo, Wenqiang Xu, Dengyu Han, Xuanfu Xu

https://doi.org/10.18632/aging.205079pp 11811—11830

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RAI2 acts as a tumor suppressor with functional significance in gastric cancer

Xiaoli Lou, Wei Deng, Lixiong Shuai, Yijing Chen, Mengmeng Xu, Jingze Xu, Yongsheng Zhang, Yongyou Wu, Zhifei Cao

https://doi.org/10.18632/aging.205135pp 11831—11844

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Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway

Longbin Wang, Ying Liu, Si Li, Zhijian Zha, Yu Chen, Qi Wang, Shujing Zhou, Xufeng Huang, Ming Xu

https://doi.org/10.18632/aging.205138pp 11845—11859

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Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression

Qirong Wen, Xiaohui Xie, Caiyuan Chen, Bolun Wen, Yaqiong Liu, Jie Zhou, Xiaobin Lin, Han Jin, Kun Shi

https://doi.org/10.18632/aging.205142pp 11860—11874

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MicroRNA-30a-3p: a potential noncoding RNA target for the treatment of arteriosclerosis obliterans

Mao Zhang, Yu Chen, Fang Niu, Xiaohui Luo, Jiangping Li, Wei Hu

https://doi.org/10.18632/aging.205154pp 11875—11890

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Comprehensive analysis reveals XCL2 as a cancer prognosis and immune infiltration-related biomarker

Wu Chen, Fan Zou, Tianbao Song, Yuqi Xia, Ji Xing, Ting Rao, Xiangjun Zhou, Jinzhuo Ning, Sheng Zhao, Weimin Yu, Fan Cheng

https://doi.org/10.18632/aging.205156pp 11891—11917

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The development and experimental validation of hypoxia-related long noncoding RNAs prognostic signature in predicting prognosis and immunotherapy of cutaneous melanoma

Gang Wang, Yuliang Sun, Qingjia Xu

https://doi.org/10.18632/aging.205157pp 11918—11939

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Integrated analysis of single-cell and bulk RNA-sequencing data reveals the prognostic value and molecular function of THSD7A in gastric cancer

Kaiyu Shen, Binyu Chen, Liu Yang, Wencang Gao

https://doi.org/10.18632/aging.205158pp 11940—11969

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Identification of epithelial-mesenchymal transition-related biomarkers in lung adenocarcinoma using bioinformatics and lab experiments

Yuanjun Cheng, Yumei Shen, Qianru Fang, Shanzhou Duan, Yifei Wang, Xiaoxiao Dai, Yongbing Chen

https://doi.org/10.18632/aging.205159pp 11970—11984

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Inhibition of keloid by ³²P isotope radiotherapy through suppressing TGF-β/Smad signaling pathway

Long Xie, Liqun Huang, Guanjie Zhang, Yingrui Su

https://doi.org/10.18632/aging.205160pp 11985—11993

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Hepatoprotective effect of syringin combined with costunolide against LPS-induced acute liver injury in L-02 cells via Rac1/AKT/NF-κB signaling pathway

Jingxin Mao, Lihong Tan, Cheng Tian, Wenxiang Wang, Hao Zhang, Zhaojing Zhu, Yan Li

https://doi.org/10.18632/aging.205161pp 11994—12020

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Utility of G protein-coupled oestrogen receptor 1 as a biomarker for pan-cancer diagnosis, prognosis and immune infiltration: a comprehensive bioinformatics analysis

Yu-Chao Fan, Wen Wu, Xue-Feng Leng, Hong-Wei Zhang

https://doi.org/10.18632/aging.205162pp 12021—12067

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The role of m6A RNA methylation regulator in meningioma

Yu Yang, Liqin Luo, Zhiwu Zhou

https://doi.org/10.18632/aging.205163pp 12068—12084

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Identification and diagnostic potential of serum microRNAs as biomarkers for early detection of Alzheimer’s disease

Ying-Hao Han, Hong-Yi Xiang, Dong Hun Lee, Lin Feng, Hu-Nan Sun, Mei-Hua Jin, Taeho Kwon

https://doi.org/10.18632/aging.205165pp 12085—12103

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Collaborating single-cell and bulk RNA sequencing for comprehensive characterization of the intratumor heterogeneity and prognostic model development for bladder cancer

Jie Wang, Zili Zuo, Zongze Yu, Zhigui Chen, Lisa Jia Tran, Jing Zhang, Jinsong Ao, Fangdie Ye, Zhou Sun

https://doi.org/10.18632/aging.205166pp 12104—12119

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USP14 predicts poorer survival outcomes and promotes tumor progression in endometrial carcinoma by activating NF-κB signaling

Xiaojin Gong, Li Jia, Lili Zhou, Tongxiu Hu

https://doi.org/10.18632/aging.205168pp 12120—12135

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Multi-omics analysis reveals PUS1 triggered malignancy and correlated with immune infiltrates in NSCLC

Yonghuang Tan, Zhaotong Wang, Yingzhao Wang, Xiaolu Tian, Yunru Huang, Guoyong Wu, Jianjun Lu

https://doi.org/10.18632/aging.205169pp 12136—12154

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Identification of circRNA-miRNA-mRNA network as biomarkers for interstitial cystitis/bladder pain syndrome

Shi-Qin Yang, Liao Peng, Le-De Lin, Yuan-Zhuo Chen, Meng-Zhu Liu, Chi Zhang, Jia-Wei Chen, De-Yi Luo

https://doi.org/10.18632/aging.205170pp 12155—12170

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CENPB promotes the proliferation of hepatocellular carcinoma and is directly regulated by miR-29a

Xuyang Wang, Laibang Luo, Youfu Zhang, Gang Liu, Zehong Fang, Zhidan Xu, Xuguang Hu

https://doi.org/10.18632/aging.205171pp 12171—12191

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N7-methylguanosine-related miRNAs predict hepatocellular carcinoma prognosis and immune therapy

Liping Ma, Qingwei Ma, Qiaomei Deng, Jilu Zhou, Yingpei Zhou, Qianqian Wei, Zhihu Huang, Xiaoxia Lao, Ping Du

https://doi.org/10.18632/aging.205172pp 12192—12208

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Effects of amyloid β (Aβ)42 and Gasdermin D on the progression of Alzheimer’s disease in vitro and in vivo through the regulation of astrocyte pyroptosis

Wenjuan Hong, Chengping Hu, Can Wang, Binggen Zhu, Ming Tian, Hongyun Qin

https://doi.org/10.18632/aging.205174pp 12209—12224

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Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin

Yuqi Xin, Qingkun Jiang, Chenshu Liu, Jiaxuan Qiu

https://doi.org/10.18632/aging.205175pp 12225—12250

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Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells

Haiyan Du, Haochen Wu, Qinyang Kang, Mianmian Liao, Meirong Qin, Ning Chen, Houshuang Huang, Danping Huang, Ping Wang, Guangdong Tong

https://doi.org/10.18632/aging.205176pp 12251—12263

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Influences and mechanism of erythropoietin on the cognitive function of vascular dementia rats

Zhipeng Tang, Xiuqin Li, Nan Yin, Ming Zhao, Qingchuan Hu, Peiyuan Lv

https://doi.org/10.18632/aging.205178pp 12264—12274

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Identification of M5c regulator-medicated methylation modification patterns for prognosis and immune microenvironment in glioma

Zhenyong Xiao, Jinwei Li, Cong Liang, Yamei Liu, Yuxiu Zhang, Yuxia Zhang, Quan Liu, Xianlei Yan

https://doi.org/10.18632/aging.205179pp 12275—12295

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A systematic framework for identifying prognostic necroptosis-related lncRNAs and verification of lncRNA CRNDE/miR-23b-3p/IDH1 regulatory axis in glioma

Yangxia Chen, Di Hu, Fang Wang, Cheng Huang, Hesong Xie, Ling Jin

https://doi.org/10.18632/aging.205180pp 12296—12313

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Cuproptosis-related gene DLAT serves as a prognostic biomarker for immunotherapy in clear cell renal cell carcinoma: multi-database and experimental verification

Shuaishuai Huang, Congbo Cai, Kena Zhou, Xue Wang, Xue Wang, Dong Cen, Guobin Weng

https://doi.org/10.18632/aging.205181pp 12314—12329

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A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma

Qiang Chen, Hongbo Zhao, Jing Hu

https://doi.org/10.18632/aging.205183pp 12330—12368

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CCL19: a novel prognostic chemokine modulates the tumor immune microenvironment and outcomes of cancers

Qiang Gu, Shifang Zhou, Cong Chen, Zhi Wang, Wenhao Xu, Jiarong Zhang, Shiyin Wei, Jianfeng Yang, Hongjing Chen

https://doi.org/10.18632/aging.205184pp 12369—12387

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A neural network model was constructed by screening the potential biomarkers of aortic dissection based on genes associated with pyroptosis

Cheng Chen, Lulu Gao, Hongwei Ge, Weibin Huang, Rong Zhao, Renjun Gu, Ziyun Li, Xin Wang

https://doi.org/10.18632/aging.205187pp 12388—12399

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Shenmai injection ameliorates doxorubicin-induced myocardial injury by suppressing autophagy-apoptosis via miR-30a

Yanyang Li, Lu Fan, Xiaoming Wang, Shichao Lv

https://doi.org/10.18632/aging.205188pp 12400—12412

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Construction and validation of a novel angiogenesis pattern to predict prognosis and immunotherapy efficacy in colorectal cancer

Zhiyong Li, Yang Liu, Peng Guo, Yunwei Wei

https://doi.org/10.18632/aging.205189pp 12413—12450

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Abnormal low expression of SFTPC promotes the proliferation of lung adenocarcinoma by enhancing PI3K/AKT/mTOR signaling transduction

Baile Zuo, Lin Wang, Xiaoyan Li, Xin Li, Jinping Wang, Yanlu Xiong, Jie Lei, Xi Zhang, Yifan Chen, Qiongwen Liu, Jinke Jiao, Mengru Sui, Jinhan Fan, Ningxue Wu, Zewen Song, Guoyin Li

https://doi.org/10.18632/aging.205191pp 12451—12475

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