Volume 15, Issue 21

PME-1-regulated neural cell death: new therapeutic opportunities?

Liesbeth Guffens, Rita Derua, Veerle Janssens,

https://doi.org/10.18632/aging.205303 pp 11694—11696

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Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model

Qing Cao, Manasa Kumar, Allea Frazier, Jamal B. Williams, Shengkai Zhao, Zhen Yan,

https://doi.org/10.18632/aging.205057 pp 11697—11719

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Parental age effect on the longevity and healthspan in Drosophila melanogaster and Caenorhabditis elegans

Camille Lenzi, Alexis Piat, Pascal Schlich, Judith Ducau, Jean-Claude Bregliano, Hugo Aguilaniu, Anne Laurençon,

https://doi.org/10.18632/aging.205098 pp 11720—11739

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1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway

Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, Ikuro Maruyama,

https://doi.org/10.18632/aging.205228 pp 11740—11763

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Antibiotics that target mitochondria extend lifespan in C. elegans

Gloria Bonuccelli, Darren R. Brooks, Sally Shepherd, Federica Sotgia, Michael P. Lisanti,

https://doi.org/10.18632/aging.205229 pp 11764—11781

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Hub gene identification and molecular subtype construction for Helicobacter pylori in gastric cancer via machine learning methods and NMF algorithm

Lianghua Luo, Ahao Wu, Xufeng Shu, Li Liu, Zongfeng Feng, Qingwen Zeng, Zhonghao Wang, Tengcheng Hu, Yi Cao, Yi Tu, Zhengrong Li,

https://doi.org/10.18632/aging.205053 pp 11782—11810

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Systematic analysis of glutamine metabolism family genes and exploration of the biological role of GPT in colorectal cancer

Weiqi Dai, Wenhui Mo, Wenqiang Xu, Dengyu Han, Xuanfu Xu,

https://doi.org/10.18632/aging.205079 pp 11811—11830

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RAI2 acts as a tumor suppressor with functional significance in gastric cancer

Xiaoli Lou, Wei Deng, Lixiong Shuai, Yijing Chen, Mengmeng Xu, Jingze Xu, Yongsheng Zhang, Yongyou Wu, Zhifei Cao,

https://doi.org/10.18632/aging.205135 pp 11831—11844

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Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway

Longbin Wang, Ying Liu, Si Li, Zhijian Zha, Yu Chen, Qi Wang, Shujing Zhou, Xufeng Huang, Ming Xu,

https://doi.org/10.18632/aging.205138 pp 11845—11859

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Lipid reprogramming induced by the NNMT-ABCA1 axis enhanced membrane fluidity to promote endometrial cancer progression

Qirong Wen, Xiaohui Xie, Caiyuan Chen, Bolun Wen, Yaqiong Liu, Jie Zhou, Xiaobin Lin, Han Jin, Kun Shi,

https://doi.org/10.18632/aging.205142 pp 11860—11874

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MicroRNA-30a-3p: a potential noncoding RNA target for the treatment of arteriosclerosis obliterans

Mao Zhang, Yu Chen, Fang Niu, Xiaohui Luo, Jiangping Li, Wei Hu,

https://doi.org/10.18632/aging.205154 pp 11875—11890

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Comprehensive analysis reveals XCL2 as a cancer prognosis and immune infiltration-related biomarker

Wu Chen, Fan Zou, Tianbao Song, Yuqi Xia, Ji Xing, Ting Rao, Xiangjun Zhou, Jinzhuo Ning, Sheng Zhao, Weimin Yu, Fan Cheng,

https://doi.org/10.18632/aging.205156 pp 11891—11917

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The development and experimental validation of hypoxia-related long noncoding RNAs prognostic signature in predicting prognosis and immunotherapy of cutaneous melanoma

Gang Wang, Yuliang Sun, Qingjia Xu,

https://doi.org/10.18632/aging.205157 pp 11918—11939

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Integrated analysis of single-cell and bulk RNA-sequencing data reveals the prognostic value and molecular function of THSD7A in gastric cancer

Kaiyu Shen, Binyu Chen, Liu Yang, Wencang Gao,

https://doi.org/10.18632/aging.205158 pp 11940—11969

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Identification of epithelial-mesenchymal transition-related biomarkers in lung adenocarcinoma using bioinformatics and lab experiments

Yuanjun Cheng, Yumei Shen, Qianru Fang, Shanzhou Duan, Yifei Wang, Xiaoxiao Dai, Yongbing Chen,

https://doi.org/10.18632/aging.205159 pp 11970—11984

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Inhibition of keloid by ³²P isotope radiotherapy through suppressing TGF-β/Smad signaling pathway

Long Xie, Liqun Huang, Guanjie Zhang, Yingrui Su,

https://doi.org/10.18632/aging.205160 pp 11985—11993

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Hepatoprotective effect of syringin combined with costunolide against LPS-induced acute liver injury in L-02 cells via Rac1/AKT/NF-κB signaling pathway

Jingxin Mao, Lihong Tan, Cheng Tian, Wenxiang Wang, Hao Zhang, Zhaojing Zhu, Yan Li,

https://doi.org/10.18632/aging.205161 pp 11994—12020

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Utility of G protein-coupled oestrogen receptor 1 as a biomarker for pan-cancer diagnosis, prognosis and immune infiltration: a comprehensive bioinformatics analysis

Yu-Chao Fan, Wen Wu, Xue-Feng Leng, Hong-Wei Zhang,

https://doi.org/10.18632/aging.205162 pp 12021—12067

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The role of m6A RNA methylation regulator in meningioma

Yu Yang, Liqin Luo, Zhiwu Zhou,

https://doi.org/10.18632/aging.205163 pp 12068—12084

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Identification and diagnostic potential of serum microRNAs as biomarkers for early detection of Alzheimer’s disease

Ying-Hao Han, Hong-Yi Xiang, Dong Hun Lee, Lin Feng, Hu-Nan Sun, Mei-Hua Jin, Taeho Kwon,

https://doi.org/10.18632/aging.205165 pp 12085—12103

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Collaborating single-cell and bulk RNA sequencing for comprehensive characterization of the intratumor heterogeneity and prognostic model development for bladder cancer

Jie Wang, Zili Zuo, Zongze Yu, Zhigui Chen, Lisa Jia Tran, Jing Zhang, Jinsong Ao, Fangdie Ye, Zhou Sun,

https://doi.org/10.18632/aging.205166 pp 12104—12119

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USP14 predicts poorer survival outcomes and promotes tumor progression in endometrial carcinoma by activating NF-κB signaling

Xiaojin Gong, Li Jia, Lili Zhou, Tongxiu Hu,

https://doi.org/10.18632/aging.205168 pp 12120—12135

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Multi-omics analysis reveals PUS1 triggered malignancy and correlated with immune infiltrates in NSCLC

Yonghuang Tan, Zhaotong Wang, Yingzhao Wang, Xiaolu Tian, Yunru Huang, Guoyong Wu, Jianjun Lu,

https://doi.org/10.18632/aging.205169 pp 12136—12154

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Identification of circRNA-miRNA-mRNA network as biomarkers for interstitial cystitis/bladder pain syndrome

Shi-Qin Yang, Liao Peng, Le-De Lin, Yuan-Zhuo Chen, Meng-Zhu Liu, Chi Zhang, Jia-Wei Chen, De-Yi Luo,

https://doi.org/10.18632/aging.205170 pp 12155—12170

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CENPB promotes the proliferation of hepatocellular carcinoma and is directly regulated by miR-29a

Xuyang Wang, Laibang Luo, Youfu Zhang, Gang Liu, Zehong Fang, Zhidan Xu, Xuguang Hu,

https://doi.org/10.18632/aging.205171 pp 12171—12191

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N7-methylguanosine-related miRNAs predict hepatocellular carcinoma prognosis and immune therapy

Liping Ma, Qingwei Ma, Qiaomei Deng, Jilu Zhou, Yingpei Zhou, Qianqian Wei, Zhihu Huang, Xiaoxia Lao, Ping Du,

https://doi.org/10.18632/aging.205172 pp 12192—12208

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Effects of amyloid β (Aβ)42 and Gasdermin D on the progression of Alzheimer’s disease in vitro and in vivo through the regulation of astrocyte pyroptosis

Wenjuan Hong, Chengping Hu, Can Wang, Binggen Zhu, Ming Tian, Hongyun Qin,

https://doi.org/10.18632/aging.205174 pp 12209—12224

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Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin

Yuqi Xin, Qingkun Jiang, Chenshu Liu, Jiaxuan Qiu,

https://doi.org/10.18632/aging.205175 pp 12225—12250

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Polyphyllin I attenuates the invasion and metastasis via downregulating GRP78 in drug-resistant hepatocellular carcinoma cells

Haiyan Du, Haochen Wu, Qinyang Kang, Mianmian Liao, Meirong Qin, Ning Chen, Houshuang Huang, Danping Huang, Ping Wang, Guangdong Tong,

https://doi.org/10.18632/aging.205176 pp 12251—12263

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Influences and mechanism of erythropoietin on the cognitive function of vascular dementia rats

Zhipeng Tang, Xiuqin Li, Nan Yin, Ming Zhao, Qingchuan Hu, Peiyuan Lv,

https://doi.org/10.18632/aging.205178 pp 12264—12274

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Identification of M5c regulator-medicated methylation modification patterns for prognosis and immune microenvironment in glioma

Zhenyong Xiao, Jinwei Li, Cong Liang, Yamei Liu, Yuxiu Zhang, Yuxia Zhang, Quan Liu, Xianlei Yan,

https://doi.org/10.18632/aging.205179 pp 12275—12295

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A systematic framework for identifying prognostic necroptosis-related lncRNAs and verification of lncRNA CRNDE/miR-23b-3p/IDH1 regulatory axis in glioma

Yangxia Chen, Di Hu, Fang Wang, Cheng Huang, Hesong Xie, Ling Jin,

https://doi.org/10.18632/aging.205180 pp 12296—12313

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Cuproptosis-related gene DLAT serves as a prognostic biomarker for immunotherapy in clear cell renal cell carcinoma: multi-database and experimental verification

Shuaishuai Huang, Congbo Cai, Kena Zhou, Xue Wang, Xue Wang, Dong Cen, Guobin Weng,

https://doi.org/10.18632/aging.205181 pp 12314—12329

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A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and therapeutic response in lung adenocarcinoma

Qiang Chen, Hongbo Zhao, Jing Hu,

https://doi.org/10.18632/aging.205183 pp 12330—12368

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CCL19: a novel prognostic chemokine modulates the tumor immune microenvironment and outcomes of cancers

Qiang Gu, Shifang Zhou, Cong Chen, Zhi Wang, Wenhao Xu, Jiarong Zhang, Shiyin Wei, Jianfeng Yang, Hongjing Chen,

https://doi.org/10.18632/aging.205184 pp 12369—12387

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A neural network model was constructed by screening the potential biomarkers of aortic dissection based on genes associated with pyroptosis

Cheng Chen, Lulu Gao, Hongwei Ge, Weibin Huang, Rong Zhao, Renjun Gu, Ziyun Li, Xin Wang,

https://doi.org/10.18632/aging.205187 pp 12388—12399

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Shenmai injection ameliorates doxorubicin-induced myocardial injury by suppressing autophagy-apoptosis via miR-30a

Yanyang Li, Lu Fan, Xiaoming Wang, Shichao Lv,

https://doi.org/10.18632/aging.205188 pp 12400—12412

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Construction and validation of a novel angiogenesis pattern to predict prognosis and immunotherapy efficacy in colorectal cancer

Zhiyong Li, Yang Liu, Peng Guo, Yunwei Wei,

https://doi.org/10.18632/aging.205189 pp 12413—12450

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Abnormal low expression of SFTPC promotes the proliferation of lung adenocarcinoma by enhancing PI3K/AKT/mTOR signaling transduction

Baile Zuo, Lin Wang, Xiaoyan Li, Xin Li, Jinping Wang, Yanlu Xiong, Jie Lei, Xi Zhang, Yifan Chen, Qiongwen Liu, Jinke Jiao, Mengru Sui, Jinhan Fan, Ningxue Wu, Zewen Song, Guoyin Li,

https://doi.org/10.18632/aging.205191 pp 12451—12475

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lncRNA HOXC-AS2 promotes the progression of hypopharyngeal cancer by binding to the P62 protein mediating the autophagy process

Yuandi Xiang, Guoquan Huang, Jie Wang, Qingquan Hua,

https://doi.org/10.18632/aging.205192 pp 12476—12496

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Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis

Yi-Jing Yin, Yong-Hong Zhang, Yu Wang, Hao Jiang, Jia-Bao Zhang, Shuang Liang, Bao Yuan,

https://doi.org/10.18632/aging.205193 pp 12497—12512

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Oxidative stress and autophagy-mediated immune patterns and tumor microenvironment infiltration characterization in gastric cancer

Jifeng Liu, Biao Zhang, Yunshu Zhang, Huahui Zhao, Xu Chen, Lei Zhong, Dong Shang,

https://doi.org/10.18632/aging.205194 pp 12513—12536

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Cyclosporin A-mediated translocation of HuR improves MTX-induced cognitive impairment in a mouse model via NCOA4-mediated ferritinophagy

Huang Ding, Rong Xiang, Yifan Jia, Jishi Ye, Zhongyuan Xia,

https://doi.org/10.18632/aging.205195 pp 12537—12550

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D-galactose causes sinoatrial node dysfunction: from phenotype to mechanism

Heng Zhang, Chen Chen, Yue Liu, Wei Chen, Jing Qi, Yue Xu, Lu Ren, Guanlin Yang, Dongyu Min, Zhuang Liu, Xintong Cai, Miao Hao, Guanzhen Xu, Ping Hou,

https://doi.org/10.18632/aging.205196 pp 12551—12569

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Identification and validation of ubiquitination-related signature and subgroups in immune microenvironment of tuberculosis

Peipei Zhou, Jie Shen, Xiao Ge, Haien Cheng, Yanli Sun, Meng Li, Heng Li, Zhengjun Yi, Zhenpeng Li,

https://doi.org/10.18632/aging.205198 pp 12570—12587

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Characterization of the immune cell function landscape in head and neck squamous carcinoma to assist in prognosis prediction and immunotherapy

Wenlun Wang, Zhouyi Zhang, Wenming Li, Dongmin Wei, Jianing Xu, Ye Qian, Shengda Cao, Dapeng Lei,

https://doi.org/10.18632/aging.205201 pp 12588—12617

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High-mobility group box-1 impedes skeletal muscle regeneration via downregulation of Pax-7 synthesis by increasing miR-342-5p expression

Trung-Loc Ho, Yu-Liang Lai, Chin-Jung Hsu, Chen-Ming Su, Chih-Hsin Tang,

https://doi.org/10.18632/aging.205202 pp 12618—12632

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KIFC1 promotes proliferation and pseudo-bipolar division of ESCC through the transportation of Aurora B kinase

Bin Du, Lingyu Wei, Jia Wang, Yanyan Li, Jing Huo, Jinsheng Wang, Pu Wang,

https://doi.org/10.18632/aging.205203 pp 12633—12650

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Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer

Lichun Wu, Jie Chu, Lijuan Shangguan, Mingfei Cao, Feng Lu,

https://doi.org/10.18632/aging.205204 pp 12651—12673

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Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels the heterogeneity of cancer-associated fibroblasts in TNBC

Xiaoqing Wu, Wenping Lu, Weixuan Zhang, Dongni Zhang, Heting Mei, Mengfan Zhang, Yongjia Cui, Zhili Zhuo,

https://doi.org/10.18632/aging.205205 pp 12674—12697

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Retraction for: Cationic solid lipid nanoparticles loaded by integrin β1 plasmid DNA attenuates IL-1β-induced apoptosis of chondrocyte

Yuejiang Zhao, Hanwen Chen, Lu Wang, Zhiyuan Guo, Shijie Liu, Simin Luo,

https://doi.org/10.18632/aging.205326 pp 12698

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Volume 15, Issue 21

About the Cover

Editorial

Liesbeth Guffens, Rita Derua, Veerle Janssens,

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Research Papers

Qing Cao, Manasa Kumar, Allea Frazier, Jamal B. Williams, Shengkai Zhao, Zhen Yan,

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Camille Lenzi, Alexis Piat, Pascal Schlich, Judith Ducau, Jean-Claude Bregliano, Hugo Aguilaniu, Anne Laurençon,

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Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, Ikuro Maruyama,

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Gloria Bonuccelli, Darren R. Brooks, Sally Shepherd, Federica Sotgia, Michael P. Lisanti,

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Lianghua Luo, Ahao Wu, Xufeng Shu, Li Liu, Zongfeng Feng, Qingwen Zeng, Zhonghao Wang, Tengcheng Hu, Yi Cao, Yi Tu, Zhengrong Li,

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Weiqi Dai, Wenhui Mo, Wenqiang Xu, Dengyu Han, Xuanfu Xu,

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Xiaoli Lou, Wei Deng, Lixiong Shuai, Yijing Chen, Mengmeng Xu, Jingze Xu, Yongsheng Zhang, Yongyou Wu, Zhifei Cao,

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Longbin Wang, Ying Liu, Si Li, Zhijian Zha, Yu Chen, Qi Wang, Shujing Zhou, Xufeng Huang, Ming Xu,

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Qirong Wen, Xiaohui Xie, Caiyuan Chen, Bolun Wen, Yaqiong Liu, Jie Zhou, Xiaobin Lin, Han Jin, Kun Shi,

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Mao Zhang, Yu Chen, Fang Niu, Xiaohui Luo, Jiangping Li, Wei Hu,

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Wu Chen, Fan Zou, Tianbao Song, Yuqi Xia, Ji Xing, Ting Rao, Xiangjun Zhou, Jinzhuo Ning, Sheng Zhao, Weimin Yu, Fan Cheng,

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Gang Wang, Yuliang Sun, Qingjia Xu,

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Kaiyu Shen, Binyu Chen, Liu Yang, Wencang Gao,

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Yuanjun Cheng, Yumei Shen, Qianru Fang, Shanzhou Duan, Yifei Wang, Xiaoxiao Dai, Yongbing Chen,

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Long Xie, Liqun Huang, Guanjie Zhang, Yingrui Su,

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Jingxin Mao, Lihong Tan, Cheng Tian, Wenxiang Wang, Hao Zhang, Zhaojing Zhu, Yan Li,

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Yu-Chao Fan, Wen Wu, Xue-Feng Leng, Hong-Wei Zhang,

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Yu Yang, Liqin Luo, Zhiwu Zhou,

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