Advance | Aging

Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice

Hiromichi Tsushima, Hirobumi Tada, Azusa Asai, Mikako Hirose, Tohru Hosoyama, Atsushi Watanabe, Taro Murakami, Masataka Sugimoto,

https://doi.org/10.18632/aging.205976

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Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Joseph S. Spina, Tracy L. Carr, Lucy A. Phillips, Heather L. Knight, Nancy E. Crosbie, Sarah M. Lloyd, Manisha A. Jhala, Tony J. Lam, Jozsef Karman, Meghan E. Clements, Tovah A. Day, Justin D. Crane, William J. Housley,

https://doi.org/10.18632/aging.205994

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CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma

Yongbin Di, Haolei Zhang, Bohao Zhang, Tianke Li, Dan Li,

https://doi.org/10.18632/aging.205703

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SHP2 mediates STAT3/STAT6 signaling pathway in TAM to inhibit proliferation and metastasis of lung adenocarcinoma

Guojing Chai, Yingbo Nan, Haili Zhao, Qingchuan Hu,

https://doi.org/10.18632/aging.205799

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RGC32 promotes the progression of ccRCC by activating the NF-κB/SHP2/EGFR signaling pathway

Jing Zhang, Yindi Sun, Kai Tang, Huirong Xu, Junjuan Xiao, Yan Li,

https://doi.org/10.18632/aging.205890

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G-CSF promotes the development of hepatocellular carcinoma by activating the PI3K/AKT/mTOR pathway in TAM

Heng Cao, Shunxiang Wang,

https://doi.org/10.18632/aging.205922

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An immune biomarker associated with EMT serves as a predictor for prognosis and drug response in bladder cancer

Yike Jiang, Zichuan Yu, Hao Zheng, Xuanrui Zhou, Minqin Zhou, Xitong Geng, Yanting Zhu, Shuhan Huang, Yiyang Gong, Liangyun Guo,

https://doi.org/10.18632/aging.205927

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Precision prognostication in breast cancer: unveiling a long non-coding RNA-based model linked to disulfidptosis for tailored immunotherapeutic strategies

Chenglu Jiang, Shengke Zhang, Lai Jiang, Zipei Chen, Haiqing Chen, Jinbang Huang, Xuancheng Zhou, Jingyi Tang, Xinrui Gao, Hao Chi, Guanhu Yang, Shangke Huang,

https://doi.org/10.18632/aging.205946

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Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway

Chengyao Zhang, Zhiya Hu, Yongxin Fu, Jiawu Wang,

https://doi.org/10.18632/aging.205947

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Characterization of the gut microbiota and fecal metabolome in the osteosarcoma mouse model

Yuan Li, Xiaochen Qiao, Yi Feng, Ruhao Zhou, Kun Zhang, Yongchun Pan, Ting Yan, Lei Yan, Sen Yang, Xiaochun Wei, Pengcui Li, Chaojian Xu, Zhi Lv, Zhi Tian,

https://doi.org/10.18632/aging.205951

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Prognostic relevance and validation of ARPC1A in the progression of low-grade glioma

Jingyuan Dai, Jiahui Gao, Hongchao Dong,

https://doi.org/10.18632/aging.205952

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Cathepsin L induces cellular senescence by upregulating CUX1 and p16^INK4a

Yuwei Wu, Danli Jiang, Qing Liu, Shaoyang Yan, Xiuzhen Liu, Ting Wu, Wei Sun, Gang Li,

https://doi.org/10.18632/aging.205955

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Identification of differentially expressed genes to predict the risk of heart failure in older patients with hypertrophic cardiomyopathy

Hao Dong, Chufan Yin, Dongping Xiao, Yong Tang,

https://doi.org/10.18632/aging.205956

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Needle-scalpel therapy inhibits the apoptosis of nucleus pulposus cells via the SDF-1/CXCR4 axis in a rat degenerative cervical intervertebral disc model

Wenlong Yang, Muqing Liu, Qinran Sun, Lei Liu, Wenqing Wu, Fangming Liu, Zhizhen Liu,

https://doi.org/10.18632/aging.205959

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Disorder of neuroplasticity aggravates cognitive impairment via neuroinflammation associated with intestinal flora dysbiosis in chronic heart failure

Jie Chen, Xiaohong Wei, Xuefen Wu, Qian Zhang, Guiyang Xia, Huan Xia, Hongcai Shang, Sheng Lin,

https://doi.org/10.18632/aging.205960

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Identifying novel circadian rhythm biomarkers for diagnosis and prognosis of melanoma by an integrated bioinformatics and machine learning approach

Yi Xu, Churuo Zeng, Jie Bin, Hua Tang, Wei Li,

https://doi.org/10.18632/aging.205961

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Development and validation of a nomogram to predict overall survival in patients with glioma: a population-based study

Wei Huang, Yuhe Lei, Xiongbin Cao, Gengrui Xu, Xiaokang Wang,

https://doi.org/10.18632/aging.205967

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Identification of immunotherapy-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognostic signature in gastric carcinoma

Jianxin Li, Ting Han, Jieyi Yang, Xin Wang, Yinchun Wang, Rui Yang, Qingqiang Yang,

https://doi.org/10.18632/aging.205968

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Luteolin targets the AGE-RAGE signaling to mitigate inflammation and ferroptosis in chronic atrophic gastritis

Nailin Zhang, Pingping Chen, Xiaoyan Liang, Jianhui Sun, Qiquan Liu, Shengjiang Guan, Qiao Wang,

https://doi.org/10.18632/aging.205969

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Exploring the mechanism by which Angelica sinensis improves haematopoietic function in aplastic anaemia

Zetao Chen, Li Cheng, Jing Zhang, Xing Cui,

https://doi.org/10.18632/aging.205971

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Cyclin L1 participates in Adriamycin resistance and progression of osteosarcoma via PI3K/AKT-mTOR pathway

Yanbin Zhang, Tao Zhang, Long Chen, Zijun Guo, Xiaobing Jiang,

https://doi.org/10.18632/aging.205972

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Exploring the prognostic analysis of autophagy and tumor microenvironment based on monocyte cells in lung cancer

Bo Tao, Ziming Wang, Dacheng Xie, Hongxue Cui, Bin Zhao, Juanjuan Li, Liang Guo,

https://doi.org/10.18632/aging.205973

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Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC

Jie Zheng, Wenhao Lu, Chengbang Wang, Shaohua Chen, Qingyun Zhang, Cheng Su,

https://doi.org/10.18632/aging.205974

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Pan-cancer analysis of T-cell proliferation regulatory genes as potential immunotherapeutic targets

Ruqiong Wei, Shihui Xiao, Shijian Zhao, Wenliang Guo, Ying Liu, Marìa del Mar Requena Mullor, Raquel Alarcòn Rodrìguez, Qingjun Wei, Yinteng Wu,

https://doi.org/10.18632/aging.205977

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Integrative pan-cancer analysis reveals the prognostic and immunotherapeutic value of ALKBH7 in HNSC

Tianyu Wang, Bojian Lin, Boyu Cai, Zhiwen Cao, Caiquan Liang, Shunyu Wu, Enhong Xu, Li Li, Hu Peng, Huanhai Liu,

https://doi.org/10.18632/aging.205981

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Unveiling diabetic nephropathy: a novel diagnostic model through single-cell sequencing and co-expression analysis

Guoyi Wang, Jinwen Zhao, Min Zhou, Haiyuan Lu, Fei Mao,

https://doi.org/10.18632/aging.205982

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An updated immunosenescence exploration in healthy Chinese donors: circular elevated PD-1 on T cell and increased Ki67 on CD8+ T cell towards aging

Yue Chang, Wei Cao, Lianfeng Lu, Yang Han, Lin Qin, Baotong Zhou, Taisheng Li,

https://doi.org/10.18632/aging.205985

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LncRNA DANCR promotes macrophage lipid accumulation through modulation of membrane cholesterol transporters

Guo-Jun Zhao, Yu Wang, Jun-Hong An, Wan-Ying Tang, Xiao-Dan Xu, Kun Ren,

https://doi.org/10.18632/aging.205992

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Pan-cancer analysis of disulfidptosis with potential implications in prognosis, immune microenvironment, and drug resistance in human cancer

Fobao Lai, Wanrong Zheng, Chengqian Zhong, Zhiyong Chen,

https://doi.org/10.18632/aging.205993

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Identification of Escherichia coli strains using MALDI-TOF MS combined with long short-term memory neural networks

Qiqi Mao, Xie Zhang, Zeping Xu, Ya Xiao, Yufei Song, Feng Xu,

https://doi.org/10.18632/aging.205995

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Genetic effect of thyroid function-related diseases on acute respiratory distress syndrome: a Mendelian randomization study

Peilong Li, Haifeng Liu, Feng Li, Mingze Sui, Kai Liu, Hongmin Fu,

https://doi.org/10.18632/aging.205996

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Integrated transcriptomics identifies prognostic significance and therapeutic response of cancer-associated fibroblast subpopulations in ovarian cancer

Shimeng Wan, Ziyan Liang, Shijie Yao, Anjin Wang, Xuelian Liu, Hao He, Hongbing Cai, Yang Gao, Hua Wang,

https://doi.org/10.18632/aging.205997

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Characteristics of auto-quantified tumor-infiltrating lymphocytes and the prognostic value in adenocarcinoma of the esophagogastric junction, gastric adenocarcinoma, and esophageal squamous cell carcinoma

Hao Dong, Longqing Yao, Jiahui Fan, Peipei Gao, Xiaorong Yang, Ziyu Yuan, Tiejun Zhang, Ming Lu, Xingdong Chen, Chen Suo,

https://doi.org/10.18632/aging.205999

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Efficacy of Compound Danshen Dripping Pills in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a meta-analysis

Kuan Xu, Yan Zhu, Gang Hu,

https://doi.org/10.18632/aging.206000

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Sevoflurane impedes neuropathic pain by maintaining endoplasmic reticulum stress and oxidative stress homeostasis through inhibiting the activation of the PLCγ/CaMKII/IP3R signaling pathway

An Xie, Xianjie Zhang, Feng Ju, Yukai Zhou, Dan Wu, Jia Han,

https://doi.org/10.18632/aging.206001

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Pro-apoptotic gene BAX is a pan-cancer predictive biomarker for prognosis and immunotherapy efficacy

Siying Wang, Xuyu Chen, Xiaofei Zhang, Kang Wen, Xin Chen, Jingyao Gu, Juan Li, Zhaoxia Wang,

https://doi.org/10.18632/aging.206003

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Consensus clustering and novel risk score model construction based on m6A methylation regulators to evaluate the prognosis and tumor immune microenvironment of early-stage lung adenocarcinoma

Miao He, Yuxue Zhi, Chao Li, Changming Zhao, Guangquan Yang, Jing Lv, Hong You, Hai Huang, Xiaoyu Cao,

https://doi.org/10.18632/aging.206004

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AK7-deficiency reversal inhibits ccRCC progression and boosts anti-PD1 immunotherapy sensitivity

Yigang Jin, Minjie Chen, Fei Chen, Zhaofeng Gao, Xiaoping Li, Lingyu Hu, Dandan Cai, Siqi Zhao, Zhengwei Song,

https://doi.org/10.18632/aging.206006

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LIMK1 promotes the development of cervical cancer by up-regulating the ROS/Src-FAK/cofilin signaling pathway

Yajing Jia, Yongping Li, Naiyi Du, Wei Zhao, Yakun Liu,

https://doi.org/10.18632/aging.206007

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PART1 facilitates tumorigenesis and inhibits ferroptosis by regulating the miR-490-3p/SLC7A11 axis in hepatocellular carcinoma

Decheng Li, Meiling Wan, Xiaoling Liu, Suvash Chandra Ojha, Yunjian Sheng, Yaling Li, Changfeng Sun, Cunliang Deng,

https://doi.org/10.18632/aging.206009

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Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Minghua Meng, Meiling Huang, Cuicui Liu, Jiming Wang, Weihua Ren, Shaomin Cui, Jianhua Gu, Jinlan Xie, Bin Ma, Guangzhu Yang, Shuncheng He,

https://doi.org/10.18632/aging.203138

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Identification of an immune subtype predicting survival risk and immune activity in hepatocellular carcinoma

Feng Zhao, Nuo Xu, Jiali Yang, Bo Li, Jianwei Shi, Yuanyuan Zheng, Longjin Xu,

https://doi.org/10.18632/aging.202953

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Advance Publications

Research Papers

Hiromichi Tsushima, Hirobumi Tada, Azusa Asai, Mikako Hirose, Tohru Hosoyama, Atsushi Watanabe, Taro Murakami, Masataka Sugimoto,

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Joseph S. Spina, Tracy L. Carr, Lucy A. Phillips, Heather L. Knight, Nancy E. Crosbie, Sarah M. Lloyd, Manisha A. Jhala, Tony J. Lam, Jozsef Karman, Meghan E. Clements, Tovah A. Day, Justin D. Crane, William J. Housley,

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Yongbin Di, Haolei Zhang, Bohao Zhang, Tianke Li, Dan Li,

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Guojing Chai, Yingbo Nan, Haili Zhao, Qingchuan Hu,

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Jing Zhang, Yindi Sun, Kai Tang, Huirong Xu, Junjuan Xiao, Yan Li,

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Heng Cao, Shunxiang Wang,

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Yike Jiang, Zichuan Yu, Hao Zheng, Xuanrui Zhou, Minqin Zhou, Xitong Geng, Yanting Zhu, Shuhan Huang, Yiyang Gong, Liangyun Guo,

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Chenglu Jiang, Shengke Zhang, Lai Jiang, Zipei Chen, Haiqing Chen, Jinbang Huang, Xuancheng Zhou, Jingyi Tang, Xinrui Gao, Hao Chi, Guanhu Yang, Shangke Huang,

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Chengyao Zhang, Zhiya Hu, Yongxin Fu, Jiawu Wang,

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Yuan Li, Xiaochen Qiao, Yi Feng, Ruhao Zhou, Kun Zhang, Yongchun Pan, Ting Yan, Lei Yan, Sen Yang, Xiaochun Wei, Pengcui Li, Chaojian Xu, Zhi Lv, Zhi Tian,

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Jingyuan Dai, Jiahui Gao, Hongchao Dong,

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Yuwei Wu, Danli Jiang, Qing Liu, Shaoyang Yan, Xiuzhen Liu, Ting Wu, Wei Sun, Gang Li,

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Hao Dong, Chufan Yin, Dongping Xiao, Yong Tang,

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Wenlong Yang, Muqing Liu, Qinran Sun, Lei Liu, Wenqing Wu, Fangming Liu, Zhizhen Liu,

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Jie Chen, Xiaohong Wei, Xuefen Wu, Qian Zhang, Guiyang Xia, Huan Xia, Hongcai Shang, Sheng Lin,

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Yi Xu, Churuo Zeng, Jie Bin, Hua Tang, Wei Li,

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Wei Huang, Yuhe Lei, Xiongbin Cao, Gengrui Xu, Xiaokang Wang,

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Jianxin Li, Ting Han, Jieyi Yang, Xin Wang, Yinchun Wang, Rui Yang, Qingqiang Yang,

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Nailin Zhang, Pingping Chen, Xiaoyan Liang, Jianhui Sun, Qiquan Liu, Shengjiang Guan, Qiao Wang,

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Zetao Chen, Li Cheng, Jing Zhang, Xing Cui,

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