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Meeting Report|Volume 18|pp 513—530

Foundations of Gerophysics

Maximilian Unfried1,2, Weihan Huai1,2, Kamil Pabis1,2, Sandra Jose1,2, Zhi Meng Lim1, Uri Alon3, Marija Cvijovic4,5, Nir Eynon6, Peter Fedichev7, Yumi Kim8, Leong Kim Whye9, Csaba Kerepesi10,11, Woon-Puay Koh1,12, Dmitrii Kriukov13,14, Matt Kaeberlein15, Feng Ling16,17, Glen Pridham3, Michael Rera18, Steffen Rulands19, Andrew Rutenberg20, Kumar Selvarajoo21,22,23, Ben Shenhar3, Morten Scheibye-Knudsen24, Andrei E. Tarkhov25, Andrew Teschendorff26, Weilan Wang1,27, Ee Hou Yong28, Yifan Yang29, Jan Gruber1,2, Brian K. Kennedy1,2,30
  • 1Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore 117456, Singapore
  • 2Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore 117596, Singapore
  • 3Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
  • 4Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg 412 96, Sweden
  • 5Department of Mathematical Sciences, University of Gothenburg, Göteborg 412 58, Sweden
  • 6Australian Regenerative Medicine Institute (ARMI), Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria 3800, Australia
  • 7GERO PTE. LTD., Singapore 069535, Singapore
  • 8ieumBio Co. Ltd., and Biomedical Engineering, UNIST, Ulsan 44919, Republic of Korea
  • 9Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore
  • 10Institute for Computer Science and Control (SZTAKI), Hungarian Research Network (HUNREN), Budapest 1111, Hungary
  • 11HUN-REN-SZTAKI-SU Rejuvenation Research Group, Office for Supported Research Groups (TKI), Hungarian Research Network (HUN-REN), Budapest 1052, Hungary
  • 12Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Singapore
  • 13Artificial Intelligence Research Institute, Moscow 121170, Russian Federation
  • 14Skolkovo Institute of Science and Technology, Moscow 121205, Russian Federation
  • 15Optispan, Tukwila, WA 98168, USA
  • 16Institute of High Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore 138632, Singapore
  • 17Department of Physics, National University of Singapore, Singapore 117551, Singapore
  • 18Université Paris Cité, Functional and Adaptive Biology, UMR 8251, CNRS, F-75013 Paris, France
  • 19Ludwig-Maximilians-Universität München, Arnold-Sommerfeld-Center for Theoretical Physics, München 80333, Germany
  • 20Department of Physics and Atmospheric Science, Dalhousie University, Halifax B3H 4R2, Nova Scotia, Canada
  • 21Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore 138632, Singapore
  • 22Synthetic Biology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117456, Singapore
  • 23School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
  • 24Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark
  • 25Retro Biosciences Inc., Redwood, CA 94063, USA
  • 26Shanghai Institute for Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China
  • 27NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore 119228, Singapore
  • 28Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
  • 29Center for Interdisciplinary Studies, Westlake University, Hangzhou, Zhejiang, China
  • 30Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore 117593, Singapore
Received: March 19, 2026Accepted: April 2, 2026Published: May 14, 2026
https://doi.org/10.18632/aging.206378

Copyright: © 2026 Unfried et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The inaugural Global Conference on Gerophysics convened 160 researchers across physics, biology, computation, and medicine in Singapore on March 5–6, 2025. With 31 speakers, the two-day event explored how physical laws, and quantitative principles unify aging science, linking biological processes to longevity patterns. Sessions covered diverse aging aspects, from developmental stages to species comparisons. The meeting showcased innovative methods to study aging, emphasizing data-driven insights. A central theme was bridging theory and experiment to advance understanding. It concluded with a consensus around (1) shared multi-modal datasets; (2) physics-based definitions for “aging”, “rejuvenation”, and “healthspan”; (3) models predicting intervention outcomes; and (4) translational links between non-human species and human research. These priorities outline a practical path for a quantitative, predictive Gerophysics, building on the 2025 conference’s insights to shape future aging research.