Interviews with Outstanding Authors

Testimonial: Dr. Frank Pun from Insilico Medicine

Dr. Frank Pun, Associate Director (Project & Operations) and Application Science Lead at Insilico Medicine, describes his experience publishing a research paper that he co-authored, entitled, “Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine” with Aging (Aging-US). DOI - https://doi.org/10.18632/aging.203960

Testimonial: Dr. Brian Chen from FOXO Technologies

Dr. Brian Chen, adjunct faculty at the Herbert Wertheim School of Public Health and Human Longevity Science at UC San Diego and the Chief Science Officer of FOXO Technologies, describes his experience publishing numerous papers with Aging (Aging-US).

Testimonial: Dennis Mangan from MTOR LLC

Dennis Mangan from MTOR LLC in Bakersfield, California describes the experience publishing his theory article, “Iron: an underrated factor in aging” in Volume 13, Issue 19 of Aging (Aging-US).

DOI - https://doi.org/10.18632/aging.203612

The puzzling interplay between p53 and Sp1

Dr. Ariella Oppenheim from the Department of Hematology, Hebrew University Faculty of Medicine, Jerusalem, Israel, details an editorial she co-authored that was published by Aging (Aging-US) in Volume 9, Issue 5, entitled, “The puzzling interplay between p53 and Sp1.

DOI - https://doi.org/10.18632/aging.101238 (PDF download)

Full text - https://www.aging-us.com/article/101238

DNA Methylation-based Measures of Biological Age

Aging-US published "DNA methylation-based measures of biological age: meta-analysis predicting time to death" in 2016, which reported that estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans.

DOI - https://doi.org/10.18632/aging.101020

Epigenetic Age of the Pre-frontal Cortex

Aging-US published "Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning" in 2015, which reported that there is an urgent need to develop molecular biomarkers of brain age in order to advance our understanding of age related neurodegeneration.

DOI - https://doi.org/10.18632/aging.100864

Testimonial from Dr. Junhua Li with the University of Essex

Aging-US testimonial from Dr. Junhua Li with the University of Essex talking about his experience publishing "Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation"

DOI - https://doi.org/10.18632/aging.102023

tea drinking brain efficiency fMRI DTI default mode network hemispheric asymmetry

Dr. Velia M. Fowler and Dr. Catherine Cheng

Interview with Dr. Velia M. Fowler and Dr. Catherine Cheng from the Department of Molecular Medicine, The Scripps Research Institute about their paper " Age-related changes in eye lens biomechanics, morphology, refractive index and transparency"

DOI - https://doi.org/10.18632/aging.102584

fiber cell strain epithelial cell cataract stiffness

Interview with Dr. Alejandro Martin-Montalvo and Dr. Benoit Raymond Gauthier

Interview with Dr. Alejandro Martin-Montalvo and Dr. Benoit Raymond Gauthier from the Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER about their paper " Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging"

DOI - https://doi.org/10.18632/aging.102285

lifespan healthspan thyroid hormones hyperthyroidism hypothyroidism glucose metabolism

Interview with Dr. Lei Feng

Interview with Dr. Lei Feng from the Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore about his paper " Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation"

DOI - https://doi.org/10.18632/aging.102023

tea drinking brain efficiency fMRI DTI default mode network hemispheric asymmetry

Interview with Dr. Julija Jurić

Interview with Dr. Julija Jurić from the Genos Glycoscience Research Laboratory talking about her paper "Effects of estradiol on biological age measured using the glycan age index"

DOI - https://doi.org/10.18632/aging.104060

biological age glycan age estrogen aging biomarkers glycosylation

Testimonial from Dr. Dale E. Bredesen with UCLA & The Buck Institute for Research on Aging

Aging-US testimonial from Dr. Dale E. Bredesen with UCLA & The Buck Institute for Research on Aging talking about his experience publishing "Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics"

Alzheimer’s disease neurodegeneration complex chronic disorder network biology systems biology

Interview with Dr. Dale E. Bredesen

Interview with Dr. Dale E. Bredesen from UCLA & The Buck Institute for Research on Aging talking about his paper "Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics"

DOI - https://doi.org/10.18632/aging.103883

Alzheimer’s disease neurodegeneration complex chronic disorder network biology systems biology

Testimonial from Dr. Kara Fitzgerald

Aging-US testimonial from Dr. Kara Fitzgerald ND IFMCP with The Institute for Functional Medicine in Federal Way Washington USA talking about their experience publishing "Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial"

DNA methylation epigenetic aging lifestyle biological clock

Interview with Dr. Kara Fitzgerald

Interview with Dr. Kara Fitzgerald from The Institute for Functional Medicine talking about her paper "Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial"

DOI - https://doi.org/10.18632/aging.202913

DNA methylation epigenetic aging lifestyle biological clock

Interview with Dr. David A. Sinclair

Interview with Dr. David A. Sinclair from Glenn Laboratories for Aging Research at Harvard Medical School talking about his paper "Why does COVID-19 disproportionately affect older people?"

DOI - https://doi.org/10.18632/aging.103344

aging cytokine storm COVID-19 epigenetic clock immunity

Interview with Dr. Alex Zhavoronkov

Interview with Dr. Alex Zhavoronkov from Insilico Medicine & The Biogerontology Research Foundation talking about their paper "Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections"

DOI - https://doi.org/10.18632/aging.102988

COVID-19 SARS-CoV-2 coronavirus sirolimus rapalog

Interview with Dr. Gil Atzmon

Interview with Dr. Gil Atzmon from the Department of Medicine and Genetics at Albert Einstein College of Medicine, in the Bronx, NY 10461, USA as well as the Department of Human Biology, Faculty of Natural Science, at the University of Haifa, in Haifa, Israel talking about their featured cover paper for Volume 9 Issue 1"The complex genetics of gait speed: genome-wide meta-analysis approach"

Full Text

gait speed meta-analysis aging GWAS

Interview with Dr. Brian Kennedy & Dr. Linda Partridge

Left - Dr. Brian Kennedy from the Buck Institute for Research on Aging, Novato, CA, USA and the Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore.

Right - Dame Linda Partridge DBE FMedSci, currently the Weldon Professor of Biometry at the Department of Genetics, Evolution and Environment of University College London, director of UCL's Institute of Healthy Aging and founding director of the Max Planck Institute for the Biology of Aging.

In this interview they are talking about their meeting report on the 2nd interventions in aging conference published in Volume 9 Issue 4 of Aging.


healthspan organismal aging epigenetics longevity cellular mechanisms metabolism

Interview with Dr. Marina P. Antoch

Interview with Dr. Marina P. Antoch from the Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA speaking about their Featured Cover Paper in Volume 9 Issue 3 of Aging "Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice"

aging high fat diet obesity rapamycin rapatar chronological age

Interview with Dr. Ganesh V. Halade

Interview with Dr. Ganesh V. Halade from the Division of Cardiovascular Disease Department of Medicine, The University of Alabama at Birmingham, AL 35233, USA talking about their paper in Aging, Albany NY Volume 8 issue 11 "Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction"

aging non-resolving inflammation lipid mediators lipoxygenase macrophages myocardial infarction

Interview with Dr. Robert J. Shmookler Reis and Dr. Srinivas Ayyadevara

Video interview with Dr. Robert J. Shmookler Reis and Dr. Srinivas Ayyadevara from the Reynolds Institute on Aging, Dept. of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR talking about their featured cover paper in Aging Volume 8 Issue 12 "Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans"

protein aggregation skeletal muscle aging sarcopenia proteostasis

Interview with Dr. Dale Bredesen

Video interview with Dr. Dale Bredesen of Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA and the Buck Institute for Research on Aging, Novato, CA talking about their featured cover paper in Aging Volume 6 Issue 9 - "Reversal of cognitive decline: A novel therapeutic program"

Alzheimer's dementia mild cognitive impairment neurobehavioral disorders neuroinflammation neurodegeneration systems biology

Interview with Dr. Steve Horvath

Interview with Dr. Steve Horvath - Department of Human Genetics and Biostatistics University of California, Los Angeles David Geffen School of Medicine 695 Charles E. Young Drive South Los Angeles, CA 90095-7088, USA talking about their featured cover paper in Aging Volume 8 Issue 9 - "DNA methylation-based measures of biological age: meta-analysis predicting time to death"

all-cause mortality lifespan epigenetics epigenetic clock DNA methylation mortality

Interview with Dr. Leo Tsuda

Interview with Dr. Leo Tsuda from the Center for Development

of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu, Aichi, Japan talking about their paper published in Aging Volume 8 Issue 3 "Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception".

aging inner hair cells deafness Alzheimer's disease amyloid-β

Interview with Dr. Andrei Gudkov

Video interview with Dr. Andrei Gudkov, an Editor-in-chief of Oncotarget, and Senior Vice President for Basic Science at Roswell Park Cancer Institute in Buffalo, NY sharing findings from, “Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells” , a study that may play a role in delaying age-related diseases. Dr. Gudkov's study has identified macrophage cells as being an associated with cellular senescence. This subtype may hold potential for anti-aging treatment. Courtesy of Roswell Park Cancer Institute .

chronological aging inflammation inflammaging senescence-associated beta-galactosidase p16INK4a senescence-associated secretory phenotype clodronate

Interview with Dr. Vera Gorbunova

Video interview with Dr. Vera Gorbunova, Doris Johns Cherry Professor; Professor of Biology; Associate Professor of Oncology, Department of Biology, University of Rochester, Rochester, NY - talking about their cover paper in Aging - Volume 8 Issue 5 - "Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan"

fibroblasts oxygen senescence humanrodents

Interview with Dr. Patricia Rousselle

Video interview with Dr. Patricia Rousselle, Head of the Cell / Microenvironment Cross-Talk and Tissue Repair Laboratory in the Biologie Tissulaire et Ingénierie Thérapeutique Department in France - talking about their cover paper in Aging - Volume 8 Issue 4 - "Perlecan expression influences the keratin 15‐positive cell population fate in the epidermis of aging skin"

basement membrane perlecan keratinocyte skin aging keratin 15 stem cell