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• Research PaperVolume 17, Issue 1pp 97-115

  Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc^1638N/+ mice

  Relevance score: 0.00

  Kamendra Kumar, Bo-Hyun Moon, Santosh Kumar, Jerry Angdisen, Bhaskar V.S. Kallakury, Albert J. Fornace, Shubhankar Suman

  Keywords: senescence-associated secretory phenotype, senolytic agent, carcinogenesis, inflammation, β-catenin

  Published in Aging on January 8, 2025

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• Research PaperVolume 16, Issue 19pp 12685-12696

  Use of the senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in a mouse animal model

  Relevance score: 0.00

  Erryn Tappy, Haolin Shi, Jessica Pruszynski, Maria Florian-Rodriguez

  Keywords: pelvic organ prolapse, cellular senescence, senolytic agents, animal model

  Published in Aging on September 26, 2024

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• Research PaperVolume 11, Issue 2pp 771-782

  The curcumin analog EF24 is a novel senolytic agent

  Relevance score: 0.00

  Wen Li, Yonghan He, Rongping Zhang, Guangrong Zheng, Daohong Zhou

  Keywords: cellular senescence, aging, curcumin, EF24, senolytic agent

  Published in Aging on January 28, 2019

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• Research PaperVolume 8, Issue 11pp 2915-2926

  Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

  Relevance score: 0.00

  Yingying Wang, Jianhui Chang, Xingui Liu, Xuan Zhang, Suping Zhang, Xin Zhang, Daohong Zhou, Guangrong Zheng

  Keywords: piperlongumine, aging, senescent cells, senolytic agents, ABT-263, reactive oxygen species, synergistic effect

  Published in Aging on November 19, 2016

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• Research PaperVolume 17, Issue 1pp 16-32

  Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing

  Relevance score: 0.00

  Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Joy Ha, Jannat Dhillon, Grace H. Shin, Jack Crouch, Adam C. Gower, Sami Gritli, Daniel S. Roh

  Keywords: senolytic, senescence, aging, wound healing, ABT-263

  Published in Aging on December 3, 2024

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• Research PaperVolume 15, Issue 23pp 13581-13592

  Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema

  Relevance score: 0.00

  Alberta Palazzo, Gabriela Makulyte, Delphine Goerhig, Jean-Jacques Médard, Vincent Gros, François Trottein, Serge Adnot, David Vindrieux, Jean-Michel Flaman, David Bernard

  Keywords: senolytic, cigarette smoke, lung disease, cellular senescence, calcium channel

  Published in Aging on December 12, 2023

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• Research PaperVolume 14, Issue 24pp 10137-10152

  Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

  Relevance score: 0.00

  Xiang-Ke Chen, Chen Zheng, Stephen Heung-Sang Wong, Alvin Chun-Hang Ma

  Keywords: physical inactivity, obesity, immune aging, premature senescence, senolytic

  Published in Aging on December 29, 2022

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• Research PaperVolume 10, Issue 11pp 3294-3307

  Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

  Relevance score: 0.00

  Bela Ozsvari, John R. Nuttall, Federica Sotgia, Michael P. Lisanti

  Keywords: drug repurposing, aging, senescence, senolytic drugs, antibiotics, azithromycin, roxithromycin

  Published in Aging on November 14, 2018

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• Research PaperVolume 16, Issue 13pp 10694-10723

  Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

  Relevance score: 0.00

  Joseph S. Spina, Tracy L. Carr, Lucy A. Phillips, Heather L. Knight, Nancy E. Crosbie, Sarah M. Lloyd, Manisha A. Jhala, Tony J. Lam, Jozsef Karman, Meghan E. Clements, Tovah A. Day, Justin D. Crane, William J. Housley

  Keywords: cellular senescence, fibrosis, senolytic, senomorphic, SASP, alveolar epithelial cell

  Published in Aging on June 29, 2024

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• Research PaperVolume 15, Issue 6pp 1808-1832

  Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail

  Relevance score: 0.00

  Jonathan J. Petrocelli, Naomi M.M.P. de Hart, Marisa J. Lang, Elena M. Yee, Patrick J. Ferrara, Dennis K. Fix, Amandine Chaix, Katsuhiko Funai, Micah J. Drummond

  Keywords: skeletal muscle atrophy, inflammation, senolytic, AMPK, protein breakdown

  Published in Aging on March 20, 2023

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• Priority Research PaperVolume 14, Issue 3pp 1068-1086

  Senescence-associated tumor growth is promoted by 12-Lipoxygenase

  Relevance score: 0.00

  Shilpa Patil, Jessica L. Reedy, Bradley T. Scroggins, Ayla O. White, Seokjoo Kwon, Uma Shankavaram, Alfonso López-Coral, Eun Joo Chung, Deborah E. Citrin

  Keywords: senescence, radiation, senolytic, metastasis, Alox12

  Published in Aging on February 14, 2022

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• Research PaperVolume 12, Issue 12pp 11337-11348

  Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin

  Relevance score: 0.00

  Arantzazu Sierra-Ramirez, José Luis López-Aceituno, Luis Filipe Costa-Machado, Adrián Plaza, Marta Barradas, Pablo Jose Fernandez-Marcos

  Keywords: senescence, obesity, senolytic, diabetes, mouse model

  Published in Aging on June 25, 2020

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• Research PaperVolume 15, Issue 19pp 9984-10009

  BMAL1 modulates senescence programming via AP-1

  Relevance score: 0.00

  Sarah K. Jachim, Jian Zhong, Tamas Ordog, Jeong-Heon Lee, Aditya V. Bhagwate, Nagaswaroop Kengunte Nagaraj, Jennifer J. Westendorf, João F. Passos, Aleksey V. Matveyenko, Nathan K. LeBrasseur

  Keywords: AP-1, circadian clock, cellular senescence, senolytic, transcription regulation

  Published in Aging on October 10, 2023

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• Research PaperVolume 15, Issue 14pp 6641-6657

  Human senescent fibroblasts trigger progressive lung fibrosis in mice

  Relevance score: 0.00

  Fernanda Hernandez-Gonzalez, Neus Prats, Valentina Ramponi, José Alberto López-Domínguez, Kathleen Meyer, Mònica Aguilera, María Isabel Muñoz Martín, Daniel Martínez, Alvar Agusti, Rosa Faner, Jacobo Sellarés, Federico Pietrocola, Manuel Serrano

  Keywords: mouse model, cellular senescence, pulmonary fibrosis, antifibrotics, senolytic

  Published in Aging on July 1, 2023

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• EditorialVolume 14, Issue 14pp 5614-5616

  Nutlin-3a for age-related macular degeneration

  Relevance score: 0.00

  Hyewon Chung, Chaekyu Kim

  Keywords: anti-aging, cellular senescence, regeneration, retina, senolytic

  Published in Aging on July 16, 2022

• Research PaperVolume 13, Issue 12pp 16567-16576

  Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1

  Relevance score: 0.00

  Tania Xu Yar Lee, Jinfu Wu, Wei-Horng Jean, Giancarlo Condello, Ahmad Alkhatib, Chao-Chieh Hsieh, Yu-Wen Hsieh, Chih-Yang Huang, Chia-Hua Kuo

  Keywords: p16^INK4a, resistance exercise, Rg1, senolytic, cellular senescence, CD4

  Published in Aging on June 28, 2021

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• Research PerspectiveVolume 12, Issue 24pp 24481-24483

  The Ercc1^-/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions

  Relevance score: 0.00

  Alec Wong, Tra Kieu, Paul D. Robbins

  Keywords: cellular senescence, aging, DNA repair, DNA damage, senolytic

  Published in Aging on December 22, 2020

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• Research PaperVolume 12, Issue 13pp 12750-12770

  Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

  Relevance score: 0.00

  Hao Yang, Cheng Chen, Hao Chen, Xiaojun Duan, Juan Li, Yi Zhou, Weinan Zeng, Liu Yang

  Keywords: osteoarthritis, inflammation, cellular senescence, senolytic, chondrocytes

  Published in Aging on July 1, 2020

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• Research PerspectiveVolume 12, Issue 8pp 6511-6517

  COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

  Relevance score: 0.00

  Camillo Sargiacomo, Federica Sotgia, Michael P. Lisanti

  Keywords: COVID-19, corona virus, aging, senescence, senolytic drug therapy, prevention, viral replication, drug repurposing, antibiotic, Azithromycin, Hydroxy-chloroquine, Rapamycin, Doxycycline, Quercetin

  Published in Aging on March 30, 2020

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• CommentaryVolume 10, Issue 12pp 4289-4293

  Paradoxes of senolytics

  Relevance score: 0.00

  Mikhail V. Blagosklonny

  Keywords: senescence, cancer, diseases, senolytic, mTOR, gerosuppressants

  Published in Aging on December 28, 2018