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Volume 14, Issue 24

December 31, 2022pp 9775—10216

About the Cover

The cover features Figure 1 "A schematic diagram of potential APOE-related mechanism of Alzheimer’s disease (AD), from Kulminski et al.

Editorials

Leveraging pathway analysis in a human skin model of healthy aging

Dimitrios Tsitsipatis, Myriam Gorospe, Allison B. Herman

https://doi.org/10.18632/aging.204456pp 9775—9776

Are aged pTreg cells “the more the better”?

Weikan Wang, Rachel Thomas, Dong-Ming Su

https://doi.org/10.18632/aging.204454pp 9777—9778

Single short reprogramming early in life increases healthspan

Ollivier Milhavet, Jean-Marc Lemaitre

https://doi.org/10.18632/aging.204457pp 9779—9781

Research Papers

Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer’s disease biomarkers

Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, for the Alzheimer’s Disease Neuroimaging Initiative

https://doi.org/10.18632/aging.204384pp 9782—9804

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12-year evolution of multimorbidity patterns among older adults based on Hidden Markov Models

Albert Roso-Llorach, Davide L. Vetrano, Caterina Trevisan, Sergio Fernández, Marina Guisado-Clavero, Lucía A. Carrasco-Ribelles, Laura Fratiglioni, Concepción Violán, Amaia Calderón-Larrañaga

https://doi.org/10.18632/aging.204395pp 9805—9817

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Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV

Mikki Schantell, Brittany K. Taylor, Rachel K. Spooner, Pamela E. May, Jennifer O’Neill, Brenda M. Morsey, Tina Wang, Trey Ideker, Sara H. Bares, Howard S. Fox, Tony W. Wilson

https://doi.org/10.18632/aging.204437pp 9818—9831

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Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs

Dimitrios Tsitsipatis, Krystyna Mazan-Mamczarz, Ying Si, Allison B. Herman, Jen-Hao Yang, Abhishek Guha, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Rachel Munk, Xiaoling Yang, Supriyo De, Brijesh K. Singh, Ritchie Ho, Myriam Gorospe, Peter H. King

https://doi.org/10.18632/aging.204450pp 9832—9859

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C-C motif chemokine ligand 2 promotes myogenesis of myoblasts via the AKT-mTOR pathway

Mi Kyung Kwak, Eun Suk Ha, Jiwoo Lee, Yun Mi Choi, Beom-Jun Kim, Eun-Gyoung Hong

https://doi.org/10.18632/aging.204451pp 9860—9876

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SOX2-high cancer cells exhibit an aggressive phenotype, with increases in stemness, proliferation and invasion, as well as higher metabolic activity and ATP production

Marta Mauro-Lizcano, Federica Sotgia, Michael P. Lisanti

https://doi.org/10.18632/aging.204452pp 9877—9889

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Sevoflurane-induced POCD-associated exosomes delivered miR-584-5p regulates the growth of human microglia HMC3 cells through targeting BDNF

Jia Zhao, Wei Zhang, Shentong Wang, Zinan Li, Yuqi Huang, Longyun Li

https://doi.org/10.18632/aging.204398pp 9890—9907

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Early life exercise training and inhibition of apoLpp mRNA expression to improve age-related arrhythmias and prolong the average lifespan in Drosophila melanogaster

Meng Ding, Qiu Fang Li, Tian Hang Peng, Tong Quan Wang, Han Hui Yan, Chao Tang, Xiao Ya Wang, Yin Guo, Lan Zheng

https://doi.org/10.18632/aging.204422pp 9908—9923

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A novel long noncoding RNA AC092718.4 as a prognostic biomarker and promotes lung adenocarcinoma progression

Siqin Chen, Yang Yu, Yixiao Yuan, Xi Chen, Fan Zhou, Yongwu Li, Ping Wang, Xiulin Jiang, Sha Tian, Wenjun Ren

https://doi.org/10.18632/aging.204426pp 9924—9941

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Qi Ling decoction enhances abiraterone treatment via suppression of autophagy in castration resistant prostate cancer

Yigeng Feng, Hongwen Cao, Zixi Song, Lei Chen, Dan Wang, Renjie Gao

https://doi.org/10.18632/aging.204427pp 9942—9950

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A nomogram for predicting prognosis of multiple myeloma patients based on a ubiquitin-proteasome gene signature

Dexiang Ji, Yong Liu, Wenjie Sun, Qing Shi, Guoan Chen, Zhiwang Song, Yanxia Jiang

https://doi.org/10.18632/aging.204432pp 9951—9968

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Fatty acid metabolism-related signature predicts survival in patients with clear cell renal carcinoma

Rongjiang Wang, Junwen Shen, Yu Chen, Jianguo Gao, Jianxiang Yao

https://doi.org/10.18632/aging.204433pp 9969—9979

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The prognostic value of NLRP1/NLRP3 and its relationship with immune infiltration in human gastric cancer

Ping Wang, Yulan Gu, Jianke Yang, Jiamin Qiu, Yeqiong Xu, Zengxiang Xu, Jiguang Gao, Chuandan Wan

https://doi.org/10.18632/aging.204438pp 9980—10008

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Role of m6A modification and novel circ_0066715/ miR-486-5p/ ETS1 axis in rheumatoid arthritis macrophage polarization progression

Lei Wan, Jian Liu, Chuanbing Huang, Ziheng Zhu, Fangze Li, Guanghan Sun, Kun Wang, Shu Li, Ximeng Ma, Xi Chen, Wang Yuan

https://doi.org/10.18632/aging.204439pp 10009—10026

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High MCM8 expression correlates with unfavorable prognosis and induces immune cell infiltration in hepatocellular carcinoma

Meng Yu, Huaxiang Wang, Hongyang Xu, Yuhang Lv, Qingsong Li

https://doi.org/10.18632/aging.204440pp 10027—10049

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SGOL2 promotes prostate cancer progression by inhibiting RAB1A ubiquitination

Tingting Lv, Dongwei He, Xiaokuan Zhang, Xiaojin Guo, Zijie Li, Aili Zhang, Bo Fan, Zhiyu Wang

https://doi.org/10.18632/aging.204443pp 10050—10066

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Starvation-induced long non-coding RNAs are significant for prognosis evaluation of bladder cancer

Chunlin Zhang, Xuesong Bai, Xiang Peng, Wei Shi, Yang Li, Guo Chen, Haitao Yu, Zhenwei Feng, Yuanzhong Deng

https://doi.org/10.18632/aging.204444pp 10067—10080

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SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells

Zhipeng Tang, Pei Zhao, Wanxing Zhang, Qian Zhang, Ming Zhao, He Tan

https://doi.org/10.18632/aging.204446pp 10081—10092

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Development of a 7-miRNA prognostic signature for patients with bladder cancer

Yingjie Xv, Ming Qiu, Zhaojun Liu, Mingzhao Xiao, Fen Wang

https://doi.org/10.18632/aging.204447pp 10093—10106

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A comprehensive analysis of the FOX family for predicting kidney renal clear cell carcinoma prognosis and the oncogenic role of FOXG1

Wenjie Yang, Hualin Chen, Lin Ma, Jie Dong, Mengchao Wei, Xiaoqiang Xue, Yingjie Li, Zhaoheng Jin, Weifeng Xu, Zhigang Ji

https://doi.org/10.18632/aging.204448pp 10107—10124

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Exosomes derived from human umbilical cord mesenchymal stem cells promote osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis

Shi-Wei Ren, Guang-Qing Cao, Qing-Run Zhu, Min-Gang He, Fang Wu, Su-Mei Kong, Zhao-Yan Zhang, Qiang Wang, Feng Wang

https://doi.org/10.18632/aging.204453pp 10125—10136

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Moderate-vigorous physical activity attenuates premature senescence of immune cells in sedentary adults with obesity: a pilot randomized controlled trial

Xiang-Ke Chen, Chen Zheng, Stephen Heung-Sang Wong, Alvin Chun-Hang Ma

https://doi.org/10.18632/aging.204458pp 10137—10152

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Sevoflurane postconditioning ameliorates cerebral ischemia-reperfusion injury in rats via TLR4/MyD88/TRAF6 signaling pathway

Zijun Zhao, Yishuai Li, Fei Chi, Li Ma, Yanan Li, Zhiyong Hou, Qiujun Wang

https://doi.org/10.18632/aging.204461pp 10153—10170

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The tumor microenvironment in gastrointestinal adenocarcinomas revealed a prognostic and immunotherapeutic biomarker

Yong Zhang, Lu Li, Feifei Chu, Lei Zhang, Li Zhang, Huili Wu, Kunkun Li

https://doi.org/10.18632/aging.204463pp 10171—10216

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