Volume 12, Issue 12

June 30, 2020pp 11161—12431

About the Cover

The cover features Figure 5 "SIRT6 prevents collision between transcription and DSB repair machineries“ from Rezazadeh et al.

Editorials

COVID-19

Reversing immunosenescence for prevention of COVID-19

Robert T. Brooke, Gregory M. Fahy

https://doi.org/10.18632/aging.103636pp 11161—11162

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PANoptosis components, regulation, and implications

R.K. Subbarao Malireddi, Rebecca E. Tweedell, Thirumala-Devi Kanneganti

https://doi.org/10.18632/aging.103528pp 11163—11164

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Priority Research Papers

SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair

Sarallah Rezazadeh, David Yang, Seyed Ali Biashad, Denis Firsanov, Masaki Takasugi, Michael Gilbert, Gregory Tombline, Natarajan V. Bhanu, Benjamin A. Garcia, Andrei Seluanov, Vera Gorbunova

https://doi.org/10.18632/aging.103567pp 11165—11184

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The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

Kelvin Yen, Hemal H. Mehta, Su-Jeong Kim, YanHe Lue, James Hoang, Noel Guerrero, Jenna Port, Qiuli Bi, Gerardo Navarrete, Sebastian Brandhorst, Kaitlyn Noel Lewis, Junxiang Wan, Ronald Swerdloff, Julie A. Mattison, Rochelle Buffenstein, Carrie V. Breton, Christina Wang, Valter Longo, Gil Atzmon, Douglas Wallace, Nir Barzilai, Pinchas Cohen

https://doi.org/10.18632/aging.103534pp 11185—11199

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Endothelin-1 induces cellular senescence and fibrosis in cultured myoblasts. A potential mechanism of aging-related sarcopenia

Elena Alcalde-Estévez, Ana Asenjo-Bueno, Patricia Sosa, Gemma Olmos, Patricia Plaza, María Ángeles Caballero-Mora, Diego Rodríguez-Puyol, María Piedad Ruíz-Torres, Susana López-Ongil

https://doi.org/10.18632/aging.103450pp 11200—11223

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Research Papers

COVID-19

Treatment strategies of hospitalized patients with coronavirus disease-19

Yaxiong Huang, Chunlin Cai, Jinglei Zang, Jun Xie, Dan Xu, Fang Zheng, Tao Zhan, Kang Huang, Yikai Wang, Xiao Wang, Zhe-Yu Hu, Yapeng Deng, Yuanlin Xie

https://doi.org/10.18632/aging.103370pp 11224—11237

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COVID-19

Prognosis analysis of patients with mental disorders with COVID-19: a single-center retrospective study

Yan Wan, Juan Wu, Lihua Ni, Qinqin Luo, Cheng Yuan, Fang Fan, Hong Liu, Changjiang Zhang, Yuandi Xiang, Qin Xie

https://doi.org/10.18632/aging.103371pp 11238—11244

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COVID-19

Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study

Yi Han, Haidong Zhang, Sucheng Mu, Wei Wei, Chaoyuan Jin, Chaoyang Tong, Zhenju Song, Yunfei Zha, Yuan Xue, Guorong Gu

https://doi.org/10.18632/aging.103372pp 11245—11258

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COVID-19

Lessons from a lumbar burst fracture patient infected with SARS-CoV-2

Shuangqi Yu, Hexing Zhang, Wei Chen, Song Wan, Yi Zhang, Xunzheng Xiong, Fan Ding

https://doi.org/10.18632/aging.103414pp 11259—11262

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COVID-19

De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2

Xiaoqiang Huang, Robin Pearce, Yang Zhang

https://doi.org/10.18632/aging.103416pp 11263—11276

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COVID-19

Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response

Jens-Ole Bock, Ignacio Ortea

https://doi.org/10.18632/aging.103524pp 11277—11286

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COVID-19

Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019

Jia-Kui Sun, Wen-Hao Zhang, Lei Zou, Ying Liu, Jing-Jing Li, Xiao-Hua Kan, Lian Dai, Qian-Kun Shi, Shou-Tao Yuan, Wen-Kui Yu, Hong-Yang Xu, Wei Gu, Jian-Wei Qi

https://doi.org/10.18632/aging.103526pp 11287—11295

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COVID-19

Clinical characteristics of older and younger patients infected with SARS-CoV-2

Zhiguo Zhou, Min Zhang, Yali Wang, Fang Zheng, Yaxiong Huang, Kang Huang, Qizhi Yu, Chunlin Cai, Dong Chen, Yi Tian, Jianhua Lei, Xinqiang Xiao, Erik De Clercq, Guangdi Li, Yuanlin Xie, Guozhong Gong

https://doi.org/10.18632/aging.103535pp 11296—11305

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COVID-19

ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19

Guilhem Bousquet, Géraldine Falgarone, David Deutsch, Sophie Derolez, Marilucy Lopez-Sublet, François-Xavier Goudot, Khadaoudj Amari, Yurdagul Uzunhan, Olivier Bouchaud, Frédéric Pamoukdjian

https://doi.org/10.18632/aging.103583pp 11306—11313

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Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age

Daniel R. Machin, Yauling Auduong, Venkateswara R. Gogulamudi, Yu Liu, Md. Torikul Islam, Lisa A. Lesniewski, Anthony J. Donato

https://doi.org/10.18632/aging.103322pp 11314—11324

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CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD⁺/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats

Yoshio Ogura, Munehiro Kitada, Jing Xu, Itaru Monno, Daisuke Koya

https://doi.org/10.18632/aging.103410pp 11325—11336

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Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin

Arantzazu Sierra-Ramirez, José Luis López-Aceituno, Luis Filipe Costa-Machado, Adrián Plaza, Marta Barradas, Pablo Jose Fernandez-Marcos

https://doi.org/10.18632/aging.103607pp 11337—11348

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Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1

Shanshan Jiang, Hui Li, Lianhua Piao, Zheng Jin, Jingyi Liu, Sitong Chen, Luwei Lucy Liu, Yujie Shao, Sheng Zhong, Bo Wu, Weihang Li, Jiaxin Ren, Yu Zhang, Hao Wang, Rihua Jin

https://doi.org/10.18632/aging.103113pp 11349—11363

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Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1α mitochondrial metabolic pathway

Zhen Zhou, Dan Ma, Peifan Li, Ping Wang, Ping Liu, Danna Wei, Jun Wang, Zhong Qin, Qin Fang, Jishi Wang

https://doi.org/10.18632/aging.103174pp 11364—11385

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Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress

Zhihong Wang, Yun Lin, Shang Jin, Tiannan Wei, Zhihai Zheng, Weimin Chen

https://doi.org/10.18632/aging.103186pp 11386—11397

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Immune profiling reveals prognostic genes in high-grade serous ovarian cancer

Yong Wu, Lingfang Xia, Ping Zhao, Yu Deng, Qinhao Guo, Jun Zhu, Xiaojun Chen, Xingzhu Ju, Xiaohua Wu

https://doi.org/10.18632/aging.103199pp 11398—11415

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Comparison of prognostic prediction models for rectal gastrointestinal stromal tumor

Liu Jiaxin, Zhou Peiyun, Tang Zheng, Yuan Wei, Shen Shanshan, Ren Lei, Xing Zhengwen, Fang Yong, Gao Xiaodong, Xue Anwei, Shen Kuntang, Hou Yingyong

https://doi.org/10.18632/aging.103204pp 11416—11430

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Chestnut polysaccharides benefit spermatogenesis through improvement in the expression of important genes

Shuai Yu, Yong Zhao, Fa-Li Zhang, Ya-Qi Li, Wei Shen, Zhong-Yi Sun

https://doi.org/10.18632/aging.103205pp 11431—11445

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microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway

Qin Sun, Jun Zeng, Yang Liu, JingYan Chen, Qing-Cui Zeng, Yan-Qiu Chen, Li-Li Tu, Ping Chen, Fan Yang, Min Zhang

https://doi.org/10.18632/aging.103230pp 11446—11465

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Androgen receptor affects the response to immune checkpoint therapy by suppressing PD-L1 in hepatocellular carcinoma

Guangyi Jiang, Liang Shi, Xueyong Zheng, Xinjie Zhang, Ke Wu, Boqiang Liu, Peijian Yan, Xiao Liang, Tunan Yu, Yifan Wang, Xiujun Cai

https://doi.org/10.18632/aging.103231pp 11466—11484

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CTRP13 attenuates the expression of LN and CAV-1 Induced by high glucose via CaMKKβ/AMPK pathway in rLSECs

Qi Zhang, Xiang’e Niu, Limin Tian, Jing Liu, Ruilan Niu, Jinxing Quan, Jing Yu, Wenyan Lin, Zibing Qian, Peiyun Zeng

https://doi.org/10.18632/aging.103234pp 11485—11499

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COVID-19

Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer

Feng Sun, Ke Wu, Zhixian Yao, Xingyu Mu, Zhong Zheng, Menghao Sun, Yong Wang, Zhihong Liu, Yiyong Zhu

https://doi.org/10.18632/aging.103236pp 11500—11516

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hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis

Shan Li, Fangmin Song, Xu Lei, Jingtao Li, Fang Li, Huabing Tan

https://doi.org/10.18632/aging.103257pp 11517—11529

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Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis

Guanghua Liu, Jingmin Zhou, Yuanlin Piao, Xin Zhao, Yuzhi Zuo, Zhigang Ji

https://doi.org/10.18632/aging.103300pp 11530—11549

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Exosome-transmitted long non-coding RNA SENP3-EIF4A1 suppresses the progression of hepatocellular carcinoma

Jianchu Wang, Jian Pu, Ying Zhang, Tianwei Yao, Zongjiang Luo, Wenchuan Li, Guidan Xu, Juan Liu, Wujun Wei, Yibin Deng

https://doi.org/10.18632/aging.103302pp 11550—11567

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Integrative analysis of miRNAs-mRNAs reveals that miR-182 up-regulation contributes to proliferation and invasion of nasopharyngeal carcinoma by targeting PTEN

Zhaohui Shi, Rushi Wang, Ligui Huang, Xiaodong Chen, Min Xu, Dingjun Zha, Yanhong Ma

https://doi.org/10.18632/aging.103316pp 11568—11578

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Long-term PM_2.5 exposure increases the risk of non-small cell lung cancer (NSCLC) progression by enhancing interleukin-17a (IL-17a)-regulated proliferation and metastasis

Xie Chao, Liu Yi, Li Lan Lan, Han Yun Wei, Dong Wei

https://doi.org/10.18632/aging.103319pp 11579—11602

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Over-expression of microRNA-145 drives alterations in β-adrenergic signaling and attenuates cardiac remodeling in heart failure post myocardial infarction

Zhebo Liu, Bo Tao, Suzhen Fan, Shengyu Cui, Yong Pu, Liqiang Qiu, Hao Xia, Lin Xu

https://doi.org/10.18632/aging.103320pp 11603—11622

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Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis

Jinglan Jin, Huan Liu, Meishan Jin, Wanyu Li, Hongqin Xu, Feng Wei

https://doi.org/10.18632/aging.103324pp 11623—11635

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PLK1 Inhibition alleviates transplant-associated obliterative bronchiolitis by suppressing myofibroblast differentiation

Jizhang Yu, Heng Xu, Jikai Cui, Shanshan Chen, Hao Zhang, Yanqiang Zou, Jing Zhao, Sheng Le, Lang Jiang, Zhang Chen, Hao Liu, Dan Zhang, Jiahong Xia, Jie Wu

https://doi.org/10.18632/aging.103330pp 11636—11652

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Long non-coding RNA RP11-59H7.3 promotes cell proliferation and invasion metastasis in colorectal cancer by miR-139-5p/NOTCH1 axis

Xiaojian Zhu, Chen Luo, Fanqin Bu, Kang Lin, Zhengming Zhu

https://doi.org/10.18632/aging.103331pp 11653—11666

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M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT

Guang-Zhao Huang, Qing-Qing Wu, Ze-Nan Zheng, Ting-Ru Shao, Yue-Chuan Chen, Wei-Sen Zeng, Xiao-Zhi Lv

https://doi.org/10.18632/aging.103333pp 11667—11684

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Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2

Cheng Chen, Meng Wei, Chao Wang, Danping Sun, Peng Liu, Xin Zhong, Wenbin Yu

https://doi.org/10.18632/aging.103334pp 11685—11697

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Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway

Yueqi Chen, Yiran Wang, Junxian Hu, Yong Tang, Zhansong Tian, Wenhui Hu, Fanchun Zeng, Jiulin Tan, Qijie Dai, Zhiyong Hou, Fei Luo, Jianzhong Xu, Shiwu Dong

https://doi.org/10.18632/aging.103337pp 11698—11716

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Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling

Hanhan Dai, Minjing Li, Wei Yang, Xiucui Sun, Peiyuan Wang, Xia Wang, Jiaqi Su, Xu Wang, Xuemei Hu, Mingdong Zhao

https://doi.org/10.18632/aging.103338pp 11717—11731

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Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway

Sunli Hu, Zhenxuan Shao, Chenxi Zhang, Liang Chen, Abdullah Al Mamun, Ning Zhao, Jinfeng Cai, Zhiling Lou, Xiangyang Wang, Jiaoxiang Chen

https://doi.org/10.18632/aging.103339pp 11732—11753

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miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity

Yu Zhuang, Shouguo Wang, Haodong Fei, Feng Ji, Peng Sun

https://doi.org/10.18632/aging.103341pp 11754—11767

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L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model

Zhou Zeng, Xiyu Gong, Zhiping Hu

https://doi.org/10.18632/aging.103342pp 11768—11780

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Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions

Zhezhi Deng, Li Zhou, Yuge Wang, Siyuan Liao, Yinong Huang, Yilong Shan, Sha Tan, Qin Zeng, Lisheng Peng, Haiwei Huang, Zhengqi Lu

https://doi.org/10.18632/aging.103348pp 11781—11793

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GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of α2M

Chang Liu, Zhi Li, Lu Xu, Yu Shi, Xiaojie Zhang, Sha Shi, Kezuo Hou, Yibo Fan, Ce Li, Xiaoxun Wang, Lu Zhou, Yunpeng Liu, Xiujuan Qu, Xiaofang Che

https://doi.org/10.18632/aging.103349pp 11794—11811

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FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma

Usama Khamis Hussein, Sang Hoon Ha, Asmaa Gamal Ahmed, Kyoung Min Kim, See-Hyoung Park, Chan Young Kim, Keun Sang Kwon, Zhongkai Zhang, Sang-A Lee, Ho Sung Park, Byung-Hyun Park, Ho Lee, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Kyu Yun Jang

https://doi.org/10.18632/aging.103351pp 11812—11834

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Anticoagulation delay does not affect the functional outcome of cerebral venous thrombosis

Kangxiang Ji, Longfei Wu, Wenbo Zhao, Chuanjie Wu, Yaoming Xu, Jiangang Duan, Ran Meng, Feng Yan, Jian Chen, Di Wu, Yinghao Luo, Xunming Ji

https://doi.org/10.18632/aging.103353pp 11835—11842

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Serum exosomal long noncoding RNAs lnc-FAM72D-3 and lnc-EPC1-4 as diagnostic biomarkers for hepatocellular carcinoma

Zhicheng Yao, Changchang Jia, Yan Tai, Hao Liang, Zhaozhong Zhong, Zhiyong Xiong, Meihai Deng, Qi Zhang

https://doi.org/10.18632/aging.103355pp 11843—11863

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Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia

Si-Liang Chen, Fang Hu, Da-Wei Wang, Zhe-Yuan Qin, Yang Liang, Yu-Jun Dai

https://doi.org/10.18632/aging.103357pp 11864—11877

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Development and validation of a risk score for predicting mortality after resection of primary hepatocellular carcinoma

Xiang Zhou, Bin-Bin Cai, Xiang-Qing Hou, Xing-Kai Kang, Xiang-Xiang Xu, Wei-Ming Wang

https://doi.org/10.18632/aging.103360pp 11878—11892

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Association of the NCAN-TM6SF2-CILP2-PBX4-SUGP1-MAU2 SNPs and gene-gene and gene-environment interactions with serum lipid levels

Guo-Xiong Deng, Rui-Xing Yin, Yao-Zong Guan, Chun-Xiao Liu, Peng-Fei Zheng, Bi-Liu Wei, Jin-Zhen Wu, Liu Miao

https://doi.org/10.18632/aging.103361pp 11893—11913

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Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study

Jovia L. Nierenberg, Jiang He, Changwei Li, Xiaoying Gu, Mengyao Shi, Alexander C. Razavi, Xuenan Mi, Shengxu Li, Lydia A. Bazzano, Amanda H. Anderson, Hua He, Wei Chen, Jack M. Guralnik, Jason M. Kinchen, Tanika N. Kelly

https://doi.org/10.18632/aging.103362pp 11914—11941

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Biomarkers of aging and lung function in the normative aging study

Cuicui Wang, Allan Just, Jonathan Heiss, Brent A. Coull, Lifang Hou, Yinan Zheng, David Sparrow, Pantel S. Vokonas, Andrea Baccarelli, Joel Schwartz

https://doi.org/10.18632/aging.103363pp 11942—11966

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Establishment of a novel risk score model by comprehensively analyzing the immunogen database of bladder cancer to indicate clinical significance and predict prognosis

Lingyun Liu, Jinghai Hu, Yu Wang, Tao Sun, Xiang Zhou, Xinyuan Li, Fuzhe Ma

https://doi.org/10.18632/aging.103364pp 11967—11989

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The impact of the cumulative burden of LDL-c and hs-CRP on cardiovascular risk: a prospective, population-based study

Jinglin Mo, Zimo Chen, Jie Xu, Anxin Wang, Xia Meng, Xingquan Zhao, Hao Li, Shouling Wu, Yongjun Wang

https://doi.org/10.18632/aging.103365pp 11990—12001

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Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway

Feng Wei, Aixue Wang, Qing Wang, Wenrui Han, Rong Rong, Lijuan Wang, Sijia Liu, Yimeng Zhang, Chao Dong, Yanling Li

https://doi.org/10.18632/aging.103366pp 12002—12018

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APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly

Jinping Sun, Zhibao Zhu, Kewei Chen, Dongfeng Wei, Xin Li, He Li, Junying Zhang, Xiaochun Chen, Yaojing Chen, Zhanjun Zhang

https://doi.org/10.18632/aging.103367pp 12019—12031

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CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses

Di Wang, Juan Du, Yangzi Song, Beibei Wang, Rui Song, Yu Hao, Yongqin Zeng, Jiang Xiao, Hong Zheng, Hui Zeng, Hongxin Zhao, Yaxian Kong

https://doi.org/10.18632/aging.103368pp 12032—12050

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Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer

Yuxuan Song, Donghui Jin, Jingyi Chen, Zhiwen Luo, Guangyuan Chen, Yongjiao Yang, Xiaoqiang Liu

https://doi.org/10.18632/aging.103369pp 12051—12073

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Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9

Zhixian Xu, Tie Ke, Yongfa Zhang, Chaofeng Fu, Wubing He

https://doi.org/10.18632/aging.103375pp 12074—12085

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CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6

Tao Gong, Yu Li, Liang Feng, MingZhi Fang, Guoliang Dai, Xin Huang, Ye Yang, Shenlin Liu

https://doi.org/10.18632/aging.103376pp 12086—12106

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MiR-126 promotes esophageal squamous cell carcinoma via inhibition of apoptosis and autophagy

Mingli Li, Xiangli Meng, Mingxuan Li

https://doi.org/10.18632/aging.103379pp 12107—12118

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Serum proteomic predicts effectiveness and reveals potential biomarkers for complications in liver transplant patients

Wenjing Wang, Bo Wang, Chang Liu, Jing Yan, Xiaofan Xiong, Xiaofei Wang, Juan Yang, Bo Guo, Chen Huang

https://doi.org/10.18632/aging.103381pp 12119—12141

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Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice

Fanlin Zhou, Xiaomin Xiong, Shijie Li, Jie Liang, Xiong Zhang, Mingyuan Tian, Xiaoju Li, Minna Gao, Li Tang, Yu Li

https://doi.org/10.18632/aging.103382pp 12142—12159

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ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway

Ting Xin, Wei Lv, Dongmei Liu, Yongle Jing, Fang Hu

https://doi.org/10.18632/aging.103386pp 12160—12174

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Combined impact of body mass index and glycemic control on the efficacy of clopidogrel-aspirin therapy in patients with minor stroke or transient ischemic attack

Zimo Chen, Jinglin Mo, Jie Xu, Anxin Wang, Haiqiang Qin, Huaguang Zheng, Liping Liu, Xia Meng, Hao Li, Yongjun Wang

https://doi.org/10.18632/aging.103394pp 12175—12186

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Identification of immunological subtypes of hepatocellular carcinoma with expression profiling of immune-modulating genes

Di Cao, Meng-Ke Chen, Qing-Feng Zhang, Yu-Feng Zhou, Mei-Yin Zhang, Shi-Juan Mai, Yao-Jun Zhang, Min-Shan Chen, Xiao-Xing Li, Hui-Yun Wang

https://doi.org/10.18632/aging.103395pp 12187—12205

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Prenatal famine exposure and estimated glomerular filtration rate across consecutive generations: association and epigenetic mediation in a population-based cohort study in Suihua China

Wenbo Jiang, Tianshu Han, Wei Duan, Qiuying Dong, Wanying Hou, Huanyu Wu, Yue Wang, Zehui Jiang, Xinyi Pei, Yingying Chen, Ying Li, Changhao Sun

https://doi.org/10.18632/aging.103397pp 12206—12221

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ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants

Chia-Ling Kuo, Luke C. Pilling, Janice L. Atkins, George A. Kuchel, David Melzer

https://doi.org/10.18632/aging.103405pp 12222—12233

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A new risk model comprising genes highly correlated with CD133 identifies different tumor-immune microenvironment subtypes impacting prognosis in hepatocellular carcinoma

Huajian Yu, Xiaoqiang Zhu, Hechun Lin, Hongyu Pan, Fangyu Zhao, Miaoxin Zhu, Lei Sun, Wenjun Chai, Ming Yao, Mingxia Yan

https://doi.org/10.18632/aging.103409pp 12234—12250

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Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer’s disease after 2 years of survival

Lidija Radenovic, Marija Nenadic, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J. Czuczwar, Pavle R. Andjus, Ryszard Pluta

https://doi.org/10.18632/aging.103411pp 12251—12267

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Infertility induced by auxin in PX627 Caenorhabditis elegans does not affect mitochondrial functions and aging parameters

Benjamin Dilberger, Stefan Baumanns, Salome T. Spieth, Uwe Wenzel, Gunter P. Eckert

https://doi.org/10.18632/aging.103413pp 12268—12284

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Influences of circulatory factors on intervertebral disc aging phenotype

Changbin Lei, Debora Colangelo, Prashanti Patil, Vivian Li, Kevin Ngo, Dong Wang, Qing Dong, Matthew J. Yousefzadeh, Hongsheng Lin, Joon Lee, James Kang, Gwendolyn Sowa, Tony Wyss-Coray, Laura J. Niedernhofer, Paul D. Robbins, Derek M. Huffman, Nam Vo

https://doi.org/10.18632/aging.103421pp 12285—12304

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Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis

Biao Song, Xiaofeng Li, Qingqing Xu, Suqin Yin, Sha Wu, Xiaoming Meng, Cheng Huang, Jun Li

https://doi.org/10.18632/aging.103422pp 12305—12323

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Ovarian aging increases small extracellular vesicle CD81⁺ release in human follicular fluid and influences miRNA profiles

Rosalia Battaglia, Paolo Musumeci, Marco Ragusa, Davide Barbagallo, Marina Scalia, Massimo Zimbone, Josè Maria Lo Faro, Placido Borzì, Paolo Scollo, Michele Purrello, Elena Maria Vento, Cinzia Di Pietro

https://doi.org/10.18632/aging.103441pp 12324—12341

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Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome

Raneem Habib, Ryong Kim, Heidemarie Neitzel, Ilja Demuth, Krystyna Chrzanowska, Eva Seemanova, Renaldo Faber, Martin Digweed, Reinhard Voss, Kathrin Jäger, Karl Sperling, Michael Walter

https://doi.org/10.18632/aging.103453pp 12342—12375

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Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects

Milja Honkonen, Kati Vääräniemi, Outi Saijonmaa, Anna Nyman, Antti J. Tikkakoski, Jenni Koskela, Terho Lehtimäki, Mika Kähönen, Jukka Mustonen, Frej Fyhrquist, Ilkka Pörsti

https://doi.org/10.18632/aging.103459pp 12376—12392

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