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Research Paper|Volume 12, Issue 12|pp 11238—11244

Prognosis analysis of patients with mental disorders with COVID-19: a single-center retrospective study

Yan Wan1, Juan Wu2, Lihua Ni3, Qinqin Luo4, Cheng Yuan5, Fang Fan1, Hong Liu1, Changjiang Zhang6, Yuandi Xiang7, Qin Xie1
  • 1Psychosis Intensive Care Unit, Affiliated Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
  • 2Department of Dermatology, Wuhan First Hospital, Wuhan, Hubei, China
  • 3Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
  • 4Department of Traditional Chinese Medicine, Wuhan First Hospital, Wuhan, Hubei, China
  • 5Department of Gynecologic Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
  • 6Department of Cardiology, Enshi Tujia and Miao Autonomous Prefecture Central Hospital, Enshi, PR China
  • 7Department of Otorhinolaryngology, Wuhan First Hospital, Wuhan, Hubei, China
* Equal contribution
Received: April 19, 2020Accepted: May 14, 2020Published: June 19, 2020
https://doi.org/10.18632/aging.103371

Copyright © 2020 Wan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Our study aimed to investigate the factors affecting the prognosis of patients with mental disorders with COVID-19. All patients with mental disorders who were diagnosed with COVID-19 at the intensive care unit of Wuhan Mental Health Center during the period January 3 to March 1, 2020 were selected. The influence of the baseline characteristics, clinical symptoms, laboratory parameters and the types of mental disorders on prognosis were analyzed. According to their final prognosis, the patients were divided into the deceased group (5 patients) and the cured group (25 patients). The mortality rate of patients with dementia was significantly higher than that of patients with other mental disorders (P = 0.001). The levels of certain laboratory parameters in the serum of dementia patients were significantly increased compared with levels in nondementia patients (WBC count: 10.100±6.147 vs. 5.694±3.383, p = 0.029; neutrophil count: 8.504± 5.993 vs. 3.764 ± 2.733, P = 0.008; BUN: 8.300± 4.072 vs. 4.364 ± 1.196, P = 0.001). Our research indicated that the mortality rate of dementia patients with COVID-19 was higher than that of patients with other mental disorders. A focus on the inflammatory response of dementia patients may provide novel ideas for reducing mortality.