Volume 15, Issue 14

July 31, 2023pp 6622—7333

About the Cover

The cover features Figure 4 "The secretome of senescent human lung fibroblasts as mediator of murine lung fibrosis" from Hernandez-Gonzalez et al.

Editorials

The impact of frailty on the management of atrial fibrillation

Stephanie L. Harrison, Søren P. Johnsen, Gregory Y.H. Lip

https://doi.org/10.18632/aging.204918pp 6622—6624

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Peritoneal signalling improves hippocampal BDNF expression in aged mice

Yoshinori Takei, Yoko Amagase, Atsushi Sugiyama

https://doi.org/10.18632/aging.204919pp 6625—6626

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The theory of orchid and dandelion offers a new subtyping framework for cognitive aging

Sylvain Moreno, Emma Rodrigues, Faranak Farzan

https://doi.org/10.18632/aging.204955pp 6627—6628

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A novel theory of ageing independent of damage accumulation

James Wordsworth, Daryl Shanley

https://doi.org/10.18632/aging.204956pp 6629—6631

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Research Perspective

Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?

Mikhail V. Blagosklonny

https://doi.org/10.18632/aging.204920pp 6632—6640

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Research Papers

Human senescent fibroblasts trigger progressive lung fibrosis in mice

Fernanda Hernandez-Gonzalez, Neus Prats, Valentina Ramponi, José Alberto López-Domínguez, Kathleen Meyer, Mònica Aguilera, María Isabel Muñoz Martín, Daniel Martínez, Alvar Agusti, Rosa Faner, Jacobo Sellarés, Federico Pietrocola, Manuel Serrano

https://doi.org/10.18632/aging.204825pp 6641—6657

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Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span

Natalya Kaverina, R. Allen Schweickart, Gek Cher Chan, Joseph C. Maggiore, Diana G. Eng, Yuting Zeng, Sierra R. McKinzie, Hannah S. Perry, Adilijiang Ali, Christopher O’Connor, Beatriz Maria Veloso Pereira, Ashleigh B. Theberge, Joshua C. Vaughan, Carol J. Loretz, Anthony Chang, Neil A. Hukriede, Markus Bitzer, Jeffrey W. Pippin, Oliver Wessely, Stuart J. Shankland

https://doi.org/10.18632/aging.204897pp 6658—6689

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Parallel shift of DNA methylation and gene expression toward the mean in mouse spleen with aging

Sangkyun Jeong, Sunwha Cho, Seung Kyoung Yang, Soo A. Oh, Yong-Kook Kang

https://doi.org/10.18632/aging.204903pp 6690—6709

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Sirt3 regulates NLRP3 and participates in the effects of plantainoside D on acute lung injury sepsis

Jing Wang, Wanrong Li, Fang Zhao, Qianqian Han, Lingling Shan, Yumei Qian

https://doi.org/10.18632/aging.204628pp 6710—6720

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Th1 promotes M1 polarization of intestinal macrophages to regulate colitis-related mucosal barrier damage

Shuiliang Ruan, Liang Xu, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Caiqun Zhang, Li Guo, Wenyan Li, Chenyang Han

https://doi.org/10.18632/aging.204629pp 6721—6735

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Establishing a prognostic model based on five starvation-related long non-coding RNAs for clear cell renal cell carcinoma

Zhou Yu, Guo Chen, Zhenwei Feng, Yang Li, Haitao Yu, Wei Shi, Xin Gou, Chunlin Zhang, Xiang Peng

https://doi.org/10.18632/aging.204816pp 6736—6748

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Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng

Ke Xu, Biwen Hu, Xuhui Ding, Zhengyu Zhan

https://doi.org/10.18632/aging.204819pp 6749—6756

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PARP10 is highly expressed and associated with inferior outcomes in acute myeloid leukemia

Ling Wang, Chuang Jiang, Dandan Hu

https://doi.org/10.18632/aging.204832pp 6757—6773

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Prognostic analysis of lung adenocarcinoma based on cancer-associated fibroblasts genes using scRNA-sequencing

Han Zhang, Yuhang Wang, Kai Wang, Yun Ding, Xin Li, Shuai Zhao, Xiaoteng Jia, Daqiang Sun

https://doi.org/10.18632/aging.204838pp 6774—6797

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Molecular subtypes based on DNA sensors predict prognosis and tumor immunophenotype in hepatocellular carcinoma

Hong-Sheng Lin, Wen-Peng Pang, Hao Yuan, Yin-Zhi Kong, Fu-Li Long, Rong-Zhen Zhang, Li Yang, Qiao-Ling Fang, Ai-Ping Pan, Xiao-Hui Fan, Ming-Fen Li

https://doi.org/10.18632/aging.204870pp 6798—6821

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S14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway

Bo Su, Ran Li, Fuxing Song, Min Liu, Xianjun Sun

https://doi.org/10.18632/aging.204874pp 6822—6833

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Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis

Xiaohua Zhu, Linjie Yang, Xu Han, Chen Huang, Gongcheng Huang, Tingju Wei, Liliang Shu, Jing Xu

https://doi.org/10.18632/aging.204875pp 6834—6847

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The integration of machine learning and multi-omics analysis provides a powerful approach to screen aging-related genes and predict prognosis and immunotherapy efficacy in hepatocellular carcinoma

Jiahui Shen, Han Gao, Bowen Li, Yan Huang, Yinfang Shi

https://doi.org/10.18632/aging.204876pp 6848—6864

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Comprehensive analysis of the role of a four-gene signature based on EMT in the prognosis, immunity, and treatment of lung squamous cell carcinoma

Feng Li, Hui Wang, Can Wang, Yun Li, Jing-Yan Song, Ke-Yi Fan, Chao Li, Quan-Lin Ma, Qi Yu, Shuang-Ping Zhang

https://doi.org/10.18632/aging.204878pp 6865—6893

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Celastrol impairs tumor growth by modulating the CIP2A-GSK3β-MCL-1 axis in gastric cancer cells

Jin Wu, Feng Ye, Tao Xu

https://doi.org/10.18632/aging.204879pp 6894—6904

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Exosome-coated polydatin nanoparticles in the treatment of radiation-induced intestinal damage

Qiu Chen, Lei Yao, Quanbin Liu, Jun Hou, Xinyu Qiu, Mengyuan Chen, Zhuojun Wu, Duanmin Hu, Fengmei Cui, Tao Yan

https://doi.org/10.18632/aging.204882pp 6905—6920

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Exosomal lnc-CDHR derived from human umbilical cord mesenchymal stem cells attenuates peritoneal epithelial-mesenchymal transition through AKT/FOXO pathway

Taiwei Jiao, Yuling Huang, Haiyan Sun, Lina Yang

https://doi.org/10.18632/aging.204883pp 6921—6932

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Combined surface functionalization of MSC membrane and PDA inhibits neurotoxicity induced by Fe₃O₄ in mice based on apoptosis and autophagy through the ASK1/JNK signaling pathway

Yang Li, Te Liu, Xiuying Li, Modi Yang, Tianxin Liu, Jindian Bao, Miao Jiang, Lingling Hu, Yuzhuo Wang, Pu Shao, Jinlan Jiang

https://doi.org/10.18632/aging.204884pp 6933—6949

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Single-cell sequencing analysis reveals the relationship between tumor microenvironment cells and oxidative stress in breast cancer bone metastases

Minmin Zhang, Xiao Chai, Li Wang, Ke Mo, Wenyang Chen, Xiangtao Xie

https://doi.org/10.18632/aging.204885pp 6950—6968

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Characterization of platelet-related genes and constructing signature combined with immune-related genes for predicting outcomes and immunotherapy response in lung squamous cell carcinoma

Siyi Zhao, Han Gong, Wenhua Liang

https://doi.org/10.18632/aging.204886pp 6969—6992

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miRNA-186-5p inhibits migration, invasion and proliferation of breast cancer cells by targeting SBEM

Hui Hao, Bingsheng Wang, Lin Yang, Yinzhou Sang, Wei Xu, Wei Liu, Lili Zhang, Da Jiang

https://doi.org/10.18632/aging.204887pp 6993—7007

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KNTC1 and MCM2 are the molecular targets of gallbladder cancer

Wei Jia, Chao Wang

https://doi.org/10.18632/aging.204889pp 7008—7022

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Single-cell transcriptomics reveals the drivers and therapeutic targets of lymph node metastasis in lung adenocarcinoma

Xin Ji, Zihao Wang, Guige Wang, Lijun Tang, Zhijun Han

https://doi.org/10.18632/aging.204890pp 7023—7037

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Exploring molecular markers and drug candidates for colorectal cancer through comprehensive bioinformatics analysis

Guangyao Li, JiangPeng Zhu, Lulu Zhai

https://doi.org/10.18632/aging.204891pp 7038—7055

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Identifying the oncogenic roles of FAP in human cancers based on systematic analysis

Chao Ma, Shuaishuai Xi, He Sun, Meng Zhang, Yuanmin Pei

https://doi.org/10.18632/aging.204892pp 7056—7083

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Severe pneumonia induces immunosenescence of T cells in the lung of mice

Qingle Ma, Chenhui Weng, Chenlu Yao, Jialu Xu, Bo Tian, Yi Wu, Heng Wang, Qianyu Yang, Huaxing Dai, Yue Zhang, Fang Xu, Xiaolin Shi, Chao Wang

https://doi.org/10.18632/aging.204893pp 7084—7097

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Comparative analyses of the prognosis, tumor immune microenvironment, and drug treatment response between left-sided and right-sided colon cancer by integrating scRNA-seq and bulk RNA-seq data

Lichao Cao, Shenrui Zhang, Danni Yao, Ying Ba, Qi Weng, Jin Yang, Hezi Zhang, Yanan Ren

https://doi.org/10.18632/aging.204894pp 7098—7123

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A novel LncRNA SPIRE1/miR-181a-5p/PRLR axis in mandibular bone marrow–derived mesenchymal stem cells regulates the Th17/Treg immune balance through the JAK/STAT3 pathway in periodontitis

Bingyi Shao, Duo Zhou, Jie Wang, Deqin Yang, Jing Gao

https://doi.org/10.18632/aging.204895pp 7124—7145

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Combining WGCNA and machine learning to construct immune-related EMT patterns to predict HCC prognosis and immune microenvironment

Yating Sun, Shengfu He, Mingyang Tang, Ding Zhang, Bao Meng, Jiawen Yu, Yanyan Liu, Jiabin Li

https://doi.org/10.18632/aging.204898pp 7146—7160

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Identification and validation of a novel overall survival prediction model for immune-related genes in bone metastases of prostate cancer

Wen Bi, Weiming Guo, Gang Fan, Lei Xie, Changqing Jiang

https://doi.org/10.18632/aging.204900pp 7161—7186

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Identification of TGF-β-related genes in cardiac hypertrophy and heart failure based on single cell RNA sequencing

Kai Huang, Hao Wu, Xiangyang Xu, Lujia Wu, Qin Li, Lin Han

https://doi.org/10.18632/aging.204901pp 7187—7218

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Metastasis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma

Sen Qin, Lei Li, Da Liu

https://doi.org/10.18632/aging.204902pp 7219—7236

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Non-SMC condensin I complex subunit D2 (NCAPD2) reveals its prognostic and immunologic features in human cancers

Xiaoying Dong, Ting Liu, Zhizhao Li, Yongzhen Zhai

https://doi.org/10.18632/aging.204904pp 7237—7257

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The lipid peroxidation-derived DNA adduct γ-OHPdG as a diagnostic and prognostic biomarker in hepatocellular carcinoma

Qiwei Cao, Yazhou Zhang, Hongtao Liu, Yuxia Cheng, Mingxin Liu, Hai Zhao, Ruixue Tang, Junying Sun, Sophia Xu, Bing Sun, Qing Sun

https://doi.org/10.18632/aging.204910pp 7258—7277

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Active components and molecular mechanisms of Sagacious Confucius’ Pillow Elixir to treat cognitive impairment based on systems pharmacology

Zhitao Hou, Xinyu Yang, Ling Jiang, Liying Song, Yang Li, Dongdong Li, Yanning Che, Xiuling Zhang, Zhongren Sun, Hongcai Shang, Jing Chen

https://doi.org/10.18632/aging.204912pp 7278—7307

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Subcellular localization of nucleolar protein 14 and its proliferative function mediated by miR-17-5p and E2F4 in pancreatic cancer

Yong-Xing Du, Ying Zhou, Xiao-Hao Zheng, Yun-Jie Duan, Zong-Ting Gu, Ye-Feng Yin, Cheng-Feng Wang

https://doi.org/10.18632/aging.204915pp 7308—7323

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Review

The Eph/Ephrin system in primary bone tumor and bone cancer pain

Lujuan Wang, Wei Li, Yong Pan

https://doi.org/10.18632/aging.204852pp 7324—7332

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Retraction

Retraction: CircNF1-419 improves the gut microbiome structure and function in AD-like mice

Chen Diling, Qi Longkai, Guo Yinrui, Liu Yadi, Tang Xiaocui, Zhu Xiangxiang, Zeng Miao, Li Ran, Shuai Ou, Wang Dongdong, Xie Yizhen, Yuan Xujiang, Burton B. Yang, Wu Qingping

https://doi.org/10.18632/aging.204905pp 7333

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