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Research Paper|Volume 15, Issue 14|pp 6749—6756

Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng

Ke Xu1, Biwen Hu3, Xuhui Ding3, Zhengyu Zhan2
  • 1Department of Clinical Medicine, Medical College of Nanchang University, Nanchang 330000, Jiangxi Province, P.R. China
  • 2Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, P.R. China
  • 3Department of Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314001, Zhejiang Province, P.R. China
Received: April 7, 2023Accepted: May 31, 2023Published: June 21, 2023
https://doi.org/10.18632/aging.204819

Copyright: © 2023 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

To investigate the mechanism by which ginsenoside Rg3 regulates oxidative stress (OS) and inflammation through NF/KB pathway to delay mouse liver injury.

This work randomized Balbc mice as four groups: Normal, D-gal, Rg3-L, Rg3-H. Paraffin-embedded liver tissue sections were prepared, later, BAX/BCL-2 protein expression was observed by HE, Sirius red, TUNEL and immunofluorescence to detect apoptotic injury and α-SMA/TGF-β protein expression to detect fibrosis, and liver inflammation-related protein NF-KB was detected.

HE and TUNEL staining showed that Rg3 reduced necrotic cells and fibrosis in liver-injured mice, Rg3 increased anti-inflammatory cytokine IL-18 and reduced TNF-α, IL-1β and IL-6 expression. Conclusion: Ginsenoside Rg3 can effectively antagonize D-gal’s role in mouse liver injury, and its mechanism may be associated with regulating inflammatory pathway by Rg.