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The cover features Figure 2 "COVID-19 as a gerophilic and gerolavic infection“ from Zhavoronkov

Volume 12, Issue 8

30 April, 2020
pp 6490—7613

About the Cover

The cover features Figure 2 "COVID-19 as a gerophilic and gerolavic infection“ from Zhavoronkov


Explore This Issue

Editorial

COVID-19
Biomarkers of biological age as predictors of COVID-19 disease severity

Gordan Lauc, David Sinclair,
https://doi.org/10.18632/aging.103052 pp 6490—6491
PDF How to Cite Special Collection on COVID-19 Part 1

Research Perspectives

COVID-19
Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections

Alex Zhavoronkov,
https://doi.org/10.18632/aging.102988 pp 6492—6510
View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 1

COVID-19
COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

Camillo Sargiacomo, Federica Sotgia, Michael P. Lisanti,
https://doi.org/10.18632/aging.103001 pp 6511—6517
View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 1

Research Papers

COVID-19
ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19

Jing Yang, Hongxia Li, Shengda Hu, Yafeng Zhou,
https://doi.org/10.18632/aging.103100 pp 6518—6535
View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 1

COVID-19
Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19

Libo Zhang, Rongrong Pang, Xiang Xue, Jingjing Bao, Sheng Ye, Yudong Dai, Yishan Zheng, Qiang Fu, Zhiliang Hu, Yongxiang Yi,
https://doi.org/10.18632/aging.103102 pp 6536—6542
View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 1

Long non-coding RNA ANRIL alleviates H2O2-induced injury by up-regulating microRNA-21 in human lens epithelial cells

Shanshan Du, Jingzhi Shao, Ying Qi, Xuhui Liu, Jingjing Liu, Fengyan Zhang,
https://doi.org/10.18632/aging.102800 pp 6543—6557
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Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration

Yang Hou, Guodong Shi, Yongfei Guo, Jiangang Shi,
https://doi.org/10.18632/aging.102909 pp 6558—6569
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Long non-coding RNA MALAT1 exacerbates acute respiratory distress syndrome by upregulating ICAM-1 expression via microRNA-150-5p downregulation

Meng-Ying Yao, Wei-Hong Zhang, Wen-Tao Ma, Qiu-Hong Liu, Li-Hua Xing, Gao-Feng Zhao,
https://doi.org/10.18632/aging.102953 pp 6570—6585
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The expression of PDGF-BB predicts curative effect in locally advanced esophageal squamous cell carcinoma treated by radiotherapy

Puchun Er, Dong Qian, Wencheng Zhang, Baozhong Zhang, Hui Wei, Tian Zhang, Xi Chen, Yuwen Wang, Jingjing Zhao, Qi Wang, Qingsong Pang, Ping Wang,
https://doi.org/10.18632/aging.102993 pp 6586—6599
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PHTF2 regulates lipids metabolism in gastric cancer

Yuhua Chi, Haiyan Wang, Fengsong Wang, Mingcui Ding,
https://doi.org/10.18632/aging.102995 pp 6600—6610
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Heme oxygenase-1 inhibition mediates Gas6 to enhance bortezomib-sensitivity in multiple myeloma via ERK/STAT3 axis

Zhaoyuan Zhang, Weili Wang, Dan Ma, Jie Xiong, Xingyi Kuang, Siyu Zhang, Qin Fang, Jishi Wang,
https://doi.org/10.18632/aging.102996 pp 6611—6629
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γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling

Yen-Shuo Chiu, Jia-Lin Wu, Chi-Tai Yeh, Vijesh Kumar Yadav, Hsu-Shan Huang, Liang-Shun Wang,
https://doi.org/10.18632/aging.103003 pp 6630—6643
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LncRNA Sox2OT-V7 promotes doxorubicin-induced autophagy and chemoresistance in osteosarcoma via tumor-suppressive miR-142/miR-22

Kewei Zhu, Yang Yuan, Jie Wen, Ding Chen, Weihong Zhu, Zhengxiao Ouyang, Wanchun Wang,
https://doi.org/10.18632/aging.103004 pp 6644—6666
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Ultraconserved element uc.333 increases insulin sensitivity by binding to miR-223

Yang Zhang, Jingyu Sun, He Yao, Yajun Lin, Jie Wei, Gang Hu, Jun Guo, Jian Li,
https://doi.org/10.18632/aging.103020 pp 6667—6679
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Long intergenic non-protein coding RNA 324 prevents breast cancer progression by modulating miR-10b-5p

Bo Wang, Yangyang Zhang, Haitian Zhang, Faquan Lin, Qixin Tan, Qinghong Qin, Wei Bao, Yi Liu, Jiaying Xie, Qiyan Zeng,
https://doi.org/10.18632/aging.103021 pp 6680—6699
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Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21WAF1-PKCζ pathway in p16INK4a-silenced cells

Yun Yeong Lee, Yeon Seung Choi, Do Wan Kim, Jae Youn Cheong, Kye Yong Song, Min Sook Ryu, In Kyoung Lim,
https://doi.org/10.18632/aging.103029 pp 6700—6732
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Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence

Yongtao Wang, Tao Yu, Yanying Zhou, Shike Wang, Xunian Zhou, Limin Wang, Tianmiao Ou, Yixin Chen, Yawen Zhou, Huizhen Zhang, Ying Wang, Xiaomei Fan, Pan Chen, Frank J. Gonzalez, Aiming Yu, Peng Huang, Min Huang, Huichang Bi,
https://doi.org/10.18632/aging.103033 pp 6733—6755
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Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B

Jun Cui, Haiyan Wang, Xiaohe Zhang, Xiaodong Sun, Jin Zhang, Jinji Ma,
https://doi.org/10.18632/aging.103036 pp 6756—6773
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circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis

Yun Liu, Yue Chang, Yixuan Cai,
https://doi.org/10.18632/aging.103037 pp 6774—6792
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LINC00514 drives osteosarcoma progression through sponging microRNA-708 and consequently increases URGCP expression

Dapeng Yu, Xiangyan Xu, Sufen Li, Kai Zhang,
https://doi.org/10.18632/aging.103043 pp 6793—6807
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FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/β-catenin pathway

Xin Zhang, Jiapeng Xu, Ronglin Yan, Yu Zhang, Zunqi Hu, Hongbing Fu, Qing You, Qingping Cai, Dejun Yang,
https://doi.org/10.18632/aging.103044 pp 6808—6822
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Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21

Laura Mercurio, Daniela Lulli, Francesca Mascia, Elena Dellambra, Claudia Scarponi, Martina Morelli, Carola Valente, Maria Luigia Carbone, Sabatino Pallotta, Giampiero Girolomoni, Cristina Albanesi, Saveria Pastore, Stefania Madonna,
https://doi.org/10.18632/aging.103045 pp 6823—6851
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Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus

Jing-Ying Lin, Wei-Wen Kuo, Rathinasamy Baskaran, Chia-Hua Kuo, Yun-An Chen, William Shao-Tsu Chen, Tsung-Jung Ho, Cecilia Hsuan Day, B. Mahalakshmi, Chih-Yang Huang,
https://doi.org/10.18632/aging.103046 pp 6852—6864
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Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation

Chen Yang, Qiong Li, Xinan Chen, Zheyu Zhang, Zezhong Mou, Fangdie Ye, Shengming Jin, Xiang Jun, Feng Tang, Haowen Jiang,
https://doi.org/10.18632/aging.103047 pp 6865—6879
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PP2A subunit PPP2R2C is downregulated in the brains of Alzheimer’s transgenic mice

Waiian Leong, Wei Xu, Bo Wang, Shuaiyun Gao, Xiuyun Zhai, Cuicui Wang, Eric Gilson, Jing Ye, Yiming Lu,
https://doi.org/10.18632/aging.103048 pp 6880—6890
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Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway

Guangnan Chen, Huijie Gu, Tingting Fang, Kaifeng Zhou, Jun Xu, Xiaofan Yin,
https://doi.org/10.18632/aging.103049 pp 6891—6903
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Identification of UAP1L1 as tumor promotor in gastric cancer through regulation of CDK6

Jing Qi, Sheng Liu, Weihang Liu, Gaoqiang Cai, Guoqing Liao,
https://doi.org/10.18632/aging.103050 pp 6904—6927
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AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling

Song Gu, Hanhao Dai, Xilian Zhao, Chang Gui, Jianchao Gui,
https://doi.org/10.18632/aging.103051 pp 6928—6946
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Diabetes-induced glucolipotoxicity impairs wound healing ability of adipose-derived stem cells-through the miR-1248/CITED2/HIF-1α pathway

Shune Xiao, Dan Zhang, Zhiyuan Liu, Wenhu Jin, Guangtao Huang, Zairong Wei, Dali Wang, Chengliang Deng,
https://doi.org/10.18632/aging.103053 pp 6947—6965
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A novel immune-related genes prognosis biomarker for melanoma: associated with tumor microenvironment

Rongzhi Huang, Min Mao, Yunxin Lu, Qingliang Yu, Liang Liao,
https://doi.org/10.18632/aging.103054 pp 6966—6980
View Abstract PDF Full-Text How to Cite Special Collection on Biomarkers

Blastocyst-stage embryos provide better frozen-thawed embryo transfer outcomes for young patients with previous fresh embryo transfer failure

Lanlan Fang, Jingyan He, Yang Yan, Qiongqiong Jia, Yiping Yu, Ruizhe Zhang, Jung-Chien Cheng, Ying-Pu Sun,
https://doi.org/10.18632/aging.103055 pp 6981—6989
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USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression

Bing Han, Yue Sun, Dongdong Yang, Huijuan Zhang, Steven Mo, Xuesong Chen, Hailing Lu, Xueyan Mao, Jing Hu,
https://doi.org/10.18632/aging.103056 pp 6990—7005
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Intra-operative hyperoxia and the risk of delirium in elderly patients after cardiac surgery

Anna Kupiec, Barbara Adamik, Katarzyna Forkasiewicz-Gardynik, Waldemar Goździk,
https://doi.org/10.18632/aging.103058 pp 7006—7014
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Quercetin ameliorates diabetic encephalopathy through SIRT1/ER stress pathway in db/db mice

Tian Hu, Jing-Jing Shi, Jiansong Fang, Qi Wang, Yun-Bo Chen, Shi-Jie Zhang,
https://doi.org/10.18632/aging.103059 pp 7015—7029
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βig-h3 enhances chondrogenesis via promoting mesenchymal condensation in rat Achilles tendon heterotopic ossification model

Qiang Zhang, Yan Zhang, Meijun Yan, Kai Zhu, Qihang Su, Jie Pan, Mingjie Yang, Dong Zhou, Jun Tan,
https://doi.org/10.18632/aging.103060 pp 7030—7041
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SIRT1 regulates O-GlcNAcylation of tau through OGT

Shu Lu, Xiaomin Yin, Jia Wang, Qun Gu, Qin Huang, Nana Jin, Dandan Chu, Ziqi Xu, Fei Liu, Wei Qian,
https://doi.org/10.18632/aging.103062 pp 7042—7055
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CO2 lattice laser reverses skin aging caused by UVB

Hongyi Wang, Bingyu Guo, Qiang Hui, Feng Lin, Kai Tao,
https://doi.org/10.18632/aging.103063 pp 7056—7065
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Cutaneous wound healing in aged, high fat diet-induced obese female or male C57BL/6 mice

Marta Kopcewicz, Katarzyna Walendzik, Joanna Bukowska, Anna Kur-Piotrowska, Sylwia Machcinska, Jeffrey M. Gimble, Barbara Gawronska-Kozak,
https://doi.org/10.18632/aging.103064 pp 7066—7111
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Identification of immunologic subtype and prognosis of GBM based on TNFSF14 and immune checkpoint gene expression profiling

Shengrong Long, Mingdong Li, Jia Liu, Yi Yang, Guangyu Li,
https://doi.org/10.18632/aging.103065 pp 7112—7128
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Therapeutic options for advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer: a Bayesian network secondary analysis

Xinmin Zeng, Xuan Wan, Jun Xu, Hui Wang, Hua Chen, Qinghua Zeng, Wenxiong Zhang, Binghao Zhao,
https://doi.org/10.18632/aging.103066 pp 7129—7162
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Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility

Mei-Rong Bai, Wei-Bo Niu, Ying Zhou, Yi-Ming Gong, Yan-Jiao Lu, Xian-Xian Yu, Zhi-Liang Wei, Wenjie Wu, Huan-Lei Song, Wen-Wen Yu, Bei-Lin Gu, Wei Cai, Xun Chu,
https://doi.org/10.18632/aging.103067 pp 7163—7182
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Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas

Mohamed Elshaer, Ahmed Islam ElManawy, Ahmed Hammad, Akhileshwar Namani, Xiu Jun Wang, Xiuwen Tang,
https://doi.org/10.18632/aging.103068 pp 7183—7206
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Dynamics of outcome after aneurysmal subarachnoid hemorrhage

Alexander Hammer, Gholamreza Ranaie, Eduard Yakubov, Frank Erbguth, Markus Holtmannspoetter, Hans-Herbert Steiner, Hendrik Janssen,
https://doi.org/10.18632/aging.103069 pp 7207—7217
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Prevalence of somatic-mental multimorbidity and its prospective association with disability among older adults in China

Haibin Li, Anxin Wang, Qi Gao, Xiaonan Wang, Yanxia Luo, Xinghua Yang, Xia Li, Wei Wang, Deqiang Zheng, Xiuhua Guo,
https://doi.org/10.18632/aging.103070 pp 7218—7231
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LncRNA XIST promotes myocardial infarction by regulating FOS through targeting miR-101a-3p

Bin Lin, Jing Xu, Feng Wang, Jiaxiang Wang, Hui Zhao, Deguang Feng,
https://doi.org/10.18632/aging.103072 pp 7232—7247
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MicroRNA-375 exacerbates knee osteoarthritis through repressing chondrocyte autophagy by targeting ATG2B

Hongxing Li, Zhiling Li, Yigang Pi, Yang Chen, Lin Mei, Yong Luo, Jingping Xie, Xinzhan Mao,
https://doi.org/10.18632/aging.103073 pp 7248—7261
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Autophagy prevents hippocampal α-synuclein oligomerization and early cognitive dysfunction after anesthesia/surgery in aged rats

Ning Yang, Zhengqian Li, Dengyang Han, Xinning Mi, Miao Tian, Taotao Liu, Yue Li, Jindan He, Chongshen Kuang, Yiyun Cao, Lunxu Li, Cheng Ni, John Q. Wang, Xiangyang Guo,
https://doi.org/10.18632/aging.103074 pp 7262—7281
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HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27

Kun Yao, Leye He, Yu Gan, Jianye Liu, Jin Tang, Zhi Long, Jing Tan,
https://doi.org/10.18632/aging.103076 pp 7282—7298
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Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage

Xueyan Qi, Jin Wang,
https://doi.org/10.18632/aging.103078 pp 7299—7312
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Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging

Chonthicha Satirapod, Ning Wang, Julie A. MacDonald, Minghan Sun, Dori C. Woods, Jonathan L. Tilly,
https://doi.org/10.18632/aging.103080 pp 7313—7333
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A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ PGC-1α/ pFOXO3 pathway

Shibu Marthandam Asokan, Ting Wang, Ming-Fu Wang, Wan-Teng Lin,
https://doi.org/10.18632/aging.103081 pp 7334—7349
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Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy

Youping Zhou, Li Zhong, Shengjie Yu, Wei Shen, Can Cai, Huihong Yu,
https://doi.org/10.18632/aging.103082 pp 7350—7362
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Nudix hydrolase 1 is a prognostic biomarker in hepatocellular carcinoma

Qifeng Ou, Ning Ma, Zheng Yu, Rongchang Wang, Yucheng Hou, Ziming Wang, Fan Chen, Wen Li, Jiong Bi, Jieyi Ma, Longjuan Zhang, Qiao Su, Xiaohui Huang,
https://doi.org/10.18632/aging.103083 pp 7363—7379
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Activated CD4+ T cells-derived exosomal miR-142-3p boosts post-ischemic ventricular remodeling by activating myofibroblast

Lidong Cai, Gong Chao, Weifeng Li, Jumo Zhu, Fangfang Li, Baozhen Qi, Yong Wei, Songwen Chen, Genqing Zhou, Xiaofeng Lu, Juan Xu, Xiaoyu Wu, Guangjian Fan, Jun Li, Shaowen Liu,
https://doi.org/10.18632/aging.103084 pp 7380—7396
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c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis

Liang Li, Chenju Yi, WenJie Xia, Bihui Huang, Shichao Chen, Junyan Zhong, Xiaoyi Fang, Liuming Yang, Hongwu Xin, Shiying Silvia Zheng, Beng H Chong, Yingyun Fu, Chun Chen, Mo Yang,
https://doi.org/10.18632/aging.103086 pp 7397—7410
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PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells

Yanping Liu, Huajun Bai, Fengfeng Guo, Phung N. Thai, Xiaoling Luo, Peng Zhang, Chunli Yang, Xueqin Feng, Dan Zhu, Jun Guo, Ping Liang, Zhice Xu, Huangtian Yang, Xiyuan Lu,
https://doi.org/10.18632/aging.103088 pp 7411—7430
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Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming

Andy Chun Hang Chen, Qian Peng, Sze Wan Fong, William Shu Biu Yeung, Yin Lau Lee,
https://doi.org/10.18632/aging.103090 pp 7431—7447
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Overexpression of LINC00160 predicts poor outcome and promotes progression of clear cell renal cell carcinoma

Gong Cheng, Yi Yu, Longwang Wang, Qiufeng Pan,
https://doi.org/10.18632/aging.103091 pp 7448—7464
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ATM gene polymorphisms are associated with poor prognosis of non-small cell lung cancer receiving radiation therapy

Junjun Mou, Tao Hu, Zhiwu Wang, Wei Chen, Yang Wang, Wei Zhang,
https://doi.org/10.18632/aging.103094 pp 7465—7479
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High miR-31-5p expression promotes colon adenocarcinoma progression by targeting TNS1

Bobin Mi, Qiushi Li, Tong Li, Guohui Liu, Jiayang Sai,
https://doi.org/10.18632/aging.103096 pp 7480—7490
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RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model

Tong Zhao, Xiuzhen Liu, Zehua Sun, Jinjin Zhang, Xiaolin Zhang, Chaoyun Wang, Ruishuang Geng, Tihua Zheng, Bo Li, Qing Yin Zheng,
https://doi.org/10.18632/aging.103103 pp 7491—7510
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Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia

Yi-Jhu Lu, Yee-Jee Jan, Bor-Sheng Ko, Shu-Man Liang, Lujen Chen, Chih-Cheng Wu, Chih-Hui Chin, Cheng-Chin Kuo, Shaw-Fang Yet, Jun-Yang Liou,
https://doi.org/10.18632/aging.103104 pp 7511—7533
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Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells

Zhibiao Bai, Wei Liu, Danshuang He, Yiyang Wang, Weiwei Yi, Changqi Luo, Jieliang Shen, Zhenming Hu,
https://doi.org/10.18632/aging.103109 pp 7534—7548
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Validation of the 8th edition of the American Joint Committee on Cancer Pathological Prognostic Staging for young breast cancer patients

Juan Zhou, Jian Lei, Jun Wang, Chen-Lu Lian, Li Hua, Li-Chao Yang, San-Gang Wu,
https://doi.org/10.18632/aging.103111 pp 7549—7560
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Using a genetic algorithm to derive a highly predictive and context-specific frailty index

Alberto Zucchelli, Alessandra Marengoni, Debora Rizzuto, Amaia Calderón-Larrañaga, Maurizio Zucchelli, Roberto Bernabei, Graziano Onder, Laura Fratiglioni, Davide Liborio Vetrano,
https://doi.org/10.18632/aging.103118 pp 7561—7575
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The effect of rapamycin on bovine oocyte maturation success and metaphase telomere length maintenance

Pawel Kordowitzki, Meriem Hamdi, Aksinya Derevyanko, Dimitrios Rizos, Maria Blasco,
https://doi.org/10.18632/aging.103126 pp 7576—7584
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PTX3 modulates the immunoflogosis in tumor microenvironment and is a prognostic factor for patients with clear cell renal cell carcinoma

Giuseppe Stefano Netti, Giuseppe Lucarelli, Federica Spadaccino, Giuseppe Castellano, Margherita Gigante, Chiara Divella, Maria Teresa Rocchetti, Federica Rascio, Vito Mancini, Giovanni Stallone, Giuseppe Carrieri, Loreto Gesualdo, Michele Battaglia, Elena Ranieri,
https://doi.org/10.18632/aging.103169 pp 7585—7602
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LUCS: a high-resolution nucleic acid sequencing tool for accurate long-read analysis of individual DNA molecules

Sofia Annis, Zoë Fleischmann, Robert Logan, Zachary Mullin-Bernstein, Melissa Franco, Josefin Saürich, Jonathan L. Tilly, Dori C. Woods, Konstantin Khrapko,
https://doi.org/10.18632/aging.103171 pp 7603—7613
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