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Research Paper|Volume 12, Issue 8|pp 7056—7065

CO2 lattice laser reverses skin aging caused by UVB

Hongyi Wang1, Bingyu Guo1, Qiang Hui1, Feng Lin1, Kai Tao1
  • 1Reconstructive and Plastic Surgery, General Hospital of Northern Theater Command, Shenyang, P.R.China
* Equal contribution
Received: October 7, 2019Accepted: March 24, 2020Published: April 20, 2020
https://doi.org/10.18632/aging.103063

Copyright © 2020 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesis and proliferation of primary human skin fibroblasts, inhibited cell senescence, and induced expression of superoxide dismutase (SOD) and the signaling protein SMAD3. In addition, this laser reversed cell cycle arrest and fibroblast apoptosis induced by UVB irradiation, and restored fibroblast proliferation inhibited by SMAD3 silencing. Using a rat model of photoaging, our results show that the laser increased collagen expression and dermal thickness, demonstrating that the CO2 lattice laser has a profound therapeutic effect on photoaged skin. Together, our in vitro and in vivo data show that the CO2 lattice laser can reverse the skin aging caused by UVB, and indicate that this effect is mediated through SMAD3.