Volume 14, Issue 14

31 July, 2022
pp 5612—5959

About the Cover

The cover features Figure 6 "Multi-region methylation data recapitulates strong PCBrainAge acceleration associations in test data" from Thrush et al.

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Editorials

Metformin and breast cancer: an opportunity for pharmacogenetics

Elisabet Cuyàs, Begoña Martin-Castillo, Javier A. Menendez,

https://doi.org/10.18632/aging.204180 pp 5612—5613

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Nutlin-3a for age-related macular degeneration

Hyewon Chung, Chaekyu Kim,

https://doi.org/10.18632/aging.204187 pp 5614—5616

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Restoring rhythm to prevent age-related fractures

Annelies E. Smit, Maaike Schilperoort, Elizabeth M. Winter,

https://doi.org/10.18632/aging.204192 pp 5617—5619

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Research Papers

Common electrocardiogram measures are not associated with telomere length

Aenne S. von Falkenhausen, Rebecca Freudling, Melanie Waldenberger, Christian Gieger, Annette Peters, Martina Müller-Nurasyid, Stefan Kääb, Moritz F. Sinner,

https://doi.org/10.18632/aging.204149 pp 5620—5627

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Short-term resveratrol treatment restored the quality of oocytes in aging mice

Naoki Okamoto, Yorino Sato, Yuta Kawagoe, Takahiko Shimizu, Kazuhiro Kawamura,

https://doi.org/10.18632/aging.204157 pp 5628—5640

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Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease

Kyra L. Thrush, David A. Bennett, Christopher Gaiteri, Steve Horvath, Christopher H. van Dyck, Albert T. Higgins-Chen, Morgan E. Levine,

https://doi.org/10.18632/aging.204196 pp 5641—5668

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Transcription factor KLF4 regulated STAT1 to promote M1 polarization of macrophages in rheumatoid arthritis

Qiao Ye, Fang Luo, Tingting Yan,

https://doi.org/10.18632/aging.204128 pp 5669—5680

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A bi-directional Mendelian randomization study of the sarcopenia-related traits and osteoporosis

Xue-Ying Ma, Hui-Min Liu, Wan-Qiang Lv, Chuan Qiu, Hong-Mei Xiao, Hong-Wen Deng,

https://doi.org/10.18632/aging.204145 pp 5681—5698

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Increased cytochrome C threonine 50 phosphorylation in aging heart as a novel defensive signaling against hypoxia/reoxygenation induced apoptosis

Fanqi Li, Haoxuan Sun, Xiaolong Lin, Qiuyu Li, Donghui Zhao, Zichao Cheng, Jinghua Liu, Qian Fan,

https://doi.org/10.18632/aging.204159 pp 5699—5709

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Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells

Wei-Lun Tsai, Jin-Shiung Cheng, Pei-Feng Liu, Tsung-Hsien Chang, Wei-Chih Sun, Wen-Chi Chen, Chih-Wen Shu,

https://doi.org/10.18632/aging.204170 pp 5710—5726

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The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation

Xiaojun Chen, Jiangyan Wang, Lin Tang, Qiuying Ye, Qunwei Dong, Zhangwei Li, Li Hu, Chenghong Ma, Jiake Xu, Ping Sun,

https://doi.org/10.18632/aging.204172 pp 5727—5748

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Red blood cell distribution width in different time-points of peripheral thrombolysis period in acute ischemic stroke is associated with prognosis

Mingli He, Hongrui Wang, Yi Tang, Bing Cui, Bingchao Xu, Xiaoqin Niu, Yongan Sun, Guanghui Zhang, Xiaobing He, Bei Wang, Bei Xu, Zaipo Li, Yu Zhang, Yibo Wang,

https://doi.org/10.18632/aging.204174 pp 5749—5767

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Identification of the ferroptosis-related ceRNA network related to prognosis and tumor immunity for gastric cancer

Zhiping Xiang, Xingguo Zhou, Geofrey Mahiki Mranda, Ying Xue, Yu Wang, Tian Wei, Junjian Liu, Yinlu Ding,

https://doi.org/10.18632/aging.204176 pp 5768—5782

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The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma

Zhongzhong Wan, Xingrun Li, Xinru Luo, Bofan Wang, Xiang Zhou, Ao Chen,

https://doi.org/10.18632/aging.204178 pp 5783—5799

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Moxibustion exhibits therapeutic effects on spinal cord injury via modulating microbiota dysbiosis and macrophage polarization

Zhuang Zhang, Rubo Sui, Lili Ge, Dongjian Xia,

https://doi.org/10.18632/aging.204184 pp 5800—5811

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Elucidating the pharmacological mechanism by which Si-Wu-Tang induces cellular senescence in breast cancer via multilevel data integration

Minhong Zhao, Botao Pan, Yanjun He, Bo Niu, Xiuan Gao,

https://doi.org/10.18632/aging.204185 pp 5812—5837

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Overexpression of 14-3-3ζ primes disease recurrence, metastasis and resistance to chemotherapy by inducing epithelial-mesenchymal transition in NSCLC

Lingyun Wei, Nan Hu, Mingxiang Ye, Zhilong Xi, Zhen Wang, Lei Xiong, Nan Yang, Yi Shen,

https://doi.org/10.18632/aging.204188 pp 5838—5854

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Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury

Jia-Long Tang, Meng Xin, Li-Chao Zhang,

https://doi.org/10.18632/aging.204189 pp 5855—5877

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MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer

Changan Zhao, Jiyu Miao, Ruifang Sun, Rui Liang, Wenhu Chen, Yi Gao, Xiaofei Wang, Shuiping Han, Wenbao Zhao, Ting Lei, Chen Huang,

https://doi.org/10.18632/aging.204190 pp 5878—5894

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Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma

Kexin Zhang, Jian Zhou, Tong Wu, Qunyan Tian, Tang Liu, Wanchun Wang, Hua Zhong, Ziyuan Chen, Xungang Xiao, Gen Wu,

https://doi.org/10.18632/aging.204191 pp 5895—5907

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microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Qiangfeng Yu, Zhe Xiu, Yizeng Jian, Jianyin Zhou, Xiaopeng Chen, Xiang Chen, Chunxiang Chen, Hongbao Chen, Sijia Yang, Libo Yin, Wenlong Zeng,

https://doi.org/10.18632/aging.204193 pp 5908—5924

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miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts

Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Tzu-Ling Huang, Zhih-Cherng Chen, Chi-Long Chen, Jan-Show Chu, Ping Yen Liu,

https://doi.org/10.18632/aging.204194 pp 5925—5945

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The RIPK family: expression profile and prognostic value in lung adenocarcinoma

Guo Li, Zhijie Xu, Jinwu Peng, Yuanliang Yan, Yong Liu, Xin Zhang, Yuanzheng Qiu, Chencheng Fu,

https://doi.org/10.18632/aging.204195 pp 5946—5958

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Correction

Correction for: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, Sally Logan, Ryan Bradley,

https://doi.org/10.18632/aging.204197 pp 5959

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