Volume 14, Issue 14

July 31, 2022pp 5612—5959

About the Cover

The cover features Figure 6 "Multi-region methylation data recapitulates strong PCBrainAge acceleration associations in test data" from Thrush et al.

Editorials

Metformin and breast cancer: an opportunity for pharmacogenetics

Elisabet Cuyàs, Begoña Martin-Castillo, Javier A. Menendez

https://doi.org/10.18632/aging.204180pp 5612—5613

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Nutlin-3a for age-related macular degeneration

Hyewon Chung, Chaekyu Kim

https://doi.org/10.18632/aging.204187pp 5614—5616

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Restoring rhythm to prevent age-related fractures

Annelies E. Smit, Maaike Schilperoort, Elizabeth M. Winter

https://doi.org/10.18632/aging.204192pp 5617—5619

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Research Papers

Common electrocardiogram measures are not associated with telomere length

Aenne S. von Falkenhausen, Rebecca Freudling, Melanie Waldenberger, Christian Gieger, Annette Peters, Martina Müller-Nurasyid, Stefan Kääb, Moritz F. Sinner

https://doi.org/10.18632/aging.204149pp 5620—5627

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Short-term resveratrol treatment restored the quality of oocytes in aging mice

Naoki Okamoto, Yorino Sato, Yuta Kawagoe, Takahiko Shimizu, Kazuhiro Kawamura

https://doi.org/10.18632/aging.204157pp 5628—5640

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Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease

Kyra L. Thrush, David A. Bennett, Christopher Gaiteri, Steve Horvath, Christopher H. van Dyck, Albert T. Higgins-Chen, Morgan E. Levine

https://doi.org/10.18632/aging.204196pp 5641—5668

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Transcription factor KLF4 regulated STAT1 to promote M1 polarization of macrophages in rheumatoid arthritis

Qiao Ye, Fang Luo, Tingting Yan

https://doi.org/10.18632/aging.204128pp 5669—5680

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A bi-directional Mendelian randomization study of the sarcopenia-related traits and osteoporosis

Xue-Ying Ma, Hui-Min Liu, Wan-Qiang Lv, Chuan Qiu, Hong-Mei Xiao, Hong-Wen Deng

https://doi.org/10.18632/aging.204145pp 5681—5698

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Increased cytochrome C threonine 50 phosphorylation in aging heart as a novel defensive signaling against hypoxia/reoxygenation induced apoptosis

Fanqi Li, Haoxuan Sun, Xiaolong Lin, Qiuyu Li, Donghui Zhao, Zichao Cheng, Jinghua Liu, Qian Fan

https://doi.org/10.18632/aging.204159pp 5699—5709

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Sofosbuvir induces gene expression for promoting cell proliferation and migration of hepatocellular carcinoma cells

Wei-Lun Tsai, Jin-Shiung Cheng, Pei-Feng Liu, Tsung-Hsien Chang, Wei-Chih Sun, Wen-Chi Chen, Chih-Wen Shu

https://doi.org/10.18632/aging.204170pp 5710—5726

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The therapeutic effect of Fufang Zhenshu Tiaozhi (FTZ) on osteoclastogenesis and ovariectomized-induced bone loss: evidence from network pharmacology, molecular docking and experimental validation

Xiaojun Chen, Jiangyan Wang, Lin Tang, Qiuying Ye, Qunwei Dong, Zhangwei Li, Li Hu, Chenghong Ma, Jiake Xu, Ping Sun

https://doi.org/10.18632/aging.204172pp 5727—5748

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Red blood cell distribution width in different time-points of peripheral thrombolysis period in acute ischemic stroke is associated with prognosis

Mingli He, Hongrui Wang, Yi Tang, Bing Cui, Bingchao Xu, Xiaoqin Niu, Yongan Sun, Guanghui Zhang, Xiaobing He, Bei Wang, Bei Xu, Zaipo Li, Yu Zhang, Yibo Wang

https://doi.org/10.18632/aging.204174pp 5749—5767

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Identification of the ferroptosis-related ceRNA network related to prognosis and tumor immunity for gastric cancer

Zhiping Xiang, Xingguo Zhou, Geofrey Mahiki Mranda, Ying Xue, Yu Wang, Tian Wei, Junjian Liu, Yinlu Ding

https://doi.org/10.18632/aging.204176pp 5768—5782

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The miR-590-3p/CFHR3/STAT3 signaling pathway promotes cell proliferation and metastasis in hepatocellular carcinoma

Zhongzhong Wan, Xingrun Li, Xinru Luo, Bofan Wang, Xiang Zhou, Ao Chen

https://doi.org/10.18632/aging.204178pp 5783—5799

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Moxibustion exhibits therapeutic effects on spinal cord injury via modulating microbiota dysbiosis and macrophage polarization

Zhuang Zhang, Rubo Sui, Lili Ge, Dongjian Xia

https://doi.org/10.18632/aging.204184pp 5800—5811

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Elucidating the pharmacological mechanism by which Si-Wu-Tang induces cellular senescence in breast cancer via multilevel data integration

Minhong Zhao, Botao Pan, Yanjun He, Bo Niu, Xiuan Gao

https://doi.org/10.18632/aging.204185pp 5812—5837

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Overexpression of 14-3-3ζ primes disease recurrence, metastasis and resistance to chemotherapy by inducing epithelial-mesenchymal transition in NSCLC

Lingyun Wei, Nan Hu, Mingxiang Ye, Zhilong Xi, Zhen Wang, Lei Xiong, Nan Yang, Yi Shen

https://doi.org/10.18632/aging.204188pp 5838—5854

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Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury

Jia-Long Tang, Meng Xin, Li-Chao Zhang

https://doi.org/10.18632/aging.204189pp 5855—5877

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MBD1/HDAC3-miR-5701-FGFR2 axis promotes the development of gastric cancer

Changan Zhao, Jiyu Miao, Ruifang Sun, Rui Liang, Wenhu Chen, Yi Gao, Xiaofei Wang, Shuiping Han, Wenbao Zhao, Ting Lei, Chen Huang

https://doi.org/10.18632/aging.204190pp 5878—5894

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Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma

Kexin Zhang, Jian Zhou, Tong Wu, Qunyan Tian, Tang Liu, Wanchun Wang, Hua Zhong, Ziyuan Chen, Xungang Xiao, Gen Wu

https://doi.org/10.18632/aging.204191pp 5895—5907

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microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Qiangfeng Yu, Zhe Xiu, Yizeng Jian, Jianyin Zhou, Xiaopeng Chen, Xiang Chen, Chunxiang Chen, Hongbao Chen, Sijia Yang, Libo Yin, Wenlong Zeng

https://doi.org/10.18632/aging.204193pp 5908—5924

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miR-21 upregulation exacerbates pressure overload-induced cardiac hypertrophy in aged hearts

Wei-Ting Chang, Jhih-Yuan Shih, Yu-Wen Lin, Tzu-Ling Huang, Zhih-Cherng Chen, Chi-Long Chen, Jan-Show Chu, Ping Yen Liu

https://doi.org/10.18632/aging.204194pp 5925—5945

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The RIPK family: expression profile and prognostic value in lung adenocarcinoma

Guo Li, Zhijie Xu, Jinwu Peng, Yuanliang Yan, Yong Liu, Xin Zhang, Yuanzheng Qiu, Chencheng Fu

https://doi.org/10.18632/aging.204195pp 5946—5958

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Correction

Correction for: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Kara N. Fitzgerald, Romilly Hodges, Douglas Hanes, Emily Stack, David Cheishvili, Moshe Szyf, Janine Henkel, Melissa W. Twedt, Despina Giannopoulou, Josette Herdell, Sally Logan, Ryan Bradley

https://doi.org/10.18632/aging.204197pp 5959

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