Volume 15, Issue 19

October 15, 2023pp 9892—10813

About the Cover

The cover features Figure 4 "BMAL1 contributes to AP-1 mediated transcriptional control of the senescence program and confers resistance to apoptosis" from Jachim et al.

Editorials

Neuronal HLH-30/TFEB modulates thermoresistance and longevity in C. elegans

Louis R. Lapierre

https://doi.org/10.18632/aging.204849pp 9892—9893

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Learning by motor imagery in older adults

Arnaud Saimpont, Angèle Métais, Christian Collet

https://doi.org/10.18632/aging.205185pp 9894—9895

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Research Papers

Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses

Alejandro Acevedo, Felipe Torres, Miguel Kiwi, Felipe Baeza-Lehnert, L. Felipe Barros, Dasfne Lee-Liu, Christian González-Billault

https://doi.org/10.18632/aging.204663pp 9896—9912

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Reduction of double-strand DNA break repair exacerbates vascular aging

Samuel I. Bloom, Jordan R. Tucker, Daniel R. Machin, Hossein Abdeahad, AdeLola O. Adeyemo, Tyler G. Thomas, R. Colton Bramwell, Lisa A. Lesniewski, Anthony J. Donato

https://doi.org/10.18632/aging.205066pp 9913—9947

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Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome

Daisuke Sawada, Hisaya Kato, Hiyori Kaneko, Daisuke Kinoshita, Shinichiro Funayama, Takuya Minamizuka, Atsushi Takasaki, Katsushi Igarashi, Masaya Koshizaka, Aki Takada-Watanabe, Rito Nakamura, Kazuto Aono, Ayano Yamaguchi, Naoya Teramoto, Yukari Maeda, Tomohiro Ohno, Aiko Hayashi, Kana Ide, Shintaro Ide, Mayumi Shoji, Takumi Kitamoto, Yusuke Endo, Hideyuki Ogata, Yoshitaka Kubota, Nobuyuki Mitsukawa, Atsushi Iwama, Yasuo Ouchi, Naoya Takayama, Koji Eto, Katsunori Fujii, Tomozumi Takatani, Tadashi Shiohama, Hiromichi Hamada, Yoshiro Maezawa, Koutaro Yokote

https://doi.org/10.18632/aging.205078pp 9948—9964

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Live while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging

Tuguldur Enkhbaatar, Marek Skoneczny, Karolina Stępień, Mateusz Mołoń, Adrianna Skoneczna

https://doi.org/10.18632/aging.205102pp 9965—9983

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BMAL1 modulates senescence programming via AP-1

Sarah K. Jachim, Jian Zhong, Tamas Ordog, Jeong-Heon Lee, Aditya V. Bhagwate, Nagaswaroop Kengunte Nagaraj, Jennifer J. Westendorf, João F. Passos, Aleksey V. Matveyenko, Nathan K. LeBrasseur

https://doi.org/10.18632/aging.205112pp 9984—10009

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Identification of an endoplasmic reticulum stress-related prognostic risk model with excellent prognostic and clinical value in oral squamous cell carcinoma

Mingyang Cheng, Xin Fan, Mu He, Xianglin Dai, Xiaoli Liu, Jinming Hong, Laiyu Zhang, Lan Liao

https://doi.org/10.18632/aging.204983pp 10010—10030

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Huangqi Guizhi Wuwu decoction promotes M2 microglia polarization and synaptic plasticity via Sirt1/NF-κB/NLRP3 pathway in MCAO rats

Zhijie Ou, Min Zhao, Ying Xu, Yan Wu, Lina Qin, Li Fang, Hong Xu, Juping Chen

https://doi.org/10.18632/aging.204989pp 10031—10056

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LncRNA LINC00667 gets involved in clear cell renal cell carcinoma development and chemoresistance by regulating the miR-143-3p/ZEB1 axis

Jianjun Zhao, Pengjie Chen, Chao Tan, Xiaolong Cheng, Weichuan Zhang, Chong Shen, Dongli Zhang

https://doi.org/10.18632/aging.205029pp 10057—10071

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Exploring anti-acute kidney injury mechanism of Dahuang-Gancao decoction by network pharmacology and experimental validation

Rui Wang, Yi An, Yifang Xu, Chengyin Li, Qiyuan Wang, Yinshui Zou, Guangzhi Wang

https://doi.org/10.18632/aging.205033pp 10072—10088

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Eriocitrin inhibits epithelial-mesenchymal transformation (EMT) in lung adenocarcinoma cells via triggering ferroptosis

Minglang Gao, Kai Lai, Yu Deng, Zilong Lu, Congkuan Song, Wenjie Wang, Chenzhen Xu, Ning Li, Qing Geng

https://doi.org/10.18632/aging.205049pp 10089—10104

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SNHG25 promotes colorectal cancer metastasis by regulating MMP2

Tao Gong, Yu Li, Liang Feng, Qingyu Xu, Guoliang Dai, Min Li, Yi Wang, Shenlin Liu

https://doi.org/10.18632/aging.205060pp 10105—10116

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Causal association between placental growth factor and coronary heart disease: a Mendelian randomization study

Bo Zuo, Sha Zhu, Guoting Zhong, Haoyang Bu, Hui Chen

https://doi.org/10.18632/aging.205061pp 10117—10132

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Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1

Peina Meng, Zhaoyang Chen, Tianhui Sun, Lili Wu, Yifan Wang, Tianwei Guo, Jin Yang, Jiebin Zhu

https://doi.org/10.18632/aging.205062pp 10133—10145

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GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis

Kairong Liang, Zhaoxiong Guo, Shizhen Zhang, Danmin Chen, Renheng Zou, Yuhao Weng, Chengxiang Peng, Zhichao Xu, Jingbai Zhang, Xiaorui Liu, Xiao Pang, Yunxiang Ji, Degui Liao, Miaoling Lai, Huaidong Peng, Yanbin Ke, Zhaotao Wang, Yezhong Wang

https://doi.org/10.18632/aging.205063pp 10146—10167

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Identification and validation of obesity related genes signature based on microenvironment phenotypes in prostate adenocarcinoma

Linghui Liang, Jinwei Shang, Yuwei Zhang, Yuxin Xu, Yihui Zhouteng, Jianxiang Wen, Yuxin Zhao, Ninghan Feng, Ruizhe Zhao

https://doi.org/10.18632/aging.205065pp 10168—10192

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CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway

Zhentang Yu, Xijia Jiang, Jianjian Yin, Lei Han, Chengwei Xiong, Zhennan Huo, Jie Xu, Jingjing Shang, Kun Xi, Luming Nong, Yong Huang, Xindie Zhou

https://doi.org/10.18632/aging.205067pp 10193—10212

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Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis

Jun-ming Huang, Zhe Wang, Guo-Bin Qi, Qi Lai, A-lan Jiang, Yue-Qi Zhang, Kun Chen, Xiu-Hui Wang

https://doi.org/10.18632/aging.205068pp 10213—10236

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Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer’s disease

Guang-Zhi Liu, Tian-Tong Niu, Qian Yu, Bao-Lei Xu, Xiao-Qing Li, Bo-Yi Yuan, Guo-Bin Yuan, Ting-Ting Yang, Hui-Qin Li, Yi Sun

https://doi.org/10.18632/aging.205072pp 10237—10252

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Development of a prognostic model based on anoikis-related genes for predicting clinical prognosis and immunotherapy of hepatocellular carcinoma

Mu Pang, Xizhe Sun, Ting He, Huichao Liang, Hao Yang, Jun Chen

https://doi.org/10.18632/aging.205073pp 10253—10271

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Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma

Xiaokun Zhao, Jian Zhang, Jiahao Liu, Shengzhong Luo, Rui Ding, Xinxin Miao, Tianlong Wu, Jingyu Jia, Xigao Cheng

https://doi.org/10.18632/aging.205074pp 10272—10290

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Dendrobium officinale polysaccharide decreases podocyte injury in diabetic nephropathy by regulating IRS-1/AKT signal and promoting mitophagy

Huahua Li, Jin Zheng, Yacen Wu, Hong Zhou, Suli Zeng, Quanqing Li

https://doi.org/10.18632/aging.205075pp 10291—10306

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The integrated single-cell analysis developed an immunogenic cell death signature to predict lung adenocarcinoma prognosis and immunotherapy

Pengpeng Zhang, Haotian Zhang, Junjie Tang, Qianhe Ren, Jieying Zhang, Hao Chi, Jingwen Xiong, Xiangjin Gong, Wei Wang, Haoran Lin, Jun Li, Chenjun Huang

https://doi.org/10.18632/aging.205077pp 10305—10329

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Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer

Bo Wang, Shuwen Ge, Zihao Wang, Wantong Wang, Yuting Wang, Hongrui Leng, Xiaoxin Ma

https://doi.org/10.18632/aging.205080pp 10322—10346

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Mitochondrial-related genes markers that predict survival in patients with head and neck squamous cell carcinoma affect immunomodulation through hypoxia, glycolysis, and angiogenesis pathways

Zhonghua Li, Haoxi Cai, Jinyang Zheng, Xun Chen, Guancheng Liu, Yunxia Lv, Hui Ye, Gengming Cai

https://doi.org/10.18632/aging.205081pp 10347—10369

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Bridging the gap between clear cell renal cell carcinoma and cutaneous melanoma: the role of SCARB1 in dysregulated cholesterol metabolism

Lebin Song, Shuai Wang, Xi Zhang, Ninghong Song, Yan Lu, Chao Qin

https://doi.org/10.18632/aging.205083pp 10370—10388

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Novel diagnostic biomarkers of oxidative stress, immunological characterization and experimental validation in Alzheimer’s disease

Di Hu, Xiaocong Mo, Luo Jihang, Cheng Huang, Hesong Xie, Ling Jin

https://doi.org/10.18632/aging.205084pp 10389—10406

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PLCL1 suppresses tumour progression by regulating AMPK/mTOR-mediated autophagy in renal cell carcinoma

Zhou Pan, Jing Huang, Huajie Song, Yusha Xiao, Ting Liu, Yan Zeng, Hengcheng Zhu, Kang Yang

https://doi.org/10.18632/aging.205085pp 10407—10427

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Mitochondrial dysfunction following repeated administration of alprazolam causes attenuation of hippocampus-dependent memory consolidation in mice

Siqing Zhu, Jingjing Shi, Qian Jin, Yi Zhang, Ruihua Zhang, Xuejun Chen, Chen Wang, Tong Shi, Liqin Li

https://doi.org/10.18632/aging.205087pp 10428—10452

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An immune signature to predict the prognosis of ATRX-wildtype glioma patients and guide immune checkpoint blockade therapy

Wenpeng Cao, Ping Sun, Shipeng Luo, Zhirui Zeng, Chaolun Xiao, Wenfeng Yu, Shan Lei

https://doi.org/10.18632/aging.205088pp 10453—10472

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Prognostic value and immune landscapes of cuproptosis-related lncRNAs in esophageal squamous cell carcinoma

Xiang Zhang, Nan Feng, Bo Wu, Zishun Guo, Tiewen Pan, Xiandong Tao, Hongyang Zheng, Wenxiong Zhang

https://doi.org/10.18632/aging.205089pp 10473—10500

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A SARS-CoV-2 related signature that explores the tumor microenvironment and predicts immunotherapy response in esophageal squamous cell cancer

Qianhe Ren, Pengpeng Zhang, Shengyi Zhang, Wenhui Chen, Hao Chi, Wei Wang, Wei Zhang, Haoran Lin, Yue Yu

https://doi.org/10.18632/aging.205090pp 10501—10523

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Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway

Kaochang Zhao, Hanxiang Nie, Zheng Tang, Guozhong Chen, Jizhen Huang

https://doi.org/10.18632/aging.205092pp 10524—10539

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Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling

Jianhua Wang, Hongyan Zhan, Mingming Wang, Hua Song, Jianhua Sun, Gang Zhao

https://doi.org/10.18632/aging.205093pp 10540—10548

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Identifying endoplasmic reticulum stress-related molecular subtypes and prognostic model for predicting the immune landscape and therapy response in pancreatic cancer

Biao Zhang, Xu Chen, Zhizhou Wang, Fangyue Guo, Xiaonan Zhang, Bingqian Huang, Shurong Ma, Shilin Xia, Dong Shang

https://doi.org/10.18632/aging.205094pp 10549—10579

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Impact of alternating amino acid sequences on beta-amyloid-induced neurotoxicity and neuroinflammation in Alzheimer's disease

Zhixin Li, Minqi Peng, Chen Wang, Jiaan Yang, Xiang Li, Jing Zhao

https://doi.org/10.18632/aging.205095pp 10580—10592

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UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells

Yuhui Zheng, Dongliang Shi, Linlin Chen, Yinghong Yang, Meihong Yao

https://doi.org/10.18632/aging.205097pp 10593—10606

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TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer

Jun-Jie Ma, Cheng Xiang, Jian-Wei Wang

https://doi.org/10.18632/aging.205100pp 10607—10626

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Evaluation of time-dependent phenotypes of myocardial ischemia-reperfusion in mice

Xiang-Min Meng, Jing-Han Yuan, Zhen-Fang Zhou, Qi-Pu Feng, Bing-Mei Zhu

https://doi.org/10.18632/aging.205103pp 10627—10639

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Multi-omics analysis of MRPL-13 as a tumor-promoting marker from pan-cancer to lung adenocarcinoma

Xugang Zhong, Zeju He, Yong Fan, Li Yin, Zheping Hong, Yu Tong, Qing Bi, Senbo Zhu

https://doi.org/10.18632/aging.205104pp 10640—10680

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Analysis of potential biomarkers for diabetic kidney disease based on single-cell RNA-sequencing integrated with a single-cell sequencing assay for transposase-accessible chromatin

Yan Shi, Zuishuang Guo, Fengxun Liu, Shaokang Pan, Dan Gao, Sijie Zhou, Zhenjie Liu, Feng Wang, Dongwei Liu, Zhangsuo Liu

https://doi.org/10.18632/aging.205107pp 10681—10704

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Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension

Ting Wang, Shuyan Li, Xiu-Miao Li, Chaopeng Li, Fang Wang, Qin Jiang

https://doi.org/10.18632/aging.205108pp 10705—10731

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Micheliolide prevents estrogen deficiency-induced bone loss via inhibiting osteoclast bone resorption

Ziyang Gan, Junming Huang, Mingyou Xu, Xingshi Yuan, Xifu Shang, Xi Chen, Kun Chen

https://doi.org/10.18632/aging.205111pp 10732—10745

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A pan-cancer analysis of the role of HOXD1, HOXD3, and HOXD4 and validation in renal cell carcinoma

Lumin Wang, Xiaofei Wang, Haifeng Sun, Wenjing Wang, Li Cao

https://doi.org/10.18632/aging.205116pp 10746—10766

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Modified iPOND revealed the role of mutant p53 in promoting helicase function and telomere maintenance

Qianqian Wang, Kailong Hou, Jun Yang, Haili Li, Cui Li, Yanduo Zhang, Jie Tian, Chuanbiao Li, Bing Guo, Shuting Jia, Ying Luo

https://doi.org/10.18632/aging.205117pp 10767—10784

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PD-L1-related IncRNAs are associated with malignant characteristics and immune microenvironment in glioma

Zhiwei Xia, Ruxin Tu, Fangkun Liu, Hao Zhang, Ziyu Dai, Zeyu Wang, Peng Luo, Shiqing He, Gelei Xiao, Jie Feng, Quan Cheng

https://doi.org/10.18632/aging.205120pp 10785—10810

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Correction

Correction for: Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1

Hui Dong, Zhuanzhuan Qiang, Dongdong Chai, Jiali Peng, Yangyang Xia, Rong Hu, Hong Jiang

https://doi.org/10.18632/aging.205167pp 10811—10812

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Retraction

Retraction: Long non-coding RNA ANRIL alleviates H2O2-induced injury by up-regulating microRNA-21 in human lens epithelial cellss

Shanshan Du, Jingzhi Shao, Ying Qi, Xuhui Liu, Jingjing Liu, Fengyan Zhang

https://doi.org/10.18632/aging.205115pp 10813

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