Aging
Navigate
Submit an Article
Research Paper|Volume 15, Issue 19|pp 10785—10810

PD-L1-related IncRNAs are associated with malignant characteristics and immune microenvironment in glioma

Zhiwei Xia1, Ruxin Tu2,4, Fangkun Liu3, Hao Zhang3,5, Ziyu Dai3, Zeyu Wang3,6, Peng Luo7, Shiqing He8, Gelei Xiao3, Jie Feng2,4,9, Quan Cheng3,4
  • 1Department of Neurology, Hunan Aerospace Hospital, Changsha 410205, Hunan, P.R. China
  • 2Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, P.R. China
  • 3Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, P.R. China
  • 4National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, P.R. China
  • 5Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. China
  • 6MRC Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Little France, Edinburgh, EH16 4UU, UK
  • 7Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, P.R. China
  • 8Department of Neurosurgery, Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, P.R. China
  • 9Hunan Clinical Research Center for Cerebrovascular Disease, Changsha 410008, Hunan Province, P.R. China
* Equal contribution and shared first authorship
Received: March 14, 2023Accepted: August 21, 2023Published: October 12, 2023
https://doi.org/10.18632/aging.205120

Copyright: © 2023 Xia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The expression of long non-coding RNA (lncRNA) can function as diagnostic and therapeutic biomarker for tumors. This research explores the role of PD-L1-related lncRNAs in affecting malignant characteristics and the immune microenvironment of glioma.

Methods: Downloading gene expression profiles and clinicopathological information of glioma from TCGA and CGGA databases, 6 PD-L1-related lncRNAs were identified through correlation analysis, Cox and LASSO regression analysis, establishing the risk score model based on them. Bioinformatics analysis and cell experiments in vitro were adopted to verify the effects of LINC01271 on glioma.

Results: Risk scores based on 6 PD-L1-related lncRNAs (AL355974.3, LINC01271, AC011899.3, MIR4500HG, LINC02594, AL357055.3) can reflect malignant characteristics and immunotherapy response of glioma. Patients with high LINC01271 expression had a worse prognosis, a higher abundance of M1 subtype macrophages in the immune microenvironment, and a higher degree of tumor malignancy. Experiments in vitro confirmed its positive regulatory effect on the proliferation and migration of glioma cells.

Conclusions: The risk score model based on 6 PD-L1-related lncRNAs can reflect the malignant characteristics and prognosis of glioma. LINC01271 can independently be used as a new target for prognosis evaluation and therapy.