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Volume 17, Issue 1

January 31, 2025pp 1—279

About the Cover

The cover features a photo of Dr. Mikhail Blagosklonny from Barzilai review in honor of his memory. He will be remembered as a brilliant and extraordinary scientist who dedicated his life to science.

Priority Review

Mikhail ‘Misha’ Blagosklonny’s enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin

David A. Barzilai

https://doi.org/10.18632/aging.206189pp 1—15

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Research Papers

Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing

Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Joy Ha, Jannat Dhillon, Grace H. Shin, Jack Crouch, Adam C. Gower, Sami Gritli, Daniel S. Roh

https://doi.org/10.18632/aging.206165pp 16—32

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Neurocognitive disparities: investigating ethnicity and mental health in rural aging adults

Carol Fadalla, Jonathan Singer, Peter Rerick, Lauren Elliott, Elisabeth McLean, Sydnie Schneider, Lauren Chrzanowski, Veronica Molinar-Lopez, Volker Neugebauer

https://doi.org/10.18632/aging.206166pp 33—50

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Association between physical activity practice and sleep quality of older people in social isolation during the COVID-19 pandemic and Health Guidelines and future studies for the post-COVID period: a systematic review

Alexandro Andrade, Ana Cecília Rosatelli de Freitas Bastos, Anderson D’Oliveira, Guilherme Torres Vilarino

https://doi.org/10.18632/aging.206180pp 51—66

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Characterization of DNA methylation clock algorithms applied to diverse tissue types

Mark Richardson, Courtney Brandt, Niyati Jain, James L. Li, Kathryn Demanelis, Farzana Jasmine, Muhammad G. Kibriya, Lin Tong, Brandon L. Pierce

https://doi.org/10.18632/aging.206182pp 67—96

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Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc^1638N/+ mice

Kamendra Kumar, Bo-Hyun Moon, Santosh Kumar, Jerry Angdisen, Bhaskar V.S. Kallakury, Albert J. Fornace Jr., Shubhankar Suman

https://doi.org/10.18632/aging.206183pp 97—115

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The profile of oxidative stress markers (arachidonic and linoleic acid derivatives) in patients with benign prostatic hyperplasia in relation to metabolic syndrome

Weronika Ratajczak, Kinga Walczakiewicz, Maria Laszczyńska, Krzysztof Chmielowiec, Joanna Palma, Arleta Drozd, Anna Lubkowska, Olimpia Sipak

https://doi.org/10.18632/aging.206187pp 116—130

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EpiAge: a next-generation sequencing-based ELOVL2 epigenetic clock for biological age assessment in saliva and blood across health and disease

David Cheishvili, Sonia Do Carmo, Filippo Caraci, Margherita Grasso, A Claudio Cuello, Moshe Szyf

https://doi.org/10.18632/aging.206188pp 131—160

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Oct4, Sox2, Klf4, c-My (OSKM) gene therapy in the hypothalamus prolongs fertility and ovulation in female rats

Maria D. Gallardo, Mauricio Girard, Enrique L. Portiansky, Rodolfo G. Goya

https://doi.org/10.18632/aging.206191pp 161—169

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Age-invariant genes: multi-tissue identification and characterization of murine reference genes

John T. González, Kyra Thrush-Evensen, Margarita Meer, Morgan E. Levine, Albert T. Higgins-Chen

https://doi.org/10.18632/aging.206192pp 170—202

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Comprehensive analysis of LMNB2 in pan-cancer and identification of its biological role in sarcoma

Yonghui Guo, Min Zhang, Yingrui Luo, Yingshi Li, Yanxia Xu, Nisha Wang

https://doi.org/10.18632/aging.205962pp 203—216

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The comparison of serum bone-turnover markers in different stage of chronic kidney disease and the associated impact of intradialytic cycling in patients with end-stage renal disease

Yi-Chou Hou, Chia-Ter Chao, Li-Jane Shih, Kuo-Wang Tsai, Shyh-Min Lin, Ruei-Ming Chen, Kuo-Cheng Lu

https://doi.org/10.18632/aging.206177pp 217—231

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Treadmill intervention attenuates motor deficit with 6-OHDA-induced Parkinson’s disease rat via changes in lipid profiles in brain and muscle

Binar Panunggal, Tu-Hsueh Yeh, Shu-Ping Tsao, Chun-Hsu Pan, Wei-Ting Shih, Ya-Tin Lin, Amelia Faradina, Chia-Lang Fang, Hui-Yu Huang, Shih-Yi Huang

https://doi.org/10.18632/aging.206181pp 232—250

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Review

Deep learning and generative artificial intelligence in aging research and healthy longevity medicine

Dominika Wilczok

https://doi.org/10.18632/aging.206190pp 251—275

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Correction

Correction for: The association between KLF4 as a tumor suppressor and the prognosis of hepatocellular carcinoma after curative resection

Min Xue, Chenhao Zhou, Yan Zheng, Ziping Zhang, Shun Wang, Yan Fu, Manar Atyah, Xiaolong Xue, Le Zhu, Qiongzhu Dong, Huliang Jia, Ning Ren, Ruolei Hu

https://doi.org/10.18632/aging.206197pp 276—277

Retraction

Retraction of: LINC00265 targets miR-382-5p to regulate SAT1, VAV3 and angiogenesis in osteosarcoma

Ying Xiao, Chunling Li, Hongyue Wang, Yijun Liu

https://doi.org/10.18632/aging.206195pp 278—279