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Volume 15, Issue 23

December 15, 2023pp 13579—14506

About the Cover

The cover features Figure 5 "Graphical abstract of known differences of SARS-CoV-2 delta and omicron variant entry and findings of our study obtained from mRNA sequence data of 24 h post infection" from Hornung et al.

Editorial

Aging and neuronal death

Fang Fang, Robert Usselman, Renee Reijo Pera

https://doi.org/10.18632/aging.205433pp 13579—13580

Research Papers

Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema

Alberta Palazzo, Gabriela Makulyte, Delphine Goerhig, Jean-Jacques Médard, Vincent Gros, François Trottein, Serge Adnot, David Vindrieux, Jean-Michel Flaman, David Bernard

https://doi.org/10.18632/aging.205259pp 13581—13592

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Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence

Franziska Hornung, Nilay Köse-Vogel, Claude Jourdan Le Saux, Antje Häder, Lea Herrmann, Luise Schulz, Lukáš Radosa, Thurid Lauf, Tim Sandhaus, Patrick Samson, Torsten Doenst, Daniel Wittschieber, Gita Mall, Bettina Löffler, Stefanie Deinhardt-Emmer

https://doi.org/10.18632/aging.205297pp 13593—13607

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Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction

Geum-Hwa Lee, Hwa-Young Lee, Young-Je Lim, Ji-Hyun Kim, Su-Jin Jung, Eun-Soo Jung, Soo-Wan Chae, Juwon Lee, Junghyun Lim, Mohammad Mamun Ur Rashid, Kyung Hyun Min, Han-Jung Chae

https://doi.org/10.18632/aging.205343pp 13608—13627

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Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes

Michaela E. Copp, Jacqueline Shine, Hannon L. Brown, Kirti R. Nimmala, Oliver B. Hansen, Susan Chubinskaya, John A. Collins, Richard F. Loeser, Brian O. Diekman

https://doi.org/10.18632/aging.205394pp 13628—13645

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Cabozantinib prevents AGEs-induced degradation of type 2 collagen and aggrecan in human chondrocytes

Yang Dong, Lianfang Lin, Yuan Ji, Xu Cheng, Zhiwu Zhang

https://doi.org/10.18632/aging.205186pp 13646—13654

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Down-regulation of EZH2 genes targeting RUNX3 affects proliferation, invasion, and metastasis of human colon cancer cells by Wnt/β-catenin signaling pathway

Guanli Liang, Lei Han, Ming Qu, Jun Xue, Dandan Xu, Xueliang Wu, Yonggang Lu

https://doi.org/10.18632/aging.205197pp 13655—13668

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Atorvastatin mitigates memory deficits and brain monocyte infiltration in chronic hypercholesterolemia

Fengchao Gong, Qian Shi, Xiaojie Mou, Kang Wang, Qianqian Wang, Haitao Wang

https://doi.org/10.18632/aging.205217pp 13669—13679

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Adiponectin inhibits LPS-induced nucleus pulposus cell pyroptosis through the miR-135a-5p/TXNIP signaling pathway

Shuang Wu, Shida Liu, Rui Huang, Youbing Zhou, Yongcheng Zou, Wei Yang, Jian Zhang

https://doi.org/10.18632/aging.205226pp 13680—13692

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The antioxidant Glycitin protects against intervertebral disc degeneration through antagonizing inflammation and oxidative stress in nucleus pulposus cells

Wei Zhao, Yanpei Li, Xiang Cheng, Hui Wei, Peng Li, Lixia Fan, Kaiwen Liu, Shuai Zhang, Hao Wang

https://doi.org/10.18632/aging.205251pp 13693—13709

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A glycosylation-related signature predicts survival in pancreatic cancer

Huidong Hu, Bingsheng He, Mingang He, Hengmin Tao, Baosheng Li

https://doi.org/10.18632/aging.205258pp 13710—13737

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Involvement of RFC3 in tamoxifen resistance in ER-positive breast cancer through the cell cycle

Jintao Zhu, Lei Ye, Shishen Sun, Jie Yuan, Jianfeng Huang, Zhiqiang Zeng

https://doi.org/10.18632/aging.205260pp 13738—13752

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PBRM1 mutation and WDR72 expression as potential combinatorial biomarker for predicting the response to Nivolumab in patients with ccRCC: a tumor marker prognostic study

Qinzheng Chang, Jiajia Sun, Shuo Zhao, Luchao Li, Nianzhao Zhang, Lei Yan, Yidong Fan, Jikai Liu

https://doi.org/10.18632/aging.205261pp 13753—13775

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Prognostic role of long non-coding RNA USP30-AS1 in ovarian cancer: insights into immune cell infiltration in the tumor microenvironment

Jian Xiong, Junyan Chen, Xiang Sun, Rui Zhao, Kefei Gao

https://doi.org/10.18632/aging.205262pp 13776—13798

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Integrating scRNA-seq and bulk RNA-seq to characterize infiltrating cells in the colorectal cancer tumor microenvironment and construct molecular risk models

Qi Wang, Yi-Fan Zhang, Chen-Long Li, Yang Wang, Li Wu, Xing-Ru Wang, Tai Huang, Ge-Liang Liu, Xing Chen, Qi Yu, Pei-Feng He

https://doi.org/10.18632/aging.205263pp 13799—13821

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Identification and validation of feature genes associated with M1 macrophages in preeclampsia

Panpan Hu, Shanshun Luo, Guangjin Qu, Qiqi Luo, Yu Tian, Kun Huang, Tingting Sun

https://doi.org/10.18632/aging.205264pp 13822—13839

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Prognostic significance and immune characteristics of APOE in gastric cancer

Xiulan Peng, Zhen Cai, Duansi Chen, Fei Ye, Lifeng Hong

https://doi.org/10.18632/aging.205265pp 13840—13853

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Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats

Mingyu Jiang, Jicheng Dai, Chunming Jiang, Yanbo Pan, Mingyong Ren, Mengnan Xing

https://doi.org/10.18632/aging.205266pp 13854—13864

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S14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB

Yunlong Wu, Hui Zhang, Lingbo Guan, Xiangli Jia, Mei Wang

https://doi.org/10.18632/aging.205267pp 13865—13875

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lncRNA TUSC7 regulates oxidative stress level by targeting miR-23b in colorectal cancer and thus inhibits cell proliferation, migration and invasion

Haopeng Ye, Weidan Ren, Guiwei Liu, Qingjin Guo

https://doi.org/10.18632/aging.205270pp 13876—13887

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HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

Peiyi Yin, Yongbin Wu, Xiang Long, Shuqiang Zhu, Shiwei Chen, Feng Lu, Kun Lin, Jianjun Xu

https://doi.org/10.18632/aging.205272pp 13888—13900

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Crosstalk of cuproptosis-related prognostic signature and competing endogenous RNAs regulation in hepatocellular carcinoma

Jun Zhu, Jingyan Wang, Hong Liu, Tong Lei, Jiankang Yang, Sheng Lan, Haokun Jian, Hanlu Fang, Yu Zhang, Kuiwu Ren, Fei Zhong

https://doi.org/10.18632/aging.205273pp 13901—13919

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Has-miR-300—GADD45B promotes melanoma growth via cell cycle

Long Chen, Chenglong Fang, Xiaoxue Yuan, Mengqi Liu, Ping Wu, Li Zhong, Zhiyong Chen

https://doi.org/10.18632/aging.205276pp 13920—13943

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SEMA3G, downregulated by ncRNAs, correlates with favorable prognosis and tumor immune infiltration in kidney renal clear cell carcinoma

Jian Yuan, Guorong Yuan

https://doi.org/10.18632/aging.205277pp 13944—13960

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Cathepsin V drives lung cancer progression by shaping the immunosuppressive environment and adhesion molecules cleavage

Lifei Zhu, Qi Zeng, Jinxiang Wang, Fan Deng, Shi Jin

https://doi.org/10.18632/aging.205278pp 13961—13979

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lncRNA GPRC5D-AS1 as a ceRNA inhibits skeletal muscle aging by regulating miR-520d-5p

Miao Yu, Xiuting He, Ting Liu, Jie Li

https://doi.org/10.18632/aging.205279pp 13980—13997

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Modified Chaishao Liujunzi Decoction inhibits bile acid-induced gastric intestinal metaplasia: from network prediction to experimental verification

Zheyu Sun, Yuna Liu, Haiyan Deng, Shaohua Wang, Jing Zhang, Chongyi Xing, Chunfeng Xu

https://doi.org/10.18632/aging.205285pp 13998—14018

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Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats

Parthasarathi Barik, Wei-Wen Kuo, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Cecilia Hsuan Day, Jayasimharayalu Daddam, Michael Yu-Chih Chen, V. Vijaya Padma, Marthandam Asokan Shibu, Chih-Yang Huang

https://doi.org/10.18632/aging.205287pp 14019—14038

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Association of modifiable risk factors with obstructive sleep apnea: a Mendelian randomization study

Ye Li, Yuyang Miao, Jin Tan, Qiang Zhang

https://doi.org/10.18632/aging.205288pp 14039—14065

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Obesity, birth weight, and lifestyle factors for frailty: a Mendelian randomization study

Yingzhen Gu, Zuozhi Li, Aimin Dang, Wei Zhang, Jinxing Liu, Xiaorong Han, Yifan Li, Naqiang Lv

https://doi.org/10.18632/aging.205290pp 14066—14085

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Transcriptome research of human amniocytes identifies hub genes associated with developmental dysplasia in down syndrome

Zhenglong Guo, Hai Xiao, Wenke Yang, Tao Li, Bingtao Hao, Shixiu Liao

https://doi.org/10.18632/aging.205291pp 14086—14108

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Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer

Longjun Zang, Baoming Zhang, Yanling Zhou, Fusheng Zhang, Xiaodong Tian, Zhongming Tian, Dongjie Chen, Qingwang Miao

https://doi.org/10.18632/aging.205293pp 14109—14140

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Comprehensive analysis reveals key genes and environmental toxin exposures underlying treatment response in ulcerative colitis based on in-silico analysis and Mendelian randomization

Yizhou Huang, Jie Liu, Dingbao Liang

https://doi.org/10.18632/aging.205294pp 14141—14171

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Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer’s disease-like neuropathology and cognitive deficits

Ling Lei, Yong Luo, Dongkun Kang, Fumin Yang, Dongli Meng, Jian-Zhi Wang, Rong Liu, Xiaochuan Wang, Hong-Lian Li

https://doi.org/10.18632/aging.205295pp 14172—14191

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The positive efficacy of dexmedetomidine on the clinical outcomes of patients undergoing renal transplantation: evidence from meta-analysis

Shanshan Guo, Degong Jia, Xueqi Liu, Li Gao, Huaying Wang, Chaoyi Chen, Yonggui Wu

https://doi.org/10.18632/aging.205296pp 14192—14209

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Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy

Mengxi Wang, Xiaozhuo Xu, Jianghong Li, Ziwei Gao, Yuhan Ding, Xiaohu Chen, Qian Xiang, Le Shen

https://doi.org/10.18632/aging.205298pp 14210—14241

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Two lncRNA signatures with cuproptosis as a novel prognostic model and clinicopathological value for endometrioid endometrial adenocarcinoma

Hongrong Wu, Ruilin Lin, Liangli Hong

https://doi.org/10.18632/aging.205299pp 14242—14262

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Integrated multi-omics analysis for lung adenocarcinoma in Xuanwei, China

Boyi Jiang, Jiapeng Yang, Rui He, Dong Wang, Yunchao Huang, Guangqiang Zhao, Mingjie Ning, Teng Zeng, Guangjian Li

https://doi.org/10.18632/aging.205300pp 14263—14291

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Delivering umbilical cord mesenchymal stem cell exosomes through hydrogel ameliorates vaginal atrophy in ovariectomized rats

Tao Zhang, Dandan Li, Yanting Wang, Chi Zhang, Wenlan Yang, Guolan Gao

https://doi.org/10.18632/aging.205302pp 14292—14305

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DOK7, a target of miR-299-5p, suppresses the progression of bladder cancer

Xuemei Tian, Dan Liu, Peng He, Lijun Li, Yu Wang, Mingxing Qiu

https://doi.org/10.18632/aging.205304pp 14306—14322

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Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation

Qian Gao, Yonggang Lu, Weiling Zhou

https://doi.org/10.18632/aging.205305pp 14323—14332

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Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma

Xinti Sun, Fei Meng, Minyu Nong, Hao Fang, Chenglu Lu, Yan Wang, Peng Zhang

https://doi.org/10.18632/aging.205306pp 14333—14371

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Melatonin exhibits partial protective effects against gemcitabine- and cisplatin-induced kidney and reproductive injuries in mice

Shao-Chuan Wang, Hsuan-Chih Hsu, Ya-Chuan Chang, Chia-Ying Yu, Chien-Te Liu, Wen-Wei Sung

https://doi.org/10.18632/aging.205307pp 14372—14383

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Integration of genomics and transcriptomics highlights the crucial role of chromosome 5 open reading frame 34 in various human malignancies

Yilin Li, Yong Zhang, Dan Sun, Xiaofeng Zhang, Shangqin Long, Jiuxiang Feng, Zhongmin Wang

https://doi.org/10.18632/aging.205310pp 14384—14410

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MicroRNA 211-5p inhibits cancer cell proliferation and migration in pancreatic cancer by targeting BMP2

Dan Li, Chen Luo, Jianyong Deng, Yongkang Xu, Shumin Fu, Kan Liu, Jianbing Wu

https://doi.org/10.18632/aging.205320pp 14411—14421

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Integrative analysis of single-cell and bulk RNA seq to reveal the prognostic model and tumor microenvironment remodeling mechanisms of cuproptosis-related genes in colorectal cancer

Bowen Chu, Yaohui Wang, Jiwen Yang, Bohan Dong

https://doi.org/10.18632/aging.205324pp 14422—14444

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The effect of nutritional biochemical indexes on the hospitalization outcome of COVID-19

Peng Wang, Wenying Shi, Xiaodi Zhao, Guanan Zhao, Lidan Ding, Sen Zhang, Jiaxin Li

https://doi.org/10.18632/aging.205335pp 14445—14456

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MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88/NF-κB pathway to alleviate osteoarthritis progression

Jiayi Chen, Zhutong Liu, He Sun, Mange Liu, Jiangliang Wang, Chenxiao Zheng, Xuewei Cao

https://doi.org/10.18632/aging.205373pp 14457—14472

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Review

Traditional herbs: mechanisms to combat cellular senescence

Lei Wang, Jiahui Wang, Zhihui Yang, Yue Wang, Tiejian Zhao, Weisheng Luo, Tianjian Liang, Zheng Yang

https://doi.org/10.18632/aging.205269pp 14473—14505

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Retraction

Retraction for: Exosomes derived from human umbilical cord mesenchymal stem cells promote osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis

Shi-Wei Ren, Guang-Qing Cao, Qing-Run Zhu, Min-Gang He, Fang Wu, Su-Mei Kong, Zhao-Yan Zhang, Qiang Wang, Feng Wang

https://doi.org/10.18632/aging.205437pp 14506