Research Paper Volume 15, Issue 23 pp 14411—14421
MicroRNA 211-5p inhibits cancer cell proliferation and migration in pancreatic cancer by targeting BMP2
- 1 Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 2 Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 3 Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 4 Jiangxi Province Medical College of Nanchang University, Nanchang, Jiangxi Province, China
- 5 Department of General Surgery, Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
Received: November 28, 2022 Accepted: November 1, 2023 Published: December 6, 2023
https://doi.org/10.18632/aging.205320How to Cite
Copyright: © 2023 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
MicroRNAs (miRNAs) are essential to the tumour growth and metastasis of several cancers. However, the implied functions of miR-211-5p in pancreatic cancer (PC) remains poorly known. In the present study, we discovered that miR-211-5p was a significantly downregulated miRNA in PC tissues compared to adjacent non-tumour tissues. Moreover, we revealed that miR-211-5p overexpression suppressed the proliferation and metastasis of PC cells. Mechanistically, miR-211-5p directly bond to 3'UTR of bone morphogenetic protein-2 (BMP2) and negatively regulated its expression. Rescue experiments showed that the biological function of miR-211-5p was reversed by BMP-2 overexpression in PC cells. Clinical data indicated that BMP2 expression was negatively correlated with miR-211-5p levels in PC patients. Our study provided evidence that miR-211-5p served as a significant suppressor in PC, provided potential targets for prognosis and treatment of patients with PC.
Abbreviations
PC: pancreatic cancer; BMP2: bone morphogenetic protein-2; MiR-211-5p: MicroRNA-211-5p; 3′-UTR: 3′-untranslated region; SD: standard deviation; ANOVA: one-way analysis of variance; miRNA: microribonucleic acid; Wt: wide type; Mut: mutated type; N.S: no significance; GEPIA: Gene Expression Profiling Interactive Analysis.