Aging
Navigate
Submit an Article
Research Paper|Volume 15, Issue 23|pp 13693—13709

The antioxidant Glycitin protects against intervertebral disc degeneration through antagonizing inflammation and oxidative stress in nucleus pulposus cells

Wei Zhao1, Yanpei Li2, Xiang Cheng3, Hui Wei4, Peng Li1, Lixia Fan6, Kaiwen Liu1, Shuai Zhang1, Hao Wang5
  • 1Department of Orthopaedic Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • 2Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • 3Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China
  • 4Rehabilitation Center, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • 5Department of Trauma Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • 6Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
* Equal contribution
Received: May 8, 2023Accepted: October 23, 2023Published: November 28, 2023
https://doi.org/10.18632/aging.205251

Copyright: © 2023 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Intervertebral disc degeneration (IVDD) is a kind of typical degenerative disorder of the skeletal muscle system caused by many factors including aging, abnormal mechanical stress and inflammatory responses. Glycitin is a natural isoflavone extracted from legumes. Previous studies have found that it is anti-inflammatory and promotes wound repair. However, the role of Glycitin in IVDD has not been elucidated. In the present research, we were surprised that Glycitin antagonized the NF-κB pathway activity. In addition, we also found that Glycitin alleviated TNF-α-induced metabolic disorders, extracellular matrix degradation, oxidative stress, inflammation responses, and mitochondrial damage. Furthermore, in in vivo experimental study, we discovered Glycitin attenuated IVDD. The results revealed that Glycitin alleviated the degenerative phenotype of IVDD. According to this research, Glycitin has anti-inflammatory properties that might exert a protective function in IVDD, suggesting a prospective therapeutic approach for IVDD.