Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 14, Issue 3

15 February, 2022
pp 1068—1591

About the Cover

The cover features Figure 3 "Senostatic therapy with mTOR inhibition prevents IR-enhanced tumor growth" from Patil et al.

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Priority Research Paper

Senescence-associated tumor growth is promoted by 12-Lipoxygenase

Shilpa Patil, Jessica L. Reedy, Bradley T. Scroggins, Ayla O. White, Seokjoo Kwon, Uma Shankavaram, Alfonso López-Coral, Eun Joo Chung, Deborah E. Citrin,

https://doi.org/10.18632/aging.203890 pp 1068—1086

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Research Papers

COVID-19
The effect of age on ventilation management and clinical outcomes in critically ill COVID–19 patients––insights from the PRoVENT–COVID study

Liselotte Hol, Paula Van Oosten, Sunny Nijbroek, Anissa Tsonas, Michela Botta, Ary Serpa Neto, Frederique Paulus, Marcus Schultz, PRoVENT–COVID, Collaborative group,

https://doi.org/10.18632/aging.203863 pp 1087—1109

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COVID-19
Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling

Xiaolan You, Xingyu Jiang, Chuanmeng Zhang, Kejia Jiang, Xiaojun Zhao, Ting Guo, Xiaowei Zhu, Jingjing Bao, Hongmei Dou,

https://doi.org/10.18632/aging.203874 pp 1110—1127

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Work-related stress and well-being in association with epigenetic age acceleration: A Northern Finland Birth Cohort 1966 Study

Anna Freni-Sterrantino, Giovanni Fiorito, Angelo D’Errico, Oliver Robinson, Marianna Virtanen, Leena Ala-Mursula, Marjo-Riitta Järvelin, Justiina Ronkainen, Paolo Vineis,

https://doi.org/10.18632/aging.203872 pp 1128—1156

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Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1^dw/dw) mouse

Erik P. Rader, Marshall A. Naimo, James Ensey, Brent A. Baker,

https://doi.org/10.18632/aging.203875 pp 1157—1185

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Breast cancer mortality as a function of age

Azadeh Nasrazadani, Juan Luis Gomez Marti, Kevin E. Kip, Oscar C. Marroquin, Lara Lemon, Steve D. Shapiro, Adam M. Brufsky,

https://doi.org/10.18632/aging.203881 pp 1186—1199

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Binding of the angiogenic/senescence inducer CCN1/CYR61 to integrin α₆β₁ drives endocrine resistance in breast cancer cells

Ingrid Espinoza, Lin Yang, Travis Vander Steen, Luciano Vellon, Elisabet Cuyàs, Sara Verdura, Lester Lau, Javier A. Menendez, Ruth Lupu,

https://doi.org/10.18632/aging.203882 pp 1200—1213

View Abstract PDF Full-Text How to Cite Special Collection on Cancer Therapeutics

Ribosomal DNA methylation in human and mouse oocytes increases with age

Ramya Potabattula, Tom Trapphoff, Marcus Dittrich, Kinga Fic, Grazyna E. Ptak, Stefan Dieterle, Thomas Haaf,

https://doi.org/10.18632/aging.203891 pp 1214—1232

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PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway

Mihyang Do, Jeongmin Park, Yubing Chen, So-Young Rah, Thu-Hang Thi Nghiem, Jeong Heon Gong, Seong-A Ju, Byung-Sam Kim, Rina Yu, Jeong Woo Park, Stefan W. Ryter, Young-Joon Surh, Uh-Hyun Kim, Yeonsoo Joe, Hun Taeg Chung,

https://doi.org/10.18632/aging.203899 pp 1233—1252

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Puerarin inhibits FUNDC1-mediated mitochondrial autophagy and CSE-induced apoptosis of human bronchial epithelial cells by activating the PI3K/AKT/mTOR signaling pathway

Li Wang, Weizhou Jiang, Jing Wang, Yuanyuan Xie, Weisi Wang,

https://doi.org/10.18632/aging.203317 pp 1253—1264

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Hesperidin suppresses ERS-induced inflammation in the pathogenesis of non-alcoholic fatty liver disease

Qi Xie, Shuqing Gao, Min Lei, Zengning Li,

https://doi.org/10.18632/aging.203817 pp 1265—1279

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Predicting neuropsychiatric symptoms of persons with dementia in a day care center using a facial expression recognition system

Liang-Yu Chen, Tsung-Hsien Tsai, Andy Ho, Chun-Hsien Li, Li-Ju Ke, Li-Ning Peng, Ming-Hsien Lin, Fei-Yuan Hsiao, Liang-Kung Chen,

https://doi.org/10.18632/aging.203869 pp 1280—1291

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Effect of visfatin on K_ATP channel upregulation in colonic smooth muscle cells in diabetic colon dysmotility

Ting Yu, Lin Zhang, Yan Wang, Xiaoxue Shen, Lin Lin, Yurong Tang,

https://doi.org/10.18632/aging.203871 pp 1292—1306

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Inhibiting effect of miR-29 on proliferation and migration of uterine leiomyoma via the STAT3 signaling pathway

Dai Huang, Hongyuan Xue, Weihua Shao, Xiaoxi Wang, Hongjuan Liao, Yuquan Ye,

https://doi.org/10.18632/aging.203873 pp 1307—1320

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CTRP3 alleviates cardiac ischemia/reperfusion injury via LAMP1/JIP2/JNK signaling pathway

Yanbin Song, Yunqing Zhang, Zhaofei Wan, Junqiang Pan, Feng Gao, Fei Li, Jing Zhou, Junmin Chen,

https://doi.org/10.18632/aging.203876 pp 1321—1335

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Hyperintensities of middle frontal gyrus in patients with diabetic optic neuropathy: a dynamic amplitude of low-frequency fluctuation study

Lin Yang, Ang Xiao, Qiu-Yu Li, Hui-Feng Zhong, Ting Su, Wen-Qing Shi, Ping Ying, Rong-Bin Liang, San-Hua Xu, Yi Shao, Qiong Zhou,

https://doi.org/10.18632/aging.203877 pp 1336—1350

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Identification and external validation of the hub genes associated with cardiorenal syndrome through time-series and network analyses

Jingjing Liang, Xiaohui Huang, Weiwen Li, Yunzhao Hu,

https://doi.org/10.18632/aging.203878 pp 1351—1373

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Identification of immune-related cells and genes in the breast invasive carcinoma microenvironment

Xingfeng Chen, Yujing Wang, Yue Li, Geli Liu, Kui Liao, Fangzhou Song,

https://doi.org/10.18632/aging.203879 pp 1374—1388

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Sublethal heat treatment promotes breast cancer metastasis and its molecular mechanism revealed by quantitative proteomic analysis

Shujun Xia, Xiaoyu Li, Shangyan Xu, Xiaofeng Ni, Weiwei Zhan, Wei Zhou,

https://doi.org/10.18632/aging.203884 pp 1389—1406

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A web-based calculator for predicting the prognosis of patients with sarcoma on the basis of antioxidant gene signatures

Kun Quan, Zhiyou Cao, Qiang Xu, Meisong Zhu, Xuqiang Liu, Min Dai,

https://doi.org/10.18632/aging.203885 pp 1407—1428

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Identification and validation of an immune-related gene pairs signature for three urologic cancers

Biao Xie, Kangjie Li, Hong Zhang, Guichuan Lai, Dapeng Li, Xiaoni Zhong,

https://doi.org/10.18632/aging.203886 pp 1429—1447

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Screening of antibacterial compounds with novel structure from the FDA approved drugs using machine learning methods

Wen-Xing Li, Xin Tong, Peng-Peng Yang, Yang Zheng, Ji-Hao Liang, Gong-Hua Li, Dahai Liu, Dao-Gang Guan, Shao-Xing Dai,

https://doi.org/10.18632/aging.203887 pp 1448—1472

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Identification of an EMT-related lncRNA signature and LINC01116 as an immune-related oncogene in hepatocellular carcinoma

Haisu Tao, Yuxin Zhang, Tong Yuan, Jiang Li, Junjie Liu, Yixiao Xiong, Jinghan Zhu, Zhiyong Huang, Ping Wang, Huifang Liang, Erlei Zhang,

https://doi.org/10.18632/aging.203888 pp 1473—1491

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Identification and validation of a twelve immune infiltration-related lncRNA prognostic signature for bladder cancer

Chen-Qian Liu, Qi-Dong Xia, Jian-Xuan Sun, Jin-Zhou Xu, Jun-Lin Lu, Zheng Liu, Jia Hu, Shao-Gang Wang,

https://doi.org/10.18632/aging.203889 pp 1492—1507

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Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy

Tiegang Li, Weiqi Wang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Zheng Yan, Rixin Zhang, Min Yang,

https://doi.org/10.18632/aging.203894 pp 1508—1528

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Construction and validation of a prognostic risk model of angiogenesis factors in skin cutaneous melanoma

Songyun Zou, Yonggang Zhang, Limei Zhang, Dengchuan Wang, Shi Xu,

https://doi.org/10.18632/aging.203895 pp 1529—1548

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Reviews

Cholesterol metabolism in aging simultaneously altered in liver and nervous system

Valéria Sutti Nunes, Guilherme da Silva Ferreira, Eder Carlos Rocha Quintão,

https://doi.org/10.18632/aging.203880 pp 1549—1561

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The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure

Ling Rui Li, Gautam Sethi, Xing Zhang, Cui Liu Liu, Yan Huang, Qun Liu, Bo Xu Ren, Feng Ru Tang,

https://doi.org/10.18632/aging.203893 pp 1562—1588

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Corrections

Correction for: microRNA-363-3p reduces endothelial cell inflammatory responses in coronary heart disease via inactivation of the NOX4-dependent p38 MAPK axis

Tao Zhou, Suining Li, Liehong Yang, Daokang Xiang,

https://doi.org/10.18632/aging.203865 pp 1589

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Correction for: Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats

Xiangyu Chu, Tao Yu, Xiaojian Huang, Yang Xi, Bowei Ni, Rui Zhang, Hongbo You,

https://doi.org/10.18632/aging.203892 pp 1590—1591

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