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The cover features Figure 5 "KB1541 ameliorates senescence phenotypes" from Lee et al.

Volume 14, Issue 2

31 January, 2022
pp 530—1067

About the Cover

The cover features Figure 5 "KB1541 ameliorates senescence phenotypes" from Lee et al.

Explore This Issue

Meeting Report

Meeting Report: Aging Research and Drug Discovery

Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shiqing Cai, Brian H. Chen, Maria Ermolaeva, Collin Y. Ewald, Luigi Ferrucci, Maria Carolina Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim N. Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt H. Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James L. Kirkland, Michael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter D. Longo, Yu-Xuan Lu, Michael R. MacArthur, Andrea B. Maier, Christina Manakanatas, Sarah J. Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegué, Michael A. Petr, James Peyer, Dina Radenkovic, Thomas A. Rando, Suresh Rattan, Christian G. Riedel, Lenhard Rudolph, Ruixue Ai, Manuel Serrano, Björn Schumacher, David A. Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano, Kris Verburgh, Eric Verdin, Jan Vijg, Rudi G.J. Westendorp, Alessandra Zonari, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen,
https://doi.org/10.18632/aging.203859 pp 530—543
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Research Papers

COVID-19
Severe versus common COVID-19: an early warning nomogram model

Yanxin Chang, Xuying Wan, Xiaohui Fu, Ziyu Yang, Zhijie Lu, Zhenmeng Wang, Li Fu, Lei Yin, Yongjie Zhang, Qian Zhang,
https://doi.org/10.18632/aging.203832 pp 544—556
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COVID-19
Association between tocilizumab treatment and clinical outcomes of COVID-19 patients: a systematic review and meta-analysis

Jingwen Peng, Xiaodong She, Huan Mei, Hailin Zheng, Meihua Fu, Guanzhao Liang, Qiong Wang, Weida Liu,
https://doi.org/10.18632/aging.203834 pp 557—571
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Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile

Adam Krzystyniak, Malgorzata Wesierska, Gregory Petrazzo, Agnieszka Gadecka, Magdalena Dudkowska, Anna Bielak-Zmijewska, Grazyna Mosieniak, Izabela Figiel, Jakub Wlodarczyk, Ewa Sikora,
https://doi.org/10.18632/aging.203835 pp 572—595
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Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study

Anette Arild, Torgil Vangberg, Hanne Nikkels, Stian Lydersen, Ulrik Wisløff, Dorthe Stensvold, Asta K. Håberg,
https://doi.org/10.18632/aging.203843 pp 596—622
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A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk

Erin Macdonald-Dunlop, Nele Taba, Lucija Klarić, Azra Frkatović, Rosie Walker, Caroline Hayward, Tõnu Esko, Chris Haley, Krista Fischer, James F. Wilson, Peter K. Joshi,
https://doi.org/10.18632/aging.203847 pp 623—659
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Comparing qPCR and DNA methylation-based measurements of telomere length in a high-risk pediatric cohort

Waylon J. Hastings, Laura Etzel, Christine M. Heim, Jennie G. Noll, Emma J. Rose, Hannah M.C. Schreier, Chad E. Shenk, Xin Tang, Idan Shalev,
https://doi.org/10.18632/aging.203849 pp 660—677
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Targeting regulation of ATP synthase 5 alpha/beta dimerization alleviates senescence

Yun Haeng Lee, Doyoung Choi, Geonhee Jang, Ji Yun Park, Eun Seon Song, Haneur Lee, Myeong Uk Kuk, Junghyun Joo, Soon Kil Ahn, Youngjoo Byun, Joon Tae Park,
https://doi.org/10.18632/aging.203858 pp 678—707
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S-Klotho level and physiological markers of cardiometabolic risk in healthy adult men

Agnieszka Żelaźniewicz, Judyta Nowak-Kornicka, Bogusław Pawłowski,
https://doi.org/10.18632/aging.203861 pp 708—727
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Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis

Asha Rani, Jolie Barter, Ashok Kumar, Julie A. Stortz, McKenzie Hollen, Dina Nacionales, Lyle L. Moldawer, Philip A. Efron, Thomas C. Foster,
https://doi.org/10.18632/aging.203868 pp 728—746
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Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma

Xinghua Huang, Huaxiang Wang, Fengfeng Xu, Lizhi Lv, Ruling Wang, Bin Jiang, Tingting Liu, Huanzhang Hu, Yi Jiang,
https://doi.org/10.18632/aging.203809 pp 747—769
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Impact of marital status on survival in patients with stage 1A NSCLC

Liu Huang, Shu Peng, Chenyu Sun, Lian Chen, Qian Chu, Sudip Thapa, Vanisha Chummun, Lu Zhang, Peng Zhang, Eric L. Chen, Ce Cheng, Yuan Chen,
https://doi.org/10.18632/aging.203838 pp 770—779
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Integrin αEβ7 is involved in the intestinal barrier injury of sepsis

Jia-Kui Sun, Qian Zhang, Xiao Shen, Jing Zhou, Xiang Wang, Su-Ming Zhou, Xin-Wei Mu,
https://doi.org/10.18632/aging.203839 pp 780—788
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A dynamic model to predict long-term outcomes in patients with prolonged disorders of consciousness

Junwei Kang, Lianghua Huang, Yunliang Tang, Gengfa Chen, Wen Ye, Jun Wang, Zhen Feng,
https://doi.org/10.18632/aging.203840 pp 789—799
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The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease

Chunyan Li, Yang Zheng, Ying Liu, Guo Hong Jin, Haizhou Pan, Fenghui Yin, Jun Wu,
https://doi.org/10.18632/aging.203841 pp 800—810
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Immunological significance of survival-related alternative splicing in uveal melanoma

Deqian Kong, Li Li, Huajun Wang, Ke Li, Guangying Zheng,
https://doi.org/10.18632/aging.203842 pp 811—825
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A new signature based on alternative polyadenylation for prognostic prediction and therapeutic responses in low-grade glioma

Yuzhi Wang, Yunfei Xu, Yi Zhang,
https://doi.org/10.18632/aging.203844 pp 826—844
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Tumor microenvironment-related multigene prognostic prediction model for breast cancer

Kai Hong, Yingjue Zhang, Lingli Yao, Jiabo Zhang, Xianneng Sheng, Yu Guo,
https://doi.org/10.18632/aging.203845 pp 845—868
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Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma

Zixuan Wu, Xuyan Huang, Minjie Cai, Peidong Huang, Zunhui Guan,
https://doi.org/10.18632/aging.203846 pp 869—891
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The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1

Yifeng Yuan, Jiangang Sun, Hang Zhou, Shen Wang, Caijian He, Tianpeng Chen, Mouhao Fang, Shaohua Li, Shifa Kang, Xiaosheng Huang, Binbin Tang, Bocheng Liang, Yingdelong Mao, Jianyou Li, Xiaolin Shi, Kang Liu,
https://doi.org/10.18632/aging.203848 pp 892—906
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A radiomics model predicts the response of patients with advanced gastric cancer to PD-1 inhibitor treatment

Zhiwen Liang, Ai Huang, Linfang Wang, Jianping Bi, Bohua Kuang, Yong Xiao, Dandan Yu, Ma Hong, Tao Zhang,
https://doi.org/10.18632/aging.203850 pp 907—922
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Age-related alterations of brain metabolic network based on [18F]FDG-PET of rats

Xin Xue, Jia-Jia Wu, Bei-Bei Huo, Xiang-Xin Xing, Jie Ma, Yu-Lin Li, Mou-Xiong Zheng, Xu-Yun Hua, Jian-Guang Xu,
https://doi.org/10.18632/aging.203851 pp 923—942
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The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis

Wei Gu, Le Sun, Jian Wang, Xiaowei Chen,
https://doi.org/10.18632/aging.203852 pp 943—960
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Integrative bioinformatics and experimental analysis revealed TEAD as novel prognostic target for hepatocellular carcinoma and its roles in ferroptosis regulation

Xinxin Ren, Xiang Wang, Yuanliang Yan, Xi Chen, Yuan Cai, Qiuju Liang, Bi Peng, Zhijie Xu, Qingchun He, Fanhua Kang, Jianbo Li, Wenqin Zhang, Qianhui Hong, Jinwu Peng, Muzhang Xiao,
https://doi.org/10.18632/aging.203853 pp 961—974
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The prevalence of small intestinal bacterial overgrowth in diabetes mellitus: a systematic review and meta-analysis

Xin Feng, Xiao-Qing Li,
https://doi.org/10.18632/aging.203854 pp 975—988
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A novel pyroptosis-related signature predicts prognosis and response to treatment in breast carcinoma

Haochen Yu, Yong Fu, Zhenrong Tang, Linshan Jiang, Chi Qu, Han Li, Zhaofu Tan, Dan Shu, Yang Peng, Shengchun Liu,
https://doi.org/10.18632/aging.203855 pp 989—1013
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A comprehensive analysis of age-related metabolomics and transcriptomics reveals metabolic alterations in rat bone marrow mesenchymal stem cells

Xiao Yu, Hui Sun, Xingyu Gao, Chang Zhang, Yanan Sun, Huan Wang, Haiying Zhang, Yingai Shi, Xu He,
https://doi.org/10.18632/aging.203857 pp 1014—1032
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Pan-cancer analysis reveals NUP37 as a prognostic biomarker correlated with the immunosuppressive microenvironment in glioma

Ya He, Jingang Li, Lan Shen, Hui Zhou, Wei Fei, Guangliang Zhang, Zhen Li, Fei Wang, Yuetao Wen,
https://doi.org/10.18632/aging.203862 pp 1033—1047
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Review

Acquired resistance for immune checkpoint inhibitors in cancer immunotherapy: challenges and prospects

Xunrui Chen, Wenhui Zhang, Wenyan Yang, Min Zhou, Feng Liu,
https://doi.org/10.18632/aging.203833 pp 1048—1064
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Corrections

Correction for: Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway

Chenyang Han, Yi Yang, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Li Guo, Caiqun Zhang, Qiao Ye,
https://doi.org/10.18632/aging.203864 pp 1065—1066
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Correction for: Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-β/Smad3 signaling pathway

Yu Zhang, Jingjing Xiang, Ni Zhu, Hangping Ge, Xianfu Sheng, Shu Deng, Junfa Chen, Lihong Yu, Yan Zhou, Jianping Shen,
https://doi.org/10.18632/aging.203870 pp 1067
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