Esther Meron1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark, Maria Thaysen1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark, Suzanne Angeli2Buck Institute for Research on Aging, Novato, CA 94945, USA, Adam Antebi3Max Planck Institute for Biology of Ageing, Cologne, Germany, Nir Barzilai4,Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA5Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Joseph A. Baur6Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, PA 19104, USA, Simon Bekker-Jensen1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark, Maria Birkisdottir7,Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands8Department of Neuroscience, Erasmus MC, Rotterdam, Netherlands, Evelyne Bischof9Shanghai University of Medicine and Health Sciences, College of Clinical Medicine, Shanghai, China, Jens Bruening10Max Planck Institute for Metabolism Research, Cologne, Germany, Anne Brunet11Department of Genetics, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA, Abigail Buchwalter12Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA, Filipe Cabreiro13,Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK14CECAD Research Center, Faculty of Medicine, University of Cologne, Cologne, Germany, Shiqing Cai15Institute of Neuroscience, Chinese Academy of Science, Shanghai, China, Brian H. Chen16,FOXO Technologies Inc, Minneapolis, MN 55402, USA17The Herbert Wertheim School of Public Health and Human Longevity Science, UC San Diego, La Jolla, CA 92093, USA, Maria Ermolaeva18Leibniz Institute on Aging, Jena, Germany, Collin Y. Ewald19Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland, Luigi Ferrucci20Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, Maria Carolina Florian21Program for Regenerative Medicine, IDIBELL, Barcelona, Spain, Kristen Fortney22BioAge Labs, Inc., Richmond, CA 94804, USA, Adam Freund23Arda Therapeutics, San Carlos, CA 94070, USA, Anastasia Georgievskaya24HautAI OÜ, Tallinn, Estonia, Vadim N. Gladyshev25Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA, David Glass26Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, Tyler Golato27Molecule, Schaffhausen, Switzerland, Vera Gorbunova28Departments of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA, Jan Hoejimakers29Department of Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands, Riekelt H. Houtkooper30Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands, Sibylle Jager31L’Oréal Research and Innovation, Aulnay-sous-Bois, France, Frank Jaksch32ChromaDex Corp, Los Angeles, CA 90024, USA, Georges Janssens30Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands, Martin Borch Jensen33Gordian Biotechnology, San Francisco, CA 94107, USA, Matt Kaeberlein34Departments of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA, Gerard Karsenty35Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA, Peter de Keizer36Department of Molecular Cancer Research, Center for Molecular Medicine, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands, Brian Kennedy2,Buck Institute for Research on Aging, Novato, CA 94945, USA37,Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore38Center for Healthy Longevity, National University Health System, Singapore, James L. Kirkland39Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA, Michael Kjaer40Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, Guido Kroemer41Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France, Kai-Fu Lee42Sinovation Ventures and Sinovation AI Institute, Beijing, China, Jean-Marc Lemaitre43Institute for Regenerative Medicine and Biotherapies, INSERM UMR 1183, Montpellier, France, David Liaskos44Nagi Bioscience, Ecublens, Switzerland, Valter D. Longo45USC Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA, Yu-Xuan Lu3Max Planck Institute for Biology of Ageing, Cologne, Germany, Michael R. MacArthur46Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland, Andrea B. Maier38,Center for Healthy Longevity, National University Health System, Singapore47,Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands48Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Christina Manakanatas49Max Perutz Labs, The University of Vienna, Vienna, Austria, Sarah J. Mitchell46Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland, Alexey Moskalev50,Institute of Biology of FRC Komi Science Center of Ural Division of RAS, Syktyvkar, Russia51Russian Clinical and Research Center of Gerontology, Moscow, Russia, Laura Niedernhofer52Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA, Ivan Ozerov53Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong, Linda Partridge3Max Planck Institute for Biology of Ageing, Cologne, Germany, Emmanuelle Passegué54Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA, Michael A. Petr1,Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark55Tracked.bio, Copenhagen, Denmark, James Peyer56Cambrian Biopharma, New York, NY 11205, USA, Dina Radenkovic57Hooke London by Health and Longevity Optimisation, London, UK, Thomas A. Rando58Department of Neurology and Neurological Sciences and Paul F. Glenn Center for Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA, Suresh Rattan59Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark, Christian G. Riedel60Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden, Lenhard Rudolph18Leibniz Institute on Aging, Jena, Germany, Ruixue Ai61Department of Clinical Molecular Biology | UiO, University of Oslo and Akershus University Hospital, Norway, Manuel Serrano62Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, Björn Schumacher14CECAD Research Center, Faculty of Medicine, University of Cologne, Cologne, Germany, David A. Sinclair63Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 94107, USA, Ryan Smith64TruDiagnostic, Lexington, KY 40503, USA, Yousin Suh65Departments of Obstetrics and Gynecology, Genetics and Development, Columbia University, New York, NY 10027, USA, Pam Taub66Division of Cardiovascular Medicine, University of California, San Diego, CA 92093, USA, Alexandre Trapp25Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA, Anne-Ulrike Trendelenburg67Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA, Dario Riccardo Valenzano3,Max Planck Institute for Biology of Ageing, Cologne, Germany18Leibniz Institute on Aging, Jena, Germany, Kris Verburgh68Longevity Vision Fund, New York, NY 10022, USA, Eric Verdin2Buck Institute for Research on Aging, Novato, CA 94945, USA, Jan Vijg4Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Rudi G.J. Westendorp69Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Alessandra Zonari70OneSkin, San Francisco, CA 94107, USA, Daniela Bakula1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark, Alex Zhavoronkov53Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong, Morten Scheibye-Knudsen1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
- 1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
- 2Buck Institute for Research on Aging, Novato, CA 94945, USA
- 3Max Planck Institute for Biology of Ageing, Cologne, Germany
- 4Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- 5Institute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- 6Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, PA 19104, USA
- 7Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands
- 8Department of Neuroscience, Erasmus MC, Rotterdam, Netherlands
- 9Shanghai University of Medicine and Health Sciences, College of Clinical Medicine, Shanghai, China
- 10Max Planck Institute for Metabolism Research, Cologne, Germany
- 11Department of Genetics, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
- 12Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
- 13Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
- 14CECAD Research Center, Faculty of Medicine, University of Cologne, Cologne, Germany
- 15Institute of Neuroscience, Chinese Academy of Science, Shanghai, China
- 16FOXO Technologies Inc, Minneapolis, MN 55402, USA
- 17The Herbert Wertheim School of Public Health and Human Longevity Science, UC San Diego, La Jolla, CA 92093, USA
- 18Leibniz Institute on Aging, Jena, Germany
- 19Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland
- 20Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
- 21Program for Regenerative Medicine, IDIBELL, Barcelona, Spain
- 22BioAge Labs, Inc., Richmond, CA 94804, USA
- 23Arda Therapeutics, San Carlos, CA 94070, USA
- 24HautAI OÜ, Tallinn, Estonia
- 25Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
- 26Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA
- 27Molecule, Schaffhausen, Switzerland
- 28Departments of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA
- 29Department of Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
- 30Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
- 31L’Oréal Research and Innovation, Aulnay-sous-Bois, France
- 32ChromaDex Corp, Los Angeles, CA 90024, USA
- 33Gordian Biotechnology, San Francisco, CA 94107, USA
- 34Departments of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA
- 35Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
- 36Department of Molecular Cancer Research, Center for Molecular Medicine, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
- 37Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore
- 38Center for Healthy Longevity, National University Health System, Singapore
- 39Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
- 40Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- 41Centre de Recherche des Cordeliers, Université de Paris, Sorbonne Université, Inserm U1138, Paris, France
- 42Sinovation Ventures and Sinovation AI Institute, Beijing, China
- 43Institute for Regenerative Medicine and Biotherapies, INSERM UMR 1183, Montpellier, France
- 44Nagi Bioscience, Ecublens, Switzerland
- 45USC Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA
- 46Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland
- 47Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
- 48Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, Singapore
- 49Max Perutz Labs, The University of Vienna, Vienna, Austria
- 50Institute of Biology of FRC Komi Science Center of Ural Division of RAS, Syktyvkar, Russia
- 51Russian Clinical and Research Center of Gerontology, Moscow, Russia
- 52Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
- 53Insilico Medicine, Hong Kong Science and Technology Park, Hong Kong
- 54Columbia Stem Cell Initiative, Columbia University, New York, NY 10032, USA
- 55Tracked.bio, Copenhagen, Denmark
- 56Cambrian Biopharma, New York, NY 11205, USA
- 57Hooke London by Health and Longevity Optimisation, London, UK
- 58Department of Neurology and Neurological Sciences and Paul F. Glenn Center for Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA
- 59Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
- 60Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden
- 61Department of Clinical Molecular Biology | UiO, University of Oslo and Akershus University Hospital, Norway
- 62Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain
- 63Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 94107, USA
- 64TruDiagnostic, Lexington, KY 40503, USA
- 65Departments of Obstetrics and Gynecology, Genetics and Development, Columbia University, New York, NY 10027, USA
- 66Division of Cardiovascular Medicine, University of California, San Diego, CA 92093, USA
- 67Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA
- 68Longevity Vision Fund, New York, NY 10022, USA
- 69Department of Public Health, University of Copenhagen, Copenhagen, Denmark
- 70OneSkin, San Francisco, CA 94107, USA
* Equal contribution
