Volume 13, Issue 15

15 August, 2021
pp 19080—19947

About the Cover

The cover features Figure 3 " Comparison of the production of inflammatory cytokines and chemokines by NC HUVEC and IR HUVEC“ from Budamagunta et al.

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Editorials

Targeting FTO for cancer therapy and more

Ying Qing, Rui Su, Jianjun Chen,

https://doi.org/10.18632/aging.203404 pp 19080—19082

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Age influences the distribution of diffuse gliomas

Alexandre Roux, Pascale Varlet, Johan Pallud,

https://doi.org/10.18632/aging.203414 pp 19083—19084

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Glioma: interaction of acquired and germline genetics

Jeanette E. Eckel-Passow, Daniel H. Lachance, Robert B. Jenkins,

https://doi.org/10.18632/aging.203428 pp 19085—19087

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Priority Research Paper

Senescence-associated hyper-activation to inflammatory stimuli in vitro

Vivekananda Budamagunta, Sahana Manohar-Sindhu, Yang Yang, Yonghan He, Dmitry O. Traktuev, Thomas C. Foster, Daohong Zhou,

https://doi.org/10.18632/aging.203396 pp 19088—19107

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Research Papers

Features of age-related response to sleep deprivation: in vivo experimental studies

Maria Novozhilova, Tatiana Mishchenko, Elena Kondakova, Tatiana Lavrova, Maria Gavrish, Svetlana Aferova, Claudio Franceschi, Maria Vedunova,

https://doi.org/10.18632/aging.203372 pp 19108—19126

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The life in a gradient: calcium, the lncRNA SPRR2C and mir542/mir196a meet in the epidermis to regulate the aging process

Sven Breunig, Veronika Wallner, Katharina Kobler, Herbert Wimmer, Peter Steinbacher, Maria Karolin Streubel, Johannes Bischof, Jutta Duschl, Claudia Neuhofer, Wolfgang Gruber, Fritz Aberger, Michael Breitenbach, Elisabeth Russe, Gottfried Wechselberger, Albert Duranton, Klaus Richter, Mark Rinnerthaler,

https://doi.org/10.18632/aging.203385 pp 19127—19144

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Epigenetic age prediction in semen – marker selection and model development

Aleksandra Pisarek, Ewelina Pośpiech, Antonia Heidegger, Catarina Xavier, Anna Papież, Danuta Piniewska-Róg, Vivian Kalamara, Ramya Potabattula, Michał Bochenek, Marta Sikora-Polaczek, Aneta Macur, Anna Woźniak, Jarosław Janeczko, Christopher Phillips, Thomas Haaf, Joanna Polańska, Walther Parson, Manfred Kayser, Wojciech Branicki,

https://doi.org/10.18632/aging.203399 pp 19145—19164

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Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging

Livius V. d’Uscio, Zvonimir S. Katusic,

https://doi.org/10.18632/aging.203401 pp 19165—19185

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Health trajectories after age 60: the role of individual behaviors and the social context

Amaia Calderón-Larrañaga, Xiaonan Hu, Miriam Haaksma, Debora Rizzuto, Laura Fratiglioni, Davide L. Vetrano,

https://doi.org/10.18632/aging.203407 pp 19186—19206

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Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages

Mahamat Babagana, Kyu-Seon Oh, Sayantan Chakraborty, Alicja Pacholewska, Mohammad Aqdas, Myong-Hee Sung,

https://doi.org/10.18632/aging.203422 pp 19207—19229

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LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer

Xianxia Huang, Xuemei Liu, Bo Du, Xueling Liu, Mei Xue, Qingxin Yan, Xiaohong Wang, Qian Wang,

https://doi.org/10.18632/aging.202565 pp 19230—19242

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Glioma stem cell-derived exosomal miR-944 reduces glioma growth and angiogenesis by inhibiting AKT/ERK signaling

Jianxin Jiang, Jun Lu, Xiaolin Wang, Bing Sun, Xiaoxing Liu, Yasuo Ding, Guangzhong Gao,

https://doi.org/10.18632/aging.203243 pp 19243—19259

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Downregulation of lncRNA SBF2-AS1 inhibits hepatocellular carcinoma proliferation and migration by regulating the miR-361-5p/TGF-β1 signaling pathway

Yan-Hui Wu, Bin Yu, Wei-Xun Chen, Xi Ai, Wei Zhang, Wei Dong, Ya-Jie Shao,

https://doi.org/10.18632/aging.203248 pp 19260—19271

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lncRNA ANRIL aggravates the chemoresistance of pancreatic cancer cells to gemcitabine by targeting inhibition of miR-181a and targeting HMGB1-induced autophagy

Lei Wang, Rongrong Bi, Lei Li, Kun Zhou, Hang Yin,

https://doi.org/10.18632/aging.203251 pp 19272—19281

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Evaluation of the cargo contents and potential role of extracellular vesicles in osteoporosis

Jifeng Xu, Yu Chen, Dongsheng Yu, Li Zhang, Xiaofan Dou, Gang Wu, Yaping Wang, Shuijun Zhang,

https://doi.org/10.18632/aging.203264 pp 19282—19292

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Apremilast ameliorates IL-1α-induced dysfunction in epidermal stem cells

Yuxi Jia, Xiangru Chen, Jing Sun,

https://doi.org/10.18632/aging.203265 pp 19293—19305

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LncRNA-HAGLR motivates triple negative breast cancer progression by regulation of WNT2 via sponging miR-335-3p

Liting Jin, Chenggang Luo, Xinhong Wu, Manxiu Li, Shun Wu, Yaojun Feng,

https://doi.org/10.18632/aging.203272 pp 19306—19316

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The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma

Peiyi Xie, Yanglin Chen, Hongfei Zhang, Guichao Zhou, Qing Chao, Jiangwen Wang, Yue Liu, Jiayu Fang, Jing Xie, Jing Zhen, Zhiyuan Wang, Liang Hao, Da Huang,

https://doi.org/10.18632/aging.203293 pp 19317—19338

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Characterization of familial hypercholesterolemia in Taiwanese ischemic stroke patients

Hsin Tung, Hsueh-Ju Lin, Po-Lin Chen, Tsai-Jung Lu, Pei-Pei Jhan, Jun-Peng Chen, Yi-Ming Chen, Chen-Chin Wu, Yung-Yang Lin, Tzu-Hung Hsiao,

https://doi.org/10.18632/aging.203320 pp 19339—19351

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Identification of immune-related genes that predict prognosis and risk of bladder cancer: bioinformatics analysis of TCGA database

Liqiang Guo, Qiong Wu, Zhen Ma, Mingzhen Yuan, Shengtian Zhao,

https://doi.org/10.18632/aging.203333 pp 19352—19374

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THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection

LingNan He, WeiJun Wang, HuiYing Shi, Chen Jiang, HaiLing Yao, YuRui Zhang, Wei Qian, Rong Lin,

https://doi.org/10.18632/aging.203334 pp 19375—19396

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Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis

Chuankun Zhou, Shutao Gao, Xi Yuan, Zixing Shu, Song Li, Xuying Sun, Jun Xiao, Hui Liu,

https://doi.org/10.18632/aging.203349 pp 19397—19414

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Development and validation of an intra-tumor heterogeneity-related signature to predict prognosis of bladder cancer: a study based on single-cell RNA-seq

Ranran Zhou, Jingjing Liang, Qi Chen, Hu Tian, Cheng Yang, Cundong Liu,

https://doi.org/10.18632/aging.203353 pp 19415—19441

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CC16-TNF-α negative feedback loop formed between Clara cells and normal airway epithelial cells protects against diesel exhaust particles exposure-induced inflammation

Ting Hu, Fenglan Sun, Xinjuan Yu, Qinghai Li, Long Zhao, Wanming Hao, Wei Han,

https://doi.org/10.18632/aging.203356 pp 19442—19459

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Pedunculoside protects against LPS-induced mastitis in mice by inhibiting inflammation and maintaining the integrity of blood-milk barrier

Xingchi Kan, Guiqiu Hu, Bingxu Huang, Wenjin Guo, Yaping Huang, Yingsheng Chen, Ping Xu, Xiangyu Cai, Shoupeng Fu, Juxiong Liu,

https://doi.org/10.18632/aging.203357 pp 19460—19474

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FK506 binding protein 10: a key actor of collagen crosslinking in clear cell renal cell carcinoma

Yubai Zhang, Yue Yin, Sijia Liu, Lei Yang, Changhua Sun, Ruihua An,

https://doi.org/10.18632/aging.203359 pp 19475—19485

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A combined hypoxia and immune gene signature for predicting survival and risk stratification in triple-negative breast cancer

Xia Yang, Xin Weng, Yajie Yang, Meng Zhang, Yingjie Xiu, Wenfeng Peng, Xuhui Liao, Meiquan Xu, Yanhua Sun, Xia Liu,

https://doi.org/10.18632/aging.203360 pp 19486—19509

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UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson’s disease mice after oral administration of Wen-Shen-Yang-Gan decoction

Guoxue Zhu, Wang Wang, Chang Chen, Lili Tang, Yan Liang, Zhennian Zhang, Yan Lu, Yang Zhao,

https://doi.org/10.18632/aging.203361 pp 19510—19528

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Brain reactivity to emotional stimuli in women with premenstrual dysphoric disorder and related personality characteristics

Mingzhou Gao, Mingqi Qiao, Li An, Guangbin Wang, Jieqiong Wang, Chunhong Song, Fengqin Wei, Yanhong Yu, Tao Gong, Dongmei Gao,

https://doi.org/10.18632/aging.203363 pp 19529—19541

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Physical exercise prevents age-related heart dysfunction induced by high-salt intake and heart salt-specific overexpression in Drosophila

Deng-Tai Wen, Lan Zheng, Kai Lu, Wen-Qi Hou,

https://doi.org/10.18632/aging.203364 pp 19542—19560

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Effect of age as a continuous variable in early-stage endometrial carcinoma: a multi-institutional analysis in China

Shuai Sun, Lijuan Zou, Tiejun Wang, Zi Liu, Jianli He, Xiaoge Sun, Wei Zhong, Fengju Zhao, Xiaomei Li, Sha Li, Hong Zhu, Zhanshu Ma, Wenhui Wang, Meng Jin, Fuquan Zhang, Xiaorong Hou, Lichun Wei, Ke Hu,

https://doi.org/10.18632/aging.203367 pp 19561—19574

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Plasmatic exosome-derived circRNAs panel act as fingerprint for glioblastoma

Dongyan Xia, Xuhui Gu,

https://doi.org/10.18632/aging.203368 pp 19575—19586

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LncRNA AC136007.2 alleviates cerebral ischemic-reperfusion injury by suppressing autophagy

Na Liu, Aini Peng, Haiyan Sun, Yuansu Zhuang, Ming Yu, Qun Wang, Jinping Wang,

https://doi.org/10.18632/aging.203369 pp 19587—19597

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Computational research of mTORC1 inhibitor on cerebral ischemia-reperfusion injury

Hui Li, Wenzhuo Yang, Zhenhua Wang, Xu Wang, Yulei Hao, Jianxin Xi, Han Lu, Zhishan Du, Jiachun Feng, Bao Zhang, Di Ma,

https://doi.org/10.18632/aging.203371 pp 19598—19613

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Global, regional, and national burden of blindness and vision loss due to common eye diseases along with its attributable risk factors from 1990 to 2019: a systematic analysis from the global burden of disease study 2019

Xiaorong Yang, Hui Chen, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Qiufeng He, Ming Lu,

https://doi.org/10.18632/aging.203374 pp 19614—19642

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The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca²⁺ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

Tong Gao, Peng Yang, Dongliang Fu, Mengru Liu, Xinyi Deng, Mingjing Shao, Jiangquan Liao, Hong Jiang, Xianlun Li,

https://doi.org/10.18632/aging.203375 pp 19643—19656

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Diagnostic performance of microRNAs in testicular germ cell tumors: a systematic review and meta-analysis

Xi-Yi Zhao, Yu-Lu Gao, Dan-Feng Li, Hong-Chao Liu, Rui-Fang Zhu, Chang-Tai Zhu,

https://doi.org/10.18632/aging.203376 pp 19657—19677

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Identification of inflammation-related DNA methylation biomarkers in periodontitis patients based on weighted co-expression analysis

Pengcheng Wang, Bingbing Wang, Zheng Zhang, Zuomin Wang,

https://doi.org/10.18632/aging.203378 pp 19678—19695

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Immune cell infiltration-associated signature in colon cancer and its prognostic implications

Dan Deng, Xin Luo, Sifang Zhang, Zhijie Xu,

https://doi.org/10.18632/aging.203380 pp 19696—19709

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Active wearable device utilization improved physical performance and IGF-1 among community-dwelling middle-aged and older adults: a 12-month prospective cohort study

Wei-Ju Lee, Li-Ning Peng, Ming-Hsien Lin, Ching-Hui Loh, Liang-Kung Chen,

https://doi.org/10.18632/aging.203383 pp 19710—19721

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The role of age at menarche and age at menopause in Alzheimer’s disease: evidence from a bidirectional mendelian randomization study

Mingli Li, Jiali Lin, Shuang Liang, Zefeng Chen, Yulan Bai, Xinyang Long, Shengzhu Huang, Zengnan Mo,

https://doi.org/10.18632/aging.203384 pp 19722—19749

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Dual inhibition of FGFR4 and BCL-xL inhibits multi-resistant ovarian cancer with BCL2L1 gain

Ting Guo, Chao Gu, Bin Li, Congjian Xu,

https://doi.org/10.18632/aging.203386 pp 19750—19759

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miRNA-221-3p derived from M2-polarized tumor-associated macrophage exosomes aggravates the growth and metastasis of osteosarcoma through SOCS3/JAK2/STAT3 axis

Wei Liu, Qiuping Long, Wei Zhang, Dehui Zeng, Bingbing Hu, Shengyao Liu, Li Chen,

https://doi.org/10.18632/aging.203388 pp 19760—19775

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Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis

Mei-Ling Xu, Tian-Cheng Liu, Feng-Xiang Dong, Ling-Xin Meng, Ai-Xia Ling, Shan Liu,

https://doi.org/10.18632/aging.203389 pp 19776—19788

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Comprehensive analysis of new prognostic signature based on ferroptosis-related genes in clear cell renal cell carcinoma

Bin Zheng, Zhihong Niu, Shubin Si, Guiting Zhao, Jianwei Wang, Zhongshun Yao, Fajuan Cheng, Wei He,

https://doi.org/10.18632/aging.203390 pp 19789—19804

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MiR-195-5p and miR-205-5p in extracellular vesicles isolated from diabetic foot ulcer wound fluid decrease angiogenesis by inhibiting VEGFA expression

Jing Liu, Jiahuan Wang, Wan Fu, Xiaoyi Wang, Hongxing Chen, Xiaoying Wu, Guojuan Lao, Yuxi Wu, Mengdie Hu, Chuan Yang, Li Yan, Meng Ren,

https://doi.org/10.18632/aging.203393 pp 19805—19821

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Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma

Quan Liu, Wei Cui, Chao Yang, Li-Ping Du,

https://doi.org/10.18632/aging.203394 pp 19822—19834

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Bisphosphonates and breast cancer survival: a meta-analysis and trial sequential analysis of 81508 participants from 23 prospective epidemiological studies

YuPeng Liu, Shu Zhao, YuXue Zhang, Justina Ucheojor Onwuka, QingYuan Zhang, XiaoDong Liu,

https://doi.org/10.18632/aging.203395 pp 19835—19866

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Efficacy of graphene oxide-loaded cationic antimicrobial peptide AWRK6 on the neutralization of endotoxin activity and in the treatment of sepsis

Bo Song, Hongli Zhao, Haiyan Yang, Shengji Wang,

https://doi.org/10.18632/aging.203397 pp 19867—19877

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CCL2 associated with CD38 expression during ex vivo expansion in human cord blood-derived hematopoietic stem cells

Chao-Ling Yao, Poyin Huang, Tsai-Chi Liu, Yung-Kai Lin, Ching-Yun Chen, Yi-Ting Lai, Tzu−Yun Chin, Tsung-Yu Tseng, Yi-Chiung Hsu,

https://doi.org/10.18632/aging.203398 pp 19878—19893

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Establishing a three-miRNA signature as a prognostic model for colorectal cancer through bioinformatics analysis

Yiming Wang, Lumi Huang, Nan Shan, Huiwen Ma, Songmei Lu, Xingyue Chen, Hao Long,

https://doi.org/10.18632/aging.203400 pp 19894—19907

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A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis

Xin Xie, Fu-Kang Sun, Xin Huang, Cheng-He Wang, Jun Dai, Ju-Ping Zhao, Chen Fang, Wei He,

https://doi.org/10.18632/aging.203408 pp 19908—19919

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Review

Cellular senescence in lymphoid organs and immunosenescence

Vivekananda Budamagunta, Thomas C. Foster, Daohong Zhou,

https://doi.org/10.18632/aging.203405 pp 19920—19941

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Corrections

Correction for: Establishing immune scoring model based on combination of the number, function, and phenotype of lymphocytes

Guoxing Tang, Xu Yuan, Ying Luo, Qun Lin, Zhishui Chen, Xue Xing, Huijuan Song, Shiji Wu, Hongyan Hou, Jing Yu, Liyan Mao, Weiyong Liu, Feng Wang, Ziyong Sun,

https://doi.org/10.18632/aging.203423 pp 19942—19944

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Correction for: Supplementary research on K150del variant of activated protein C

Wen-Yi Lin, Liang Tang, Xuan Lu, Yu Hu,

https://doi.org/10.18632/aging.203437 pp 19945

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Correction for: RNA-seq reveals the diverse effects of substrate stiffness on epidermal ovarian cancer cells

Xiaoxu Yang, Guohui Wang, Xiaolei Huang, Min Cheng, Yangyang Han,

https://doi.org/10.18632/aging.203438 pp 19946—19947

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