Volume 13, Issue 16

31 August, 2021
pp 19948—20853

About the Cover

The cover features Figure 1 " Association of subjective cognitive complaints and age with cortical thickness and white matter integrity“ from Cedres et al.

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Editorials

Microbiota-associated molecular genotoxicity

Irene Maier,

https://doi.org/10.18632/aging.203446 pp 19948—19949

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The role of KRT17 in colorectal cancer

Daisuke Ujiie, Hirokazu Okayama, Koji Kono,

https://doi.org/10.18632/aging.203471 pp 19950—19951

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Challenges in targeting the tryptophan metabolism in cancer immunotherapy

Julia Schollbach, Stefan Löb,

https://doi.org/10.18632/aging.203492 pp 19952—19953

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Research Papers

COVID-19
COVID-19 mortality rate in children is U-shaped

Nina Khera, Didac Santesmasses, Csaba Kerepesi, Vadim N. Gladyshev,

https://doi.org/10.18632/aging.203442 pp 19954—19962

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The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline

Nira Cedres, Patricia Diaz-Galvan, Lucio Diaz-Flores, J-Sebastian Muehlboeck, Yaiza Molina, José Barroso, Eric Westman, Daniel Ferreira,

https://doi.org/10.18632/aging.203467 pp 19963—19977

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TGF-β2 and collagen play pivotal roles in the spheroid formation and anti-aging of human dermal papilla cells

Hyunju Kim, Nahyun Choi, Doo Yeong Kim, So Yoon Kim, Seung Yong Song, Jong-Hyuk Sung,

https://doi.org/10.18632/aging.203419 pp 19978—19995

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Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults

Rachel K. Spooner, Brittany K. Taylor, Emma L’Heureux, Mikki Schantell, Yasra Arif, Pamela E. May, Brenda Morsey, Tina Wang, Trey Ideker, Howard S. Fox, Tony W. Wilson,

https://doi.org/10.18632/aging.203433 pp 19996—20015

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Oral administration of berberine represses macrophage activation-associated benign prostatic hyperplasia: a pivotal involvement of the NF-κB

Bo-Ram Jin, Hyo-Jin An,

https://doi.org/10.18632/aging.203434 pp 20016—20028

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Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors

Ted Kheng Siang Ng, David Bruce Matchar, Timothy V. Pyrkov, Peter O. Fedichev, Angelique Wei-Ming Chan, Brian Kennedy,

https://doi.org/10.18632/aging.203447 pp 20029—20049

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Effects of Siberian fir terpenes extract Abisil on antioxidant activity, autophagy, transcriptome and proteome of human fibroblasts

Anastasiya Lipatova, George Krasnov, Pavel Vorobyov, Pavel Melnikov, Olga Alekseeva, Yulia Vershinina, Alexander Brzhozovskiy, Daria Goliusova, Faniya Maganova, Natalia Zakirova, Anna Kudryavtseva, Alexey Moskalev,

https://doi.org/10.18632/aging.203448 pp 20050—20080

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Effect of diabetic kidney disease on therapeutic strategies for coronary artery disease: ten year follow-up

Daniel Valente Batista, Whady Hueb, Eduardo Gomes Lima, Paulo Cury Rezende, Cibele Larrosa Garzillo, Rosa Maria Rahmi Garcia, Jaime Paula Pessoa Linhares Filho, Eduardo Bello Martins, Carlos Vicente Serrano Junior, Jose Antonio Franchini Ramires, Roberto Kalil Filho,

https://doi.org/10.18632/aging.203476 pp 20081—20093

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Overexpressed DEPDC1B contributes to the progression of hepatocellular carcinoma by CDK1

Xiao-Wei Dang, Qi Pan, Zhen-Hai Lin, Hao-Hao Wang, Lu-Hao Li, Lin Li, Dong-Qi Shen, Pei-Ju Wang,

https://doi.org/10.18632/aging.203016 pp 20094—20115

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LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway

Chang-Jun Tong, Qing-Chun Deng, Di-Jun Ou, Xia Long, He Liu, Kang Huang,

https://doi.org/10.18632/aging.203047 pp 20116—20130

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Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells

Ying Li, ODA Harunori, Shihu Fu, Fuyuan Xing, Huawan Wu, Juan Wang, Aihua Chen, Xinhua Ren, Dawei Peng, Xia Ling, Ming Shi, Hongjin Wu,

https://doi.org/10.18632/aging.203279 pp 20131—20148

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25-Hydroxycholesterol protecting from cerebral ischemia-reperfusion injury through the inhibition of STING activity

Feihong Lin, Xinyu Yao, Chang Kong, Xia Liu, Zhangfan Zhao, Suhuan Rao, Lu Wang, Shan Li, Junlu Wang, Qinxue Dai,

https://doi.org/10.18632/aging.203337 pp 20149—20163

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Identification of 4-methylation driven genes based prognostic signature in thyroid cancer: an integrative analysis based on the methylmix algorithm

Zhiwei Chen, Xiaoli Liu, Fangfang Liu, Guolie Zhang, Haijian Tu, Wei Lin, Haifeng Lin,

https://doi.org/10.18632/aging.203338 pp 20164—20178

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Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt signaling pathway

Jia Luo, Yigui Jiang, Lianhui Wu, Dexiang Zhuo, Shengjun Zhang, Xiang Jiang, Yingming Sun, Yue Huang,

https://doi.org/10.18632/aging.203342 pp 20179—20191

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Hsa-circ-0007292 promotes the osteogenic differentiation of posterior longitudinal ligament cells via regulating SATB2 by sponging miR-508-3p

Anlong Jiang, Nanxiang Wang, Xinxing Yan, Yunheng Jiang, Chengchao Song, Hui Chi, Guanghua Chen, Feng Wu, Ye Ji, Jinglong Yan,

https://doi.org/10.18632/aging.203381 pp 20192—20217

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ERCC6L promotes cell growth and metastasis in gastric cancer through activating NF-κB signaling

Dehu Chen, Qinghong Liu, Gan Cao,

https://doi.org/10.18632/aging.203387 pp 20218—20228

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Autophagic flux in cancer cells at the invasive front in the tumor-stroma border

Fei Yan, Xuexi Zhang, Rongying Tan, Mingchen Li, Zengtuan Xiao, Hao Wang, Zhenfa Zhang, Zhenyi Ma, Zhe Liu,

https://doi.org/10.18632/aging.203406 pp 20229—20245

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Identification of effective natural PIK3CA H1047R inhibitors by computational study

Naimeng Liu, Xinhui Wang, Xuan Li, Xiaye Lv, Haoqun Xie, Zhen Guo, Jing Wang, Gaojing Dou, Ye Du, Dong Song,

https://doi.org/10.18632/aging.203409 pp 20246—20257

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DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis

Zhiqiang Luo, Yanchao Ma, Tianning Di, Bing Ma, Hongwei Li, Jiangdong An, Yonggang Wang, Haihong Zhang,

https://doi.org/10.18632/aging.203410 pp 20258—20276

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Comprehensive analysis of ubiquitin-proteasome system genes related to prognosis and immunosuppression in head and neck squamous cell carcinoma

Juncheng Wang, Jianing Li, Luan Zhang, Yuexiang Qin, Fengyu Zhang, Rulong Hu, Huihong Chen, Yongquan Tian, Zhifeng Liu, Yuxi Tian, Xin Zhang,

https://doi.org/10.18632/aging.203411 pp 20277—20301

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Regulation of follistatin-like 3 expression by miR-486-5p modulates gastric cancer cell proliferation, migration and tumor progression

Zhou-Tong Dai, Yuan Xiang, Xiao-Yu Zhang, Qi-Bei Zong, Qi-Fang Wu, You Huang, Chao Shen, Jia-Peng Li, Sreenivasan Ponnambalam, Xing-Hua Liao,

https://doi.org/10.18632/aging.203412 pp 20302—20318

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Inhibition of endoplasmic reticulum stress reverses synaptic plasticity deficits in striatum of DYT1 dystonia mice

Huaying Cai, Linhui Ni, Xingyue Hu, Xianjun Ding,

https://doi.org/10.18632/aging.203413 pp 20319—20334

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Proteomic characterization of secretory granules in dopaminergic neurons indicates chromogranin/secretogranin-mediated protein processing impairment in Parkinson’s disease

Gehua Wen, Hao Pang, Xu Wu, Enzhu Jiang, Xique Zhang, Xiaoni Zhan,

https://doi.org/10.18632/aging.203415 pp 20335—20358

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LncRNA GACAT1 targeting miRNA-149 regulates the molecular mechanism of proliferation, apoptosis and autophagy of oral squamous cell carcinoma cells

Jingxin Chen, Xubin Chen, Liangbin Fu, Jimin Chen, Yang Chen, Feng Liu,

https://doi.org/10.18632/aging.203416 pp 20359—20371

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Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5

Xiaoyan Ren, Jiangang Yu, Lili Guo, Hong Ma,

https://doi.org/10.18632/aging.203417 pp 20372—20382

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Hsa_circ_0134111 promotes osteoarthritis progression by regulating miR-224-5p/CCL1 interaction

Yongbao Liu, Yanxiu Zhang,

https://doi.org/10.18632/aging.203420 pp 20383—20394

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ADAM15 correlates with prognosis, immune infiltration and apoptosis in hepatocellular carcinoma

Jun Hui Xu, Yong Jun Guan, Yi Chao Zhang, Zhen Dong Qiu, Yu Zhou, Chen Chen, Jia Yu, Wei Xing Wang,

https://doi.org/10.18632/aging.203425 pp 20395—20417

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Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro

Hua Feng, Huifang Zhou, Jianxia Lu, Qing Zhang, Xingran Tang, Yujie Shang,

https://doi.org/10.18632/aging.203426 pp 20418—20437

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Ceruloplasmin correlates with immune infiltration and serves as a prognostic biomarker in breast cancer

Fei Chen, Bihui Han, Yanxiu Meng, Yu Han, Bing Liu, Bo Zhang, Yanzhong Chang, Pengxiu Cao, Yumei Fan, Ke Tan,

https://doi.org/10.18632/aging.203427 pp 20438—20467

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The efficacy and safety of PD-1/PD-L1 immune checkpoint inhibitors in treating advanced urothelial cancer: a meta-analysis of clinical trials

Fei Li, Yu Wang, Kunfeng Xie, Yunze Fang, Yuejun Du, Lina Hou, Wanlong Tan,

https://doi.org/10.18632/aging.203429 pp 20468—20480

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miR-33a-5p inhibits the progression of esophageal cancer through the DKK1-mediated Wnt/β-catenin pathway

Qingping Song, Hui Liu, Chengyan Li, Haifeng Liang,

https://doi.org/10.18632/aging.203430 pp 20481—20494

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Anti-apoptotic and pro-survival effect of exercise training on early aged hypertensive rat cerebral cortex

Yi-Jie Liu, Zhen-Yang Cui, Ai-Lun Yang, Amadou W. Jallow, Hai-Liang Huang, Chun-Lei Shan, Shin-Da Lee,

https://doi.org/10.18632/aging.203431 pp 20495—20510

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A comprehensive transcriptomic analysis of alternate interferon signaling pathways in peripheral blood mononuclear cells in rheumatoid arthritis

Liang Han, Shenghao Tu, Pan Shen, Jiahui Yan, Yao Huang, Xin Ba, Tingting Li, Weiji Lin, Huihui Li, Kun Yu, Jing Guo, Ying Huang, Kai Qin, Yu Wang, Zhe Chen,

https://doi.org/10.18632/aging.203432 pp 20511—20533

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NLRP3 inflammasome activation contributes to the pathogenesis of cardiocytes aging

Li-Zhen Liao, Zhi-Chong Chen, Sui-Sui Wang, Wen-Bin Liu, Chang-Lin Zhao, Xiao-Dong Zhuang,

https://doi.org/10.18632/aging.203435 pp 20534—20551

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Mediation of circ_RPPH1 on miR-146b-3p/E2F2 pathway to hinder the growth and metastasis of breast carcinoma cells

Hai Feng, Shou-Zhan Sun, Fang Cheng, Nian-Qu Zhang,

https://doi.org/10.18632/aging.203439 pp 20552—20568

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NPAS2 ameliorates myocardial ischaemia/reperfusion injury in rats via CX3CL1 pathways and regulating autophagy

Jing Huang, Wan Qing, Yesheng Pan,

https://doi.org/10.18632/aging.203445 pp 20569—20584

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Prognostic and clinicopathological significance of systemic immune-inflammation index in pancreatic cancer: a meta-analysis of 2,365 patients

Yifang Shui, Mengquan Li, Jing Su, Mingxun Chen, Xiaobin Gu, Wenzhi Guo,

https://doi.org/10.18632/aging.203449 pp 20585—20597

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Knockdown of hsa_circ_0091994 constrains gastric cancer progression by suppressing the miR-324-5p/HMGA1 axis

Yi Xie, Zhao Liu, Hanfang Zhu,

https://doi.org/10.18632/aging.203450 pp 20598—20608

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Intravascular emboli relates to immunosuppressive tumor microenvironment and predicts prognosis in stage III colorectal cancer

Xiangping Song, Di Xie, Fengbo Tan, Yuan Zhou, Yuqiang Li, Zhongyi Zhou, Qian Pei, Haiping Pei,

https://doi.org/10.18632/aging.203451 pp 20609—20628

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A systematic dissection of human primary osteoblasts in vivo at single-cell resolution

Yun Gong, Junxiao Yang, Xiaohua Li, Cui Zhou, Yu Chen, Zun Wang, Xiang Qiu, Ying Liu, Huixi Zhang, Jonathan Greenbaum, Liang Cheng, Yihe Hu, Jie Xie, Xuecheng Yang, Yusheng Li, Yuntong Bai, Yu-Ping Wang, Yiping Chen, Li-Jun Tan, Hui Shen, Hong-Mei Xiao, Hong-Wen Deng,

https://doi.org/10.18632/aging.203452 pp 20629—20650

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NLRC5 attenuates inflammatory response in IL-1β-stimulated human osteoarthritis chondrocytes through the NF-κB signaling pathway

Yiping Mu, Yang Zhang, Jie Wu, Qi Li,

https://doi.org/10.18632/aging.203453 pp 20651—20660

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METTL21B is a prognostic biomarker and potential therapeutic target in low-grade gliomas

Xin Shu, Xinquan Li, Xiaochen Xiang, Qiang Wang, Qingming Wu,

https://doi.org/10.18632/aging.203454 pp 20661—20683

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Construction of an immune-related lncRNA signature as a novel prognosis biomarker for LUAD

Hang Chen, Wei Shen, Saiqi Ni, Menglu Sang, Shibo Wu, Yinyu Mu, Kaitai Liu, Ni Li, Linwen Zhu, Guodong Xu,

https://doi.org/10.18632/aging.203455 pp 20684—20697

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m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in hepatocellular carcinoma

Xiongpei Huang, Zecheng Qiu, Liusheng Li, Bin Chen, Peiyuan Huang,

https://doi.org/10.18632/aging.203456 pp 20698—20715

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N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions

Bingying Du, Yanbo Zhang, Meng Liang, Zengkan Du, Haibo Li, Cunxiu Fan, Hailing Zhang, Yan Jiang, Xiaoying Bi,

https://doi.org/10.18632/aging.203457 pp 20716—20737

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Apatinib inhibits the proliferation of gastric cancer cells via the AKT/GSK signaling pathway in vivo

Yi Chen, Nan Chen, Jin Xu, Xindong Wang, Xiaowei Wei, Cuiju Tang, Zhong Duanmu, Junfeng Shi,

https://doi.org/10.18632/aging.203458 pp 20738—20747

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Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca²⁺-Activin A circuit in chronic cerebral hypoperfusion rats

Xin Zhang, Xiaohua Shi, Jiaoqi Wang, Zhongxin Xu, Jinting He,

https://doi.org/10.18632/aging.203462 pp 20748—20761

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High red blood cell distribution width levels could increase the risk of hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke patients

Hongyang Fan, Xiaojie Liu, Sai Li, Peipei Liu, Yuxia Song, Haili Wang, Xiaojia Tang, Yuhan Luo, Jun Li, Yan Zhu, Yingzhu Chen,

https://doi.org/10.18632/aging.203465 pp 20762—20773

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NF-κB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome

Haiting Xu, Jie Zhang, Xiaoming Shi, Xiaoyang Li, Chao Zheng,

https://doi.org/10.18632/aging.203466 pp 20774—20792

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Stimulator of interferon response cGAMP interactor overcomes ERBB2-mediated apatinib resistance in head and neck squamous cell carcinoma

Guo Ye, Junbin Zhang, Chengyao Zhang,

https://doi.org/10.18632/aging.203475 pp 20793—20807

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LINC01087 inhibits glioma cell proliferation and migration, and increases cell apoptosis via miR-384/Bcl-2 axis

Yao-Hui Tian, Lin-Wei Jia, Zhi-Feng Liu, Yong-Han Chen,

https://doi.org/10.18632/aging.203478 pp 20808—20819

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Long non-coding RNA KTN1-AS1 promotes progression in pancreatic cancer through regulating microRNA-23b-3p/high-mobility group box 2 axis

Zhong-Bo Zhang, Ning Liu,

https://doi.org/10.18632/aging.203481 pp 20820—20835

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Heparanase is a novel biomarker for immune infiltration and prognosis in breast cancer

Wen-Jing Yang, Lin Shi, Xiao-Min Wang, Guo-Wang Yang,

https://doi.org/10.18632/aging.203489 pp 20836—20852

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Correction

Correction for: TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response

Zhi-Yuan Li, Zhao-Li Chen, Ting Zhang, Chao Wei, Wei-Yun Shi,

https://doi.org/10.18632/aging.203516 pp 20853

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