Volume 16, Issue 10

May 30, 2024pp 8400—9305

About the Cover

The cover features Figure 4 "Impact of sexual dimorphism on the liver proteome profiles of wild type and Wrn^Δhel/Δhel mice at four and ten months of age" from Aumailley et al.

Editorial

CCR4-NOT complex in stress resistance and longevity in C. elegans

Cheng-Wei Wu, Hadi Tabarraei

https://doi.org/10.18632/aging.205918pp 8400—8401

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Research Papers

Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats

Linda Bean, Prodip K. Bose, Asha Rani, Ashok Kumar

https://doi.org/10.18632/aging.205841pp 8402—8416

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Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model

Lucie Aumailley, Marie Julie Dubois, André Marette, Michel Lebel

https://doi.org/10.18632/aging.205866pp 8417—8445

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Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women

May A. Beydoun, Hind A. Beydoun, Jason Ashe, Michael F. Georgescu, Steve Horvath, Ake Lu, Anthony S. Zannas, Aladdin H. Shadyab, Su Yon Jung, Sylvia Wassertheil-Smoller, Ramon Casanova, Alan B. Zonderman, Robert L. Brunner

https://doi.org/10.18632/aging.205868pp 8446—8471

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Effects of PM2.5 on mucus hypersecretion in airway through miR-133b-5p/EGFR/Claudin1/MUC5AC axis

Lerong Chen, Liangliang Wu, Xiaopeng Cheng, Jianhua Huang, Jianping Peng

https://doi.org/10.18632/aging.205785pp 8472—8483

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Shexiang tongxin dropping pill alleviates myocardial injury induced by coronary microembolization by down-regulating APOC1 to inhibit STAT3 signaling pathway

Yangui Wang, Tao Wang, Tingting Ma, Jin Zhao, Weigang Qi

https://doi.org/10.18632/aging.205796pp 8484—8496

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The prognostic value and immunological role of MVP in pan-cancer study

Chunlin Li, Min Gao, Nashunbayaer Zha, Gang Guo

https://doi.org/10.18632/aging.205802pp 8497—8510

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LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4

Xinyang Zhao, Xinfeng Zhu, Chaowen Xiao, Zouxiao Hu

https://doi.org/10.18632/aging.205811pp 8511—8523

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HAMP predicts a pivotal role in modulating the malignant behaviors of non-small cell lung cancer cells

Zhifeng Li, Jinglei Liu, Ping Wang, Boyu Zhang, Guanghui He, Liwei Yang

https://doi.org/10.18632/aging.205819pp 8524—8540

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Analysis of multiple factors influencing the survival of patients with advanced gastric cancer

Xinqiang Zhu, Beibei Ge, Linchun Wen, Hailong Huang, Xiaohong Shi

https://doi.org/10.18632/aging.205820pp 8541—8551

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Identification of a fatty acid metabolism-related gene signature to predict prognosis in stomach adenocarcinoma

Lei Liu, Jing Sun, Changqing Zhong, Ang Zhang, Guodong Wang, Sheng Chen, Shuai Zhang, Min Wang, Lianyong Li

https://doi.org/10.18632/aging.205823pp 8552—8571

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IL27 and IL1RN are causally associated with acute pancreatitis: a Mendelian randomization study

Qingxu Jing, Xuxu Liu, Zhenyi Lv, Dongbo Xue

https://doi.org/10.18632/aging.205825pp 8572—8584

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MiR-371-5p regulates trophoblast cell proliferation, migration, and invasion by directly targeting ZNF516

Zhi Qiu Xie, De Fang Chen, Jie He, Linsheng Zhong, Guanzheng Luo, Ming Fang

https://doi.org/10.18632/aging.205826pp 8585—8598

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Senolytic effects of exercise in human muscles require acute inflammation

Wei-Horng Jean, Yin-Chou Lin, Pei-Yao Ang, Kazushige Goto, Chao-An Lin, Luthfia Dewi, Yu-Chieh Liao, Chih-Yang Huang, Chia-Hua Kuo

https://doi.org/10.18632/aging.205827pp 8599—8610

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A novel signature incorporating genes related to lipid metabolism and immune for prognostic and functional prediction of breast cancer

Xiao Zhao, Lvjun Yan, Zailin Yang, Hui Zhang, Lingshuang Kong, Na Zhang, Yongpeng He

https://doi.org/10.18632/aging.205828pp 8611—8629

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Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways

Xiao-Xiao Jiang, Ri Zhang, Hui-Shan Wang

https://doi.org/10.18632/aging.205829pp 8630—8644

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Mangiferin attenuates lipopolysaccharide-induced neuronal injuries in primary cultured hippocampal neurons

Hongling Tan, Dan Liang, Na Lu, Junli Zhang, Shiyan Zhang, Guojun Tan

https://doi.org/10.18632/aging.205830pp 8645—8656

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Gastrodin ameliorates neuroinflammation in Alzheimer’s disease mice by inhibiting NF-κB signaling activation via PPARγ stimulation

Haoyuan Yin, Renjie Liu, Li Bie

https://doi.org/10.18632/aging.205831pp 8657—8666

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Identification of a novel matrix metalloproteinases-related prognostic signature in hepatocellular carcinoma

Xingxing Yuan, Liuxin Yang, Jiawei Gao, Xu Mao, Yali Zhang, Wei Yuan

https://doi.org/10.18632/aging.205832pp 8667—8686

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Assessing the causal role of immune traits in rheumatoid arthritis by bidirectional Mendelian randomization analysis

Mingrui Qiu, Huiyun Shen, Weiping Ji, Qiuping Fan

https://doi.org/10.18632/aging.205833pp 8687—8696

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A cuproptosis-based prognostic model for predicting survival in low-grade glioma

Zongren Zhao, Yuanhao Ma, Yu Liu, Zhongjun Chen, Jinyu Zheng

https://doi.org/10.18632/aging.205834pp 8697—8716

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Comprehensive clinical application analysis of artificial intelligence-enabled electrocardiograms for screening multiple valvular heart diseases

Yu-Ting Lin, Chin-Sheng Lin, Chien-Sung Tsai, Dung-Jang Tsai, Yu-Sheng Lou, Wen-Hui Fang, Yung-Tsai Lee, Chin Lin

https://doi.org/10.18632/aging.205835pp 8717—8731

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miR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson’s disease models

Xiang Tao, Wenfei Zhang, Chen Chen, Yang Tao, Yun Tao, Zhibiao Chen, Ge Zhang

https://doi.org/10.18632/aging.205836pp 8732—8746

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Identification of a methyltransferase-related long noncoding RNA signature as a novel prognosis biomarker for lung adenocarcinoma

Yang Yong Sun, Shuang Li, Chang Liu, Yaqiang Pan, Ying Xiao

https://doi.org/10.18632/aging.205837pp 8747—8771

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Prediction of prognosis and immunotherapy efficacy based on metabolic landscape in lung adenocarcinoma by bulk, single-cell RNA sequencing and Mendelian randomization analyses

Yong Liu, Xiangwei Zhang, Zhaofei Pang, Yadong Wang, Haotian Zheng, Guanghui Wang, Kai Wang, Jiajun Du

https://doi.org/10.18632/aging.205838pp 8772—8809

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Systemic immune-inflammation index upon admission correlates to post-stroke cognitive impairment in patients with acute ischemic stroke

Yongqing Cheng, Honghong Zhu, Changxia Liu, Lei Li, Fangjia Lin, Yan Guo, Cong Gu, Dingming Sun, Yang Gao, Guojun He, Shifu Sun, Shouru Xue

https://doi.org/10.18632/aging.205839pp 8810—8821

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Inflammation-based lung adenocarcinoma molecular subtype identification and construction of an inflammation-related signature with bulk and single-cell RNA-seq data

Yan Gu, Chengyu Bian, Hongchang Wang, Chenghao Fu, Wentao Xue, Wenhao Zhang, Guang Mu, Yang Xia, Ke Wei, Jun Wang

https://doi.org/10.18632/aging.205840pp 8822—8842

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Molecular mechanism of Danxiong Tongmai Granules in treatment of coronary heart disease

Jiahao Ye, Ruiping Yang, Lin Li, Senjie Zhong, Ruixue Jiang, Zhixi Hu

https://doi.org/10.18632/aging.205845pp 8843—8865

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Associations of collagen type 1 α1 gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis with trial sequential analysis

Rui Guo, Shutao Gao, Nazierhan Shaxika, Aihaiti Aizezi, Haidi Wang, Xiang Feng, Zhigang Wang

https://doi.org/10.18632/aging.205846pp 8866—8879

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PDIA3 driven STAT3/PD-1 signaling promotes M2 TAM polarization and aggravates colorectal cancer progression

Jianchun Fan, Likun Wang, Chunze Zhang, Xueliang Wu, Lei Han, Xiaoyu Zhang, Shuquan Gao, Jun Xue, Qi Zhang

https://doi.org/10.18632/aging.205847pp 8880—8897

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Comprehensive prognostic and immunological analysis of Cullin2 in pan-cancer and its identification in hepatocellular carcinoma

Longmei Jia, Xiaoqiang Zhang, Tao Zhou, Jinyan Xie, Jiejing Jin, Dandan Zhang, Chao Zhu, Rong Wan

https://doi.org/10.18632/aging.205848pp 8898—8921

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Potential marker genes for chronic obstructive pulmonary disease revealed based on single-cell sequencing and Mendelian randomization analysis

Gang Sun, Yun Zhou, Xiaoxiao Han, Xiangqian Che, Shuo Yu, Di Song, Feifei Ma, Lewei Huang

https://doi.org/10.18632/aging.205849pp 8922—8943

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SLAMF8 can predict prognosis of pan-cancer and the immunotherapy response effectivity of gastric cancer

Guangyao Li, Qijiao Li, Miaomiao Ping, Ziying Jiao, Xingxing Wang, Juan Cheng, Jizheng Guo, Ya Cheng

https://doi.org/10.18632/aging.205850pp 8944—8964

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CRYAB suppresses ferroptosis and promotes osteogenic differentiation of human bone marrow stem cells via binding and stabilizing FTH1

Bo Tian, Xiaolu Li, Weiyuan Li, Zhizhou Shi, Xu He, Shengyu Wang, Xun Zhu, Na Shi, Yan Li, Ping Wan, Chongtao Zhu

https://doi.org/10.18632/aging.205851pp 8965—8979

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Higher expression of TSR2 aggravating hypertension via the PPAR signaling pathway

Ling-Bing Meng, Gai-Feng Hu, Tingting Lv, Changhua Lv, Lianfeng Liu, Ping Zhang

https://doi.org/10.18632/aging.205852pp 8980—8997

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Breast cancer clinical outcomes and tumor immune microenvironment: cross-dialogue of multiple epigenetic modification profiles

Chong Teng, Xiaowei Song, Chengjuan Fan, Siqi Man, Yuanyuan Hu, Yifei Hou, Tao Xin

https://doi.org/10.18632/aging.205853pp 8998—9022

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Jingfang granules protects against intracerebral hemorrhage by inhibiting neuroinflammation and protecting blood-brain barrier damage

Yanling Li, Qingying Yu, Huiyuan Peng, Xie Mingjun, WenHua Xu, Tingting Zheng, Tingting Zhao, Mengyao Xia, Jibiao Wu, Pantelis Stavrinou, Roland Goldbrunner, Yicheng Xie, Guimin Zhang, Yu Feng, Yongxia Guan, Feng Zheng, Peng Sun

https://doi.org/10.18632/aging.205854pp 9023—9046

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Targeting PRKDC activates the efficacy of antitumor immunity while sensitizing to chemotherapy and targeted therapy in liver hepatocellular carcinoma

Yitong Pan, Qiyao Zhu, Ting Hong, Jun Cheng, Xinhui Tang

https://doi.org/10.18632/aging.205855pp 9047—9071

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Sensitivity of substrate translocation in chaperone-mediated autophagy to Alzheimer’s disease progression

Lei Yu, Xinping Pang, Lin Yang, Kunpei Jin, Wenbo Guo, Yanyu Wei, Chaoyang Pang

https://doi.org/10.18632/aging.205856pp 9072—9105

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Defining three ferroptosis-based molecular subtypes and developing a prognostic risk model for high-grade serous ovarian cancer

Xiang Sun, Wenbin He, Baohua Lin, Weiming Huang, Danping Ye

https://doi.org/10.18632/aging.205857pp 9106—9126

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Identification and validation of lipid metabolism-related key genes as novel biomarkers in acute myocardial infarction and pan-cancer analysis

Hao Xiao, Xiaolei Cui, Liang Liu, Baopu Lv, Rui Zhang, Tuokang Zheng, Dongqi Yao, Hengbo Gao, Xinshun Gu, Yi Li, Yingping Tian

https://doi.org/10.18632/aging.205860pp 9127—9146

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Identifying competing endogenous RNA regulatory networks and hub genes in alcoholic liver disease for early diagnosis and potential therapeutic target insights

Shuai-Yang Sun, Dong Hun Lee, Hao-Cheng Liu, Yi Yang, Ying-Hao Han, Taeho Kwon

https://doi.org/10.18632/aging.205861pp 9147—9167

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Chronic stress induces Alzheimer’s disease-like pathologies through DNA damage-Chk1-CIP2A signaling

Zhuoqun Wang, Lun Zhang, Jiayu Yang, Yi Zeng, Chengke Su, Mengdong Yao, Huiliang Zhang, Wenting Hu, Yi Liu, Yiwen Lai, Xiaochuan Wang, Ji Zeng, Rong Liu

https://doi.org/10.18632/aging.205862pp 9168—9187

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