Research Paper Volume 16, Issue 10 pp 8810—8821
Systemic immune-inflammation index upon admission correlates to post-stroke cognitive impairment in patients with acute ischemic stroke
- 1 Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of Yancheng, Yancheng 224000, Jiangsu, China
- 2 Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China
- 3 Department of Rheumatology and Immunology, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of Yancheng, Yancheng 224000, Jiangsu, China
Received: November 27, 2023 Accepted: April 9, 2024 Published: May 20, 2024
https://doi.org/10.18632/aging.205839How to Cite
Copyright: © 2024 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: The purpose of this prospective study was to evaluate the association of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), with PSCI in patients with acute ischemic stroke (AIS).
Methods: First-onset AIS patients were consecutively included from January 1, 2022 to March 1, 2023. The baseline information was collected at admission. Fasting blood was drawn the next morning. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCA) 3 months after onset. Logistic regression analysis was performed to explore the correlation between SII, SIRI, and PSCI. Receiver operating characteristic (ROC) was conducted to evaluate the predictive ability of SII.
Results: 332 participants were recruited, and 193 developed PSCI. Compared with patients without PSCI, the patients with PSCI had higher SII (587.75 (337.42, 988.95) vs. 345.66 (248.44, 572.89), P<0.001) and SIRI (1.59 (0.95, 2.84) vs. 1.02 (0.63, 1.55), P=0.007). SII and SIRI negatively correlated with MoCA scores (both P<0.05). The multivariable logistic regression analysis indicated that SII was independently associated with PSCI (P<0.001), while SIRI was not. The optimal cutoff for SII to predict PSCI was 676.83×109/L.
Conclusions: A higher level of SII upon admission was independently correlated to PSCI three months later in AIS patients.
Abbreviations
PSCI: post-stroke cognitive impairment; SII: systemic immune-inflammation index; SIRI: systemic inflammation response index; AIS: acute ischemic stroke; MoCA: Montreal Cognitive Assessment; AUC: area under the curve; GBD: Global Burden of Disease; BMI: body mass index; NIHSS: National Institutes of Health Stroke Scale; TOAST: Trial of Org 10172 in Acute Stroke Treatment; TC: total cholesterol; TG: triglyceride; HDL: high-density lipoprotein; LDL: low-density lipoprotein; FPG: fasting plasma glucose; Hcy: homocysteine; UA: uric acid; HbA1c: glycosylated hemoglobin A1; OR: odds ratio; CI: confidence interval; ROC: receiver operating characteristic curve; NLR: neutrophil to lymphocyte ratio; CAD: coronary artery disease; CVD: cardiovascular disease; CSVD: cerebral small vessel disease; BBB: blood-brain barrier; EPVS: enlarged perivascular space; WMH: white matter hyperintensity.