Retraction Volume 16, Issue 10 pp 9305
Retraction for: DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis
- 1 Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, P.R. China
Received: September 29, 2023 Accepted: May 16, 2024 Published: May 31, 2024
https://doi.org/10.18632/aging.205844How to Cite
Copyright: © 2024 Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This article has been retracted: Aging has completed its investigation of this paper. We found that the immunohistochemistry image in Figure 4B, showing expression of collagen II in second generation NP cells from IVDD rats, duplicates an immunohistochemistry image from a previously published unrelated paper [1]. The authors replied that the results of their study confirmed that DNMT3B is only weakly expressed in degenerated rat intervertebral disc tissue. However, when they recently repeated the animal part of the study, they were unable to obtain results consistent with the original study. The in vivo data presented in Figure 8 “DNMT3B alleviated IVDD through TRPA1-COX2-YAP axis” were not reproducible. Consequently, all authors agreed that the article should be retracted.
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