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The cover features Figure 1 "PAM (PIK3/AKT/mTOR) signaling in glia during aging may contribute to glioma pathology“ from Duggan et al.

Volume 13, Issue 1

15 January, 2021
pp 1—1565

About the Cover

The cover features Figure 1 "PAM (PIK3/AKT/mTOR) signaling in glia during aging may contribute to glioma pathology“ from Duggan et al.


Explore This Issue

Research Papers

COVID-19
Shorter telomere lengths in patients with severe COVID-19 disease

Raul Sanchez-Vazquez, Ana Guío-Carrión, Antonio Zapatero-Gaviria, Paula Martínez, Maria A. Blasco,
https://doi.org/10.18632/aging.202463 pp 1—15
View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 2

COVID-19
Comparison of clinical characteristics among younger and elderly deceased patients with COVID-19: a retrospective study

Xueyun Tan, Shuai Zhang, Juanjuan Xu, Mei Zhou, Qi Huang, Limin Duan, Zhilei Lv, Hui Xia, Wenjing Xiao, Zhengrong Yin, Yang Jin,
https://doi.org/10.18632/aging.202139 pp 16—26
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COVID-19
Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study

Guangdi Li, Yacong Liu, Xixi Jing, Yali Wang, Miao Miao, Li Tao, Zhiguo Zhou, Yuanlin Xie, Yaxiong Huang, Jianhua Lei, Guozhong Gong, Ping Jin, Yuantao Hao, Nuno Rodrigues Faria, Erik De Clercq, Min Zhang,
https://doi.org/10.18632/aging.202456 pp 27—60
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Human placenta-derived mesenchymal stem cells trigger repair system in TAA-injured rat model via antioxidant effect

Jeeyoon Na, Joseph Song, Hyun Ho Kim, Jin Seok, Jae Yeon Kim, Ji Hye Jun, Gi Jin Kim,
https://doi.org/10.18632/aging.202348 pp 61—76
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Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels

Tianwen Huang, Lijun Fang, Raoli He, Huidan Weng, Xiaochun Chen, Qinyong Ye, Dianbo Qu,
https://doi.org/10.18632/aging.202236 pp 77—88
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Further assessment of Salvia haenkei as an innovative strategy to counteract skin photo-aging and restore the barrier integrity

Veronica Cocetta, Jessica Cadau, Miriam Saponaro, Isabella Giacomini, Stefano Dall’Acqua, Stefania Sut, Daniela Catanzaro, Genny Orso, Giorgia Miolo, Luca Menilli, Andrea Pagetta, Eugenio Ragazzi, Monica Montopoli,
https://doi.org/10.18632/aging.202464 pp 89—103
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Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan

Vanessa Brinkmann, Alfonso Schiavi, Anjumara Shaik, Daniel Rüdiger Puchta, Natascia Ventura,
https://doi.org/10.18632/aging.202316 pp 104—133
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Correlates of change in accelerometer-assessed total sedentary time and prolonged sedentary bouts among older English adults: results from five-year follow-up in the EPIC-Norfolk cohort

Dharani Yerrakalva, Samantha Hajna, Katrien Wijndaele, Kate Westgate, Kay-Tee Khaw, Nick Wareham, Simon J Griffin, Soren Brage,
https://doi.org/10.18632/aging.202497 pp 134—149
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Analysis of the aging-induced changes in the motor ability structure using large population fitness test results

Prabhat Pathak, Siddhartha Bikram Panday, Bong-Keun Jung, Jooeun Ahn,
https://doi.org/10.18632/aging.202461 pp 150—162
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Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression

Anshuman Chandra, Hanumappa Ananda, Nagendra Singh, Imteyaz Qamar,
https://doi.org/10.18632/aging.202301 pp 163—180
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The adhesion molecule ICAM-1 in diffuse large B-cell lymphoma post-rituximab era: relationship with prognostic importance and rituximab resistance

Yizhen Liu, Juan J. Gu, Ling Yang, Ping-Chiao Tsai, Ye Guo, Kai Xue, Zuguang Xia, Xiaojian Liu, Fangfang Lv, Junning Cao, Xiaonan Hong, Cory Mavis, Francisco J. Hernandez-Ilizaliturri, Qunling Zhang,
https://doi.org/10.18632/aging.202180 pp 181—193
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Prognostic potential of cardiac structural and functional parameters and N-terminal propeptide of type III procollagen in predicting cardiac fibrosis one year after myocardial infarction with preserved left ventricular ejection fraction

Anastasia Osokina, Viktoria Karetnikova, Olga Polikutina, Anna Ivanova, Olga Gruzdeva, Yulia Dyleva, Aleksandr Kokov, Natalia Brel, Tamara Pecherina, Olga Barbarash,
https://doi.org/10.18632/aging.202495 pp 194—203
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Telomere length as a function of age at population level parallels human survival curves

Paolina Crocco, Francesco De Rango, Serena Dato, Giuseppina Rose, Giuseppe Passarino,
https://doi.org/10.18632/aging.202498 pp 204—218
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LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504

Xiangkun Wu, Lihua Yan, Yongxi Liu, Lilin Shang,
https://doi.org/10.18632/aging.103498 pp 219—227
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Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis

Wen Xu, Changfeng Song, Xiaotong Wang, Yueqi Li, Xue Bai, Xin Liang, Jingjing Wu, Jianwen Liu,
https://doi.org/10.18632/aging.103669 pp 228—240
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In situ self-assembly of Au-antimiR-155 nanocomplexes mediates TLR3-dependent apoptosis in hepatocellular carcinoma cells

Liang Yin, Weijuan Cai, Yongqian Liang, Jie Yao, Xuemei Wang, Jie Shen,
https://doi.org/10.18632/aging.103799 pp 241—261
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Combined transplantation of neural stem cells and bone marrow mesenchymal stem cells promotes neuronal cell survival to alleviate brain damage after cardiac arrest via microRNA-133b incorporated in extracellular vesicles

Fang Li, Jie Zhang, Anbao Chen, Rui Liao, Yongchun Duan, Yuwei Xu, Lili Tao,
https://doi.org/10.18632/aging.103920 pp 262—278
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The burden of liver cirrhosis and underlying etiologies: results from the global burden of disease study 2017

Mimi Zhai, Jianhai Long, Sushun Liu, Chun Liu, Li Li, Leping Yang, Yamin Li, Bo Shu,
https://doi.org/10.18632/aging.104127 pp 279—300
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KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma

Sheng Hu, Weibiao Zeng, Wenxiong Zhang, Jianjun Xu, Dongliang Yu, Jinhua Peng, Yiping Wei,
https://doi.org/10.18632/aging.104144 pp 301—339
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LINC00052 ameliorates acute kidney injury by sponging miR-532-3p and activating the Wnt signaling pathway

Xiaoying Li, Pengxi Zheng, Tingting Ji, Bo Tang, Yakun Wang, Shoujun Bai,
https://doi.org/10.18632/aging.104152 pp 340—350
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ADRB1 was identified as a potential biomarker for breast cancer by the co-analysis of tumor mutational burden and immune infiltration

Jia Wang, Xiaolu Zhang, Jie Li, Xiaoran Ma, Fubin Feng, Lijuan Liu, Jibiao Wu, Changgang Sun,
https://doi.org/10.18632/aging.104204 pp 351—363
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Enhancer-bound Nrf2 licenses HIF-1α transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells

Xin Jin, Liansheng Gong, Ying Peng, Le Li, Gang Liu,
https://doi.org/10.18632/aging.202137 pp 364—375
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Genetic alterations in gastric cancer patients according to sex

Li-Wen Hsu, Kuo-Hung Huang, Ming-Huang Chen, Wen-Liang Fang, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr,
https://doi.org/10.18632/aging.202142 pp 376—388
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DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84

Wen-Shuang Gao, Yu-Juan Qu, Juan Huai, Hui Wei, Yang Zhang, Shou-Wei Yue,
https://doi.org/10.18632/aging.202144 pp 389—410
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The improved anticancer effects of Bortezomib-loaded hollow mesoporous silica nanospheres on lymphoma development

Jie Shen, Ruihuan Wang, Qing Wang, Minjuan Zhang, Chunyan Liu, Zhenxia Tao, Guohong Su,
https://doi.org/10.18632/aging.202146 pp 411—423
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LncRNA HAND2-AS1 suppressed the growth of triple negative breast cancer via reducing secretion of MSCs derived exosomal miR-106a-5p

Li Xing, Xiaolong Tang, Kaikai Wu, Xiong Huang, Yi Yi, Jinliang Huan,
https://doi.org/10.18632/aging.202148 pp 424—436
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Accumulation of LOX-1+ PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein–barr virus and relate to tumor recurrence

Xing Li, Jin-Long Li, Nan Jiang, Jie Chen, Zi-Ming Liang, Zhen-Lin Zhao, Yan-Fang Xing,
https://doi.org/10.18632/aging.202149 pp 437—449
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Comparative efficacy, safety, and acceptability of single-agent poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA-mutated HER2-negative metastatic or advanced breast cancer: a network meta-analysis

Ju Wang, Ye Zhang, Long Yuan, Lin Ren, Yi Zhang, Xiaowei Qi,
https://doi.org/10.18632/aging.202152 pp 450—459
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Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

Xiaolan Fan, Yao Zeng, Ziqiang Fan, Liang Cui, Wenhao Song, Qi Wu, Yue Gao, Deying Yang, Xueping Mao, Bo Zeng, Mingwang Zhang, Qingyong Ni, Yan Li, Tao Wang, Diyan Li, Mingyao Yang,
https://doi.org/10.18632/aging.202156 pp 460—476
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Development and validation of prognostic nomograms for early-onset locally advanced colon cancer

Yuqiang Li, Wenxue Liu, Zhongyi Zhou, Heming Ge, Lilan Zhao, Heli Liu, Xiangping Song, Dan Wang, Qian Pei, Fengbo Tan,
https://doi.org/10.18632/aging.202157 pp 477—492
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Melatonin alleviates angiotensin-II-induced cardiac hypertrophy via activating MICU1 pathway

Yi Yang, Jin Du, Rui Xu, Yang Shen, Dachun Yang, De Li, Houxiang Hu, Haifeng Pei, Yongjian Yang,
https://doi.org/10.18632/aging.202159 pp 493—515
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Development of an innovative measurement method for patellar tracking disorder

Zhe Xue, Zheng Pei, Hui Zhang, Chong Tang, Junxiu Jia, Kun Zhang, Keshi Zhang, Zhenpeng Guan,
https://doi.org/10.18632/aging.202161 pp 516—524
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Liraglutide improved the cognitive function of diabetic mice via the receptor of advanced glycation end products down-regulation

Haoqiang Zhang, Yafen Chu, Hongwei Zheng, Jing Wang, Bing Song, Yao Sun,
https://doi.org/10.18632/aging.202162 pp 525—536
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SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma

Yu-Ting Zhan, Lei Li, Ting-Ting Zeng, Ning-Ning Zhou, Xin-Yuan Guan, Yan Li,
https://doi.org/10.18632/aging.202164 pp 537—554
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Autophagy-mediated regulation patterns contribute to the alterations of the immune microenvironment in periodontitis

Xiaoqi Zhang, Yu Jin, Qingxuan Wang, Fan Jian, Minqi Li, Hu Long, Wenli Lai,
https://doi.org/10.18632/aging.202165 pp 555—577
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Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans

Tze-Hong Wong, Ting-Yu Chen, Kuo-Yun Tseng, Zih-Ying Chen, Chung-Hsing Chen, Feng-Huei Lin, Hung-Ming Wu, Shankung Lin,
https://doi.org/10.18632/aging.202166 pp 578—597
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EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma

Zhiming Chen, Ji Chen, Dandan Ren, Jiao Zhang, Ying Yang, Henghui Zhang, Beibei Mao, Haitao Ma,
https://doi.org/10.18632/aging.202169 pp 598—618
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A three-gene signature based on tumour microenvironment predicts overall survival of osteosarcoma in adolescents and young adults

Chunkai Wen, Hongxue Wang, Han Wang, Hao Mo, Wuning Zhong, Jing Tang, Yongkui Lu, Wenxian Zhou, Aihua Tan, Yan Liu, Weimin Xie,
https://doi.org/10.18632/aging.202170 pp 619—645
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MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role

Yi-Jing Hsiao, Wen-Hsin Chang, Hsuan-Yu Chen, Yin-Chen Hsu, Su-Chin Chiu, Ching-Cheng Chiang, Gee-Chen Chang, Yi-Ju Chen, Chia-Yu Wang, Yan-Ming Chen, Chien-Yu Lin, Yu-Ju Chen, Pan-Chyr Yang, Jeremy J.W. Chen, Sung-Liang Yu,
https://doi.org/10.18632/aging.202171 pp 646—674
View Abstract PDF Full-Text How to Cite Special Collection on Tumor Suppressors

A novel immune-related genes prognosis biomarker for hepatocellular carcinoma

Kunpeng Wang, Xinyi Chen, Chong Jin, Jinggang Mo, Hao Jiang, Bin Yi, Xiang Chen,
https://doi.org/10.18632/aging.202173 pp 675—693
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Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats

Peng Li, Xiaojun Li, Peng Deng, Dandan Wang, Xuehong Bai, Yujie Li, Chunxia Luo, Karine Belguise, Xiaobo Wang, Xinchuan Wei, Zhengyuan Xia, Bin Yi,
https://doi.org/10.18632/aging.202178 pp 694—713
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Identification of “regulation of RhoA activity panel” as a prognostic and predictive biomarker for gastric cancer

Wenwen Huang, Songhui Zhao, Cheng Zhang, Zhongwu Li, Sai Ge, Baofeng Lian, Hui Feng, Kai Wang, Ruihua Xu, Jiafu Ji, Jing Gao, Weiwei Shi, Lin Shen,
https://doi.org/10.18632/aging.202179 pp 714—734
View Abstract PDF Full-Text How to Cite Special Collection on Biomarkers

TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway

Wenwen Dong, Bei Luo, Chang Qiu, Xu Jiang, Bo Shen, Li Zhang, Weiguo Liu, Wenbin Zhang,
https://doi.org/10.18632/aging.202181 pp 735—749
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KRAS mutations are negatively correlated with immunity in colon cancer

Xiaorui Fu, Xinyi Wang, Jinzhong Duanmu, Taiyuan Li, Qunguang Jiang,
https://doi.org/10.18632/aging.202182 pp 750—768
View Abstract PDF Full-Text How to Cite Special Collection on Biomarkers

The microRNA miR-29c-5p inhibits cell proliferation and migration by targeting TMEM98 in head and neck carcinoma

Jingjia Li, Weixiong Chen, Lixia Luo, Lieqiang Liao, Xuequan Deng, Yuejian Wang,
https://doi.org/10.18632/aging.202183 pp 769—781
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Nitidine chloride suppresses NEDD4 expression in lung cancer cells

Jing Zhang, Ruoxue Cao, Chaoqun Lian, Tong Cao, Ying Shi, Jia Ma, Peter Wang, Jun Xia,
https://doi.org/10.18632/aging.202185 pp 782—793
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Systematic construction and validation of an epithelial–mesenchymal transition risk model to predict prognosis of lung adenocarcinoma

Yunliang Tang, Yanxia Jiang, Cheng Qing, Jiao Wang, Zhenguo Zeng,
https://doi.org/10.18632/aging.202186 pp 794—812
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Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans

Dongliang Liu, Xiaofang Zeng, Le Li, Zheng-Lin Ou,
https://doi.org/10.18632/aging.202187 pp 813—830
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Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

Junqiang Yan, Jiarui Huang, Anran Liu, Jiannan Wu, Hua Fan, Mengmeng Shen, Xiaoyi Lai, Hongxia Ma, Wenjie Sun, Jianxue Yang, Yunqi Xu,
https://doi.org/10.18632/aging.202189 pp 831—845
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Longitudinal profiling of the blood transcriptome in an African green monkey aging model

Ja-Rang Lee, Se-Hee Choe, Young-Hyun Kim, Hyeon-Mu Cho, Hye-Ri Park, Hee-Eun Lee, Yeung Bae Jin, Ji-Su Kim, Kang Jin Jeong, Sang-Je Park, Jae-Won Huh,
https://doi.org/10.18632/aging.202190 pp 846—864
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Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis

Zhaohui Liu, Yanli Meng, Yu Miao, Lili Yu, Qiannan Yu,
https://doi.org/10.18632/aging.202191 pp 865—876
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Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway

Jin Du, Guobing Yin, Yida Hu, Si Shi, Jiazhen Jiang, Xiaoyan Song, Zhetao Zhang, Zeyuan Wei, Chaoliang Tang, Haiyan Lyu,
https://doi.org/10.18632/aging.202194 pp 877—893
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The emerging role of the MiR-1272-ADAM9-CDCP1 signaling pathway in the progression of glioma

Fei Geng, Gui-Feng Lu, Yu-Jun Luo, Sky Dominguez, De-Ying Kong, Lian-Hua Shen, Xiao-Mei Luo, Xin Yang, Min Hu, Wen-Shan Lai, Zhi-Shui Jiang, Yuan-Shou Chen,
https://doi.org/10.18632/aging.202196 pp 894—909
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Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation

Jiexia Wen, Yumei Chang, Shanshan Huo, Wenyan Li, Heling Huang, Yunhuan Gao, Hongyu Lin, Jianlou Zhang, Yonghong Zhang, Yuzhu Zuo, Xuebin Cao, Fei Zhong,
https://doi.org/10.18632/aging.202202 pp 910—932
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IRF-1 contributes to the pathological phenotype of VSMCs during atherogenesis by increasing CCL19 transcription

Yongbin Shen, Zhanfeng Sun, Shuran Mao, Yingnan Zhang, Weiliang Jiang, Haitao Wang,
https://doi.org/10.18632/aging.202204 pp 933—943
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Metabolic signatures of muscle mass loss in an elderly Taiwanese population

Chi-Jen Lo, Yu-Shien Ko, Su-Wei Chang, Hsiang-Yu Tang, Cheng-Yu Huang, Yu-Chen Huang, Hung-Yao Ho, Chih-Ming Lin, Mei-Ling Cheng,
https://doi.org/10.18632/aging.202209 pp 944—956
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Bnip3 interacts with vimentin, an intermediate filament protein, and regulates autophagy of hepatic stellate cells

Jie Liu, Yuyu Xie, Zhangbo Cui, Tian Xia, Lu Wan, Haifeng Zhou, Peng Zhang, Yijie Zhang, Fei Guan, Wenqi Liu, Chunwei Shi,
https://doi.org/10.18632/aging.202211 pp 957—972
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Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy

Rui Niu, Jindan Wang, Chao Geng, Yahong Li, Lijie Dong, Lin Liu, Yuwen Chang, Jianqun Shen, Zetong Nie, Yan Zhang, Bojie Hu,
https://doi.org/10.18632/aging.202217 pp 973—990
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Assessment of real-time three-dimensional echocardiography as a tool for evaluating left atrial volume and function in patients with type 2 diabetes mellitus

Xiuyun Li, Yanyan Dong, Chao Zheng, Pengfei Wang, Maosheng Xu, Chunpeng Zou, Liang Wang,
https://doi.org/10.18632/aging.202218 pp 991—1000
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Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility

Jinmei Cheng, Yinchuan Li, Yan Zhang, Xiuxia Wang, Fei Sun, Yixun Liu,
https://doi.org/10.18632/aging.202222 pp 1001—1016
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AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1

Menglin Xu, Junfeng Wang, Haoran Li, Zhengrong Zhang, Zhengwu Cheng,
https://doi.org/10.18632/aging.202226 pp 1017—1031
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SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling

Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin,
https://doi.org/10.18632/aging.202231 pp 1032—1050
View Abstract PDF Full-Text How to Cite Special Collection on Cancer and mTOR

Targeting nerve growth factor, a new option for treatment of osteoarthritis: a network meta-analysis of comparative efficacy and safety with traditional drugs

Ziqin Cao, Jian Zhou, Zeling Long, Yihan Li, Jingjing Sun, Yingquan Luo, Wanchun Wang,
https://doi.org/10.18632/aging.202232 pp 1051—1070
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Integrated proteome and phosphoproteome analyses of peripheral blood mononuclear cells in primary Sjögren syndrome patients

Shaoying Huang, Fengping Zheng, Lixiong Liu, Shuhui Meng, Wanxia Cai, Cantong Zhang, Weier Dai, Dongzhou Liu, Xiaoping Hong, Donge Tang, Yong Dai,
https://doi.org/10.18632/aging.202233 pp 1071—1095
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The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles

Peikun Zhao, Zidai Song, Yan Wang, Han Cai, Xiaoyan Du, Changlong Li, Jianyi Lv, Xin Liu, Meng Guo, Zhenwen Chen,
https://doi.org/10.18632/aging.202235 pp 1096—1119
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Hsa_circ_0079480 promotes tumor progression in acute myeloid leukemia via miR-654-3p/HDGF axis

Qingzhu Hu, Yueli Gu, Shuxia Chen, Ying Tian, Shuo Yang,
https://doi.org/10.18632/aging.202240 pp 1120—1131
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Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury

Yujun Luo, Beibei Wang, Jianhua Liu, Faxin Ma, Dongling Luo, Zhongwen Zheng, Quan Lu, Weijie Zhou, Yue Zheng, Chen Zhang, Qiyi Wang, Weihong Sha, Hao Chen,
https://doi.org/10.18632/aging.202241 pp 1132—1152
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Construction of an mRNA-miRNA-lncRNA network prognostic for triple-negative breast cancer

Yuan Huang, Xiaowei Wang, Yiran Zheng, Wei Chen, Yabing Zheng, Guangliang Li, Weiyang Lou, Xiaojia Wang,
https://doi.org/10.18632/aging.202254 pp 1153—1175
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The 1316T>C missenses mutation in MTHFR contributes to MTHFR deficiency by targeting MTHFR to proteasome degradation

Xi Liu, Yu Li, Menghan Wang, Xiaojun Wang, Limin Zhang, Tao Peng, Wenping Liang, Zhe Wang, Hong Lu,
https://doi.org/10.18632/aging.202256 pp 1176—1185
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MicroRNA-139-5p upregulation is associated with diabetic endothelial cell dysfunction by targeting c-jun

Yu-Fang Luo, Xin-Xing Wan, Li-Ling Zhao, Zi Guo, Rui-Ting Shen, Ping-Yu Zeng, Ling-Hao Wang, Jing-Jing Yuan, Wen-Jun Yang, Chun Yue, Zhao-Hui Mo,
https://doi.org/10.18632/aging.202257 pp 1186—1211
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Therapeutic potential of targeting HSPA5 through dual regulation of two candidate prognostic biomarkers ANXA1 and PSAT1 in osteosarcoma

Xiaojun Tang, Lingli Luo, Yukun Li, Hailong Wu, Qing Hu, Haiyan Yue, Xiao He, Juan Zou, Shaoxiong Min,
https://doi.org/10.18632/aging.202258 pp 1212—1235
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High-fat diet induced discrepant peripheral and central nervous systems insulin resistance in APPswe/PS1dE9 and wild-type C57BL/6J mice

Yujie Guo, Xiaojun Ma, Pengfei Li, Shengqi Dong, Xiaochen Huang, Xiuwen Ren, Linhong Yuan,
https://doi.org/10.18632/aging.202262 pp 1236—1250
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β2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients

Zhenchao Wu, Mengdie Yan, Min Zhang, Nan Wu, Guoyuan Ma, Bingbing Wang, Youbo Fan, Xintong Du, Can Ding, Yi Liu,
https://doi.org/10.18632/aging.202266 pp 1251—1263
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A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation

Chao Wang, Xueyou Zhang, Qi Ling, Shusen Zheng, Xiao Xu,
https://doi.org/10.18632/aging.202302 pp 1264—1275
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Genomic and transcriptomic analysis of pituitary adenomas reveals the impacts of copy number variations on gene expression and clinical prognosis among prolactin-secreting subtype

Yiyuan Chen, Hua Gao, Weiyan Xie, Jing Guo, Qiuyue Fang, Peng Zhao, Chunhui Liu, Haibo Zhu, Zhuang Wang, Jichao Wang, Songbai Gui, Yazhuo Zhang, Chuzhong Li,
https://doi.org/10.18632/aging.202304 pp 1276—1293
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Exercise reduces metabolic burden while altering the immune system in aged mice

Kyeong Jin Yoon, Aram Ahn, Soo Hong Park, Seung Hee Kwak, Seong Eun Kwak, Wonsang Lee, Yong Ryoul Yang, Minji Kim, Hyun Mu Shin, Hang-Rae Kim, Hyo Youl Moon,
https://doi.org/10.18632/aging.202312 pp 1294—1313
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rTMS modulates precuneus-hippocampal subregion circuit in patients with subjective cognitive decline

Jiu Chen, Nan Ma, Guanjie Hu, Amdanee Nousayhah, Chen Xue, Wenzhang Qi, Wenwen Xu, Shanshan Chen, Jiang Rao, Wan Liu, Fuquan Zhang, Xiangrong Zhang,
https://doi.org/10.18632/aging.202313 pp 1314—1331
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CCDC170 affects breast cancer apoptosis through IRE1 pathway

Qiong Wang, Yanrui Zhao, Hong Zheng, Qinghua Wang, Wei Wang, Ben Liu, Hongwei Han, Lina Zhang, Kexin Chen,
https://doi.org/10.18632/aging.202315 pp 1332—1356
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miR-18a increases insulin sensitivity by inhibiting PTEN

Yongqiang Zhou, Ruoqi Wu, Huafang Su, Kejie Li, Chun Chen, Raoying Xie,
https://doi.org/10.18632/aging.202319 pp 1357—1368
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MicroRNA-6862 inhibition elevates sphingosine kinase 1 and protects neuronal cells from MPP+-induced apoptosis

Gang Xue, Ju-ping Chen, Ya Li, Zhi-qing Zhang, Jian-liang Zhu, Wanli Dong,
https://doi.org/10.18632/aging.202335 pp 1369—1382
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The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumors

Liyu Wang, Yu Liu, Hengchang Liu, He Tian, Yalong Wang, Guochao Zhang, Yuanyuan Lei, Liyan Xue, Bo Zheng, Tao Fan, Yujia Zheng, Fengwei Tan, Qi Xue, Shugeng Gao, Chunxiang Li, Jie He,
https://doi.org/10.18632/aging.202355 pp 1383—1409
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Prognostic and clinical significance of modified glasgow prognostic score in pancreatic cancer: a meta-analysis of 4,629 patients

Dongdong Wu, Xingmu Wang, Ge Shi, Honggang Sun, Guoxing Ge,
https://doi.org/10.18632/aging.202357 pp 1410—1421
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Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors

Yiyuan Chen, Hua Gao, Qian Liu, Weiyan Xie, Bin Li, Sen Cheng, Jing Guo, Qiuyue Fang, Haibo Zhu, Zhuang Wang, Jichao Wang, Chuzhong Li, Yazhuo Zhang,
https://doi.org/10.18632/aging.202376 pp 1422—1439
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NLRC4 gene silencing-dependent blockade of NOD-like receptor pathway inhibits inflammation, reduces proliferation and increases apoptosis of dendritic cells in mice with septic shock

Shi-Sheng Wang, Chun-Song Yan, Jun-Ming Luo,
https://doi.org/10.18632/aging.202379 pp 1440—1457
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CHIP protects against MPP+/MPTP-induced damage by regulating Drp1 in two models of Parkinson’s disease

Zhengwei Hu, Chengyuan Mao, Hui Wang, Zhongxian Zhang, Shuo Zhang, Haiyang Luo, Mibo Tang, Jing Yang, Yanpeng Yuan, Yanlin Wang, Yutao Liu, Liyuan Fan, Qimeng Zhang, Dabao Yao, Fen Liu, Jonathan C. Schisler, Changhe Shi, Yuming Xu,
https://doi.org/10.18632/aging.202389 pp 1458—1472
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Prognostic relevance of SMC family gene expression in human sarcoma

Jian Zhou, Gen Wu, Zhongyi Tong, Jingjing Sun, Jing Su, Ziqin Cao, Yingquan Luo, Wanchun Wang,
https://doi.org/10.18632/aging.202455 pp 1473—1487
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Prenatal diagnosis of PLP1 duplication by single nucleotide polymorphism array in a family with Pelizaeus-Merzbacher disease

Huili Xue, Aili Yu, Xuemei Chen, Na Lin, Min Lin, Hailong Huang, Liangpu Xu,
https://doi.org/10.18632/aging.202477 pp 1488—1497
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Reviews

COVID-19
Safety and efficacy of convalescent plasma therapy in severely and critically ill patients with COVID-19: a systematic review with meta-analysis

Luo Wenjing, Feng Yuanzheng, Jun-Ying Li, Liang V. Tang, Hu Yu,
https://doi.org/10.18632/aging.202195 pp 1498—1509
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PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging

Michael R. Duggan, Michael Weaver, Kamel Khalili,
https://doi.org/10.18632/aging.202459 pp 1510—1527
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Function of Deptor and its roles in hematological malignancies

Mario Morales-Martinez, Alan Lichtenstein, Mario I. Vega,
https://doi.org/10.18632/aging.202462 pp 1528—1564
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Correction

Correction for: miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Runhui Tian, Bo Wu, Cong Fu, Kaimin Guo,
https://doi.org/10.18632/aging.202509 pp 1565
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