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Research Paper|Volume 13, Issue 1|pp 460—476

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila

Xiaolan Fan1,2, Yao Zeng1, Ziqiang Fan1, Liang Cui1, Wenhao Song1, Qi Wu1, Yue Gao1, Deying Yang1,2, Xueping Mao1,2, Bo Zeng1,2, Mingwang Zhang1,2, Qingyong Ni1,2, Yan Li1,2, Tao Wang1,2, Diyan Li1,2, Mingyao Yang1,2
  • 1Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu, Sichuan, P. R. China
  • 2Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China
* Equal contribution
Received: February 25, 2020Accepted: July 20, 2020Published: December 3, 2020

Copyright: © 2020 Fan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Drugs or compounds have been shown to promote longevity in various approaches. We used Drosophila to explore novel natural compounds can be applied to anti-aging. Here we reported that a flavonoid named Dihydromyricetin can increase stress that tolerance and lipid levels, slow down gut dysfunction and extend Drosophila lifespan. Dihydromyricetin can also lessen pERK and pAKT signaling, consequently activating FOXO and AOP to modulate longevity. Our results suggested that DHM could be used as an effective compound for anti-aging intervention, which could likely be applied to both mammals and humans.