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Research Paper|Volume 13, Issue 1|pp 1473—1487

Prognostic relevance of SMC family gene expression in human sarcoma

Jian Zhou1, Gen Wu1,2, Zhongyi Tong3, Jingjing Sun4, Jing Su5, Ziqin Cao1, Yingquan Luo6, Wanchun Wang1
  • 1Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China
  • 2Clinical Medicine Eight-year Program, 02 Class, 2014 Grade, Central South University, Changsha 410013, Hunan Province, China
  • 3Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China
  • 4Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang, China
  • 5The Center for Medical Genetics, School of Life Science, Central South University, Changsha 410008, China
  • 6Department of General Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China
* Equal contribution
Received: August 31, 2020Accepted: November 27, 2020Published: December 30, 2020
https://doi.org/10.18632/aging.202455

Copyright: © 2020 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma.

Results: We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to the Cancer Cell Line Encyclopedia (CCLE), SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 are also highly expressed in sarcoma cell lines. Results of Gene Expression Profiling Interactive Analysis (GEPIA) indicated that high expression of SMC1A was significantly related to poor overall survival (OS) (p<0.05) and disease-free survival (DFS) in sarcoma (p<0.05). Additionally, strong expression of SMC2 was significantly related to poor OS in sarcoma (p<0.05). In contrast, SMC3, SMC4, SMC5, and SMC6 expression had no significant impact on OS or DFS in sarcoma.

Conclusions: Expression of SMC family members is significantly different in sarcoma relative to normal tissues, and SMC1A and SMC2 may be useful as prognostic biomarkers.

Methods: We performed a detailed comparison of cancer and normal tissues regarding the expression levels of mRNA for SMC family members in various cancers including sarcoma through ONCOMINE and GEPIA (Gene Expression Profile Interactive Analysis) databases.