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• ReviewVolume 10, Issue 9pp 2243-2251

  Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals

  Relevance score: 0.00

  Shunsuke Hoshino, Masaki Kobayashi, Yoshikazu Higami

  Keywords: caloric restriction, aging, growth hormone/insulin-like growth factor 1, mitochondria/redox regulation, remodeling of white adipose tissue

  Published in Aging on September 16, 2018

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• Research PaperVolume 12, Issue 2pp 1377-1396

  The role of serum growth hormone and insulin-like growth factor-1 in adult humans brain morphology

  Relevance score: 0.00

  Taoyang Yuan, Jianyou Ying, Lu Jin, Chuzhong Li, Songbai Gui, Zhenye Li, Rui Wang, Zhentao Zuo, Yazhuo Zhang

  Keywords: growth hormone (GH), insulin-like growth factor-1 (IGF-1), brain structure, structural magnetic resonance imaging analysis

  Published in Aging on January 22, 2020

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• Research PerspectiveVolume 2, Issue 12pp 1017-1022

  Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging?

  Relevance score: 0.00

  Alejandro P. Ugalde, Guillermo Mariño, Carlos López-Otín

  Keywords: progeria, cancer, growth hormone, insulin-like growth factor, longevity

  Published in Aging on December 26, 2010

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• Research PerspectiveVolume 2, Issue 8pp 523-526

  Adult Drosophila melanogaster as a model for the study of glucose homeostasis

  Relevance score: 0.00

  Aaron T. Haselton, Yih-Woei C. Fridell

  Keywords: Drosophila insulin-like peptides (DILPs), DILP-producing cells (IPCs), Insulin/Insulin-like growth factor signaling (IIS), hemolymph, adipokinetic hormone (AKH)

  Published in Aging on August 5, 2010

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• Research PaperVolume 7, Issue 4pp 241-255

  Thyroxine modifies the effects of growth hormone in Ames dwarf mice

  Relevance score: 0.00

  Andrew Do, Vinal Menon, Xu Zhi, Adam Gesing, Denise S. Wiesenborn, Adam Spong, Liou Sun, Andrzej Bartke, Michal M. Masternak

  Keywords: growth hormone, insulin, thyroxine, Ames dwarf, longevity

  Published in Aging on April 22, 2015

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• Research PaperVolume 6, Issue 12pp 1019-1032

  The suppression of ghrelin signaling mitigates age-associated thermogenic impairment

  Relevance score: 0.00

  Ligen Lin, Jong Han Lee, Odelia Y. N. Bongmba, Xiaojun Ma, Xiongwei Zhu, David Sheikh-Hamad, Yuxiang Sun

  Keywords: ghrelin, growth hormone secretagogue receptor (GHSR), brown adipose tissue (BAT), thermogenesis, insulin signaling, mitochondrial biogenesis and dynamics

  Published in Aging on December 15, 2014

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• Research PaperVolume 17, Issue 10pp 2534-2551

  Growth hormone excess drives liver aging via increased glycation stress

  Relevance score: 0.00

  Parminder Singh, Anil Gautam, Marissa N. Trujillo, Praveen Singh, Lizbeth Enriquez Najera, James J. Galligan, Lisa Hensley, Pankaj Kapahi, Andrzej Bartke

  Keywords: aging, growth hormone, glycation stress, Gly-Low

  Published in Aging on October 3, 2025

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• EditorialVolume 14, Issue 8pp 3331-3332

  Chasing Methuselah: adult inducible GHRKO mice

  Relevance score: 0.00

  John J. Kopchick, Darlene E. Berryman, Edward O. List

  Keywords: growth hormone receptor, longevity, knockout, growth hormone

  Published in Aging on April 13, 2022

• Research PaperVolume 13, Issue 5pp 6765-6781

  Growth hormone ameliorates the age-associated depletion of ovarian reserve and decline of oocyte quality via inhibiting the activation of Fos and Jun signaling

  Relevance score: 0.00

  Chuanming Liu, Shiyuan Li, Yifan Li, Jiao Tian, Xiaoling Sun, Tianran Song, Guijun Yan, Lijun Ding, Haixiang Sun

  Keywords: growth hormone, aging, oocyte quality, meiosis, apoptosis

  Published in Aging on February 17, 2021

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• Research PaperVolume 12, Issue 14pp 13939-13957

  Both ghrelin deletion and unacylated ghrelin overexpression preserve muscles in aging mice

  Relevance score: 0.00

  Emanuela Agosti, Marilisa De Feudis, Elia Angelino, Roberta Belli, Maraiza Alves Teixeira, Ivan Zaggia, Edoardo Tamiso, Tommaso Raiteri, Andrea Scircoli, Flavio L. Ronzoni, Maurizio Muscaritoli, Andrea Graziani, Flavia Prodam, Maurilio Sampaolesi, Paola Costelli, Elisabetta Ferraro, Simone Reano, Nicoletta Filigheddu

  Keywords: growth hormone secretagogue receptor, skeletal muscle atrophy, sarcopenia, inflammaging, sarcobesity

  Published in Aging on July 26, 2020

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• Research PaperVolume 7, Issue 9pp 616-628

  Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease

  Relevance score: 0.00

  Alexey Moskalev, Elizaveta Chernyagina, João Pedro de Magalhães, Diogo Barardo, Harikrishnan Thoppil, Mikhail Shaposhnikov, Arie Budovsky, Vadim E. Fraifeld, Andrew Garazha, Vasily Tsvetkov, Evgeny Bronovitsky, Vladislav Bogomolov, Alexei Scerbacov, Oleg Kuryan, Roman Gurinovich, Leslie C. Jellen, Brian Kennedy, Polina Mamoshina, Evgeniya Dobrovolskaya, Alex Aliper, Dmitry Kaminsky, Alex Zhavoronkov

  Keywords: growth hormone receptor (GHR), muscle-specific knockout, lifespan, aging, frailty, pathology, body composition

  Published in Aging on September 2, 2015

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• Research PaperVolume 7, Issue 7pp 500-512

  Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

  Relevance score: 0.00

  Edward O. List, Darlene E. Berryman, Yuji Ikeno, Gene B. Hubbard, Kevin Funk, Ross Comisford, Jonathan A. Young, Michael B. Stout, Tamar Tchkonia, Michal M. Masternak, Andrzej Bartke, James L. Kirkland, Richard A. Miller, John J. Kopchick

  Keywords: growth hormone receptor (GHR), muscle-specific knockout, lifespan, aging, frailty, pathology, body composition

  Published in Aging on June 29, 2015

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• Research PaperVolume 6, Issue 7pp 575-586

  Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

  Relevance score: 0.00

  Michael B. Stout, Tamara Tchkonia, Tamar Pirtskhalava, Allyson K. Palmer, Edward O. List, Darlene E. Berryman, Ellen R. Lubbers, Carlos Escande, Adam Spong, Michal M. Masternak, Ann L. Oberg, Nathan K. LeBrasseur, Richard A. Miller, John J. Kopchick, Andrzej Bartke, James L. Kirkland

  Keywords: adipose tissue, aging, cellular senescence, growth hormone

  Published in Aging on July 20, 2014

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• Research PaperVolume 13, Issue 11pp 14745-14767

  Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension

  Relevance score: 0.00

  Timothy A. Donlon, Randi Chen, Kamal H. Masaki, D. Craig Willcox, Richard C. Allsopp, Bradley J. Willcox, Brian J. Morris

  Keywords: hypertension, growth hormone receptor, longevity, mortality

  Published in Aging on June 1, 2021

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• EditorialVolume 11, Issue 15pp 5294-5295

  MicroRNA dysregulation influences growth hormone signaling

  Relevance score: 0.00

  Amy E. Elias, Jill A. Kreiling

  Keywords: aging, miRNAs, growth hormone receptor, growth hormone signaling, mouse, liver

  Published in Aging on August 6, 2019

• Priority Research PaperVolume 14, Issue 6pp 2442-2461

  Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice

  Relevance score: 0.00

  Xiaofang Shi, S. Joseph Endicott, Richard A. Miller

  Keywords: aging, lifespan extension, mTOR, TSC, growth hormone receptor

  Published in Aging on March 19, 2022

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• Research PaperVolume 13, Issue 2pp 1633-1648

  The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice

  Relevance score: 0.00

  Fang Zhang, Mert Icyuz, Andrzej Bartke, Liou Y. Sun

  Keywords: Ames dwarf mice, growth hormone, DNA methylation, histone H3 methylation, histone H3 acetylation

  Published in Aging on December 28, 2020

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• Priority Research PaperVolume 12, Issue 10pp 8766-8789

  Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice

  Relevance score: 0.00

  Xinna Li, Jacquelyn A. Frazier, Edward Spahiu, Madaline McPherson, Richard A. Miller

  Keywords: aging, growth hormone, uncoupling protein 1 (UCP1), adipose tissue, inflammation

  Published in Aging on May 28, 2020

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• Research PaperVolume 12, Issue 4pp 3473-3485

  Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism

  Relevance score: 0.00

  Jessica M. Hoffman, Aliza Poonawalla, Mert Icyuz, William R. Swindell, Landon Wilson, Stephen Barnes, Liou Y. Sun

  Keywords: aging, growth hormone, metabolite, mouse, transcriptomics

  Published in Aging on February 23, 2020

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• Research PaperVolume 8, Issue 3pp 539-546

  Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling

  Relevance score: 0.00

  Jacob J.E. Koopman, Diana van Heemst, David van Bodegom, Michael S. Bonkowski, Liou Y. Sun, Andrzej Bartke

  Keywords: aging, aging rate, mice, caloric restriction, growth hormone, Gompertz model

  Published in Aging on March 7, 2016

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