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Volume 14, Issue 6

March 31, 2022pp 2436—2923

About the Cover

The cover features Figure 3 "Targets associated with hallmarks of aging" from Pun et al.

Editorials

Toward establishing a worldwide net of canine biobanks

Sára Sándor, Silvan Urfer, Enikő Kubinyi

https://doi.org/10.18632/aging.203961pp 2436—2437

Targeting anxiety and senescence with senolytics

Marco Raffaele, Manlio Vinciguerra

https://doi.org/10.18632/aging.203985pp 2438—2439

Volitional control of walking in aging

Roee Holtzer

https://doi.org/10.18632/aging.203986pp 2440—2441

Priority Research Paper

Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice

Xiaofang Shi, S. Joseph Endicott, Richard A. Miller

https://doi.org/10.18632/aging.203959pp 2442—2461

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Research Papers

COVID-19

Association between social isolation and reduced mental well-being in Swedish older adults during the first wave of the COVID-19 pandemic: the role of cardiometabolic diseases

Abigail Dove, Jie Guo, Amaia Calderón-Larrañaga, Davide Liborio Vetrano, Laura Fratiglioni, Weili Xu

https://doi.org/10.18632/aging.203956pp 2462—2474

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Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

Frank W. Pun, Geoffrey Ho Duen Leung, Hoi Wing Leung, Bonnie Hei Man Liu, Xi Long, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evgeny Izumchenko, Alexey Moskalev, João Pedro de Magalhães, Alex Zhavoronkov

https://doi.org/10.18632/aging.203960pp 2475—2506

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Evaluation of the effect of age of the younger mice on the rejuvenation of the older mice by heterochronic parabiosis

Yushi Suzuki, Kento Takaya, Shiho Watanabe, Marika Otaki, Hikaru Kono, Kazuo Kishi

https://doi.org/10.18632/aging.203966pp 2507—2512

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Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)

Yigit Cakiroglu, Aysen Yuceturk, Ozge Karaosmanoglu, Sule Yildirim Kopuk, Zeynep Ece Utkan Korun, Nola Herlihy, Richard T. Scott, Bulent Tiras, Emre Seli

https://doi.org/10.18632/aging.203972pp 2513—2523

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VEGF-A-related genetic variants protect against Alzheimer’s disease

Alexandros M. Petrelis, Maria G. Stathopoulou, Maria Kafyra, Helena Murray, Christine Masson, John Lamont, Peter Fitzgerald, George Dedoussis, Frances T. Yen, Sophie Visvikis-Siest

https://doi.org/10.18632/aging.203984pp 2524—2536

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Association between serum uric acid and α-klotho protein levels in the middle-aged population

Hyo-Jung Lee, Ju-Young Choi, Jaeho Lee, Donghoon Kim, Jin-Young Min, Kyoung-Bok Min

https://doi.org/10.18632/aging.203987pp 2537—2547

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Maslinic acid protects against pressure-overload-induced cardiac hypertrophy by blocking METTL3-mediated m⁶A methylation

Ming Fang, Jun Deng, Qiangping Zhou, Zhengbang Hu, Lixia Yang

https://doi.org/10.18632/aging.203860pp 2548—2557

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COVID-19

Pan-cancer analysis revealed the significance of the GTPBP family in cancer

Yiming Hu, Liang Chen, Qikai Tang, Wei Wei, Yuan Cao, Jiaheng Xie, Jing Ji

https://doi.org/10.18632/aging.203952pp 2558—2573

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Progesterone attenuates neurological deficits and exerts a protective effect on damaged axons via the PI3K/AKT/mTOR-dependent pathway in a mouse model of intracerebral hemorrhage

Chang Liu, Weina Gao, Long Zhao, Yi Cao

https://doi.org/10.18632/aging.203954pp 2574—2589

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The TLR4/NF-κB/MAGI-2 signaling pathway mediates postoperative delirium

Wei Zhang, Ruohan Wang, Jingli Yuan, Bing Li, Luyao Zhang, Yangyang Wang, Ruilou Zhu, Jiaqiang Zhang, Ting Huyan

https://doi.org/10.18632/aging.203955pp 2590—2606

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2, 3, 5, 4’-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injury-induced pathophysiology

Yu-Hsin Chen, Yen-Chou Chen, Yu-Tang Chin, Ching-Chiung Wang, Ling-Ling Hwang, Liang-Yo Yang, Dah-Yuu Lu

https://doi.org/10.18632/aging.203958pp 2607—2627

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Five-gene signature predicts acute kidney injury in early kidney transplant patients

Xia Zhai, Hongqiang Lou, Jing Hu

https://doi.org/10.18632/aging.203962pp 2628—2644

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Clinical utility of serum fucosylated fraction of alpha-fetoprotein in the diagnostic of hepatocellular carcinoma: a comprehensive analysis with large sample size

Aibin Liu, Yanyan Li, Lin Shen, Liangfang Shen, Zhanzhan Li

https://doi.org/10.18632/aging.203963pp 2645—2664

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Adipose-derived mesenchymal stem cells may reduce intestinal epithelial damage in ulcerative colitis by communicating with macrophages and blocking inflammatory pathways: an analysis in silico

Nan Zhang, Yixuan Chen, Chengyu Huang, Mengxin Wei, Ting Li, Yufeng Lv, Qiong Song, Shaowen Mo

https://doi.org/10.18632/aging.203964pp 2665—2677

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piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure

Nier Zhong, Xiting Nong, Jiayu Diao, Guang Yang

https://doi.org/10.18632/aging.203965pp 2678—2694

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Effects of caloric overload before caloric restriction in the murine heart

Martin Maldonado, Jianying Chen, Huiqin Duan, Shuling Zhou, Lujun Yang, Mazhar Ali Raja, Tianhua Huang, Gu Jiang, Ying Zhong

https://doi.org/10.18632/aging.203967pp 2695—2719

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Tumor-associated macrophages related signature in glioma

Lin-Jian Wang, Yimeng Xue, Yongli Lou

https://doi.org/10.18632/aging.203968pp 2720—2735

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The association between rs1260326 with the risk of NAFLD and the mediation effect of triglyceride on NAFLD in the elderly Chinese Han population

Fan Yuan, Zhan Gu, Yan Bi, Ruixue Yuan, Weibo Niu, Decheng Ren, Lei Zhang, Guang He, Bao-Cheng Liu

https://doi.org/10.18632/aging.203970pp 2736—2747

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Ischemic postconditioning protects nonculprit coronary arteries against ischemia-reperfusion injury via downregulating miR-92a, miR-328 and miR-494

Jian Wang, Wu Wang, Chengying Yan, Tianzhen Wang

https://doi.org/10.18632/aging.203971pp 2748—2757

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GSDMs are potential therapeutic targets and prognostic biomarkers in clear cell renal cell carcinoma

Lei Yao, Juanni Li, Zhijie Xu, Yuanliang Yan, Kuan Hu

https://doi.org/10.18632/aging.203973pp 2758—2774

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Construction and evaluation of a nomogram for predicting survival in patients with lung cancer

Jin Ouyang, Zhijian Hu, Jianlin Tong, Yong Yang, Juan Wang, Xi Chen, Ting Luo, Shiqun Yu, Xin Wang, Shaoxin Huang

https://doi.org/10.18632/aging.203974pp 2775—2792

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Local anesthetic levobupivacaine inhibits stemness of osteosarcoma cells by epigenetically repressing MAFB though reducing KAT5 expression

Zhan Wang, Yuxin Song, Hui Zhang, Yang Yang, Suifeng Zhang, Wenji Wang

https://doi.org/10.18632/aging.203975pp 2793—2804

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Altered regional brain white matter in dry eye patients: a brain imaging study

Yun-Qing Luo, Rong-Bin Liang, San-Hua Xu, Yi-Cong Pan, Qiu-Yu Li, Hui-Ye Shu, Min Kang, Pin Yin, Li-Juan Zhang, Yi Shao

https://doi.org/10.18632/aging.203976pp 2805—2818

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Next-generation sequencing identifies HOXA6 as a novel oncogenic gene in low grade glioma

Jiang Xiulin, Chunyan Wang, Jishu Guo, Chenyang Wang, Chenglong Pan, Zhi Nie

https://doi.org/10.18632/aging.203977pp 2819—2854

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Cyclin B2 overexpression promotes tumour growth by regulating jagged 1 in hepatocellular carcinoma

Yening Xiao, Jiamei Ma, Chunliu Guo, Danni Liu, Jing Pan, Xiaoxi Huang

https://doi.org/10.18632/aging.203979pp 2855—2867

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COVID-19

TP53/BRAF mutation as an aid in predicting response to immune-checkpoint inhibitor across multiple cancer types

Jia-Zheng Cao, Gao-Sheng Yao, Fei Liu, Yi-Ming Tang, Peng-Ju Li, Zi-Hao Feng, Jun-Hang Luo, Jin-Huan Wei

https://doi.org/10.18632/aging.203980pp 2868—2879

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A systematic pan-cancer study demonstrates the oncogenic function of heterogeneous nuclear ribonucleoprotein C

Chenxi Pan, Qian Wu, Nianjie Feng

https://doi.org/10.18632/aging.203981pp 2880—2901

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Review

Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment

Zhao Shan, Wei Hong Fa, Chen Run Tian, Chen Shi Yuan, Ning Jie

https://doi.org/10.18632/aging.203969pp 2902—2919

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Corrections

Correction for: Long non-coding RNA PVT1 encapsulated in bone marrow mesenchymal stem cell-derived exosomes promotes osteosarcoma growth and metastasis by stabilizing ERG and sponging miR-183-5p

Wei Zhao, Pan Qin, Da Zhang, Xichun Cui, Jing Gao, Zhenzhu Yu, Yuting Chai, Jiaxiang Wang, Juan Li

https://doi.org/10.18632/aging.203990pp 2920—2922

Correction for: The effects of psyllium husk on gut microbiota composition and function in chronically constipated women of reproductive age using 16S rRNA gene sequencing analysis

Chuanli Yang, Shuai Liu, Hongxia Li, Xinshu Bai, Shuhua Shan, Peng Gao, Xiushan Dong

https://doi.org/10.18632/aging.203991pp 2923