Volume 14, Issue 8

April 30, 2022pp 3331—3721

About the Cover

The cover features Figure 16 "Influences of mutant and WT-TP53 on mitochondrial activity and glucose metabolism and effects of rapamycin and metformin" from McCubrey et al.

Editorials

Chasing Methuselah: adult inducible GHRKO mice

John J. Kopchick, Darlene E. Berryman, Edward O. List

https://doi.org/10.18632/aging.204016pp 3331—3332

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Intensive fasting reduces thrombosis and improves innate immunity

Yanjun Yang, Jianrong Wang

https://doi.org/10.18632/aging.204020pp 3333—3334

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SNCA-AS1 in aging and Parkinson’s disease

Stephana Carelli, Federica Rey, Cristina Cereda

https://doi.org/10.18632/aging.204025pp 3335—3336

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Research Papers

Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Sun Min Lee, Min Chul Lee, Woo Ri Bae, Kyung Jin Yoon, Hyo Youl Moon

https://doi.org/10.18632/aging.204024pp 3337—3364

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Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties

James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemysław Duda, Agnieszka Gizak

https://doi.org/10.18632/aging.204038pp 3365—3386

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miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer

Guangyu Gao, Xiaofei Guo, Wenyong Gu, Yufeng Lu, Zhigang Chen

https://doi.org/10.18632/aging.203998pp 3387—3399

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Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis

Xing Li, Chaofan Xie, Fangjun Xiao, Haitao Su, Zhen Li, Jiaxian Weng, Yongming Huang, Peiheng He

https://doi.org/10.18632/aging.204018pp 3400—3415

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The effect of D-chiro-inositol on renal protection in diabetic mice

Chunxue Fan, Dandan Zhang, Junling Zhang, Jinwei Li, Yu Wang, Linghuan Gao, Shuying Han

https://doi.org/10.18632/aging.204019pp 3416—3424

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Molecular characterization of matrix metalloproteinase gene family across primates

Yinglian Pan, Yadan Fan, Yanda Lu, Siyuan Peng, Haixue Lin, Qingchun Deng

https://doi.org/10.18632/aging.204021pp 3425—3445

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Integrated analysis of 14 lymphoma datasets revealed high expression of CXCL14 promotes cell migration in mantle cell lymphoma

Dahai Liu, Fei Qi, Wei Liu, Justin Liu, Jun Wang, Dao-Qiang Lu, Yang Xun, Min-Min Chen, Xin Chen, Shu-Ting Yang, Wen-Qiao Jiao, Zong-Ye Li, Fang Liu, Hua Yang, Wen-Xing Li

https://doi.org/10.18632/aging.204022pp 3446—3463

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Improving ovarian cancer treatment decision using a novel risk predictive tool

Zhenyi Xu, Jiali Song, Lei Cao, Zhiwei Rong, Wenjie Zhang, Jia He, Kang Li, Yan Hou

https://doi.org/10.18632/aging.204023pp 3464—3483

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Decisive gene strategy on osteoporosis: a comprehensive whole-literature-based approach for conclusive candidate gene targets

Yueh-Chun Chen, Yu-Jui Tsai, Chih-Chien Wang, Pi-Shao Ko, Wen Su, Sui-Lung Su

https://doi.org/10.18632/aging.204026pp 3484—3528

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NRIP1 aggravates lung injury caused by Pseudomonas aeruginosa in mice by increasing PIAS1 ubiquitination

Miaoyi Huang, Jianying Li, Jie Bai, Xusheng Du, Hua Guo, Bo Wang, Jiru Xu

https://doi.org/10.18632/aging.204027pp 3529—3539

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MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma in vivo and in vitro via the MEK1-mediated ERK-MMP signaling pathway

Mingbo Wang, Chao Huang, Wenda Gao, Yonggang Zhu, Fan Zhang, Zhenhua Li, Ziqiang Tian

https://doi.org/10.18632/aging.204028pp 3540—3553

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Claudin-5 relieves cognitive decline in Alzheimer’s disease mice through suppression of inhibitory GABAergic neurotransmission

Ning Zhu, Meidan Wei, Linguang Yuan, Xiaodan He, Chunli Chen, Aimin Ji, Guozeng Zhang

https://doi.org/10.18632/aging.204029pp 3554—3568

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Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks

Zixuan Wu, Zhixiang Cai, Hongshuo Shi, Xuyan Huang, Minjie Cai, Kai Yuan, Peidong Huang, Guoqi Shi, Tao Yan, Zhichao Li

https://doi.org/10.18632/aging.204030pp 3569—3596

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Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer

Xiaofei Zhang, Tiebo Mao, Haiyan Xu, Shumin Li, Ming Yue, Jingyu Ma, Jiayu Yao, Yongchao Wang, Xiao Zhang, Weiyu Ge, Yanling Wang, Daiyuan Shentu, Liwei Wang

https://doi.org/10.18632/aging.204031pp 3597—3606

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