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The cover features Figure 16 "Influences of mutant and WT-TP53 on mitochondrial activity and glucose metabolism and effects of rapamycin and metformin" from McCubrey et al.

Volume 14, Issue 8

30 April, 2022
pp 3331—3721

About the Cover

The cover features Figure 16 "Influences of mutant and WT-TP53 on mitochondrial activity and glucose metabolism and effects of rapamycin and metformin" from McCubrey et al.


Explore This Issue

Editorials

Chasing Methuselah: adult inducible GHRKO mice

John J. Kopchick, Darlene E. Berryman, Edward O. List,
https://doi.org/10.18632/aging.204016 pp 3331—3332
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Intensive fasting reduces thrombosis and improves innate immunity

Yanjun Yang, Jianrong Wang,
https://doi.org/10.18632/aging.204020 pp 3333—3334
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SNCA-AS1 in aging and Parkinson’s disease

Stephana Carelli, Federica Rey, Cristina Cereda,
https://doi.org/10.18632/aging.204025 pp 3335—3336
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Research Papers

Muscle fiber type-dependence effect of exercise on genomic networks in aged mice models

Sun Min Lee, Min Chul Lee, Woo Ri Bae, Kyung Jin Yoon, Hyo Youl Moon,
https://doi.org/10.18632/aging.204024 pp 3337—3364
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Wild type and gain of function mutant TP53 can regulate the sensitivity of pancreatic cancer cells to chemotherapeutic drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 pathway inhibitors, nutraceuticals and alter metabolic properties

James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemysław Duda, Agnieszka Gizak,
https://doi.org/10.18632/aging.204038 pp 3365—3386
View Abstract PDF Full-Text How to Cite Special Collection on p53 Part 2

miRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer

Guangyu Gao, Xiaofei Guo, Wenyong Gu, Yufeng Lu, Zhigang Chen,
https://doi.org/10.18632/aging.203998 pp 3387—3399
View Abstract PDF Full-Text How to Cite Special Collection on Tumor Suppressors

Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis

Xing Li, Chaofan Xie, Fangjun Xiao, Haitao Su, Zhen Li, Jiaxian Weng, Yongming Huang, Peiheng He,
https://doi.org/10.18632/aging.204018 pp 3400—3415
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The effect of D-chiro-inositol on renal protection in diabetic mice

Chunxue Fan, Dandan Zhang, Junling Zhang, Jinwei Li, Yu Wang, Linghuan Gao, Shuying Han,
https://doi.org/10.18632/aging.204019 pp 3416—3424
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Molecular characterization of matrix metalloproteinase gene family across primates

Yinglian Pan, Yadan Fan, Yanda Lu, Siyuan Peng, Haixue Lin, Qingchun Deng,
https://doi.org/10.18632/aging.204021 pp 3425—3445
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Integrated analysis of 14 lymphoma datasets revealed high expression of CXCL14 promotes cell migration in mantle cell lymphoma

Dahai Liu, Fei Qi, Wei Liu, Justin Liu, Jun Wang, Dao-Qiang Lu, Yang Xun, Min-Min Chen, Xin Chen, Shu-Ting Yang, Wen-Qiao Jiao, Zong-Ye Li, Fang Liu, Hua Yang, Wen-Xing Li,
https://doi.org/10.18632/aging.204022 pp 3446—3463
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Improving ovarian cancer treatment decision using a novel risk predictive tool

Zhenyi Xu, Jiali Song, Lei Cao, Zhiwei Rong, Wenjie Zhang, Jia He, Kang Li, Yan Hou,
https://doi.org/10.18632/aging.204023 pp 3464—3483
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Decisive gene strategy on osteoporosis: a comprehensive whole-literature-based approach for conclusive candidate gene targets

Yueh-Chun Chen, Yu-Jui Tsai, Chih-Chien Wang, Pi-Shao Ko, Wen Su, Sui-Lung Su,
https://doi.org/10.18632/aging.204026 pp 3484—3528
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NRIP1 aggravates lung injury caused by Pseudomonas aeruginosa in mice by increasing PIAS1 ubiquitination

Miaoyi Huang, Jianying Li, Jie Bai, Xusheng Du, Hua Guo, Bo Wang, Jiru Xu,
https://doi.org/10.18632/aging.204027 pp 3529—3539
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MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma in vivo and in vitro via the MEK1-mediated ERK-MMP signaling pathway

Mingbo Wang, Chao Huang, Wenda Gao, Yonggang Zhu, Fan Zhang, Zhenhua Li, Ziqiang Tian,
https://doi.org/10.18632/aging.204028 pp 3540—3553
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Claudin-5 relieves cognitive decline in Alzheimer’s disease mice through suppression of inhibitory GABAergic neurotransmission

Ning Zhu, Meidan Wei, Linguang Yuan, Xiaodan He, Chunli Chen, Aimin Ji, Guozeng Zhang,
https://doi.org/10.18632/aging.204029 pp 3554—3568
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Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks

Zixuan Wu, Zhixiang Cai, Hongshuo Shi, Xuyan Huang, Minjie Cai, Kai Yuan, Peidong Huang, Guoqi Shi, Tao Yan, Zhichao Li,
https://doi.org/10.18632/aging.204030 pp 3569—3596
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Synergistic blocking of RAS downstream signaling and epigenetic pathway in KRAS mutant pancreatic cancer

Xiaofei Zhang, Tiebo Mao, Haiyan Xu, Shumin Li, Ming Yue, Jingyu Ma, Jiayu Yao, Yongchao Wang, Xiao Zhang, Weiyu Ge, Yanling Wang, Daiyuan Shentu, Liwei Wang,
https://doi.org/10.18632/aging.204031 pp 3597—3606
View Abstract PDF Full-Text How to Cite Special Collection on Cancer Therapeutics

Association of CIDEB gene promoter methylation with overweight or obesity in adults

Zhiguang Ping, Zhaoyan Guo, Ming Lu, Yanzi Chen, Li Liu,
https://doi.org/10.18632/aging.204032 pp 3607—3616
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Puerarin protects against sepsis-induced myocardial injury through AMPK-mediated ferroptosis signaling

Bin Zhou, Jing Zhang, Yixuan Chen, Yang Liu, Xiaoyi Tang, Panpan Xia, Peng Yu, Shuchun Yu,
https://doi.org/10.18632/aging.204033 pp 3617—3632
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Endothelin-1-mediated miR-let-7g-5p triggers interlukin-6 and TNF-α to cause myopathy and chronic adipose inflammation in elderly patients with diabetes mellitus

Chung-Huang Tsai, Pei-Ju Huang, IT Lee, Chien-Min Chen, Min Huan Wu,
https://doi.org/10.18632/aging.204034 pp 3633—3651
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microRNA-569 inhibits tumor metastasis in pancreatic cancer by directly targeting NUSAP1

Xiaohui Guo, Yatian Li, Xiaofang Che, Kezuo Hou, Xiujuan Qu, Ce Li,
https://doi.org/10.18632/aging.204035 pp 3652—3665
View Abstract PDF Full-Text How to Cite Special Collection on Cancer Therapeutics

LncRNA136131 suppresses apoptosis of renal tubular epithelial cells in acute kidney injury by targeting the miR-378a-3p/Rab10 axis

Zhifen Wu, Jian Pan, Jurong Yang, Dongshan Zhang,
https://doi.org/10.18632/aging.204036 pp 3666—3686
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F12 as a reliable diagnostic and prognostic biomarker associated with immune infiltration in papillary thyroid cancer

Jun-Hua Luo, Xiu-Xia Zhang, Wu-Hui Sun,
https://doi.org/10.18632/aging.204037 pp 3687—3704
View Abstract PDF Full-Text How to Cite Special Collection on Biomarkers

Integrative analysis of expression, prognostic significance and immune infiltration of RFC family genes in human sarcoma

Gen Wu, Jian Zhou, Xi Zhu, Xianzhe Tang, Jie Liu, Qiong Zhou, Ziyuan Chen, Tang Liu, Wanchun Wang, Xungang Xiao, Tong Wu,
https://doi.org/10.18632/aging.204039 pp 3705—3719
View Abstract PDF Full-Text How to Cite Special Collection on Biomarkers

Correction

Correction for: CD36 upregulates DEK transcription and promotes cell migration and invasion via GSK-3β/β-catenin-mediated epithelial-to-mesenchymal transition in gastric cancer

Jin Wang, Ti Wen, Zhi Li, Xiaofang Che, Libao Gong, Zihan Jiao, Xiujuan Qu, Yunpeng Liu,
https://doi.org/10.18632/aging.204046 pp 3720—3721
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