Review Volume 10, Issue 9 pp 2243—2251
Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals
- 1 Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278-8510, Japan
- 2 Translational Research Center, Research Institute for Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan
Received: July 1, 2018 Accepted: September 10, 2018 Published: September 16, 2018
https://doi.org/10.18632/aging.101557How to Cite
Abstract
It is widely accepted that caloric restriction (CR) extends lifespan and suppresses various pathophysiological changes. CR suppresses growth hormone/insulin-like growth factor signaling and mechanistic target of rapamycin complex 1 activity, activates sirtuin and enhances mitochondrial redox regulation, but the exact mechanisms are still under debate. In this review, we discuss the mechanisms of CR using evidence from studies of animals that were genetically modified according to recent advances in molecular and genetic technologies, from the viewpoint of the adaptive response hypothesis proposed by Holliday (1989). We then explain the beneficial actions of CR, classified according to whether they operate under feeding or fasting conditions.
Abbreviations
CR: caloric restriction; GH/IGF1: growth hormone/insulin-like growth factor 1; WAT: white adipose tissue.