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The cover features Figure 4 "Multigenerational Prenatal Stress (MPS) alters disease incidence across the lifespan“ from Ambeskovic et al.

Volume 12, Issue 4

29 February, 2020
pp 3117—4044

About the Cover

The cover features Figure 4 "Multigenerational Prenatal Stress (MPS) alters disease incidence across the lifespan“ from Ambeskovic et al.


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Editorials

Can transcatheter aortic valve implantation improve cognition?

Astrid van Nieuwkerk, Jan Baan, Ronak Delewi,
https://doi.org/10.18632/aging.102851 pp 3117—3118
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Cholesterol lowering: to live longer, start younger?

Nelson Wang, Ian Wilcox, Sean Lal,
https://doi.org/10.18632/aging.102867 pp 3119—3120
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CEACAM1 promotes vascular aging processes

Florian Kleefeldt, Uwe Rueckschloss, Süleyman Ergün,
https://doi.org/10.18632/aging.102868 pp 3121—3123
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Targeting periosteal SSCs for aged bone defects

Youngjae Jeong, Dongsu Park,
https://doi.org/10.18632/aging.102869 pp 3124—3125
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Research Papers

LncRNA AK045171 protects the heart from cardiac hypertrophy by regulating the SP1/MG53 signalling pathway

Li Xu, Hongjiang Wang, Feng Jiang, Hao Sun, Dapeng Zhang,
https://doi.org/10.18632/aging.102668 pp 3126—3139
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Comparison of BRCA versus non-BRCA germline mutations and associated somatic mutation profiles in patients with unselected breast cancer

Bo Chen, Guochun Zhang, Xuerui Li, Chongyang Ren, Yulei Wang, Kai Li, Hsiaopei Mok, Li Cao, Lingzhu Wen, Minghan Jia, Cheukfai Li, Liping Guo, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Han Han-Zhang, Jing Liu, Analyn Lizaso, Ning Liao,
https://doi.org/10.18632/aging.102783 pp 3140—3155
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LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke

Yanxiao Xiang, Yayun Zhang, Yanni Xia, Hua Zhao, Anchang Liu, Yuguo Chen,
https://doi.org/10.18632/aging.102790 pp 3156—3174
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Ligustilide improves aging-induced memory deficit by regulating mitochondrial related inflammation in SAMP8 mice

Wen-Li Zhu, Jia-Yi Zheng, Wei-Wu Cai, Zhao Dai, Ben-Yue Li, Ting-Ting Xu, Hao-Fei Liu, Xiao-Qi Liu, Su-Fen Wei, Yi Luo, Hong Wang, Hua-Feng Pan, Qi Wang, Shi-Jie Zhang,
https://doi.org/10.18632/aging.102793 pp 3175—3189
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Development and validation of a nomogram to predict coronary heart disease in patients with rheumatoid arthritis in northern China

Tingting Wei, Bowen Yang, Haina Liu, Fangran Xin, Lingyu Fu,
https://doi.org/10.18632/aging.102823 pp 3190—3204
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MIR210HG promotes cell proliferation and invasion by regulating miR-503-5p/TRAF4 axis in cervical cancer

Ai-Hong Wang, Can-Hui Jin, Guan-Yi Cui, Hong-Yu Li, Yin Wang, Juan-Juan Yu, Rui-Fang Wang, Xiao-Yu Tian,
https://doi.org/10.18632/aging.102799 pp 3205—3217
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LINC00623/miR-101/HRAS axis modulates IL-1β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes

Guohua Lü, Lei Li, Bing Wang, Lei Kuang,
https://doi.org/10.18632/aging.102801 pp 3218—3237
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Peritoneal metastatic gastric carcinoma cells exhibit more malignant behavior when co-cultured with HMrSV5 cells

Lijing Wang, Zhiyuan Xu, Can Hu, Shangqi Chen, Yian Du, Ling Huang, Chengwei Shi, Shaowei Mo, Xiangdong Cheng,
https://doi.org/10.18632/aging.102803 pp 3238—3248
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The IL1β-HER2-CLDN18/CLDN4 axis mediates lung barrier damage in ARDS

Xinhua Ma, Xin Yu, Qi Zhou,
https://doi.org/10.18632/aging.102804 pp 3249—3265
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Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice

Adrian Angenendt, Romy Steiner, Arne Knörck, Gertrud Schwär, Maik Konrad, Elmar Krause, Annette Lis,
https://doi.org/10.18632/aging.102809 pp 3266—3286
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A genome-wide multiphenotypic association analysis identified candidate genes and gene ontology shared by four common risky behaviors

Jing Ye, Li Liu, Xiaoqiao Xu, Yan Wen, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Om Prakash Kafle, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiaomeng Chu, Lin Niu, Feng Zhang,
https://doi.org/10.18632/aging.102812 pp 3287—3297
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Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia

Jian Liu, Zhiwei Chen, Yunping Cui, Huixia Wei, Zhenjing Zhu, Fengxia Mao, Yingchao Wang, Yufeng Liu,
https://doi.org/10.18632/aging.102813 pp 3298—3311
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Analysis of immune-related signatures of lung adenocarcinoma identified two distinct subtypes: implications for immune checkpoint blockade therapy

Qinghua Wang, Meiling Li, Meng Yang, Yichen Yang, Fengju Song, Wei Zhang, Xiangchun Li, Kexin Chen,
https://doi.org/10.18632/aging.102814 pp 3312—3339
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Sarcopenia-related traits and coronary artery disease: a bi-directional Mendelian randomization study

Hui-Min Liu, Qiang Zhang, Wen-Di Shen, Bo-Yang Li, Wan-Qiang Lv, Hong-Mei Xiao, Hong-Wen Deng,
https://doi.org/10.18632/aging.102815 pp 3340—3353
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Cancer stem cell-specific expression profiles reveal emerging bladder cancer biomarkers and identify circRNA_103809 as an important regulator in bladder cancer

Tao Tao, Simin Yuan, Jinjian Liu, Da Shi, Mian Peng, Chong Li, Song Wu,
https://doi.org/10.18632/aging.102816 pp 3354—3370
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Identification of prognostic immune-related genes in the tumor microenvironment of endometrial cancer

Peigen Chen, Yuebo Yang, Yu Zhang, Senwei Jiang, Xiaomao Li, Jing Wan,
https://doi.org/10.18632/aging.102817 pp 3371—3387
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Cell-to-cell lactate shuttle operates in heart and is important in age-related heart failure

Agnieszka Gizak, James A. McCubrey, Dariusz Rakus,
https://doi.org/10.18632/aging.102818 pp 3388—3406
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Expression and prognostic value of long non-coding RNA H19 in glioma via integrated bioinformatics analyses

Yilei Xiao, Zipeng Zhu, Jianxiong Li, Jie Yao, Haitao Jiang, Ran Ran, Xueyuan Li, Zhiqiang Li,
https://doi.org/10.18632/aging.102819 pp 3407—3430
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Development and validation of a prognostic classifier based on HIF-1 signaling for hepatocellular carcinoma

Feiwen Deng, Dong Chen, Xiaoli Wei, Shilin Lu, Xuan Luo, Jincan He, Junting Liu, Tiebao Meng, Anli Yang, Huanwei Chen,
https://doi.org/10.18632/aging.102820 pp 3431—3450
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Existence of intratumoral tertiary lymphoid structures is associated with immune cells infiltration and predicts better prognosis in early-stage hepatocellular carcinoma

Hui Li, Jinju Wang, Hailing Liu, Tian Lan, Lin Xu, Genshu Wang, Kefei Yuan, Hong Wu,
https://doi.org/10.18632/aging.102821 pp 3451—3472
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Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism

Jessica M. Hoffman, Aliza Poonawalla, Mert Icyuz, William R. Swindell, Landon Wilson, Stephen Barnes, Liou Y. Sun,
https://doi.org/10.18632/aging.102822 pp 3473—3485
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Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of osteosarcoma

Chi Zhang, Jing-Hui Zheng, Zong-Han Lin, Hao-Yuan Lv, Zhuo-Miao Ye, Yue-Ping Chen, Xiao-Yun Zhang,
https://doi.org/10.18632/aging.102824 pp 3486—3501
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Successful aging: insights from proteome analyses of healthy centenarians

Alejandro Santos-Lozano, Pedro L. Valenzuela, Francisco Llavero, Simone Lista, Pedro Carrera-Bastos, Harald Hampel, Helios Pareja-Galeano, Beatriz G. Gálvez, Juan Antonio López, Jesús Vázquez, Enzo Emanuele, José L. Zugaza, Alejandro Lucia,
https://doi.org/10.18632/aging.102826 pp 3502—3515
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Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates

Hafiz Ishfaq Ahmad, Jiabin Zhou, Muhammad Jamil Ahmad, Gulnaz Afzal, Haiying Jiang, Xiujuan Zhang, Abdelmotaleb A. Elokil, Musarrat Abbas Khan, Linmiao Li, Huiming Li, Liu Ping, Jinping Chen,
https://doi.org/10.18632/aging.102827 pp 3516—3557
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Development and validation of a RNA binding protein-associated prognostic model for lung adenocarcinoma

Wei Li, Li-Na Gao, Pei-Pei Song, Chong-Ge You,
https://doi.org/10.18632/aging.102828 pp 3558—3573
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SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway

Shan Tian, Pailan Peng, Jiao Li, Huan Deng, Na Zhan, Zhi Zeng, Weiguo Dong,
https://doi.org/10.18632/aging.102831 pp 3574—3593
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LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis

Chunyong Han, Yiwei Fu, Ni Zeng, Jian Yin, Qian Li,
https://doi.org/10.18632/aging.102832 pp 3594—3616
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Inflammatory macrophages facilitate mechanical stress-induced osteogenesis

Fan Zhang, Le Huan, Tao Xu, Guozheng Li, Bing Zheng, Hong Zhao, Yongfei Guo, Jiangang Shi, Jingchuan Sun, Aimin Chen,
https://doi.org/10.18632/aging.102833 pp 3617—3625
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NMR-based metabonomic analysis of HUVEC cells during replicative senescence

Shenghui Yi, Kejiang Lin, Ting Jiang, Wei Shao, Caihua Huang, Bin Jiang, Qinxi Li, Donghai Lin,
https://doi.org/10.18632/aging.102834 pp 3626—3646
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The lncRNA ENSG00000254041.1 promotes cell invasiveness and associates with poor prognosis of pancreatic ductal adenocarcinoma

Bo Chen, Qiqi Zhang, Xujing Wang, Yongkun Wang, Jiaqu Cui, Huiren Zhuang, Jianying Tang,
https://doi.org/10.18632/aging.102835 pp 3647—3661
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Induction of apoptosis and ferroptosis by a tumor suppressing magnetic field through ROS-mediated DNA damage

Lin-Qing Yuan, Can Wang, Dong-Fang Lu, Xia-Di Zhao, Lin-Hua Tan, Xi Chen,
https://doi.org/10.18632/aging.102836 pp 3662—3681
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Exosomes isolated from the plasma of remote ischemic conditioning rats improved cardiac function and angiogenesis after myocardial infarction through targeting Hsp70

Qin Chen, Minghan Huang, Jiayi Wu, Qiong Jiang, Xingchun Zheng,
https://doi.org/10.18632/aging.102837 pp 3682—3693
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Identification of biomarkers related to CD8+ T cell infiltration with gene co-expression network in clear cell renal cell carcinoma

Jiaxing Lin, Meng Yu, Xiao Xu, Yutao Wang, Haotian Xing, Jun An, Jieping Yang, Chaozhi Tang, Dan Sun, Yuyan Zhu,
https://doi.org/10.18632/aging.102841 pp 3694—3712
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Identification of a lathyrane-type diterpenoid EM-E-11-4 as a novel paclitaxel resistance reversing agent with multiple mechanisms of action

Qian Liu, Pei Cai, Siwei Guo, Jiangong Shi, Hua Sun,
https://doi.org/10.18632/aging.102842 pp 3713—3729
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The role of Apolipoprotein E epsilon4 in the association between psychosocial working conditions and dementia

Kuan-Yu Pan, Weili Xu, Francesca Mangialasche, Giulia Grande, Laura Fratiglioni, Hui-Xin Wang,
https://doi.org/10.18632/aging.102843 pp 3730—3746
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Development of a four-gene prognostic model for pancreatic cancer based on transcriptome dysregulation

Jie Yan, Liangcai Wu, Congwei Jia, Shuangni Yu, Zhaohui Lu, Yueping Sun, Jie Chen,
https://doi.org/10.18632/aging.102844 pp 3747—3770
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PD-1 gene rs10204525 and rs7421861 polymorphisms are associated with increased risk and clinical features of esophageal cancer in a Chinese Han population

Bao Zang, Chen Chen, Jian-Qiang Zhao,
https://doi.org/10.18632/aging.102845 pp 3771—3790
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Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota

Jianfeng Liu, Tianhua Zhang, Yingying Wang, Chengqing Si, Xudong Wang, Rui-Tao Wang, Zhonghua Lv,
https://doi.org/10.18632/aging.102846 pp 3791—3806
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Risk score based on expression of five novel genes predicts survival in soft tissue sarcoma

Hui-Yun Gu, Chao Zhang, Jia Guo, Min Yang, Hou-Cheng Zhong, Wei Jin, Yang Liu, Li-Ping Gao, Ren-Xiong Wei,
https://doi.org/10.18632/aging.102847 pp 3807—3827
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Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk

Mirela Ambeskovic, Yaroslav Ilnytskyy, Douglas Kiss, Cheryl Currie, Tony Montina, Igor Kovalchuk, Gerlinde A.S. Metz,
https://doi.org/10.18632/aging.102848 pp 3828—3847
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Establishment and characterization of patient-derived xenografts for hormone-naïve and castrate-resistant prostate cancers to improve treatment modality evaluation

Pengpeng Wu, Rong Xu, Xue Chen, Ya Zhao, Dengxu Tan, Yong Zhao, Weijun Qin, Caiqin Zhang, Xu Ge, Changhong Shi,
https://doi.org/10.18632/aging.102854 pp 3848—3861
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Acetate attenuates perioperative neurocognitive disorders in aged mice

Cen Wen, Tao Xie, Ke Pan, Yu Deng, Zhijia Zhao, Na Li, Jinjun Bian, Xiaoming Deng, Yanping Zha,
https://doi.org/10.18632/aging.102856 pp 3862—3879
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Adipose-derived mesenchymal stem cells-derived exosome-mediated microRNA-342-5p protects endothelial cells against atherosclerosis

Xiaohui Xing, Zhongchen Li, Xin Yang, Mengyou Li, Chao Liu, Yuejiu Pang, Liyong Zhang, Xueyuan Li, Guangcun Liu, Yilei Xiao,
https://doi.org/10.18632/aging.102857 pp 3880—3898
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Clinical burden of autosomal dominant polycystic kidney disease

Peir-Haur Hung, Chien-Hung Lin, Kuan-Yu Hung, Chih-Hsin Muo, Mu-Chi Chung, Chao-Hsiang Chang, Chi-Jung Chung,
https://doi.org/10.18632/aging.102858 pp 3899—3910
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Subjective cognitive decline detected by the oscillatory connectivity in the default mode network: a magnetoencephalographic study

Chia-Hsiung Cheng, Pei-Ning Wang, Hui-Fen Mao, Fu-Jung Hsiao,
https://doi.org/10.18632/aging.102859 pp 3911—3925
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Association between sleep–wake habits and use of health care services of middle-aged and elderly adults in China

Beizhu Ye, Yimei Zhu, Xiaoyu Wang, Sheng Wei, Yuan Liang,
https://doi.org/10.18632/aging.102860 pp 3926—3935
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The circular RNA NT5E promotes non-small cell lung cancer cell growth via sponging microRNA-134

Lingyun Dong, Jiangnan Zheng, Yun Gao, Xiaoting Zhou, Weizhen Song, Jianan Huang,
https://doi.org/10.18632/aging.102861 pp 3936—3949
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Advanced maternal age alters expression of maternal effect genes that are essential for human oocyte quality

Jing-Jing Zhang, Xiaoyan Liu, Li Chen, Shouxin Zhang, Xia Zhang, Cuifang Hao, Yi-Liang Miao,
https://doi.org/10.18632/aging.102864 pp 3950—3961
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SOCS1 blocks G1-S transition in hepatocellular carcinoma by reducing the stability of the CyclinD1/CDK4 complex in the nucleus

Jun Ding, Kangdi Xu, Suwan Sun, Chao Qian, Shengyong Yin, Haiyang Xie, Lin Zhou, Shusen Zheng, Wei Zhang,
https://doi.org/10.18632/aging.102865 pp 3962—3975
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PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission

Jiachao Guo, Ranyue Ren, Xudong Yao, Yaping Ye, Kai Sun, Jiamin Lin, Genchun Wang, Fengjing Guo, Jun Xiao, Tao Xu,
https://doi.org/10.18632/aging.102866 pp 3976—3992
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Reviews

Metformin: current clinical applications in nondiabetic patients with cancer

Kailin Chen, Yajun Li, Zhen Guo, Yong Zeng, Wei Zhang, Hui Wang,
https://doi.org/10.18632/aging.102787 pp 3993—4009
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Efficacy of probiotics on cognition, and biomarkers of inflammation and oxidative stress in adults with Alzheimer’s disease or mild cognitive impairment — a meta-analysis of randomized controlled trials

Haoyue Den, Xunhu Dong, Mingliang Chen, Zhongmin Zou,
https://doi.org/10.18632/aging.102810 pp 4010—4039
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Corrections

Correction for: Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1

Qiu Tang, Zhigang Chen, Liangping Zhao,
https://doi.org/10.18632/aging.102853 pp 4040
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Correction for: Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma

Zihao Pan, Jiatong Lin, Duoguang Wu, Xiaotian He, Wenjian Wang, Xueting Hu, Lei Zhang, Minghui Wang,
https://doi.org/10.18632/aging.102884 pp 4041—4044
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