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Page: 12 of 2

• Research PaperVolume 16, Issue 20pp 12977-13011

  Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells

  Relevance score: 0.00

  Pavlo Lazarchuk, Matthew Manh Nguyen, Crina M. Curca, Maria N. Pavlova, Junko Oshima, Julia M. Sidorova

  Keywords: Werner progeria, heterochromatin, senescence, nuclear lamina, satellite repeats

  Published in Aging on October 17, 2024

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• Research PaperVolume 9, Issue 7pp 1738-1744

  Werner syndrome: a model for sarcopenia due to accelerated aging

  Relevance score: 0.00

  Masaya Yamaga, Minoru Takemoto, Mayumi Shoji, Kenichi Sakamoto, Masashi Yamamoto, Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Kazuki Kobayashi, Koutaro Yokote

  Keywords: sarcopenia, progeria, Werner syndrome

  Published in Aging on July 19, 2017

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• Research PaperVolume 9, Issue 4pp 1143-1152

  Accelerated epigenetic aging in Werner syndrome

  Relevance score: 0.00

  Anna Maierhofer, Julia Flunkert, Junko Oshima, George M. Martin, Thomas Haaf, Steve Horvath

  Keywords: Werner syndrome, progeria, epigenetics, epigenetic clock, DNA methylation

  Published in Aging on April 4, 2017

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• Research PerspectiveVolume 3, Issue 9pp 889-895

  Accelerated aging syndromes, are they relevant to normal human aging?

  Relevance score: 0.00

  Oliver Dreesen, Colin L. Stewart

  Keywords: Aging, Hutchinson-Gilford Progeria, Werner syndrome, DNA damage, telomeres, Wnt signaling, Lef1

  Published in Aging on September 14, 2011

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• Research PaperVolume 3, Issue 4pp 380-390

  Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C

  Relevance score: 0.00

  Jenny CY Ho, Ting Zhou, Wing-Hon Lai, Yinghua Huang, Yau-Chi Chan, Xingyan Li, Navy LY Wong, Yanhua Li, Ka-Wing Au, Dongsheng Guo, Jianyong Xu, Chung-Wah Siu, Duanqing Pei, Hung-Fat Tse, Miguel Angel Esteban

  Keywords: reprogramming, induced pluripotent stem cells, lamin A/C, dilated cardiomyopathy, atypical Werner syndrome, Hutchinson Gilford progeria

  Published in Aging on March 28, 2011

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• Research PaperVolume 17, Issue 4pp 937-959

  Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation

  Relevance score: 0.00

  Sofie Lautrup, Shi-Qi Zhang, Shinichiro Funayama, Lisa Lirussi, Tina Visnovska, Hoi-Hung Cheung, Marc Niere, Yuyao Tian, Hilde Loge Nilsen, Geir Selbæk, Janna Saarela, Yoshiro Maezawa, Koutaro Yokote, Per Nilsson, Wai-Yee Chan, Hisaya Kato, Mathias Ziegler, Vilhelm A. Bohr, Evandro F. Fang

  Keywords: Werner syndrome, premature aging, NAD+, mitochondria, proliferation

  Published in Aging on April 2, 2025

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• Research PaperVolume 16, Issue 22pp 13526-13533

  Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry

  Relevance score: 0.00

  Kazuto Aono, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Yukari Maeda, Hisaya Kato, Yoshiro Maezawa, Makoto Miyabayashi, Mai Ishikawa, Akiko Sekiguchi, Sei-Ichiro Motegi, Shinji Tsukamoto, Akira Taniguchi, Yukiko Shoda, Toru Yoshimura, Junji Kawashima, Kayo Yoshinaga, Hironori Nakagami, Yoichi Takami, Ken Sugimoto, Kunihiko Hashimoto, Naoki Okubo, Takashi Yoshida, Masato Ohara, Asako Kogure, Daisuke Suzuki, Masafumi Kuzuya, Kazuhisa Watanabe, Minoru Takemoto, Junko Oshima, Koutaro Yokote

  Keywords: Werner syndrome, skin ulcer, metformin, pioglitazon, progeroid syndrome

  Published in Aging on December 2, 2024

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• Research PaperVolume 16, Issue 10pp 8417-8445

  Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model

  Relevance score: 0.00

  Lucie Aumailley, Marie Julie Dubois, André Marette, Michel Lebel

  Keywords: proteomics, Werner syndrome, fatty liver, sexual dimorphism, immunoglobulins

  Published in Aging on May 24, 2024

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• Research PaperVolume 15, Issue 19pp 9948-9964

  Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome

  Relevance score: 0.00

  Daisuke Sawada, Hisaya Kato, Hiyori Kaneko, Daisuke Kinoshita, Shinichiro Funayama, Takuya Minamizuka, Atsushi Takasaki, Katsushi Igarashi, Masaya Koshizaka, Aki Takada-Watanabe, Rito Nakamura, Kazuto Aono, Ayano Yamaguchi, Naoya Teramoto, Yukari Maeda, Tomohiro Ohno, Aiko Hayashi, Kana Ide, Shintaro Ide, Mayumi Shoji, Takumi Kitamoto, Yusuke Endo, Hideyuki Ogata, Yoshitaka Kubota, Nobuyuki Mitsukawa, Atsushi Iwama, Yasuo Ouchi, Naoya Takayama, Koji Eto, Katsunori Fujii, Tomozumi Takatani, Tadashi Shiohama, Hiromichi Hamada, Yoshiro Maezawa, Koutaro Yokote

  Keywords: Werner syndrome, premature aging, lipodystrophy, stromal vascular fraction, SASP

  Published in Aging on October 3, 2023

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• Research PaperVolume 15, Issue 9pp 3273-3294

  Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry

  Relevance score: 0.00

  Yukari Maeda, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Hisaya Kato, Yoshiro Maezawa, Junji Kawashima, Kayo Yoshinaga, Mai Ishikawa, Akiko Sekiguchi, Sei-Ichiro Motegi, Hironori Nakagami, Yoshihiko Yamada, Shinji Tsukamoto, Akira Taniguchi, Ken Sugimoto, Yoichi Takami, Yukiko Shoda, Kunihiko Hashimoto, Toru Yoshimura, Asako Kogure, Daisuke Suzuki, Naoki Okubo, Takashi Yoshida, Kazuhisa Watanabe, Masafumi Kuzuya, Minoru Takemoto, Junko Oshima, Koutaro Yokote

  Keywords: disease profile, long-term follow-up, malignant neoplasm, renal function, Werner syndrome

  Published in Aging on May 1, 2023

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• Research PaperVolume 13, Issue 24pp 25717-25728

  Calcification in Werner syndrome associated with lymphatic vessels aging

  Relevance score: 0.00

  Hideyuki Ogata, Shinsuke Akita, Sanae Ikehara, Kazuhiko Azuma, Takashi Yamaguchi, Maihulan Maimaiti, Yoshiro Maezawa, Yoshitaka Kubota, Koutaro Yokote, Nobuyuki Mitsukawa, Yuzuru Ikehara

  Keywords: Werner syndrome, calcification, skin ulcer, lymphatic vessel, endoplasmic reticulum stress

  Published in Aging on December 27, 2021

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• Research PaperVolume 13, Issue 4pp 4946-4961

  Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome

  Relevance score: 0.00

  Hisaya Kato, Yoshiro Maezawa, Naoya Takayama, Yasuo Ouchi, Hiyori Kaneko, Daisuke Kinoshita, Aki Takada-Watanabe, Motohiko Oshima, Masaya Koshizaka, Hideyuki Ogata, Yoshitaka Kubota, Nobuyuki Mitsukawa, Koji Eto, Atsushi Iwama, Koutaro Yokote

  Keywords: Werner syndrome, dermal fibroblasts, adipogenesis, chondrogenesis, osteogenesis

  Published in Aging on February 24, 2021

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• Research PaperVolume 12, Issue 24pp 24940-24956

  Time gap between the onset and diagnosis in Werner syndrome: a nationwide survey and the 2020 registry in Japan

  Relevance score: 0.00

  Masaya Koshizaka, Yoshiro Maezawa, Yukari Maeda, Mayumi Shoji, Hisaya Kato, Hiyori Kaneko, Takahiro Ishikawa, Daisuke Kinoshita, Kazuki Kobayashi, Junji Kawashima, Akiko Sekiguchi, Sei-ichiro Motegi, Hironori Nakagami, Yoshihiko Yamada, Shinji Tsukamoto, Akira Taniguchi, Ken Sugimoto, Yukiko Shoda, Kunihiko Hashimoto, Toru Yoshimura, Daisuke Suzuki, Masafumi Kuzuya, Minoru Takemoto, Koutaro Yokote

  Keywords: Werner syndrome, registry, nationwide survey, premature aging, sarcopenia

  Published in Aging on December 29, 2020

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• Research PaperVolume 6, Issue 3pp 231-245

  Oxidative stress and antioxidant response in fibroblasts from Werner and Atypical Werner Syndromes

  Relevance score: 0.00

  Marta Seco-Cervera, Marta Spis, José Luis García-Giménez, José Santiago Ibañez-Cabellos, Ana Velázquez-Ledesma, Isabel Esmorís, Sergio Bañuls, Giselle Pérez-Machado, Federico V Pallardó

  Keywords: Werner Syndrome, Atypical Werner Syndrome, oxidative stress, antioxidant enzymes, thioredoxin, glutaredoxin, DNA damage, premature aging

  Published in Aging on March 31, 2014

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• Research PaperVolume 6, Issue 1pp 70-81

  Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks

  Relevance score: 0.00

  Rika Kusumoto-Matsuo, Deblina Ghosh, Parimal Karmakar, Alfred May, Dale Ramsden, Vilhelm A. Bohr

  Keywords: Werner, WRN, DNA-PK, serine phosphorylation, DSB, etoposide

  Published in Aging on January 14, 2014

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• Research PaperVolume 4, Issue 9pp 636-647

  Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging

  Relevance score: 0.00

  Alexandra Dallaire, Chantal Garand, Eric R. Paquet, Sarah J. Mitchell, Rafael de Cabo, Martin J. Simard, Michel Lebel

  Keywords: Werner syndrome, aging, microRNA, liver, mouse, nematode

  Published in Aging on September 29, 2012

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• Research PaperVolume 3, Issue 3pp 277-290

  The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

  Relevance score: 0.00

  Sophie Lachapelle, Steffi Oesterreich, Michel Lebel

  Keywords: Werner syndrome, Scaffold Attachment Factor B1, immortalization, senescence

  Published in Aging on March 20, 2011

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• Research PerspectiveVolume 3, Issue 3pp 311-318

  The Werner syndrome protein: linking the replication checkpoint response to genome stability

  Relevance score: 0.00

  Pietro Pichierri, Francesca Ammazzalorso, Margherita Bignami, Annapaola Franchitto

  Keywords: Werner syndrome protein, replication fork arrest, replication checkpoint, genome instability

  Published in Aging on March 7, 2011

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• Research PaperVolume 1, Issue 3pp 289-302

  Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity

  Relevance score: 0.00

  Baomin Li, Sita Reddy, Lucio Comai

  Keywords: Werner syndrome protein, telomere, exonuclease, aging, RecQ helicases

  Published in Aging on March 17, 2009

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• Research PaperVolume 1, Issue 2pp 219-233

  WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3

  Relevance score: 0.00

  Monika Aggarwal, Robert M. Brosh

  Keywords: Werner syndrome, helicase, topoisomerase, RecQ, Bloom's syndrome, Sgs1, genomic instability

  Published in Aging on February 5, 2009

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