Volume 15, Issue 9

15 May, 2023
pp 3219—3892

About the Cover

The cover features Figure 5 "Cytometry by time of flight (CyTOF) reveals the cellular targets of zoledronic acid treatment" from Samakkarnthai et al.

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Editorials

Tracking the dynamics of cellular senescence

Indra Heckenbach, Morten Scheibye-Knudsen,

https://doi.org/10.18632/aging.204670 pp 3219—3220

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Autoimmunity as a novel mechanism underlying sarcopenia

Tan Zhang,

https://doi.org/10.18632/aging.204703 pp 3221—3222

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Dicarbonyl stress and mitochondrial dysfunction in the aged heart

Diana Bou-Teen, Elisabet Miro-Casas, Marisol Ruiz-Meana,

https://doi.org/10.18632/aging.204704 pp 3223—3225

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Boosting autophagy in anti-tumor proteasome inhibition-mediated cardiotoxicity

Eleni-Dimitra Papanagnou, Sentiljana Gumeni, Ioannis P. Trougakos,

https://doi.org/10.18632/aging.204724 pp 3226—3227

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Onset matters in dementia with Lewy bodies

Sebastian Johannes Müller, Jens Wiltfang, Niels Hansen,

https://doi.org/10.18632/aging.204730 pp 3228—3229

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Research Papers

Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow

George R. Nahas, Lauren S. Sherman, Garima Sinha, Markos H. El Far, Andrew Petryna, Steven M. Munoz, Kimberly A. Silverio, Maran Shaker, Pujan Neopane, Veronica Mariotti, Pranela Rameshwar,

https://doi.org/10.18632/aging.204620 pp 3230—3248

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Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus

Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, Alexander M. Kulminski,

https://doi.org/10.18632/aging.204665 pp 3249—3272

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Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry

Yukari Maeda, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Hisaya Kato, Yoshiro Maezawa, Junji Kawashima, Kayo Yoshinaga, Mai Ishikawa, Akiko Sekiguchi, Sei-Ichiro Motegi, Hironori Nakagami, Yoshihiko Yamada, Shinji Tsukamoto, Akira Taniguchi, Ken Sugimoto, Yoichi Takami, Yukiko Shoda, Kunihiko Hashimoto, Toru Yoshimura, Asako Kogure, Daisuke Suzuki, Naoki Okubo, Takashi Yoshida, Kazuhisa Watanabe, Masafumi Kuzuya, Minoru Takemoto, Junko Oshima, Koutaro Yokote,

https://doi.org/10.18632/aging.204681 pp 3273—3294

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Proteostatic modulation in brain aging without associated Alzheimer’s disease-and age-related neuropathological changes

Pol Andrés-Benito, Ignacio Íñigo-Marco, Marta Brullas, Margarita Carmona, José Antonio del Rio, Joaquín Fernández-Irigoyen, Enrique Santamaría, Mónica Povedano, Isidro Ferrer,

https://doi.org/10.18632/aging.204698 pp 3295—3330

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In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, Jad G. Sfeir, Japneet Kaur, Elizabeth J. Atkinson, James R. Edwards, Graham G. Russell, Robert J. Pignolo, James L. Kirkland, Tamar Tchkonia, Laura J. Niedernhofer, David G. Monroe, Nathan K. Lebrasseur, Joshua N. Farr, Paul D. Robbins, Sundeep Khosla,

https://doi.org/10.18632/aging.204701 pp 3331—3355

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Highly multiplexed immune profiling throughout adulthood reveals kinetics of lymphocyte infiltration in the aging mouse prostate

Jonathan J. Fox, Takao Hashimoto, Héctor I. Navarro, Alejandro J. Garcia, Benjamin L. Shou, Andrew S. Goldstein,

https://doi.org/10.18632/aging.204708 pp 3356—3380

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PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer’s disease effect of licorice stem flavonoids

Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui Du,

https://doi.org/10.18632/aging.204536 pp 3381—3393

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GRB10 is a novel factor associated with gastric cancer proliferation and prognosis

Li-Li Ren, Zhi-Wen Wang, Ren Sen, Zhou-Tong Dai, Xing-Hua Liao, Li-Juan Shen,

https://doi.org/10.18632/aging.204603 pp 3394—3409

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Development and validation of a novel anoikis-related gene signature for predicting prognosis in ovarian cancer

Shuangfeng Qian, Yidan Wen, Lina Mei, Xiaofu Zhu, Hongtao Zhang, Chunyan Xu,

https://doi.org/10.18632/aging.204634 pp 3410—3426

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Biological and immunological significance of DLL3 expression in different tumor tissues: a pan-cancer analysis

Yi Zhang, Lifeng Shang, Junwei Han, Xin Shen, Haiwang Liu, Jie Yang, Hai Shi,

https://doi.org/10.18632/aging.204672 pp 3427—3441

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Identification and validation of immunogenic cell death-related score in uveal melanoma to improve prediction of prognosis and response to immunotherapy

Xiaoyan Li, Jing Kang, Jing Yue, Dawei Xu, Chunhua Liao, Huina Zhang, Jin Zhao, Qiongwen Liu, Jinke Jiao, Lin Wang, Guoyin Li,

https://doi.org/10.18632/aging.204680 pp 3442—3464

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Palmitic acid–induced microRNA-143-5p expression promotes the epithelial–mesenchymal transition of retinal pigment epithelium via negatively regulating JDP2

Yunlin Tian, Juan Shao, Shuwei Bai, Zhiguo Xu, Chunchao Bi,

https://doi.org/10.18632/aging.204684 pp 3465—3479

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A novel signature based on cancer-associated fibroblast genes to predict prognosis, immune feature, and therapeutic response in breast cancer

Yichen Wang, Wenchang Lv, Yi Yi, Qi Zhang, Jun Zhang, Yiping Wu,

https://doi.org/10.18632/aging.204685 pp 3480—3497

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A novel methionine metabolism-related signature predicts prognosis and immunotherapy response in lung adenocarcinoma

Qing-Hua Chang, Yuan-Cui Zhang, Dong-Ying Zhang, Ting Mao, Ran Chang, Nan Wang, Yun Ye, Zi-Jun Xu,

https://doi.org/10.18632/aging.204687 pp 3498—3523

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The feasibility of early detecting coronary artery disease using deep learning-based algorithm based on electrocardiography

Panli Tang, Qi Wang, Hua Ouyang, Songran Yang, Ping Hua,

https://doi.org/10.18632/aging.204688 pp 3524—3537

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m6A-mediated upregulation of lncRNA-AC026356.1 promotes cancer stem cell maintenance in lung adenocarcinoma via activating Wnt signaling pathway

Zhen Zhang, Xiaoning Tan, Ruoxia Wu, Tianhao Deng, Huazhong Wang, Xiulin Jiang, Puhua Zeng, Junqi Tang,

https://doi.org/10.18632/aging.204689 pp 3538—3548

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Exosomal miR-663b from “M1” macrophages promotes pulmonary artery vascular smooth muscle cell dysfunction through inhibiting the AMPK/Sirt1 axis

Honghong Ma, Yang Yu, Lirong Mo, Qian Chen, Hui Dong, Yan Xu, Bing Zhuan,

https://doi.org/10.18632/aging.204690 pp 3549—3571

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Increased SEMA6B expression as a potential prognostic and immune cell infiltration biomarker in thyroid cancer patients

Qinghua Lei, Yunha Wang, Junhua Li, Shanshan Wang, Yanyan Hu, Lihua Duan, Yanfei Huo, Yiping Wu, Hongzhou Liu,

https://doi.org/10.18632/aging.204691 pp 3572—3585

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miRNA155-5P participated in DDX3X targeted regulation of pyroptosis to attenuate renal ischemia/reperfusion injury

Yan Zhang, Xinghua Lv, Qian Fan, Feng Chen, Zhanhai Wan, Janvier Nibaruta, Hao Wang, Xiaoxia Wang, Yuan Yuan, Wenwen Guo, Yufang Leng,

https://doi.org/10.18632/aging.204692 pp 3586—3597

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Comprehensive analyses reveal the prognosis and biological function roles of chromatin regulators in lung adenocarcinoma

Baishuang Yang, Xueyao Rong, Chen Jiang, Meihua Long, Aibin Liu, Qiong Chen,

https://doi.org/10.18632/aging.204693 pp 3598—3620

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Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression

Ju-Pi Li, Ching-Liang Chu, Wan-Ru Chao, Cheng-Siang Yeh, Yi-Ju Lee, Dz-Chi Chen, Shun-Fa Yang, Yu-Hua Chao,

https://doi.org/10.18632/aging.204695 pp 3621—3634

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TIMP2 facilitates CIRI through activating NLRP3-mediated pyroptosis

Shaoyong Shi, Chongyang Zhang, Jiaxiang Liu,

https://doi.org/10.18632/aging.204696 pp 3635—3643

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FAM46C-mediated tumor heterogeneity predicts extramedullary metastasis and poorer survival in multiple myeloma

Weilong Zhang, Chaoling Wu, Shuang Geng, Jing Wang, Changjian Yan, Xiannian Zhang, Jia-jia Zhang, Fan Wu, Yuhong Pang, Yuping Zhong, Jianbin Wang, Wei Fu, Xin Huang, Wenming Wang, Xiaoqing Lyu, Yanyi Huang, Hongmei Jing,

https://doi.org/10.18632/aging.204697 pp 3644—3677

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Genistein exerts anti-colorectal cancer actions: clinical reports, computational and validated findings

Xiaoxia Liu, Ying Lan, Li Zhang, Xi Ye, Qingrong Shen, Guangyan Mo, Xiaoyu Chen,

https://doi.org/10.18632/aging.204702 pp 3678—3689

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MGME1 associates with poor prognosis and is vital for cell proliferation in lower-grade glioma

Feng Xiao, Jie Zeng, Haiyan Wang, Hong Zhu, Yun Guo, Zhe Zhang, Yao Xiao, Guowen Hu, Kai Huang, Qing Yang, Hua Guo,

https://doi.org/10.18632/aging.204705 pp 3690—3714

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Plasmon-activated water as a therapeutic strategy in Alzheimer’s disease by altering gut microbiota

Chia-Hsiung Cheng, Yu-Chuan Liu, Yu-Chen S.H. Yang, Kun-Ju Lin, Dean Wu, Yun-Ru Liu, Chun-Chao Chang, Chien-Tai Hong, Chaur-Jong Hu,

https://doi.org/10.18632/aging.204706 pp 3715—3737

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Comprehensive analysis of the oncogenic and immunological role of FAP and identification of the ceRNA network in human cancers

Weiqian Mai, Qingyou Liu, Jiasheng Li, Mincheng Zheng, Fuman Yan, Hui Liu, Yuhe Lei, Jinwen Xu, Jiean Xu,

https://doi.org/10.18632/aging.204707 pp 3738—3758

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LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis

Haiming Du, Senlin Hou, Lichao Zhang, Chao Liu, Tingting Yu, Wei Zhang,

https://doi.org/10.18632/aging.204709 pp 3759—3770

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The prognostic significance and immune correlation of SLC10A3 in low-grade gliomas revealed by bioinformatic analysis and multiple immunohistochemistry

Yang He, Junlin Song, Yong Qin, Dejia Mao, Dacheng Ding, Shanwu Wu, Huawei Wu,

https://doi.org/10.18632/aging.204712 pp 3771—3790

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microRNA-497 slows esophageal cancer development and reverses chemotherapy resistance through its target QKI

Yun-Xia Xie, Zhi-Hao Zhou, Shu-Wen Liu, Ye Zhang, Wen-Jing Liu, Rui-Ke Zhang, Ming-Liang He, Jian-Ge Qiu, Lin Wang, Bing-Hua Jiang,

https://doi.org/10.18632/aging.204713 pp 3791—3806

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Identification and validation of metabolism-related genes signature and immune infiltration landscape of rheumatoid arthritis based on machine learning

Zhaoyang Guo, Yuanye Ma, Yaqing Wang, Hongfei Xiang, Huifei Cui, Zuoran Fan, Youfu Zhu, Dongming Xing, Bohua Chen, Hao Tao, Zhu Guo, Xiaolin Wu,

https://doi.org/10.18632/aging.204714 pp 3807—3825

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miR-926-3p influences myocardial injury in septic mice through regulation of mTOR signaling pathway by targeting TSC1

Feng Yan, Qian Wang, Huiyu Yang, Hui Lv, Weiwei Qin,

https://doi.org/10.18632/aging.204716 pp 3826—3838

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Exploring the molecular mechanism of glycyrrhetinic acid in the treatment of gastric cancer based on network pharmacology and experimental validation

Xia Li, Yuhua Du, Shicong Huang, Yi Yang, Doudou Lu, Junfei Zhang, Yan Chen, Lei Zhang, Yi Nan, Ling Yuan,

https://doi.org/10.18632/aging.204718 pp 3839—3856

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Review

Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment

YanJun Zhang, Lijuan Zhan, Jing Li, Xue Jiang, Li Yin,

https://doi.org/10.18632/aging.204679 pp 3857—3889

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Retraction

Retraction: Role of alternative splicing of VEGF-A in the development of atherosclerosis

Naishi Zhao, Jianfeng Zhang,

https://doi.org/10.18632/aging.204732 pp 3890

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Correction

Correction for: CXCR4 knockdown enhances sensitivity of paclitaxel via the PI3K/Akt/mTOR pathway in ovarian carcinoma

Dan Zi, Qing Li, Cheng-xiong Xu, Zhi-Wei Zhou, Guan-Bin Song, Cheng-Bin Hu, Fang Wen, Han-Lin Yang, Lei Nie, Xing Zhao, Jun Tan, Shu-Feng Zhou, Zhi-Xu He,

https://doi.org/10.18632/aging.204735 pp 3891—3892

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