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Volume 15, Issue 8

April 30, 2023pp 2813—3218

About the Cover

The cover features Figure 1 "Oxidative stress-induced wounding results in a chronic wound with increased SA-β-gal expression and SASP burden" from Wyles et al.

Editorials

Anaphase II processes contribute to aneuploidy in aging oocytes

Anna Kouznetsova

https://doi.org/10.18632/aging.204640pp 2813—2814

Artificial intelligence and the aging mind

Jeyeon Lee, Leland R. Barnard, David T. Jones

https://doi.org/10.18632/aging.204644pp 2815—2816

Mitochondrial redox signaling: a key player in aging and disease

Maria Vitale, Alberto Sanz, Filippo Scialò

https://doi.org/10.18632/aging.204659pp 2817—2818

The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation

Anda Huna, Nadine Martin, David Bernard

https://doi.org/10.18632/aging.204669pp 2819—2821

Neuroimaging and machine learning for brain age estimation

Thomas D. Kocar, Michael Denkinger, Jan Kassubek

https://doi.org/10.18632/aging.204694pp 2822—2823

Research Papers

Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations

Noah Wechter, Martina Rossi, Carlos Anerillas, Dimitrios Tsitsipatis, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Supriyo De, Krystyna Mazan-Mamczarz, Myriam Gorospe

https://doi.org/10.18632/aging.204666pp 2824—2851

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A chronic wound model to investigate skin cellular senescence

Saranya P. Wyles, Parisa Dashti, Tamar Pirtskhalava, Burak Tekin, Christina Inman, Lilian Sales Gomez, Anthony B. Lagnado, Larissa Prata, Diana Jurk, João F. Passos, Tamar Tchkonia, James L. Kirkland

https://doi.org/10.18632/aging.204667pp 2852—2862

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Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform

Andrea Olsen, Zachary Harpaz, Christopher Ren, Anastasia Shneyderman, Alexander Veviorskiy, Maria Dralkina, Simon Konnov, Olga Shcheglova, Frank W. Pun, Geoffrey Ho Duen Leung, Hoi Wing Leung, Ivan V. Ozerov, Alex Aliper, Mikhail Korzinkin, Alex Zhavoronkov

https://doi.org/10.18632/aging.204678pp 2863—2876

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LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis

Kang Wang, Qing Luo, Yingfeng Zhang, Xin Xie, Wenhao Cheng, Qiunan Yao, Yingying Chen, Hong Ren, Jiuping Li, Zuanqin Pan

https://doi.org/10.18632/aging.204413pp 2877—2890

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Senescence-related genes define prognosis, immune contexture, and pharmacological response in gastric cancer

Xiaogang Shen, Meng Wang, Wenxi Chen, Yu Xu, Qiaoxia Zhou, Tengfei Zhu, Guoqiang Wang, Shangli Cai, Yusheng Han, Chunwei Xu, Wenxian Wang, Lei Meng, Hao Sun

https://doi.org/10.18632/aging.204524pp 2891—2905

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Whole-transcriptome sequencing analysis reveal mechanisms of Yiqi Huoxue Yangyin (YHY) decoction in ameliorating D-gal-induced cardiac aging

Xue Wang, Jiaqi Zhang, Chengkui Xiu, Jing Yang, Yiqing Liu, Yan Lei

https://doi.org/10.18632/aging.204532pp 2906—2919

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ESM1 promotes angiogenesis in colorectal cancer by activating PI3K/Akt/mTOR pathway, thus accelerating tumor progression

Liqun Yang, Zhigang Dong, Shuyu Li, Tieliang Chen

https://doi.org/10.18632/aging.204559pp 2920—2936

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FARSB serves as a novel hypomethylated and immune cell infiltration related prognostic biomarker in hepatocellular carcinoma

Jing Zhen, Jingying Pan, Xuanrui Zhou, Zichuan Yu, Yike Jiang, Yiyang Gong, Yongqi Ding, Yue Liu, Liangyun Guo

https://doi.org/10.18632/aging.204619pp 2937—2969

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Ubiquitin-proteasome system-mediated ubiquitination modification patterns and characterization of tumor microenvironment infiltration, stemness and cellular senescence in low-grade glioma

Jun Gu, Lijun Pang, Donghua Yan, Chunming Wang, Yuekun Song, Zhengshuai Jin, Zhenwei Xu, Yuanqing Mao, Shengzhe Liu, Sheng Chen

https://doi.org/10.18632/aging.204650pp 2970—2998

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Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion

Li-Jie Yang, Wei Wu, Wan-Rong Jiang, Cheng-Liang Zhu, Zhao-Hui Yao

https://doi.org/10.18632/aging.204654pp 2999—3020

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lncRNA TUSC7 sponges miR-10a-5p and inhibits BDNF/ERK pathway to suppress glioma cell proliferation and migration

Runhui Wang, Jia Wang, Yuanyu Wang, Liang Yang

https://doi.org/10.18632/aging.204655pp 3021—3034

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TYRO3 promotes tumorigenesis and drug resistance in colorectal cancer by enhancing the epithelial-mesenchymal transition process

Xinyu Shao, Yibin Sun, Kaiqiang Zhong, Jinrong Gu, Yang Yu, Tong Hu, Xiaoyi Kuai, Yechen Xing

https://doi.org/10.18632/aging.204656pp 3035—3051

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Association between red blood cell distribution width and ischemic stroke recurrence in patients with acute ischemic stroke: a 10-years retrospective cohort analysis

Zhan Shen, Ying Huang, Ying Zhou, Jingying Jia, Xian Zhang, Tingting Shen, Shengjie Li, Siyang Wang, Yunxiao Song, Jie Cheng

https://doi.org/10.18632/aging.204657pp 3052—3063

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Cellular senescence-related gene signature as a valuable predictor of prognosis in hepatocellular carcinoma

Shuqiao Zhang, Yilu Zheng, Xinyu Li, Shijun Zhang, Hao Hu, Weihong Kuang

https://doi.org/10.18632/aging.204658pp 3064—3093

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Identification of the pyroptosis-related gene signature and risk score model for esophageal squamous cell carcinoma

Minghong Pan, Yuanyong Wang, Zhaoyang Wang, Changjian Shao, Yingtong Feng, Peng Ding, Hongtao Duan, Xiaoya Ren, Weixun Duan, Zhiqiang Ma, Xiaolong Yan

https://doi.org/10.18632/aging.204661pp 3094—3106

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Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma

Tzuo-Yi Hsieh, Wen-Wei Sung, Ya-Chuan Chang, Chia-Ying Yu, Li-Yu Lu, Chen Dong, Tsung-Hsien Lee, Sung-Lang Chen

https://doi.org/10.18632/aging.204673pp 3107—3119

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An artificial neural network model to diagnose non-obstructive azoospermia based on RNA-binding protein-related genes

Fan Peng, Bahaerguli Muhuitijiang, Jiawei Zhou, Haoyu Liang, Yu Zhang, Ranran Zhou

https://doi.org/10.18632/aging.204674pp 3120—3140

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Profiling and integrated analysis of transcriptional addiction gene expression and prognostic value in hepatocellular carcinoma

Xiaowei Du, Hao Wang, Jing Xu, Yufei Zhang, Tingsong Chen, Gao Li

https://doi.org/10.18632/aging.204676pp 3141—3157

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Association of survival with adjuvant radiotherapy for pN0 esophageal cancer

Huijiang Gao, Yuanyong Wang, Zhihui Jiang, Guodong Shi, Shiyu Hu, Jiangshan Ai, Zhaofeng Wang, Yucheng Wei

https://doi.org/10.18632/aging.204677pp 3158—3170

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Development and validation of novel prognostic models for zinc finger proteins-related genes in soft tissue sarcoma

Junqing Li, Quan Zhou, Changsheng Zhang, Huimin Zhu, Jie Yao, Meng Zhang

https://doi.org/10.18632/aging.204682pp 3171—3190

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Review

How can we modulate aging through nutrition and physical exercise? An epigenetic approach

Ana Teresa Rajado, Nádia Silva, Filipa Esteves, David Brito, Alexandra Binnie, Inês M. Araújo, Clévio Nóbrega, José Bragança, Pedro Castelo-Branco, ALFA Score Consortium

https://doi.org/10.18632/aging.204668pp 3191—3217

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Correction

Correction for: Comprehensive analysis of prognostic value, relationship to cell cycle, immune infiltration and m6A modification of ZSCAN20 in hepatocellular carcinoma

Fang Jiayu, Yike Jiang, Xuanrui Zhou, Minqin Zhou, Jingying Pan, Yun Ke, Jing Zhen, Da Huang, Weifan Jiang

https://doi.org/10.18632/aging.204699pp 3218