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• Research PaperVolume 15, Issue 9pp 3381-3393

  PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer’s disease effect of licorice stem flavonoids

  Relevance score: 0.00

  Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui Du

  Keywords: network pharmacology, Alzheimer’s disease, licorice stem flavonoids, PI3K-Akt signalling pathway

  Published in Aging on February 22, 2023

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• Research PaperVolume 15, Issue 20pp 11162-11183

  Machine learning developed a PI3K/Akt pathway-related signature for predicting prognosis and drug sensitivity in ovarian cancer

  Relevance score: 0.00

  Xiaofang Han, Liu Yang, Hui Tian, Yuanyuan Ji

  Keywords: immunotherapy, prognostic signature, ovarian cancer, machine learning, PI3K/Akt pathway

  Published in Aging on October 17, 2023

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• Research PaperVolume 16, Issue 6pp 5091-5107

  GSG2 promotes thyroid cancer via stabilizing AURKB and activating AKT pathway

  Relevance score: 0.00

  Fenghua Zhang, Chiming Huang

  Keywords: thyroid cancer, GSG2, AURKB, AKT pathway, cell phenotypes

  Published in Aging on March 4, 2024

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• Research PaperVolume 16, Issue 4pp 3773-3789

  Yangyinghuoxue decoction exerts a treatment effect on hepatic fibrosis by PI3K/AKT pathway in rat model: based on the network pharmacology and molecular docking

  Relevance score: 0.00

  Yan-Ming Bai, Shuang Liang, Bo Zhou

  Keywords: Yangyinghuoxue decoction (YYHXD), hepatic fibrosis (HF), network pharmacology, PI3K-Akt signaling pathway, molecular docking

  Published in Aging on February 15, 2024

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• Research PaperVolume 13, Issue 4pp 5858-5874

  GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway

  Relevance score: 0.00

  Ying Liu, Dandan Wang, Mengxia Lei, Jiayi Gao, Yuqing Cui, Xiaoying Jin, Qiujie Yu, Ying Jiang, Yan Guo, Yali Liu, Li Cai, Xuesong Chen

  Keywords: GABARAP, breast cancer, EMT, prognosis, AKT/mTOR pathway

  Published in Aging on February 11, 2021

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• Research PaperVolume 11, Issue 22pp 10697-10710

  MAP2K4 interacts with Vimentin to activate the PI3K/AKT pathway and promotes breast cancer pathogenesis

  Relevance score: 0.00

  Shu Liu, Juan Huang, Yewei Zhang, Yiyi Liu, Shi Zuo, Rong Li

  Keywords: MAP2K4, breast cancer, PI3K/AKT pathway, Vimentin

  Published in Aging on November 25, 2019

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• Research PaperVolume 11, Issue 20pp 8845-8859

  COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway

  Relevance score: 0.00

  Ruiqing Long, Zhuohui Liu, Jinghui Li, Hualin Yu

  Keywords: pituitary adenoma, COL6A6, P4HA3, PI3K-Akt pathway, invasion

  Published in Aging on October 17, 2019

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• Research PaperVolume 13, Issue 5pp 6945-6956

  Silencing of miR-483-5p alleviates postmenopausal osteoporosis by targeting SATB2 and PI3K/AKT pathway

  Relevance score: 0.00

  Fujiang Zhao, Yier Xu, Yulong Ouyang, Zhexu Wen, Guihao Zheng, Ting Wan, Guicai Sun

  Keywords: postmenopausal osteoporosis, miR-483-5p, SATB2, PI3K/AKT pathway

  Published in Aging on February 17, 2021

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• Research PaperVolume 11, Issue 10pp 3376-3391

  MicroRNA-335/ID4 dysregulation predicts clinical outcome and facilitates leukemogenesis by activating PI3K/Akt signaling pathway in acute myeloid leukemia

  Relevance score: 0.00

  Jing-dong Zhou, Xi-xi Li, Ting-juan Zhang, Zi-jun Xu, Zhi-hui Zhang, Yu Gu, Xiang-mei Wen, Wei Zhang, Run-bi Ji, Zhao-qun Deng, Jiang Lin, Jun Qian

  Keywords: MiR-335, ID4, acute myeloid leukemia, prognosis, PI3K/Akt pathway

  Published in Aging on May 30, 2019

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• Research Paper

  Ginsenoside Rh4 reverses ABCB1-induced doxorubicin resistance via the PI3Kδ/AKT axis in osteosarcoma

  Relevance score: 0.00

  Tianqi Xia, Xinyan Shen, Huidong Chen, Yan Zhang, Yi Xu, Shen Zan, Daliu Min, Yonggang Wang

  Keywords: osteosarcoma, multidrug resistance, ginsenoside Rh4, ABCB1, PI3Kδ/AKT signaling pathway

  Published in Aging on July 15, 2024

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• Research PaperVolume 16, Issue 4pp 3955-3972

  Protective effects of triptolide against oxidative stress in retinal pigment epithelium cells via the PI3K/AKT/Nrf2 pathway: a network pharmacological method and experimental validation

  Relevance score: 0.00

  Fuying Pan, Qinxin Shu, Hao Xie, Long Zhao, Ping Wu, Yong Du, Jing Lu, Yuxia He, Xing Wang, Hui Peng

  Keywords: triptolide, oxidative stress, PI3K/Akt/Nrf2 pathway, network pharmacological analysis

  Published in Aging on February 21, 2024

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• Research PaperVolume 13, Issue 19pp 22843-22855

  Allicin protects against myocardial I/R by accelerating angiogenesis via the miR-19a-3p/PI3K/AKT axis

  Relevance score: 0.00

  Mengru Liu, Peng Yang, Dongliang Fu, Tong Gao, Xinyi Deng, Mingjing Shao, Jiangquan Liao, Hong Jiang, Xianlun Li

  Keywords: myocardial I/R, miR-19a-3p, PI3K/AKT pathway, angiogenesis, Allicin

  Published in Aging on October 4, 2021

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• Research PaperVolume 12, Issue 7pp 6240-6259

  Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways

  Relevance score: 0.00

  Jing Gao, Rongmu Xia, Jianbo Chen, Jing Gao, Xianyang Luo, Chunlin Ke, Caihong Ren, Jiayi Li, Yanjun Mi

  Keywords: esophageal carcinoma, genistein, proliferation, JAK1/2-STAT3 pathway, AKT/MDM2/p53 pathway

  Published in Aging on April 10, 2020

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• Research PaperVolume 13, Issue 16pp 20179-20191

  Long non-coding RNA ABHD11-AS1 promotes colorectal cancer progression and invasion through targeting the integrin subunit alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt signaling pathway

  Relevance score: 0.00

  Jia Luo, Yigui Jiang, Lianhui Wu, Dexiang Zhuo, Shengjun Zhang, Xiang Jiang, Yingming Sun, Yue Huang

  Keywords: colorectal cancer, lncRNA-ABHD11-AS1, PI3K/Akt pathway, oncogene profile

  Published in Aging on August 10, 2021

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• Research PaperVolume 13, Issue 15pp 19643-19656

  The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca²⁺ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

  Relevance score: 0.00

  Tong Gao, Peng Yang, Dongliang Fu, Mengru Liu, Xinyi Deng, Mingjing Shao, Jiangquan Liao, Hong Jiang, Xianlun Li

  Keywords: allicin, apoptosis, PI3K/Akt pathway, myocardial ischemia/reperfusion, gene expression profiling, calcium signaling pathway, GRK2, GPCR

  Published in Aging on August 3, 2021

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• Research PaperVolume 13, Issue 5pp 7120-7132

  Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway

  Relevance score: 0.00

  Wenpeng Cao, Zhirui Zeng, Zhiwei He, Shan Lei

  Keywords: pancreatic cancer, exosomal microRNAs, PTEN/AKT pathway, metastasis

  Published in Aging on February 26, 2021

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• Research PaperVolume 12, Issue 10pp 9915-9934

  ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer

  Relevance score: 0.00

  Jie Yao, Kaiyu Qian, Chen Chen, Xiaoping Liu, Donghu Yu, Xin Yan, Tongzu Liu, Sheng Li

  Keywords: circular RNA, ZNF139, bladder cancer, PI3K/AKT signaling pathway, bioinformatics

  Published in Aging on May 26, 2020

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• Research PaperVolume 13, Issue 2pp 2251-2263

  β-Arrestin-2 attenuates hepatic ischemia-reperfusion injury by activating PI3K/Akt signaling

  Relevance score: 0.00

  Xiaolong Chen, Junbin Zhang, Long Xia, Li Wang, Hui Li, Huilin Liu, Jing Zhou, Zhiying Feng, Hai Jin, JianXu Yang, Yang Yang, Bin Wu, Lei Zhang, Guihua Chen, Genshu Wang

  Keywords: hepatic ischemia-reperfusion injury, β-Arrestin-2, PI3K/Akt signaling pathway, liver transplantation, hepatic surgery

  Published in Aging on December 11, 2020

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• Research PaperVolume 16, Issue 9pp 7979-7999

  Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology

  Relevance score: 0.00

  Qinglong Liu, Zehua Luo, Mei Sun, Wenjun Li, Songqing Liu

  Keywords: Xiaochaihu decoction, breast cancer, network pharmacology, PI3K/Akt pathway, Q Exactive Orbitrap LC-MS/MS

  Published in Aging on May 13, 2024

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• Research PaperVolume 13, Issue 15pp 19375-19396

  THBS4/integrin α2 axis mediates BM-MSCs to promote angiogenesis in gastric cancer associated with chronic Helicobacter pylori infection

  Relevance score: 0.00

  LingNan He, WeiJun Wang, HuiYing Shi, Chen Jiang, HaiLing Yao, YuRui Zhang, Wei Qian, Rong Lin

  Keywords: bone marrow-derived mesenchymal stem cells (BM-MSCs), gastric cancer (GC), tumor angiogenesis, THBS4/Integrin α2 axis, PI3K/AKT pathway

  Published in Aging on August 14, 2021

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