Volume 15, Issue 20

October 31, 2023pp 10814—11693

About the Cover

The cover features Figure 9 "Summary of key findings" from Dipali et al.

Editorial

Poor communication between ER and mitochondria: a signature of ALS/FTD?

Christopher C.J. Miller, Patricia Gomez-Suaga

https://doi.org/10.18632/aging.205206pp 10814—10816

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Research Perspective

Cholinergic centro-cingulate network in Parkinson disease and normal aging

Nicolaas I. Bohnen, Sygrid van der Zee, Roger Albin

https://doi.org/10.18632/aging.205209pp 10817—10820

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Priority Research Paper

Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature

Shweta S. Dipali, Christina D. King, Jacob P. Rose, Joanna E. Burdette, Judith Campisi, Birgit Schilling, Francesca E. Duncan

https://doi.org/10.18632/aging.205190pp 10821—10855

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Research Papers

Deciphering reproductive aging in women using a NOD/SCID mouse model for distinct physiological ovarian phenotypes

María Marchante, Noelia Ramirez-Martin, Anna Buigues, Jessica Martinez, Nuria Pellicer, Antonio Pellicer, Sonia Herraiz

https://doi.org/10.18632/aging.205086pp 10856—10874

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Tissue immunoexpression of IL-6 and IL-18 in aging men with BPH and MetS and their relationship with lipid parameters and gut microbiota-derived short chain fatty acids

Weronika Ratajczak, Maria Laszczyńska, Aleksandra Rył, Barbara Dołęgowska, Olimpia Sipak, Ewa Stachowska, Marcin Słojewski, Anna Lubkowska

https://doi.org/10.18632/aging.205091pp 10875—10896

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WNT enhancing signals in pancreatic cancer are transmitted by LGR6

Jing Wang, Dominik T. Koch, Felix O. Hofmann, Daniel Härtwig, Iris Beirith, Klaus Peter Janssen, Alexandr V. Bazhin, Hanno Niess, Jens Werner, Bernhard W. Renz, Matthias Ilmer

https://doi.org/10.18632/aging.205101pp 10897—10914

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The Saccharomyces cerevisiae acetyltransferase Gcn5 exerts antagonistic pleiotropic effects on chronological ageing

Kaiqiang Li, Gabriele Mocciaro, Jules L. Griffin, Nianshu Zhang

https://doi.org/10.18632/aging.205109pp 10915—10937

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Alcohol consumption and epigenetic age acceleration across human adulthood

Mengyao Wang, Yi Li, Meng Lai, Drew R. Nannini, Lifang Hou, Roby Joehanes, Tianxiao Huan, Daniel Levy, Jiantao Ma, Chunyu Liu

https://doi.org/10.18632/aging.205153pp 10938—10971

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Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein

Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchida

https://doi.org/10.18632/aging.205164pp 10972—10995

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BTN2A2, a new biomarker and therapeutic target for glioma

Heping Wang, Shanrui Pu, Haitao Xu, Lihong Yang, Lishi Shao, Xi Chen, Xiaobin Huang, Jun Pu

https://doi.org/10.18632/aging.205039pp 10996—11011

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A comprehensive prognostic and immunological analysis of telomere-related lncRNAs in kidney renal clear cell carcinoma

Ji Chen, Dong Zhang, Xiangbin Ren, Peng Wang

https://doi.org/10.18632/aging.205056pp 11012—11032

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Dysregulated expression of slingshot protein phosphatase 1 (SSH1) disrupts circadian rhythm and WNT signaling associated to hepatocellular carcinoma pathogenesis

Shiue-Wei Lai, Yi-Chiao Cheng, Wen-Chien Huang, Vijesh Kumar Yadav, Iat-Hang Fong, Chi-Tai Yeh, Ching-Kuo Yang, Wei-Hwa Lee, Ming-Yao Chen

https://doi.org/10.18632/aging.205064pp 11033—11051

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The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma

Haitao Luo, Kai Huang, Mengqi Cheng, Xiaoyan Long, Xingen Zhu, Miaojing Wu

https://doi.org/10.18632/aging.205076pp 11052—11066

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HLA-DPA1 overexpression inhibits cancer progression, reduces resistance to cisplatin, and correlates with increased immune infiltration in lung adenocarcinoma

Ke Shi, Qian-Yun Li, Yun-Qiang Zhang, Huan Huang, Dong-Xiao Ding, Wei-Min Luo, Jun Zhang, Qiang Guo

https://doi.org/10.18632/aging.205082pp 11067—11091

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Identification and validation of a cancer-associated fibroblasts-related scoring system to predict prognosis and immune landscape in hepatocellular carcinoma through integrated analysis of single-cell and bulk RNA-sequencing

Lingling Bao, Xuede Zhang, Wenjuan Wang, Bitao Jiang

https://doi.org/10.18632/aging.205099pp 11092—11113

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Naked cuticle homolog 1 prevents mouse pulmonary arterial hypertension via inhibition of Wnt/β-catenin and oxidative stress

Shanwu Wei, Lu Lin, Wen Jiang, Jie Chen, Gu Gong, Daming Sui

https://doi.org/10.18632/aging.205105pp 11114—11130

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Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog/Gli pathway

Lanyan Hu, Mai Gao, Huifu Jiang, Lingling Zhuang, Ying Jiang, Siqi Xie, Hong Zhang, Qian Wang, Qi Chen

https://doi.org/10.18632/aging.205110pp 11131—11151

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The novel GLP-1/GIP dual agonist DA3-CH improves rat type 2 diabetes through activating AMPK/ACC signaling pathway

Jing Xu, Peng Chen, Dongzhi Wu, Qiang Zhou, Sijie Chen, Xiang Ding, Hongping Xiong

https://doi.org/10.18632/aging.205118pp 11152—11161

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Machine learning developed a PI3K/Akt pathway-related signature for predicting prognosis and drug sensitivity in ovarian cancer

Xiaofang Han, Liu Yang, Hui Tian, Yuanyuan Ji

https://doi.org/10.18632/aging.205119pp 11162—11183

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Inhibiting microRNA-200a-3p attenuates pyroptosis via targeting the SIRT1/NF-κB/NLRP3 pathway in H₂O₂-induced HAEC

Jia Liu, Youyou Yan, Dongdong Zheng, Jifeng Zhang, Junnan Wang

https://doi.org/10.18632/aging.205121pp 11184—11200

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Tryptophan metabolism-related gene expression patterns: unveiling prognostic insights and immune landscapes in uveal melanoma

Jing Wang, Tienan Zhao, Bo Li, Wei Wei

https://doi.org/10.18632/aging.205122pp 11201—11216

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Identification of cellular senescence-related signature for predicting prognosis and therapeutic response of acute myeloid leukemia

Fangmin Zhong, Yulin Yang, Fangyi Yao, Jing Liu, Xiajing Yu, Xin-Lu Wang, Bo Huang, Xiao-Zhong Wang

https://doi.org/10.18632/aging.205123pp 11217—11226

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Electroacupuncture pretreatment protects against anesthesia/surgery-induced cognitive decline by activating CREB via the ERK/MAPK pathway in the hippocampal CA1 region in aged rats

Hongjie Huang, Yanan Li, Xupeng Wang, Qi Zhang, Juan Zhao, Qiujun Wang

https://doi.org/10.18632/aging.205124pp 11227—11243

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CDKN2A was a cuproptosis-related gene in regulating chemotherapy resistance by the MAGE-A family in breast cancer: based on artificial intelligence (AI)-constructed pan-cancer risk model

Hong Wan, Xiaowei Yang, Guopeng Sang, Zhifan Ruan, Zichen Ling, Mingzhao Zhang, Chang Liu, Xiangyang Hu, Tao Guo, Juntong He, Defeng Liu, Jing Pei

https://doi.org/10.18632/aging.205125pp 11244—11267

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Integrated bulk and scRNA sequence identified anoikis-related diagnostic biomarkers and potential association with immune infiltration in type A aortic dissection

Kexiang Feng, Zhongwei Zhang, Jie Luo, Wenjie Wang, Tianjie Li, Jing Luo, Hongbo Huang

https://doi.org/10.18632/aging.205126pp 11268—11285

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STK4 is a prognostic biomarker correlated with immune infiltrates in clear cell renal cell carcinoma

Zi-Yuan Bai, Lu-Shan Peng, Run-Qi Li, Xianchu Peng, Zhe Yang

https://doi.org/10.18632/aging.205127pp 11286—11297

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Single-cell landscape and spatial transcriptomic analysis reveals macrophage infiltration and glycolytic metabolism in kidney renal clear cell carcinoma

Chen-Yueh Wen, Jui-Hu Hsiao, Yen-Dun Tony Tzeng, Renin Chang, Yi-Ling Tsang, Chen-Hsin Kuo, Chia-Jung Li

https://doi.org/10.18632/aging.205128pp 11298—11312

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Role of NF-κB pathway in kidney renal clear cell carcinoma and its potential therapeutic implications

Jiaao Sun, Feng Chen, Guangzhen Wu

https://doi.org/10.18632/aging.205129pp 11313—11330

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Exosome and lipid metabolism-related genes in pancreatic adenocarcinoma: a prognosis analysis

Jia Wu, Yajun Li, Ghulam Nabi, Xin Huang, Xu Zhang, Yuanzhen Wang, Liya Huang

https://doi.org/10.18632/aging.205130pp 11331—11368

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Comprehensive analysis of integrin αvβ3/α6β1 in prognosis and immune escape of prostate cancer

Yang Liu, Jia-Xin He, Bo Ji, Jin-Feng Wang, Lu Zhang, Zhong-Qi Pang, Jian-She Wang, Bei-Chen Ding, Ming-Hua Ren

https://doi.org/10.18632/aging.205131pp 11369—11388

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Development of an immunogenic cell death prognostic signature for predicting clinical outcome and immune infiltration characterization in stomach adenocarcinoma

Ye Liu, Lijia Zhang, Xue Lei, Xinyu Yin, Songjiang Liu

https://doi.org/10.18632/aging.205132pp 11389—11411

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Molecular characterization of ferroptosis in soft tissue sarcoma constructs a prognostic and immunotherapeutic signature through experimental and bioinformatics analyses

Zhi-Qiang Yang, Liang-Yu Guo, Kang-Wen Xiao, Chong Zhang, Min-Hao Wu, Fei-Fei Yan, Lin Cai

https://doi.org/10.18632/aging.205133pp 11412—11447

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PPIH gene regulation system and its prognostic significance in hepatocellular carcinoma: a comprehensive analysis

Jun Ye, Yilin Pang, Xunjun Yang, Chuan Zhang, Lei Shi, Zhitao Chen, Guijia Huang, Xianhe Wang, Fangyang Lu

https://doi.org/10.18632/aging.205134pp 11448—11470

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The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study

Yuanqing Cai, Huijun Sun, Xingyu Song, Jianyu Zhao, Dong Xu, Mozhen Liu

https://doi.org/10.18632/aging.205136pp 11471—11488

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Anti-cancer targets and molecular mechanisms of formononetin in treating osteosarcoma based on network pharmacology

Lizhi Chen, Yue Zhou, Zheng Weng, Shuang Liu, Ting Li, Yanfang Wang, Yang Yang, Hongmei Liu, Wenhua Huang

https://doi.org/10.18632/aging.205139pp 11489—11507

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Single-cell analysis reveals exosome-associated biomarkers for prognostic prediction and immunotherapy in lung adenocarcinoma

Shengrong Lin, Shengjie Zhou, Xin Han, Yang Yang, Hao Zhou, Xuejiao Chang, Yefeng Zhou, Yuqin Ding, Huihui Lin, Qing Hu

https://doi.org/10.18632/aging.205140pp 11508—11531

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Indoxyl sulfate induced frailty in patients with end-stage renal disease by disrupting the PGC-1α–FNDC5 axis

Yi-Chou Hou, Min-Tser Liao, Kuo-Wang Tsai, Cai-Mei Zheng, Hui-Wen Chiu, Kuo-Cheng Lu

https://doi.org/10.18632/aging.205141pp 11532—11545

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Icariin improves cognitive impairment by inhibiting ferroptosis of nerve cells

Yang Yang, Yiming Fu, Zhipeng Qin, Hongyan Pei, Liping Zhai, Qiaobing Guan, Shasha Wu, Heping Shen

https://doi.org/10.18632/aging.205144pp 11546—11553

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Comprehensive analysis of transcriptome data and experimental identification show that solute carrier 35 member A2 (SLC35A2) is a prognostic marker of colorectal cancer

Yue Wang, Liang Chen, Jing Chen, Zhenzhen Bai, Liyu Cao

https://doi.org/10.18632/aging.205145pp 11554—11570

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Metabolic and senescence characteristics associated with the immune microenvironment in non-small cell lung cancer: insights from single-cell RNA sequencing

Hongliang Liao, Zihao Wan, Yaqin Liang, Lin Kang, Renping Wan

https://doi.org/10.18632/aging.205146pp 11571—11587

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Immunobiological signatures and the emerging role of SPP1 in predicting tumor heterogeneity, malignancy, and clinical outcomes in stomach adenocarcinoma

Yanan Wu, Lingyu Ren, Yichun Tang, Zhu Zhu, Shifan Liu, Yan Jiang, Siming Zhang, Xiaocan Zhuang, Yuanbiao Chen

https://doi.org/10.18632/aging.205148pp 11588—11610

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BCL2A1 is associated with tumor-associated macrophages and unfavorable prognosis in human gliomas

Lun Gao, Zhang Ye, Shu Peng, Pan Lei, Ping Song, Zhiyang Li, Long Zhou, Qiuwei Hua, Li Cheng, Hangyu Wei, Junhui Liu, Qiang Cai

https://doi.org/10.18632/aging.205149pp 11611—11638

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Neurovascular protection of alisol A on cerebral ischemia mice through activating the AKT/GSK3β pathway

Huihong Li, Caiyun Zhang, Yangjie Zhou, Yunfei Deng, Xiaoqing Zheng, Xiehua Xue

https://doi.org/10.18632/aging.205151pp 11639—11653

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PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway

Jiacheng Zhong, Chao Yuan, Lin Liu, Yang Du, Yumin Hui, Zhiyuan Chen, Changhui Diao, Rui Yang, Guiyong Liu, Xiuheng Liu

https://doi.org/10.18632/aging.205152pp 11654—11671

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Identification of key circadian rhythm genes in skin aging based on bioinformatics and machine learning

Xiao Xiao, Hao Feng, Yangying Liao, Hua Tang, Lan Li, Ke Li, Feng Hu

https://doi.org/10.18632/aging.205155pp 11672—11689

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Corrections

Correction for: ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen

Liang Wang, Yinfeng Lyu, Yuqing Li, Kunping Li, Hui Wen, Chenchen Feng, Ning Li

https://doi.org/10.18632/aging.205255pp 11690—11691

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Correction for: miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis

Fang Li, Shan-Shan Li, Hui Chen, Jian-Zhi Zhao, Jie Hao, Jin-Ming Liu, Xiu-Guang Zu, Wei Cui

https://doi.org/10.18632/aging.205256pp 11692—11693

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