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Volume 16, Issue 4

February 28, 2024pp 3047—4074

About the Cover

The cover features Figure 2 "Volcano plots of differentially expressed transcripts versus non-senescent proliferating (NS) cells; Venn diagram showing a ‘core senescent profile’ of transcripts upregulated by all senescence inducers and heatmap of the eight candidates selected for validation at the transcriptomic level by qPCR" from Hattangady et al.

Research Perspective

On standardization of controls in lifespan studies

Olga Spiridonova, Dmitrii Kriukov, Nikolai Nemirovich-Danchenko, Leonid Peshkin

https://doi.org/10.18632/aging.205604pp 3047—3055

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Research Papers

Multiple imputation of systematically missing data on gait speed in the Swedish National Study on Aging and Care

Robert Thiesmeier, Ahmad Abbadi, Debora Rizzuto, Amaia Calderón-Larrañaga, Scott M. Hofer, Nicola Orsini

https://doi.org/10.18632/aging.205552pp 3056—3067

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Mapping the core senescence phenotype of primary human colon fibroblasts

Namita Ganesh Hattangady, Kelly Carter, Brett Maroni-Rana, Ting Wang, Jessica Lee Ayers, Ming Yu, William M. Grady

https://doi.org/10.18632/aging.205577pp 3068—3087

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Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

Edwin Lee, Natàlia Carreras-Gallo, Leilani Lopez, Logan Turner, Aaron Lin, Tavis L. Mendez, Hannah Went, Alan Tomusiak, Eric Verdin, Michael Corley, Lishomwa Ndhlovu, Ryan Smith, Varun B. Dwaraka

https://doi.org/10.18632/aging.205581pp 3088—3106

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Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort

Anne K. Bozack, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Robert O. Wright, Diane R. Gold, Emily Oken, Marie-France Hivert, Andres Cardenas

https://doi.org/10.18632/aging.205602pp 3107—3136

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Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer’s disease by activated protein C

Mohammad Kasim Fatmi, Hao Wang, Lily Slotabec, Changhong Wen, Blaise Seale, Bi Zhao, Ji Li

https://doi.org/10.18632/aging.205624pp 3137—3159

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Single-cell and bulk RNA sequencing data jointly reveals VDAC2’s impacts on prognosis and immune landscape of NSCLC

Ying Ma, Bateer Han, Qin Yu, Nashunbayaer Zha, Zhiyuan Deng, Junguo Liang, Rong Yu

https://doi.org/10.18632/aging.205517pp 3160—3184

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The high expression of TOP2A and MELK induces the occurrence of psoriasis

Xinhua Zhu, Erjia Zhang, Li Qin

https://doi.org/10.18632/aging.205519pp 3185—3199

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Transcriptomic and network analysis identifies shared and unique pathways and immune changes across fibrotic interstitial lung diseases

Wenhao Liu, Kangping Huang, Xin-Zhuang Yang, Ping Wang

https://doi.org/10.18632/aging.205530pp 3200—3230

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Sodium tanshinone IIA sulfonate inhibits tumor growth via miR-138 upregulation in intermittent hypoxia-induced xenograft mice

Xiao-Bin Zhang, Qi-Feng Gan, Xiu-Zhen He, Ya-Ting Yuan, Ling-Wang, Mao-Hong Huang, Ping-Yang Hong

https://doi.org/10.18632/aging.205531pp 3231—3240

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Gut microbiota was highly related to the immune status in chronic obstructive pulmonary disease patients

Mei Wang, Jun Song, Huizhen Yang, Xiaoyu Wu, Jin Zhang, Sheng Wang

https://doi.org/10.18632/aging.205532pp 3241—3256

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BubR1 controls starvation-induced lipolysis via IMD signaling pathway in Drosophila

Mengyou Liu, Shengye Yang, Jingsi Yang, Ping Feng, Feng Luo, Qiaoqiao Zhang, Li Yang, Hao Jiang

https://doi.org/10.18632/aging.205533pp 3257—3279

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Disulfideptosis-associated lncRNAs reveal features of prognostic, immune escape, tumor mutation, and tumor malignant progression in renal clear cell carcinoma

Xungang Li, Xinxi Deng, Taobin Liu, Wensheng Zhang, Jin Tao

https://doi.org/10.18632/aging.205534pp 3280—3301

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Exosomes as nanostructures deliver miR-204 in alleviation of mitochondrial dysfunction in diabetic nephropathy through suppressing methyltransferase-like 7A-mediated CIDEC N6-methyladenosine methylation

Juan Jin, Yiwei Shang, Siqiang Zheng, Limiao Dai, Jiyu Tang, Xueyan Bian, Qiang He

https://doi.org/10.18632/aging.205535pp 3302—3331

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Machine learning constructs a T cell-related signature for predicting prognosis and drug sensitivity in ovarian cancer

Yunzheng Zhang, Lipeng Pei

https://doi.org/10.18632/aging.205536pp 3332—3349

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Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human

Junxian He, Jindong Li, Yanqing Li, Zhenhan Xu, Menghui Ma, Haicheng Chen, Peigen Chen, Linyan Lv, Xuejun Shang, Guihua Liu

https://doi.org/10.18632/aging.205538pp 3350—3362

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Pan-cancer analysis of NUDT21 and its effect on the proliferation of human head and neck squamous cell carcinoma

Wenjing Liu, Yingna Pang, Xiaolu Yu, Doudou Lu, Yating Yang, Fandi Meng, Chengbi Xu, Ling Yuan, Yi Nan

https://doi.org/10.18632/aging.205539pp 3363—3385

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Investigation on the mechanism of the combination of eremias multiocellata and cisplatin in reducing chemoresistance of gastric cancer based on in vitro and in vivo experiments

Fan-e Cheng, Zheng Li, Xing Bai, Yanyan Jing, Junfei Zhang, Xiaoqian Shi, Tingting Li, Weiqiang Li

https://doi.org/10.18632/aging.205540pp 3386—3403

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Orexin-A alleviates ferroptosis by activating the Nrf2/HO-1 signaling pathway in traumatic brain injury

Junwei Kang, Bingkai Ren, Lianghua Huang, Xiaoyang Dong, Qi Xiong, Zhen Feng

https://doi.org/10.18632/aging.205541pp 3404—3419

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Insights into serum metabolic biomarkers for early detection of incident diabetic kidney disease in Chinese patients with type 2 diabetes by random forest

Jian-Jun Jiang, Tung-Ting Sham, Xiu-Fen Gu, Chi-On Chan, Nai-Ping Dong, Wei-Han Lim, Gao-Feng Song, Shun-Min Li, Daniel Kam-Wah Mok, Na Ge

https://doi.org/10.18632/aging.205542pp 3420—3530

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Senescence-related genes analysis in breast cancer reveals the immune microenvironment and implications for immunotherapy

Hua Zhong, Lijie Chang, Shengbin Pei, Yakun Kang, Lili Yang, Yifan Wu, Nuo Chen, Yicheng Luo, Yixiao Zhou, Jiaheng Xie, Yiqin Xia

https://doi.org/10.18632/aging.205544pp 3531—3553

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Investigation of cuproptosis regulator-mediated modification patterns and SLC30A7 function in GBM

Wanli Yu, Shikai Gui, Jiabao Xie, Lunshan Peng, Juexian Xiao, Haitao Luo, Zhennan Tao, Zujue Cheng

https://doi.org/10.18632/aging.205545pp 3554—3582

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Rutin promotes osteogenic differentiation of mesenchymal stem cells (MSCs) by increasing ECM deposition and inhibiting p53 expression

Dongyang Li, Wanru Yin, Chao Xu, Yongmin Feng, Xin Huang, Junfeng Hao, Chao Zhu

https://doi.org/10.18632/aging.205546pp 3583—3595

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Causal relationship between gut microbiota and risk of esophageal cancer: evidence from Mendelian randomization study

Kui Wang, Jiawei Wang, Yuhua Chen, Huan Long, Wei Pan, Yunfei Liu, Ming-Yi Xu, Qiang Guo

https://doi.org/10.18632/aging.205547pp 3596—3611

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New insights into ginsenoside Rg1 regulating the niche to inhibit age-induced germline stem cells depletion through targeting ECR/BMP signaling pathway in Drosophila

Baoyu Fu, Rui Ma, Fangbing Liu, Xuenan Chen, Manying Wang, Wenqi Jin, Shuai Zhang, Yanping Wang, Liwei Sun

https://doi.org/10.18632/aging.205548pp 3612—3630

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The clinicopathologic and molecular features, and treatment outcome of fumarate hydratase-deficient renal cell carcinoma: a retrospective comparison with type 2 papillary renal cell carcinoma

Junjie Bai, Xiaoyan Li, Yahui Wen, Qing Lu, Ru Chen, Rong Liu, Tong Shangguan, Yushi Ye, Jun Lin, Weizhong Cai, Deyong Kang, Jianhui Chen

https://doi.org/10.18632/aging.205549pp 3631—3646

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Comprehensive analysis of disulfidptosis-related genes: a prognosis model construction and tumor microenvironment characterization in clear cell renal cell carcinoma

Bocun Yi, Xifeng Wei, Dongze Liu, Liwei Jing, Shengxian Xu, Man Zhang, Zhengxin Liang, Ranlu Liu, Zhihong Zhang

https://doi.org/10.18632/aging.205550pp 3647—3673

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Prognostic value and therapeutic potential of IAP family in head and neck squamous cell carcinoma

Xiaoqian Yu, Weiwei Cao, Xuejie Yang, Canping Yu, Wenying Jiang, Hongbin Guo, Xiaoyun He, Cheng Mei, Chunlin Ou

https://doi.org/10.18632/aging.205551pp 3674—3693

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PMAIP1, a novel diagnostic and potential therapeutic biomarker in osteoporosis

Tao Li, Jinghong Yuan, Peichuan Xu, Jingyu Jia, Jiangminghao Zhao, Jian Zhang, Rui Ding, Xiaokun Zhao, Dingwen He, Tianlong Wu, Xigao Cheng

https://doi.org/10.18632/aging.205553pp 3694—3715

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miR-557 inhibits hepatocellular carcinoma progression through Wnt/β-catenin signaling pathway by targeting RAB10

Xiaoye Cheng, Can Wu, Haocheng Xu, Ruixiang Zou, Taiyuan Li, Shanping Ye

https://doi.org/10.18632/aging.205554pp 3716—3733

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Identification of hypoxic-related lncRNAs prognostic model for revealing clinical prognostic and immune infiltration characteristic of cutaneous melanoma

Congjuan Liao, Jiabao Yang, Liuting Chen, Zhiguang Ye

https://doi.org/10.18632/aging.205556pp 3734—3749

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Suppression of cerebral ischemia injury induced blood brain barrier breakdown by dexmedetomidine via promoting CCN1

Shuangmei Liu, Xuepeng Jia, Bo Liu, Yue Liu, Hong Yin

https://doi.org/10.18632/aging.205557pp 3750—3762

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Liraglutide improves sevoflurane-induced postoperative cognitive dysfunction via activating autophagy and inhibiting apoptosis

Ying Hu, Haijin Huang, Yao Jiang, Jingling Zhang, Yang Zhang, Ying Tian, Qin Zhang

https://doi.org/10.18632/aging.205558pp 3763—3772

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Yangyinghuoxue decoction exerts a treatment effect on hepatic fibrosis by PI3K/AKT pathway in rat model: based on the network pharmacology and molecular docking

Yan-Ming Bai, Shuang Liang, Bo Zhou

https://doi.org/10.18632/aging.205559pp 3773—3789

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MUC1 promotes RIF by regulating macrophage ROS-SHP2 signaling pathway to up-regulate inflammatory response and inhibit angiogenesis

Rongna Liu, Lin Chen, Xin Zhao, Lili Bao, Ruixia Wei, Xiaohua Wu

https://doi.org/10.18632/aging.205560pp 3790—3802

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Mitochondrial-related genes PDK2, CHDH, and ALDH5A1 served as a diagnostic signature and correlated with immune cell infiltration in ulcerative colitis

Qian Yang, Peng Zhang, Lu Han, Pengshuang Shi, Zhifang Zhao, Dejun Cui, Kunqiao Hong

https://doi.org/10.18632/aging.205561pp 3803—3822

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Development and validation of a nomogram for predicting the impact of tumor size on cancer-specific survival of locally advanced renal cell carcinoma: a SEER-based study

Junjie Bai, Qing Lu, Yahui Wen, Tong Shangguan, Yushi Ye, Jun Lin, Rong Liu, Weizhong Cai, Jianhui Chen

https://doi.org/10.18632/aging.205562pp 3823—3836

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Dickkopf-1 is an immune infiltration-related prognostic biomarker of head and neck squamous cell carcinoma

Chaofen Zhao, Lina Liu, Qianyong He, Yuanyuan Li, Jianglong Feng, Yue Chen, Yuxin Li, Xinyu Xu, Shaoyuan Zhu, Yuanmei Ye, Yajing Wen, Zhirui Zeng, Ding’an Zhou, Feng Jin

https://doi.org/10.18632/aging.205563pp 3837—3855

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An assessment system for clinical and biological interpretability in ulcerative colitis

Shiqian Zhang, Ge Zhang, Wenxiu Wang, Song-Bin Guo, Pengpeng Zhang, Fuqi Wang, Quanbo Zhou, Zhaokai Zhou, Yujia Wang, Haifeng Sun, Wenming Cui, Shuaixi Yang, Weitang Yuan

https://doi.org/10.18632/aging.205564pp 3856—3879

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Comprehensive analysis identifies crucial genes associated with immune cells mediating progression of carotid atherosclerotic plaque

Zhen Li, Junhui Liu, Zhichun Liu, Xiaonan Zhu, Rongxin Geng, Rui Ding, Haitao Xu, Shulan Huang

https://doi.org/10.18632/aging.205566pp 3880—3895

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GAS5, a long noncoding RNA, contributes to annulus fibroblast osteogenic differentiation and apoptosis in intervertebral disk degeneration via the miR-221-3p/SOX11 axis

Qi Liu, Jiaying Luo, Huan Wang, Lei Zhang, Jingwen Guo, Guoxin Jin

https://doi.org/10.18632/aging.205567pp 3896—3914

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Validation and identification of anoikis-related lncRNA signatures for improving prognosis in clear cell renal cell carcinoma

Zhenjie Zhu, Qibo Wang, Xiaowei Zeng, Shaoxing Zhu, Jinchao Chen

https://doi.org/10.18632/aging.205568pp 3915—3933

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Functional enrichment analysis reveals the involvement of DARS2 in multiple biological pathways and its potential as a therapeutic target in esophageal carcinoma

Xu-Sheng Liu, Zi-Yue Liu, Dao-Bing Zeng, Jian Hu, Xuan-Long Chen, Jiao-Long Gu, Yan Gao, Zhi-Jun Pei

https://doi.org/10.18632/aging.205569pp 3934—3954

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Protective effects of triptolide against oxidative stress in retinal pigment epithelium cells via the PI3K/AKT/Nrf2 pathway: a network pharmacological method and experimental validation

Fuying Pan, Qinxin Shu, Hao Xie, Long Zhao, Ping Wu, Yong Du, Jing Lu, Yuxia He, Xing Wang, Hui Peng

https://doi.org/10.18632/aging.205570pp 3955—3972

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MicroRNA-320a enhances LRWD1 expression through the AGO2/FXR1-dependent pathway to affect cell behaviors and the oxidative stress response in human testicular embryonic carcinoma cells

Yi-Hsiung Lin, Chia-Hui Su, Hsin-Mei Chen, Ming-Syuan Wu, Hsien-An Pan, Chia-Ning Chang, Yu-Sheng Cheng, Wen-Tsan Chang, Chien-Chih Chiu, Yen-Ni Teng

https://doi.org/10.18632/aging.205571pp 3973—3988

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Unlocking the potential of senescence-related gene signature as a diagnostic and prognostic biomarker in sepsis: insights from meta-analyses, single-cell RNA sequencing, and in vitro experiments

Jia Chen, Jinhong Si, Qiankun Li, Weihong Zhang, Jiahao He

https://doi.org/10.18632/aging.205574pp 3989—4013

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Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer

Li Wang, Menghan Li, Hongyu Yang, Fenghuan Dai, Ning Xie, Linhui Li, Meiying Zhu, Ran Ding

https://doi.org/10.18632/aging.205575pp 4014—4032

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LGALS3BP is a novel and potential biomarker in clear cell renal cell carcinoma

Lei Li, Sen Qin, Hongwei Tan, Jiexue Zhou

https://doi.org/10.18632/aging.205578pp 4033—4051

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Review

The role of long non-coding RNA in hepatocellular carcinoma

Weizheng Liang, Yan Zhao, Qingxue Meng, Wenjie Jiang, Shoulong Deng, Jun Xue

https://doi.org/10.18632/aging.205523pp 4052—4073

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Correction

Correction for: A novel six-microRNA-based model to improve prognosis prediction of breast cancer

Jianguo Lai, Hongli Wang, Zihao Pan, Fengxi Su

https://doi.org/10.18632/aging.205643pp 4074