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Review|Volume 16, Issue 4|pp 4052—4073

The role of long non-coding RNA in hepatocellular carcinoma

Weizheng Liang1,2,3, Yan Zhao4, Qingxue Meng5, Wenjie Jiang6, Shoulong Deng7, Jun Xue2,3
  • 1Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China
  • 2Department of General Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China
  • 3Tumor Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China
  • 4Department of Mathematics and Computer Science, Free University Berlin, Berlin 14195, Germany
  • 5Technology Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, Hebei, China
  • 6Department of Artificial Intelligence and Data Science, Hebei University of Technology, Tianjin 300401, China
  • 7National Health Commission of China (NHC) Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China
* Equal contribution
Received: May 19, 2023Accepted: December 12, 2023Published: February 8, 2024
https://doi.org/10.18632/aging.205523

Copyright: © 2024 Liang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hepatocellular carcinoma (HCC) is a prevalent liver malignancy with complex etiology and generally poor prognosis. Recently, long non-coding RNAs (lncRNAs), non-protein-coding RNA molecules exceeding 200 nucleotides, have emerged as pivotal players in HCC, influencing its initiation, progression, invasion, and metastasis. These lncRNAs modulate gene expression at epigenetic, transcriptional, and post-transcriptional levels, actively participating in the pathological and physiological processes of HCC. Understanding the intricate relationship between lncRNAs and HCC is important for improving prognosis and reducing mortality. This review summarizes advancements in elucidating the role of lncRNAs in HCC pathogenesis.