Volume 13, Issue 19

October 15, 2021pp 22625—23434

About the Cover

The cover features Figure 6 " Green tea catechins enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition“ from Tian et al.

Editorials

Adipokines, cell polarity disruption and breast cancer

Danila Coradini

https://doi.org/10.18632/aging.203621pp 22625—22626

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Preventing metastatic emergence of breast cancer

Alan Wells, Colin Beckwitt, Juan Luis Gomez Marti

https://doi.org/10.18632/aging.203631pp 22627—22628

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Priority Research Paper

Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition

Jing Tian, Caroline Geiss, Kim Zarse, Corina T. Madreiter-Sokolowski, Michael Ristow

https://doi.org/10.18632/aging.203597pp 22629—22648

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Research Papers

Effects of periostin deficiency on kidney aging and lipid metabolism

Jung Nam An, Hyoseon Kim, Eun Nim Kim, Ara Cho, Yeongeun Cho, Young Wook Choi, Jin Hyuk Kim, Seung Hee Yang, Bum Soon Choi, Chun Soo Lim, Yon Su Kim, Kwang Pyo Kim, Jung Pyo Lee

https://doi.org/10.18632/aging.203580pp 22649—22665

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Increased plasma brain-derived neurotrophic factor (BDNF) as a potential biomarker for and compensatory mechanism in mild cognitive impairment: a case-control study

Ted Kheng Siang Ng, Christina Coughlan, Patricia C. Heyn, Alex Tagawa, James J. Carollo, Ee Heok Kua, Rathi Mahendran

https://doi.org/10.18632/aging.203598pp 22666—22689

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Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease

Esmeralda Castelblanco, Maria R. Sarrias, Àngels Betriu, Berta Soldevila, Maria Barranco-Altirriba, Josep Franch-Nadal, Jose M. Valdivielso, Marcelino Bermudez-Lopez, Per-Henrik Groop, Elvira Fernández, Núria Alonso, Didac Mauricio

https://doi.org/10.18632/aging.203615pp 22690—22709

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Neurovascular dysfunction and neuroinflammation in a Cockayne syndrome mouse model

Gustavo Satoru Kajitani, Lear Brace, Jose Humberto Trevino-Villarreal, Kaspar Trocha, Michael Robert MacArthur, Sarah Vose, Dorathy Vargas, Roderick Bronson, Sarah Jayne Mitchell, Carlos Frederico Martins Menck, James Robert Mitchell

https://doi.org/10.18632/aging.203617pp 22710—22731

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The central role of the glutamate metabolism in long-term antiretroviral treated HIV-infected individuals with metabolic syndrome

Marco Gelpi, Flora Mikaeloff, Andreas D. Knudsen, Rui Benfeitas, Shuba Krishnan, Sara Svenssson Akusjärvi, Julie Høgh, Daniel D. Murray, Henrik Ullum, Ujjwal Neogi, Susanne D. Nielsen

https://doi.org/10.18632/aging.203622pp 22732—22751

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Exposure to ionizing radiation disrupts normal epigenetic aging in Japanese medaka

Emily M. Bertucci, Marilyn W. Mason, Olin E. Rhodes, Benjamin B. Parrott

https://doi.org/10.18632/aging.203624pp 22752—22771

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Immunological age prediction in HIV-infected, ART-treated individuals

Lesley R. de Armas, Suresh Pallikkuth, Li Pan, Stefano Rinaldi, Rajendra Pahwa, Savita Pahwa

https://doi.org/10.18632/aging.203625pp 22772—22791

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Identification of hub genes and key pathways of paraquat-induced human embryonic pulmonary fibrosis by bioinformatics analysis and in vitro studies

Xiangxia Zeng, Jinlun Hu, Mei Yan, Chunming Xie, Weigan Xu, Qiaohua Hu, Jinxia Feng, Zi Cong Gu, Yue Fu

https://doi.org/10.18632/aging.203570pp 22792—22801

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Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma

Zhili Zeng, Xiao Jiang, Zhibin Pan, Ruisheng Zhou, Zhuangteng Lin, Ying Tang, Ying Cui, Enxin Zhang, Zebiao Cao

https://doi.org/10.18632/aging.203574pp 22802—22829

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Inhibition of JAK2/STAT3 signaling pathway by panaxadiol limits the progression of pancreatic cancer

Xuhui Fan, Haotian Fu, Ni Xie, Hangcheng Guo, Tiantian Fu, Yunfeng Shan

https://doi.org/10.18632/aging.203575pp 22830—22842

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Allicin protects against myocardial I/R by accelerating angiogenesis via the miR-19a-3p/PI3K/AKT axis

Mengru Liu, Peng Yang, Dongliang Fu, Tong Gao, Xinyi Deng, Mingjing Shao, Jiangquan Liao, Hong Jiang, Xianlun Li

https://doi.org/10.18632/aging.203578pp 22843—22855

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Retrospective analysis of renal prognosis in elderly coronary artery disease patients complicated with renal insufficiency

Jun Li, Fa-Hu Liu, Jing Guo, Ya-Fen Yu, Chun-Qing Li

https://doi.org/10.18632/aging.203579pp 22856—22866

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Computational study of effective matrix metalloproteinase 9 (MMP9) targeting natural inhibitors

Naimeng Liu, Xinhui Wang, Hao Wu, Xiaye Lv, Haoqun Xie, Zhen Guo, Jing Wang, Gaojing Dou, Chenxi Zhang, Mindan Sun

https://doi.org/10.18632/aging.203581pp 22867—22882

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Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing

Zhuoran Liang, Ruolan Pan, Xia Meng, Jinxing Su, Yong Guo, Gang Wei, Zhi Zhang, Kan He

https://doi.org/10.18632/aging.203582pp 22883—22897

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Downregulation of KIF2C and TEKT2 is associated with male infertility and testicular carcinoma

Haiming Cao, Zi Wan, Fei Wang, Ziyin Liu, Xiaofeng Li, Jianquan Hou

https://doi.org/10.18632/aging.203583pp 22898—22911

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Significance of CD8⁺ T cell infiltration-related biomarkers and the corresponding prediction model for the prognosis of kidney renal clear cell carcinoma

Yuan Tian, Yumei Wei, Hongmei Liu, Heli Shang, Yuedong Xu, Tong Wu, Wei Liu, Alan Huang, Qi Dang, Yuping Sun

https://doi.org/10.18632/aging.203584pp 22912—22933

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Agomelatine might be more appropriate for elderly, depressed, type 2 diabetes mellitus patients than paroxetine/fluoxetine

Zihong Liang, Yanbo Jia, Lizhen Zhao, Runxiu Zhu, Xuemei He, Bagen Tong, Fan Yang, Lixia Hao, Pengfei Cui, Jun Yuan

https://doi.org/10.18632/aging.203586pp 22934—22946

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A novel prognostic signature based on immune-related genes of diffuse large B-cell lymphoma

Zizheng Wu, Qingpei Guan, Xue Han, Xianming Liu, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianhuo Wang, Huilai Zhang

https://doi.org/10.18632/aging.203587pp 22947—22962

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RUNX2 and LAMC2: promising pancreatic cancer biomarkers identified by an integrative data mining of pancreatic adenocarcinoma tissues

Guihua Jin, Qingqing Ruan, Fugen Shangguan, Linhua Lan

https://doi.org/10.18632/aging.203589pp 22963—22984

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Vitellogenin 2 promotes muscle development and stimulates the browning of white fat

Yilei Li, Xiaoli Sun, Yun Bai, Yunyan Ji, Huawei Ren, Xiuju Yu, Yi Yan, Xiaoyan He, Yanjun Dong, Liping Zhang, Xiaomao Luo, Haidong Wang

https://doi.org/10.18632/aging.203590pp 22985—23003

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lncRNA MEG3 aggravated neuropathic pain and astrocyte overaction through mediating miR-130a-5p/CXCL12/CXCR4 axis

Jiacai Dong, Rui Xia, Zhonggui Zhang, Cheng Xu

https://doi.org/10.18632/aging.203592pp 23004—23019

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DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma

Hao Wu, Jinrui Zhang, Yi Bai, Sai Zhang, Zhixin Zhang, Wen Tong, Pinsheng Han, Bing Fu, Yamin Zhang, Zhongyang Shen

https://doi.org/10.18632/aging.203593pp 23020—23035

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Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma

Yuchao Fan, Xiao Liang, Deshui Yu

https://doi.org/10.18632/aging.203594pp 23036—23071

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Establishment of a novel ferroptosis-related lncRNA pair prognostic model in colon adenocarcinoma

Hong Li, Lili Liu, Tianyi Huang, Ming Jin, Zhen Zheng, Hui Zhang, Meng Ye, Kaitai Liu

https://doi.org/10.18632/aging.203599pp 23072—23095

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Zhoushi Qi Ling decoction represses docetaxel resistance and glycolysis of castration-resistant prostate cancer via regulation of SNHG10/miR-1271-5p/TRIM66 axis

Hongwen Cao, Dan Wang, Peng Sun, Lei Chen, Yigeng Feng, Renjie Gao

https://doi.org/10.18632/aging.203602pp 23096—23107

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METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse

Baiqing He, Jian Wang

https://doi.org/10.18632/aging.203604pp 23108—23118

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Ribosome profiling reveals translatome remodeling in cancer cells in response to zinc oxide nanoparticles

Saisai Wei, Wenhao Guo, Yu Qian, Jie Xiang, Kangli Liu, Xiang-Jing Gao, Xiangwei Gao, Yicheng Chen

https://doi.org/10.18632/aging.203606pp 23119—23132

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Short-term high-fat diet favors the appearances of apoptosis and gliosis by activation of ERK1/2/p38MAPK pathways in brain

Chao-Jin Xu, Mei-Qi Li, Li-Zhao, Wei-Guang Chen, Jun-Ling Wang

https://doi.org/10.18632/aging.203607pp 23133—23148

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Comprehensive analysis of aberrant alternative splicing related to carcinogenesis and prognosis of papillary thyroid cancer

Xiaobo Zheng, Li Feng, Yunfan Yin, Chune Yu, Xiujing He, Jiao Zhu, Ming Zhang, Jing Yu, Mingqing Xu

https://doi.org/10.18632/aging.203608pp 23149—23168

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LncRNA-SNHG1 promotes macrophage M2-like polarization and contributes to breast cancer growth and metastasis

Shoukai Zong, Wei Dai, Xiangting Guo, Kai Wang

https://doi.org/10.18632/aging.203609pp 23169—23181

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Decreased gray matter volume and increased white matter volume in patients with neovascular age-related macular degeneration: a voxel-based morphometry study

Yan-Kun Shen, Qian-Min Ge, Yi-Cong Pan, Hui-Ye Shu, Li-Juan Zhang, Qiu-Yu Li, Rong-Bin Liang, Yi Shao, Yao Yu

https://doi.org/10.18632/aging.203610pp 23182—23192

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Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome

Weiwei Zhang, Wusan Wang, Chaozhuang Shen, Xiaohu Wang, Zhichen Pu, Qin Yin

https://doi.org/10.18632/aging.203611pp 23193—23209

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Integrated analysis of tumor-associated macrophage infiltration and prognosis in ovarian cancer

Qianxia Tan, Huining Liu, Jie Xu, Yanqun Mo, Furong Dai

https://doi.org/10.18632/aging.203613pp 23210—23232

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Long non-coding RNA CRNDE as potential biomarkers facilitate inflammation and apoptosis in alcoholic liver disease

Yifeng Yan, Liang Ren, Yan Liu, Liang Liu

https://doi.org/10.18632/aging.203614pp 23233—23244

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Identification of potential target genes of non-small cell lung cancer in response to resveratrol treatment by bioinformatics analysis

Peng Gao, Guanghui Ren

https://doi.org/10.18632/aging.203616pp 23245—23261

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Whole-exome sequencing of rectal cancer identifies locally recurrent mutations in the Wnt pathway

Yi Yang, Xiaodong Gu, Zhenyang Li, Chuang Zheng, Zihao Wang, Minwei Zhou, Zongyou Chen, Mengzhen Li, Dongbing Li, Jianbin Xiang

https://doi.org/10.18632/aging.203618pp 23262—23283

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Transcriptome research identifies four hub genes related to primary myelofibrosis: a holistic research by weighted gene co-expression network analysis

Weihang Li, Yingjing Zhao, Dong Wang, Ziyi Ding, Chengfei Li, Bo Wang, Xiong Xue, Jun Ma, Yajun Deng, Quancheng Liu, Guohua Zhang, Ying Zhang, Kai Wang, Bin Yuan

https://doi.org/10.18632/aging.203619pp 23284—23307

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Transcriptome and proteome analysis of the antitumor activity of maslinic acid against pancreatic cancer cells

Hewei Zhang, Lijun Kong, Yan Zhang, Cheng Wang, Linxiao Sun

https://doi.org/10.18632/aging.203623pp 23308—23327

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Effects of Yu Linzhu on ovarian function and oocyte mitochondria in natural aging mice

Zhen Yang, Mao-Lin Wei, Xiao-Ying Dong

https://doi.org/10.18632/aging.203626pp 23328—23337

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A novel mutation in PCK2 gene causes primary angle-closure glaucoma

Menghan Xu, Jin Yang, Jiayue Sun, Xuemei Xing, Zheng Liu, Tao Liu

https://doi.org/10.18632/aging.203627pp 23338—23347

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Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study

Hsin-Yu Liu, Li-Ning Peng, Wei-Ju Lee, Ming-Yueh Chou, Chih-Kuang Liang, Fei-Yuan Hsiao, Ming-Hsien Lin, Liang-Kung Chen

https://doi.org/10.18632/aging.203629pp 23348—23360

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piRNA-36741 regulates BMP2-mediated osteoblast differentiation via METTL3 controlled m6A modification

Jianmin Liu, Ming Chen, Longyang Ma, Xingbo Dang, Gongliang Du

https://doi.org/10.18632/aging.203630pp 23361—23375

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Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis

Yangyang Liu, Lu Liang, Liang Ji, Fuquan Zhang, Donglai Chen, Shanzhou Duan, Hao Shen, Yao Liang, Yongbing Chen

https://doi.org/10.18632/aging.203632pp 23376—23392

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Cosmc transfection decreases malignant behavior of Tn⁺ cells and enhances sensitivity to apoptosis when induced by Apo2L/TRAIL via alteration of O-glycan structure

Ruisong Ding, Xingyou Hu, Wen Hu, Zhenzhen Du, Panpan Huang, Mengyang Wang, Jiaoyue Sheng, Yanchao Ma, Ailing Wang, Xiying Luan, Menghua Dong, Qizhi Cao, Yanfen Zou, Tao Hu

https://doi.org/10.18632/aging.203633pp 23393—23406

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Theory Article

Iron: an underrated factor in aging

Dennis Mangan

https://doi.org/10.18632/aging.203612pp 23407—23415

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Review

Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics

Rocio I.R. Macias, Maria J. Monte, Maria A. Serrano, Jesús M. González-Santiago, Isabel Martín-Arribas, André L. Simão, Rui E. Castro, Javier González-Gallego, José L. Mauriz, Jose J.G. Marin

https://doi.org/10.18632/aging.203620pp 23416—23434

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