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Volume 16, Issue 6

March 31, 2024pp 4948—5795

About the Cover

The cover features Figure 2 "Reduced surface areas in postmenopausal women compared to premenopausal women" from Kim et al.

Research Papers

Targeting mitochondrial dysfunction using methylene blue or mitoquinone to improve skeletal aging

Sher Bahadur Poudel, Dorra Frikha-Benayed, Ryan R. Ruff, Gozde Yildirim, Manisha Dixit, Ron Korstanje, Laura Robinson, Richard A. Miller, David E. Harrison, John R. Strong, Mitchell B. Schaffler, Shoshana Yakar

https://doi.org/10.18632/aging.205147pp 4948—4964

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Altered brain morphology and functional connectivity in postmenopausal women: automatic segmentation of whole-brain and thalamic subnuclei and resting-state fMRI

Gwang-Won Kim, Kwangsung Park, Yun-Hyeon Kim, Gwang-Woo Jeong

https://doi.org/10.18632/aging.205662pp 4965—4979

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CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction

Alcir L. Dafre, Saadia Zahid, Jessica Jorge Probst, Antonio Currais, Jingting Yu, David Schubert, Pamela Maher

https://doi.org/10.18632/aging.205673pp 4980—4999

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Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model

Peramaiyan Rajendran, Fatma J. Al-Saeedi, Rebai Ben Ammar, Basem M. Abdallah, Enas M. Ali, Najla Khaled Al Abdulsalam, Sujatha Tejavat, Duaa Althumairy, Vishnu Priya Veeraraghavan, Sarah Abdulaziz Alamer, Gamal M. Bekhet, Emad A. Ahmed

https://doi.org/10.18632/aging.205677pp 5000—5026

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Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress

Yaqin Chai, Xing Gu, HongJun Zhang, Xinting Xu, Lizhan Chen

https://doi.org/10.18632/aging.205468pp 5027—5037

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The protective effects of Arctiin in asthma by attenuating airway inflammation and inhibiting p38/NF-κB signaling

Lang Yuan, Chao Sun

https://doi.org/10.18632/aging.205584pp 5038—5049

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Omilancor mitigates the senescence of nucleus pulposus cells induced by DDP through targeting MAP2K6

Fang Yafeng, Shi Xinpeng, Wei Rong, Cui Guofeng

https://doi.org/10.18632/aging.205588pp 5050—5064

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The protective effects of Irbesartan in cognitive impairment in hypertension

Shengyun Hao, Qian He, Yuan Yuan, Qiong Mu

https://doi.org/10.18632/aging.205589pp 5065—5076

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FOXQ1 inhibits the progression of osteoarthritis by regulating pyroptosis

Zhihuan Luo, Hui Zeng, Kanghua Yang, Yihai Wang

https://doi.org/10.18632/aging.205600pp 5077—5090

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GSG2 promotes thyroid cancer via stabilizing AURKB and activating AKT pathway

Fenghua Zhang, Chiming Huang

https://doi.org/10.18632/aging.205605pp 5091—5107

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Portulaca oleracea L. polysaccharide inhibits ovarian cancer via inducing ACSL4-dependent ferroptosis

Liping Xia, Mo Yang, Yan Liu

https://doi.org/10.18632/aging.205608pp 5108—5122

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The comprehensive landscape of prognosis, immunity, and function of the GLI family by pan-cancer and single-cell analysis

Yinteng Wu, Wenliang Guo, Tao Wang, Ying Liu, Marìa del Mar Requena Mullor, Raquel Alarcòn Rodrìguez, Shijian Zhao, Ruqiong Wei

https://doi.org/10.18632/aging.205630pp 5123—5148

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A novel immune-related lncRNA signature predicts the prognosis and immune landscape in ccRCC

Longlong Dai, Daen Pan, Jiafei Jin, Wenhui Lv

https://doi.org/10.18632/aging.205633pp 5149—5162

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Novel histone acetylation-related lncRNA signature for predicting prognosis and tumor microenvironment in esophageal carcinoma

Batter Han, Ying Ma, Pengjie Yang, Fangchao Zhao, Haiyong Zhu, Shujun Li, Rong Yu, Subudao Bao

https://doi.org/10.18632/aging.205636pp 5163—5183

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BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury

Jun Gu, Jingyi Wu, Chunming Wang, Zhenwei Xu, Zhengshuai Jin, Donghua Yan, Sheng Chen

https://doi.org/10.18632/aging.205638pp 5184—5206

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Allicin treats myocardial infarction in I/R through the promotion of the SHP2 axis to inhibit p-PERK-mediated oxidative stress

Tong Gao, Mengru Liu, Dongliang Fu, Yajun Xue, Jiangquan Liao, Peng Yang, Xianlun Li

https://doi.org/10.18632/aging.205640pp 5207—5223

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Development and validation of a novel biomarker panel for Crohn’s disease and rheumatoid arthritis diagnosis and treatment

Hao Zhang, Wenhao Qiao, Ran Liu, Zuoxiu Shi, Jie Sun, Shuxiao Dong

https://doi.org/10.18632/aging.205644pp 5224—5248

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Molecular characterization of Golgi apparatus-related genes indicates prognosis and immune infiltration in osteosarcoma

Jian Zhang, Jiahao Liu, Rui Ding, Xinxin Miao, Jianjian Deng, Xiaokun Zhao, Tianlong Wu, Xigao Cheng

https://doi.org/10.18632/aging.205645pp 5249—5263

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COP9 signalosome complex is a prognostic biomarker and corresponds with immune infiltration in hepatocellular carcinoma

Jiahui Liu, Dexing Han, Junfeng Xuan, Jinye Xie, Weijia Wang, Quan Zhou, Kang Chen

https://doi.org/10.18632/aging.205646pp 5264—5287

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Comprehensive assessment of regulatory T-cells-related scoring system for predicting the prognosis, immune microenvironment and therapeutic response in hepatocellular carcinoma

Bitao Jiang, Xiaojuan Ye, Wenjuan Wang, Jiajia He, Shuyan Zhang, Song Zhang, Lingling Bao, Xin Xu

https://doi.org/10.18632/aging.205649pp 5288—5310

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Construction of an oxidative phosphorylation-related gene signature for predicting prognosis and identifying immune infiltration in osteosarcoma

Peng Zhou, Jin Zhang, Jinyan Feng, Guowen Wang

https://doi.org/10.18632/aging.205650pp 5311—5335

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Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice

Yuyi Yuan, Shuangjiao Deng, Jia Yang, Zhexing Shou, Chunzhu Wei, Lijuan Zhang, Feng Zhu, Fei Gao, Xingxing Liu, Yujin Liu, Qianyun Chen, Heng Fan

https://doi.org/10.18632/aging.205651pp 5336—5353

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Cancer cachexia reduces the efficacy of immune checkpoint inhibitors in cancer patients

Yean Yu, Li Yan, Tianhui Huang, Zhenfu Wu, Juan Liu

https://doi.org/10.18632/aging.205652pp 5354—5369

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Comprehensive analysis of gene expression profiles of annulus fibrosus subtypes and hub genes in intervertebral disc degeneration

Xiaokun Zhao, Jian Zhang, Jiahao Liu, Jinghong Yuan, Tianlong Wu, Xigao Cheng

https://doi.org/10.18632/aging.205653pp 5370—5386

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Network pharmacology and experimental evaluation strategies to decipher the underlying pharmacological mechanism of Traditional Chinese Medicine CFF-1 against prostate cancer

Yong Wei, Mingxia Zhu, Ye Chen, Qianying Ji, Jun Wang, Luming Shen, Xin Yang, Haibin Hu, Xin Zhou, Qingyi Zhu

https://doi.org/10.18632/aging.205654pp 5387—5411

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A comprehensive investigation on the receptor BSG expression reveals the potential risk of healthy individuals and cancer patients to 2019-nCoV infection

Yongbiao Huang, Haiting Zhou, Yuan Wang, Lingyan Xiao, Wan Qin, Long Li

https://doi.org/10.18632/aging.205655pp 5412—5434

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Identification of key lncRNAs in age-related macular degeneration through integrated bioinformatics and experimental validation

Yuying Ji, Chengguo Zuo, Nanying Liao, Liwei Yao, Ruijun Yang, Hui Chen, Feng Wen

https://doi.org/10.18632/aging.205656pp 5435—5451

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Cyclocarya paliurus leaves alleviate high-sucrose diet-induced obesity by improving intestinal metabolic disorders

Ye Yao, Xiaojuan Wang, Dongyu Li, Shujuan Chen, Chengjie Li, Haiyu Guan, Dongsheng Wang, Xiaoli Nie

https://doi.org/10.18632/aging.205657pp 5452—5470

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Integrated single-cell sequencing, spatial transcriptome sequencing and bulk RNA sequencing highlights the molecular characteristics of parthanatos in gastric cancer

Xiuli Qiao, Jiaao Sun, Pingping Ren, Hui Guo, Hua Xu, Chongchan Bao, Chunmeng Jiang

https://doi.org/10.18632/aging.205658pp 5471—5500

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Structural insights into human EMC and its interaction with VDAC

Mingyue Li, Chunli Zhang, Yuntao Xu, Shaobai Li, Chenhui Huang, Jian Wu, Ming Lei

https://doi.org/10.18632/aging.205660pp 5501—5525

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Cinobufotalin regulates the USP36/c-Myc axis to suppress malignant phenotypes of colon cancer cells in vitro and in vivo

Yongjun Hu, Ming Luo

https://doi.org/10.18632/aging.205661pp 5526—5544

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A pyrimidine metabolism-related signature for prognostic and immunotherapeutic response prediction in hepatocellular carcinoma by integrating analyses

Shihang Zhang, Ouyang Qin, Shu Wu, Huanming Xu, Wei Huang, Song Hailiang

https://doi.org/10.18632/aging.205663pp 5545—5566

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CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN

Lina Zhou, Guilan Zhai, Ge Tian

https://doi.org/10.18632/aging.205664pp 5567—5580

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Correlation between S100A7 and immune characteristics, methylation, tumor stemness and tumor heterogeneity in pan-cancer and its role in chemotherapy resistance in breast cancer

Yilun Li, Xiaolu Yang, Tingting Jin, Qiuli Li, Xiaolong Li, Li Ma

https://doi.org/10.18632/aging.205665pp 5581—5600

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WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma

Qiankun Ji, Yazhou Guo, Zibo Li, Xiaoyang Zhang

https://doi.org/10.18632/aging.205666pp 5601—5617

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Predicting the prognosis of glioma patients with TERT promoter mutations and guiding the specific immune profile of immune checkpoint blockade therapy

Wenpeng Cao, Jinzhi Lan, Chujiao Hu, Jinping Kong, Limin Xiang, Zhixue Zhang, Yating Sun, Zhirui Zeng, Shan Lei

https://doi.org/10.18632/aging.205668pp 5618—5633

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Identification and validation of ferroptosis-related gene SLC2A1 as a novel prognostic biomarker in AKI

Huaying Wang, Yuanyuan Li, Xinran Liu, Yonggui Wu

https://doi.org/10.18632/aging.205669pp 5634—5650

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Single cell RNA-seq identifies a FOS/JUN-related monocyte signature associated with clinical response of heart failure patients with mesenchymal stem cell therapy

Hui Yuan, Pengfei Zhang, Yuanfeng Xin, Zhongmin Liu, Bingren Gao

https://doi.org/10.18632/aging.205670pp 5651—5675

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Identification and validation of a novel signature based on macrophage marker genes for predicting prognosis and drug response in kidney renal clear cell carcinoma by integrated analysis of single cell and bulk RNA sequencing

Xiaoxu Chen, Zheyu Zhang, Zheng Qin, Xiao Zhu, Kaibin Wang, Lijuan Kang, Changying Li, Haitao Wang

https://doi.org/10.18632/aging.205671pp 5676—5702

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M1 intestinal macrophages-derived exosomes promote colitis progression and mucosal barrier injury

Rui Du, Sihan Chen, Chenyang Han, Zhongmei He, Hongyan Pei, Yang Yang

https://doi.org/10.18632/aging.205672pp 5703—5710

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Relationship between fatty acid intake and aging: a Mendelian randomization study

Yuhua Chen, Lian Yang, Kui Wang, Yu An, Yuping Wang, Ya Zheng, Yongning Zhou

https://doi.org/10.18632/aging.205674pp 5711—5739

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Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

Shu-Hui Lin, Jeng-Wei Lu, Wang-Ting Hsieh, Ying-Erh Chou, Tzu-Cheng Su, Tun-Jen Tsai, Yun-Jung Tsai, Po-Jen Yang, Shun-Fa Yang

https://doi.org/10.18632/aging.205675pp 5740—5750

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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveal the characteristics of disulfidptosis and a prognostic signature in BLCA

Hao Deng, Fan Cheng, Shaoping Cheng

https://doi.org/10.18632/aging.205686pp 5751—5771

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Review

Considering the response in addition to the challenge – a narrative review in appraisal of a motor reserve framework

Daniel Zeller, Shawn Hiew, Thorsten Odorfer, Carine Nguemeni

https://doi.org/10.18632/aging.205667pp 5772—5791

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Corrections

Correction for: Apremilast ameliorates IL-1α-induced dysfunction in epidermal stem cells

Yuxi Jia, Xiangru Chen, Jing Sun

https://doi.org/10.18632/aging.205318pp 5792—5794

Correction for: KIFC1 promotes proliferation and pseudo-bipolar division of ESCC through the transportation of Aurora B kinase

Bin Du, Lingyu Wei, Jia Wang, Yanyan Li, Jing Huo, Jinsheng Wang, Pu Wang

https://doi.org/10.18632/aging.205719pp 5795