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• Research PaperVolume 4, Issue 10pp 715-722

  New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53^−/− mice by delaying carcinogenesis

  Relevance score: 0.00

  Maria Comas, Ilia Toshkov, Karen K. Kuropatwinski, Olga B. Chernova, Alexander Polinsky, Mikhail V. Blagosklonny, Andrei V. Gudkov, Marina P. Antoch

  Keywords: mTOR pathway, p53−/−, lifespan, rapamycin, oral formulation, cancer prevention

  Published in Aging on October 29, 2012

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• Research PaperVolume 15, Issue 4pp 1210-1227

  Inhibition of apoptosis through AKT-mTOR pathway in ovarian cancer and renal cancer

  Relevance score: 0.00

  Hongrun Chen, Lianfeng Zhang, Meini Zuo, Xiaowen Lou, Bin Liu, Taozhu Fu

  Keywords: Akt-mTOR pathway, renal cancer, ovarian cancer, bioinformatics, verification, biomarker

  Published in Aging on February 27, 2023

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• Research Paper

  Chronic stress promotes premature ovarian failure in mice by inhibiting ovarian granulosa cell autophagy through PI3K-AKTmTOR pathway

  Relevance score: 0.00

  Zhibin Zhao, Xuefei Yuan, Baohua Zhao, Kai He

  Keywords: PI3K-AKT-mTOR pathway, premature ovarian failure (POF), ovarian granulosa cells (OGCs), chronic stress

  Published in Aging on October 8, 2024

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• Research PaperVolume 15, Issue 8pp 2920-2936

  ESM1 promotes angiogenesis in colorectal cancer by activating PI3K/Akt/mTOR pathway, thus accelerating tumor progression

  Relevance score: 0.00

  Liqun Yang, Zhigang Dong, Shuyu Li, Tieliang Chen

  Keywords: ESM1, PI3K/Akt/mTOR pathway, CRC, angiogenesis

  Published in Aging on March 7, 2023

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• Research PaperVolume 13, Issue 10pp 13626-13643

  E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer

  Relevance score: 0.00

  Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu

  Keywords: gastric cancer, E2F2, autophagy, metastasis, PI3K/Akt/mTOR pathway

  Published in Aging on April 21, 2021

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• Research PaperVolume 13, Issue 4pp 5858-5874

  GABARAP suppresses EMT and breast cancer progression via the AKT/mTOR signaling pathway

  Relevance score: 0.00

  Ying Liu, Dandan Wang, Mengxia Lei, Jiayi Gao, Yuqing Cui, Xiaoying Jin, Qiujie Yu, Ying Jiang, Yan Guo, Yali Liu, Li Cai, Xuesong Chen

  Keywords: GABARAP, breast cancer, EMT, prognosis, AKT/mTOR pathway

  Published in Aging on February 11, 2021

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• Research PaperVolume 16, Issue 13pp 10799-10812

  G-CSF promotes the development of hepatocellular carcinoma by activating the PI3K/AKT/mTOR pathway in TAM

  Relevance score: 0.00

  Heng Cao, Shunxiang Wang

  Keywords: hepatocellular carcinoma, granulocyte colony-stimulating factor, PI3K/AKT/mTOR signaling pathway, tumor-associated macrophages

  Published in Aging on July 1, 2024

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• Research PaperVolume 15, Issue 19pp 10407-10427

  PLCL1 suppresses tumour progression by regulating AMPK/mTOR-mediated autophagy in renal cell carcinoma

  Relevance score: 0.00

  Zhou Pan, Jing Huang, Huajie Song, Yusha Xiao, Ting Liu, Yan Zeng, Hengcheng Zhu, Kang Yang

  Keywords: renal cell carcinoma, autophagy, PLCL1, AMPK/mTOR pathway

  Published in Aging on October 6, 2023

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• Research PaperVolume 13, Issue 4pp 5525-5538

  QiShenYiQi pill activates autophagy to attenuate reactive myocardial fibrosis via the PI3K/AKT/mTOR pathway

  Relevance score: 0.00

  Shichao Lv, Peng Yuan, Chunmiao Lu, Jianping Dong, Meng Li, Fan Qu, Yaping Zhu, Junping Zhang

  Keywords: reactive myocardial fibrosis, traditional Chinese medicine, autophagy, PI3K/AKT/mTOR pathway

  Published in Aging on February 11, 2021

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• Research PaperVolume 12, Issue 16pp 16142-16154

  LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway

  Relevance score: 0.00

  Yan Liu, Li Ma, Fugen Shangguan, Xuena Zhao, Wenjie Wang, Zhiyue Gao, Huimin Zhou, Guiwu Qu, Yumei Huang, Jing An, Jiangnan Xue, Shude Yang, Qizhi Cao

  Keywords: LAIR-1, ovarian cancer, PI3K-AKT-mTOR pathway, eEF1A2, cell proliferation

  Published in Aging on July 4, 2020

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• Research PaperVolume 11, Issue 21pp 9794-9810

  LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

  Relevance score: 0.00

  Honghai Song, Jiaming Liu, Xin Wu, Yang Zhou, Xuanyin Chen, Jiangwei Chen, Keyu Deng, Chunxia Mao, Shanhu Huang, Zhili Liu

  Keywords: osteosarcoma, LHX2, autophagy, mTOR pathway, miR-129-5p

  Published in Aging on November 13, 2019

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• Research PaperVolume 13, Issue 1pp 1032-1050

  SPOCK1/SIX1axis promotes breast cancer progression by activating AKT/mTOR signaling

  Relevance score: 0.00

  Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin

  Keywords: SPOCK1, SIX1, EMT, breast cancer, AKT/mTOR signaling pathway

  Published in Aging on December 3, 2020

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• Research PaperVolume 15, Issue 18pp 9661-9675

  Aberrant expression of AKR1B1 indicates poor prognosis and promotes gastric cancer progression by regulating the AKT-mTOR pathway

  Relevance score: 0.00

  Luojie Liu, Lihua Zhu, Zhengwu Cheng, Yibin Sun, Yuqing Zhou, Jiwei Cao

  Keywords: AKR1B1, gastric cancer, prognosis, AKT-mTOR pathway, proliferation and migration

  Published in Aging on September 24, 2023

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• Research PaperVolume 15, Issue 6pp 2308-2320

  Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice

  Relevance score: 0.00

  Minghui Hu, Muxuan Han, Hao Zhang, Zifa Li, Kaiyong Xu, Huaixing Kang, Jiancheng Zong, Feng Zhao, Yuanxiang Liu, Wei Liu

  Keywords: curcumin, exercise fatigue, anti-fatigue effects, treadmill test, PI3K/Akt/AMPK/mTOR pathway

  Published in Aging on March 28, 2023

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• Research PaperVolume 16, Issue 8pp 6937-6953

  High-dose Vitamin C injection ameliorates against sepsis-induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways in rats

  Relevance score: 0.00

  Ya-Nan Cui, Na Tian, Yan-Hai Luo, Ji-Jun Zhao, Cheng-Fei Bi, Yi Gou, Jia Liu, Ke Feng, Jun-Fei Zhang

  Keywords: High-dose Vitamin C, sepsis-induced myocardial injury, apoptosis, autophagy, inflammatory, MAPK, NF-κB and PI3K/AKT/mTOR signaling pathways

  Published in Aging on April 19, 2024

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• Research PaperVolume 12, Issue 23pp 24208-24218

  SRT2183 impairs ovarian cancer by facilitating autophagy

  Relevance score: 0.00

  Tingting Sun, Yanfen Hu, Weipeng He, Yuru Shang, Xiaohong Yang, Liyun Gong, Xianbin Zhang, Peng Gong, Guofen Yang

  Keywords: STR2183, autophagy, apoptosis, AKT/mTOR pathway, p38 MAPK pathway

  Published in Aging on November 20, 2020

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• Research PaperVolume 6, Issue 8pp 675-689

  Metabolic clock generates nutrient anticipation rhythms in mTOR signaling

  Relevance score: 0.00

  Rohini V. Khapre, Sonal A. Patel, Anna A. Kondratova, Amol Chaudhary, Nikkhil Velingkaar, Marina P. Antoch, Roman V. Kondratov

  Keywords: Food anticipation, metabolism, mTOR signaling pathway, biological clocks, circadian clocks

  Published in Aging on August 26, 2014

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• Research PaperVolume 10, Issue 7pp 1640-1648

  Caloric restriction effects on liver mTOR signaling are time-of-day dependent

  Relevance score: 0.00

  Richa Tulsian, Nikkhil Velingkaar, Roman Kondratov

  Keywords: metabolism, mTOR signaling pathway, aging, glucose, biological clocks, circadian clocks, insulin sensitivity, protein translation

  Published in Aging on July 16, 2018

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• Research PaperVolume 14, Issue 2pp 892-906

  The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1

  Relevance score: 0.00

  Yifeng Yuan, Jiangang Sun, Hang Zhou, Shen Wang, Caijian He, Tianpeng Chen, Mouhao Fang, Shaohua Li, Shifa Kang, Xiaosheng Huang, Binbin Tang, Bocheng Liang, Yingdelong Mao, Jianyou Li, Xiaolin Shi, Kang Liu

  Keywords: osteoporosis, CKIP-1, AKT/mTOR signaling pathway, apoptosis, QiangGuYin

  Published in Aging on January 24, 2022

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• Research PaperVolume 10, Issue 7pp 1649-1665

  Sodium fluoride induces splenocyte autophagy via the mammalian targets of rapamycin (mTOR) signaling pathway in growing mice

  Relevance score: 0.00

  Ping Kuang, Huidan Deng, Huan Liu, Hengmin Cui, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao

  Keywords: sodium fluoride, autophagy, mTOR signaling pathway, spleen, mouse

  Published in Aging on July 22, 2018

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