Volume 11, Issue 21

15 November, 2019
pp 9221—9960

About the Cover

The cover features Figure 3 "Calculated bioenergetic health index (BHI) from young and old CD4⁺ T cells" from Bektas et al.

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Editorials

Post-TAVI outcomes: devil lies in the details

Ignacio J. Amat-Santos, Pablo Díez-Villanueva, Javier López Diaz,

https://doi.org/10.18632/aging.102382 pp 9221—9222

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Hepatic ductular reaction: a double-edged sword

Tianliang Sun, Stefano Annunziato, Jan S. Tchorz,

https://doi.org/10.18632/aging.102386 pp 9223—9224

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CCL21 and prognosis in acute coronary syndrome

Thor Ueland, Pål Aukrust, Kenneth Caidahl,

https://doi.org/10.18632/aging.102443 pp 9225—9226

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Risk assessment to prevent heart failure

Arjun Sinha, Donald M. Lloyd-Jones, Sadiya S. Khan,

https://doi.org/10.18632/aging.102444 pp 9227—9228

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Not afraid of low diastolic blood pressure anymore?

Maciej Siński, Piotr Sobieraj, Jacek Lewandowski,

https://doi.org/10.18632/aging.102445 pp 9229—9230

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Should population-based research steer individual health decisions?

Kai O. Hensel, Michelle R. Longmire, Jöran Köchling,

https://doi.org/10.18632/aging.102446 pp 9231—9233

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Priority Research Paper

Age-associated changes in human CD4⁺ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Arsun Bektas, Shepherd H. Schurman, Marta Gonzalez-Freire, Christopher A. Dunn, Amit K. Singh, Fernando Macian, Ana Maria Cuervo, Ranjan Sen, Luigi Ferrucci,

https://doi.org/10.18632/aging.102438 pp 9234—9263

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Research Papers

Dopaminergic neuron injury in Parkinson’s disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway

Li-Min Zhang, Meng-Han Wang, He-Cheng Yang, Tian Tian, Gui-Fang Sun, Yang-Fei Ji, Wen-Tao Hu, Xi Liu, Jian-Ping Wang, Hong Lu,

https://doi.org/10.18632/aging.102330 pp 9264—9279

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Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway

Junyi Shen, Yongjie Zhou, Xiaoyun Zhang, Wei Peng, Chihan Peng, Qiang Zhou, Chuan Li, Tianfu Wen, Yujun Shi,

https://doi.org/10.18632/aging.102332 pp 9280—9294

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Zinc-induced protective effect for testicular ischemia-reperfusion injury by promoting antioxidation via microRNA-101-3p/Nrf2 pathway

Zhiqiang Qin, Kai Zhu, Jianxin Xue, Pu Cao, Luwei Xu, Zheng Xu, Kai Liang, Jiageng Zhu, Ruipeng Jia,

https://doi.org/10.18632/aging.102348 pp 9295—9309

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Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

Tingting Xu, Xiangting Ge, Chun Lu, Wei Dai, Hongjin Chen, Zhongxiang Xiao, Liqin Wu, Guang Liang, Songmin Ying, Yali Zhang, Yuanrong Dai,

https://doi.org/10.18632/aging.102371 pp 9310—9327

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Bioinformatic profiling of prognosis-related genes in the breast cancer immune microenvironment

Fang Bai, Yuchun Jin, Peng Zhang, Hongliang Chen, Yipeng Fu, Mingdi Zhang, Ziyi Weng, Kejin Wu,

https://doi.org/10.18632/aging.102373 pp 9328—9347

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Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

Lin Li, Beibei Chen, Ruyuan Zhu, Rui Li, Yimiao Tian, Chenyue Liu, Qiangqiang Jia, Lili Wang, Jinfa Tang, Dandan Zhao, Fangfang Mo, Yan Liu, Yu Li, Alexander N. Orekhov, Dieter Brömme, Dongwei Zhang, Sihua Gao,

https://doi.org/10.18632/aging.102376 pp 9348—9368

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Extension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling

Shin-Hae Lee, Hye-Yeon Lee, Mira Yu, Eunbyul Yeom, Ji-Hyeon Lee, Ah Yoon, Kyu-Sun Lee, Kyung-Jin Min,

https://doi.org/10.18632/aging.102387 pp 9369—9387

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Elevated ceramides 18:0 and 24:1 with aging are associated with hip fracture risk through increased bone resorption

Beom-Jun Kim, Jin Young Lee, So Jeong Park, Seung Hum Lee, Su Jung Kim, Hyun Ju Yoo, Sarah I. Rivera De Pena, Meghan McGee-Lawrence, Carlos M. Isales, Jung-Min Koh, Mark W. Hamrick,

https://doi.org/10.18632/aging.102389 pp 9388—9404

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Systematic identification of lncRNA-based prognostic biomarkers for glioblastoma

Mingdong Li, Shengrong Long, Jinqu Hu, Zan Wang, Chao Geng, Shaowu Ou,

https://doi.org/10.18632/aging.102393 pp 9405—9423

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Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease

Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang,

https://doi.org/10.18632/aging.102394 pp 9424—9441

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Long noncoding RNA DNM3OS promotes prostate stromal cells transformation via the miR-29a/29b/COL3A1 and miR-361/TGFβ1 axes

Ruizhe Wang, Mengda Zhang, Zhenyu Ou, Wei He, Lingxiao Chen, Junjie Zhang, Yao He, Ran Xu, Shusuan Jiang, Lin Qi, Long Wang,

https://doi.org/10.18632/aging.102395 pp 9442—9460

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Catalpol induces autophagy and attenuates liver steatosis in ob/ob and high-fat diet-induced obese mice

Huihui Ren, Dan Wang, Lu Zhang, Xiaonang Kang, Yaling Li, Xinrong Zhou, Gang Yuan,

https://doi.org/10.18632/aging.102396 pp 9461—9477

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Identifying hub genes of clear cell renal cell carcinoma associated with the proportion of regulatory T cells by weighted gene co-expression network analysis

Ye-Hui Chen, Shao-Hao Chen, Jian Hou, Zhi-Bin Ke, Yu-Peng Wu, Ting-Ting Lin, Yong Wei, Xue-Yi Xue, Qing-Shui Zheng, Jin-Bei Huang, Ning Xu,

https://doi.org/10.18632/aging.102397 pp 9478—9491

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Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms

Daiki Koyama, Xinghui Sun, Masaki Sasai, Shigenobu Matsumura, Kazuo Inoue, Kousaku Ohinata,

https://doi.org/10.18632/aging.102400 pp 9492—9499

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ER-depletion lowering the 'hypothalamus-uterus-kidney' axis functions by perturbing the renal ERβ/Ptgds signalling pathway

Yan-Ru Liu, Zhi-Shu Tang, Jin-Ao Duan, Lin Chen, Jing Sun, Rui Zhou, Zhong-Xing Song, Xin-Bo Shi, Hui-Yuan Zhu,

https://doi.org/10.18632/aging.102401 pp 9500—9529

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Proteome and phosphoproteome reveal mechanisms of action of atorvastatin against esophageal squamous cell carcinoma

Qiang Yuan, Christopher D. Dong, Yang Ge, Xinhuan Chen, Zhenzhen Li, Xin Li, Qiqi Lu, Feng Peng, Xiangyu Wu, Jimin Zhao, Kangdong Liu,

https://doi.org/10.18632/aging.102402 pp 9530—9543

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Tree-based classification system incorporating the HVTT-PVTT score for personalized management of hepatocellular carcinoma patients with macroscopic vascular invasion

Fei Cao, Lujun Shen, Han Qi, Lin Xie, Ze Song, Shuanggang Chen, Weijun Fan,

https://doi.org/10.18632/aging.102403 pp 9544—9555

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Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury

Meili Zhai, Chong Liu, Yuexiang Li, Peijun Zhang, Zhiqiang Yu, He Zhu, Li Zhang, Qian Zhang, Jianbo Wang, Jinhua Wang,

https://doi.org/10.18632/aging.102404 pp 9556—9568

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TGF-β- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223

Wentao Liu, Ruo Feng, Xingxing Li, Dingyang Li, Wenlong Zhai,

https://doi.org/10.18632/aging.102405 pp 9569—9580

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Long non-coding RNA PVT1 encapsulated in bone marrow mesenchymal stem cell-derived exosomes promotes osteosarcoma growth and metastasis by stabilizing ERG and sponging miR-183-5p

Wei Zhao, Pan Qin, Da Zhang, Xichun Cui, Jing Gao, Zhenzhu Yu, Yuting Chai, Jiaxiang Wang, Juan Li,

https://doi.org/10.18632/aging.102406 pp 9581—9596

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A cluster of long non-coding RNAs exhibit diagnostic and prognostic values in renal cell carcinoma

Gong Cheng, Di Liu, Huageng Liang, Hongmei Yang, Ke Chen, Xiaoping Zhang,

https://doi.org/10.18632/aging.102407 pp 9597—9615

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Association of CD44 gene rs187115 polymorphism with colorectal cancer risk and prognosis in Chinese Han population: a case-control study

Qian Wan, Dan Zhang, Qing Zhou, Ming Li, Yujuan Wang, Yang Song, Tianshu Xu,

https://doi.org/10.18632/aging.102408 pp 9616—9625

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Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation

Lei Shi, Youshan Zhao, Chengming Fei, Juan Guo, Yan Jia, Dong Wu, Lingyun Wu, Chunkang Chang,

https://doi.org/10.18632/aging.102409 pp 9626—9642

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Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling

Hongxia Liu, Ningning Liu, Yali Zhao, Xiaoshan Zhu, Changsong Wang, Qinqin Liu, Chunfang Gao, Xusheng Zhao, Juntang Li,

https://doi.org/10.18632/aging.102410 pp 9643—9660

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The increased gray matter volumes of precentral gyri in Parkinson's disease patients with diphasic dyskinesia

Yan Zhi, Min Wang, Yong-Sheng Yuan, Yu-Ting Shen, Ke-Wei Ma, Cai-Ting Gan, Qian-Qian Si, Li-Na Wang, Sheng-Wu Cao, Ke-Zhong Zhang,

https://doi.org/10.18632/aging.102412 pp 9661—9671

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Glycogen synthase kinase-3β suppresses the expression of protein phosphatase methylesterase-1 through β-catenin

Nana Jin, Ruirui Shi, Yanli Jiang, Dandan Chu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu,

https://doi.org/10.18632/aging.102413 pp 9672—9688

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Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression

Xinglong Dai, Xiong Guo, Jianjun Liu, Anqi Cheng, Xudong Peng, Lang Zha, Ziwei Wang,

https://doi.org/10.18632/aging.102414 pp 9689—9708

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Association of homocysteine with carotid-femoral pulse wave velocity in a southern Chinese population

Tingjun Wang, Guoyan Xu, Xiaoqi Cai, Jin Gong, Qunfang Xie, Liangdi Xie,

https://doi.org/10.18632/aging.102416 pp 9709—9718

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Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway

Lifang Ma, Hongyuan Jiang, Xin Xu, Congcong Zhang, Yongjie Niu, Zhixian Wang, Yuquan Tao, Yan Li, Feng Cai, Xiao Zhang, Xinghe Wang, Yongchun Yu,

https://doi.org/10.18632/aging.102420 pp 9719—9737

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Selected by gene co-expression network and molecular docking analyses, ENMD-2076 is highly effective in glioblastoma-bearing rats

Sheng Zhong, Yang Bai, Bo Wu, Junliang Ge, Shanshan Jiang, Weihang Li, Xinhui Wang, Junan Ren, Haiyang Xu, Yong Chen, Gang Zhao,

https://doi.org/10.18632/aging.102422 pp 9738—9766

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Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway

Hsiao-Chi Tsai, Shih-Ping Cheng, Chien-Kuo Han, Yuan-Li Huang, Shih-Wei Wang, Jie-Jen Lee, Cheng-Ta Lai, Yi-Chin Fong, Chih-Hsin Tang,

https://doi.org/10.18632/aging.102423 pp 9767—9777

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Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2

Yanhua Du, Jun Lin, Rulin Zhang, Wanli Yang, Heng Quan, Lijuan Zang, Yaqin Han, Bing Li, Hong Sun, Jun Wu,

https://doi.org/10.18632/aging.102425 pp 9778—9793

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LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

Honghai Song, Jiaming Liu, Xin Wu, Yang Zhou, Xuanyin Chen, Jiangwei Chen, Keyu Deng, Chunxia Mao, Shanhu Huang, Zhili Liu,

https://doi.org/10.18632/aging.102427 pp 9794—9810

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The TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila

Junmeng Xi, Jiadong Cai, Yang Cheng, Yuanyuan Fu, Wanhong Wei, Zhenbo Zhang, Ziheng Zhuang, Yue Hao, Mary A. Lilly, Youheng Wei,

https://doi.org/10.18632/aging.102428 pp 9811—9828

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Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals

Kurt Whittemore, Eva Martínez-Nevado, Maria A. Blasco,

https://doi.org/10.18632/aging.102430 pp 9829—9845

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Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice

Chao Huang, Wenjing Ma, Qihui Luo, Liangqin Shi, Yu Xia, Chengjie Lao, Wentao Liu, Yuanfeng Zou, Anchun Cheng, Riyi Shi, Zhengli Chen,

https://doi.org/10.18632/aging.102433 pp 9846—9861

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Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders

Xian Li, Shu-Guang Chu, Xue-Ning Shen, Xiao-He Hou, Wei Xu, Ya-Nan Ou, Qiang Dong, Lan Tan, Jin-Tai Yu,

https://doi.org/10.18632/aging.102435 pp 9862—9874

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Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1

Fong-Yu Cheng, Yu-Hsuan Lee, Yung-Ho Hsu, I-Jen Chiu, Yu-Jhe Chiu, Yuh-Feng Lin, Hui-Wen Chiu,

https://doi.org/10.18632/aging.102437 pp 9875—9892

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Suppression effect of body weight on the association between cigarette smoking and telomere length: the Bogalusa Heart Study

Miaoying Yun, Shengxu Li, Yinkun Yan, Tao Zhang, Lydia Bazzano, Jiang He, Wei Chen,

https://doi.org/10.18632/aging.102439 pp 9893—9900

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Innate sensitivity to stress facilitates inflammation, alters metabolism and shortens lifespan in a mouse model of social hierarchy

Maryia Bairachnaya, Oryan Agranyoni, Marina Antoch, Izhak Michaelevski, Albert Pinhasov,

https://doi.org/10.18632/aging.102440 pp 9901—9911

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Molecular basis of senescence transmitting in the population of human endometrial stromal cells

Anastasiia Griukova, Pavel Deryabin, Alla Shatrova, Elena Burova, Valeria Severino, Annarita Farina, Nikolay Nikolsky, Aleksandra Borodkina,

https://doi.org/10.18632/aging.102441 pp 9912—9931

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Reviews

Emerging roles of piRNAs in cancer: challenges and prospects

Ye Cheng, Qian Wang, Wei Jiang, Yonghua Bian, Yang zhou, Anxing Gou, Wenling Zhang, Kai Fu, Weihong Shi,

https://doi.org/10.18632/aging.102417 pp 9932—9946

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Aging and stress induced β cell senescence and its implication in diabetes development

Na Li, Furong Liu, Ping Yang, Fei Xiong, Qilin Yu, Jinxiu Li, Zhiguang Zhou, Shu Zhang, Cong-Yi Wang,

https://doi.org/10.18632/aging.102432 pp 9947—9959

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Correction

Correction for: Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21

Hongzhi Wan, Ying Yang, Miao Li, Xin Liu, Yeying Sun, Kexin Wang, Chunxiang Zhang, Qingyin Zheng, Chaoyun Wang,

https://doi.org/10.18632/aging.102458 pp 9960

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