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• Research PaperVolume 10, Issue 11pp 3294-3307

  Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

  Relevance score: 0.00

  Bela Ozsvari, John R. Nuttall, Federica Sotgia, Michael P. Lisanti

  Keywords: drug repurposing, aging, senescence, senolytic drugs, antibiotics, azithromycin, roxithromycin

  Published in Aging on November 14, 2018

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• Research PaperVolume 15, Issue 11pp 5144-5163

  Network medicine framework identified drug-repurposing opportunities of pharmaco-active compounds of Angelica acutiloba (Siebold & Zucc.) Kitag. for skin aging

  Relevance score: 0.00

  Jiaxin Mo, Zunjiang Li, Hankun Chen, Zhongyu Lu, Banghan Ding, Xiaohong Yuan, Yuan Liu, Wei Zhu

  Keywords: network medicine framework, drug-repurposing opportunities, Angelica acutiloba (Siebold & Zucc.) Kitag., skin aging, pharmaco-active compounds

  Published in Aging on June 12, 2023

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• Research PaperVolume 12, Issue 19pp 19022-19044

  Target RNA modification for epigenetic drug repositioning in neuroblastoma: computational omics proximity between repurposing drug and disease

  Relevance score: 0.00

  Pei Ma, Lifeng Yue, Sen Zhang, Dacheng Hao, Zhihong Wu, Lijia Xu, Guanhua Du, Peigen Xiao

  Keywords: neuroblastoma, drug repurposing, gene expression, the connectivity map, L1000 FWD

  Published in Aging on October 12, 2020

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• Research PaperVolume 8, Issue 9pp 2127-2152

  In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state

  Relevance score: 0.00

  Alexander Aliper, Aleksey V. Belikov, Andrew Garazha, Leslie Jellen, Artem Artemov, Maria Suntsova, Alena Ivanova, Larisa Venkova, Nicolas Borisov, Anton Buzdin, Polina Mamoshina, Evgeny Putin, Andrew G. Swick, Alexey Moskalev, Alex Zhavoronkov

  Keywords: geroprotector, drug discovery, screening, drug repurposing, aging

  Published in Aging on September 24, 2016

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• Research PaperVolume 17, Issue 11pp 2844-2858

  REVIVE: a computational platform for systematically identifying rejuvenating chemical and genetic perturbations

  Relevance score: 0.00

  Sascha Jung, Javier Arcos Hodar, Tejwasi Venkata S. Badam, Antonio del Sol

  Keywords: computational modeling, machine learning, aging, rejuvenation, drug repurposing

  Published in Aging on November 25, 2025

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• Research PaperVolume 13, Issue 13pp 17407-17427

  Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways

  Relevance score: 0.00

  Linjuan Huang, Ling Zhao, Jing Zhang, Fang He, Hao Wang, Qing Liu, Deyao Shi, Na Ni, William Wagstaff, Connie Chen, Russell R. Reid, Rex C. Haydon, Hue H. Luu, Le Shen, Tong-Chuan He, Liangdan Tang

  Keywords: ovarian cancer, cisplatin, chemoresistance, cisplatin resistance, mebendazole (MBZ), drug repurposing

  Published in Aging on July 7, 2021

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• Research PerspectiveVolume 12, Issue 8pp 6511-6517

  COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?

  Relevance score: 0.00

  Camillo Sargiacomo, Federica Sotgia, Michael P. Lisanti

  Keywords: COVID-19, corona virus, aging, senescence, senolytic drug therapy, prevention, viral replication, drug repurposing, antibiotic, Azithromycin, Hydroxy-chloroquine, Rapamycin, Doxycycline, Quercetin

  Published in Aging on March 30, 2020

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• Research PaperVolume 8, Issue 8pp 1593-1606

  Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

  Relevance score: 0.00

  Marco Fiorillo, Rebecca Lamb, Herbert B. B. Tanowitz, Anna Rita Rita Cappello, Ubaldo E. E. Martinez-Outschoorn, Federica Sotgia, Michael P. P. Lisanti

  Keywords: bedaquiline, mitochondria, tumor-initiating cells (TICs), cancer stem-like cells (CSCs), drug repurposing

  Published in Aging on June 22, 2016

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• Research PaperVolume 16, Issue 1pp 627-647

  Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis

  Relevance score: 0.00

  Yang-Che Wu, Chin-Sheng Huang, Ming-Shou Hsieh, Chih-Ming Huang, Syahru Agung Setiawan, Chi-Tai Yeh, Kuang-Tai Kuo, Shao-Cheng Liu

  Keywords: drug-tolerant persister cancer cells, tumor organoids, ferroptosis, FSP1

  Published in Aging on January 10, 2024

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• Research PaperVolume 15, Issue 24pp 14996-15024

  ATRX is a predictive marker for endocrinotherapy and chemotherapy resistance in HER2-/HR+ breast cancer through the regulation of the AR, GLI3 and GATA2 transcriptional network

  Relevance score: 0.00

  Hongyan Qian, Rui Ji, Cheng Shen, Yinze Wei, Chenyi Sheng, Qichao Ni, Jing Pan, Yifan Chi, Huan You, Ying Miao, Minxin Shi, Xianghua Huang, Aiguo Shen

  Keywords: ATRX, drug resistance, biomarker, breast cancer, transcription factor

  Published in Aging on December 20, 2023

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• Research PaperVolume 14, Issue 17pp 7038-7051

  The downregulated drug-metabolism related ALDH6A1 serves as predictor for prognosis and therapeutic immune response in gastric cancer

  Relevance score: 0.00

  Yuan Cai, Rong Zeng, Jinwu Peng, Wei Liu, Qingchun He, Zhijie Xu, Ning Bai

  Keywords: ALDH6A1, gastric cancer, drug-metabolism, prognosis, immune regulation

  Published in Aging on September 12, 2022

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• Research PaperVolume 12, Issue 22pp 22700-22718

  Drug-selected population in melanoma A2058 cells as melanoma stem-like cells retained angiogenic features – the potential roles of heparan-sulfate binding ANGPTL4 protein

  Relevance score: 0.00

  Chia-Yu Shih, Yu-Che Cheng, ChiaoHui Hsieh, TingTing Tseng, ShihSheng Jiang, Shao-Chen Lee

  Keywords: drug resistance, melanoma stem-like cells, angiopoietin-like 4 protein

  Published in Aging on November 10, 2020

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• Research PaperVolume 12, Issue 19pp 19711-19739

  Risk of hospitalization from drug-drug interactions in the Elderly: real-world evidence in a large administrative database

  Relevance score: 0.00

  Floor Swart, Giampaolo Bianchi, Jacopo Lenzi, Marica Iommi, Lorenzo Maestri, Emanuel Raschi, Marco Zoli, Fabrizio De Ponti, Elisabetta Poluzzi

  Keywords: drug-drug interactions, adverse drug reactions, elderly, case-control study, real-world evidence

  Published in Aging on October 5, 2020

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• EditorialVolume 15, Issue 12pp 5232-5234

  Advances in cancer therapy: clinical benefit of new cancer drugs

  Relevance score: 0.00

  Daniel Tobias Michaeli, Julia Caroline Michaeli, Thomas Michaeli

  Keywords: cancer drug, clinical benefit, overall survival, progression-free survival, clinical trial

  Published in Aging on June 19, 2023

• Research PaperVolume 13, Issue 12pp 16316-16340

  Comprehensive signature analysis of drug metabolism differences in the White, Black and Asian prostate cancer patients

  Relevance score: 0.00

  Yang Liu, Jia-Wei Zhou, Cun-Dong Liu, Jian-Kun Yang, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qi-Zhao Zhou, Kang-Yi Xue, Wen-Bing Guo, Ming Xia, Jun-Hao Zhou, Ji-Ming Bao, Cheng Yang, Hai-Feng Duan, Hong-Yi Wang, Zhi-Peng Huang, Shan-Chao Zhao, Ming-Kun Chen

  Keywords: prostate cancer, race, drug resistance, drug metabolism, comprehensive signature

  Published in Aging on June 18, 2021

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• Research PaperVolume 13, Issue 6pp 8620-8627

  The whole term efficacy of different treatments in paroxysmal atrial fibrillation in aging: a meta-analysis of randomized controlled trials

  Relevance score: 0.00

  Yinan Sun, Lu Wang, Xiaoyun Yang

  Keywords: paroxysmal atrial fibrillation, catheter ablation, antiarrhythmic drug, quality of life

  Published in Aging on March 10, 2021

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• Research PaperVolume 12, Issue 11pp 10754-10771

  How non-drug interventions affect the quality of life of patients suffering from progressive cognitive decline and their main caregiver

  Relevance score: 0.00

  Benedetta Leidi-Maimone, Marie-Laure Notter-Bielser, Marie-Hélène Laouadi, Sarah Perrin, Hélène Métraux, Daniel Damian, Camille F. Chavan, Mélanie Nsir, Gwendoline Cibelli, Marie-Jo Tâche, Marie-Louise Montandon, Joseph Ghika, Jean-François Démonet, Anne-Véronique Dürst, Andrea Brioschi Guevara

  Keywords: non-drug intervention, quality of life, MCI, caregiver, dementia

  Published in Aging on June 9, 2020

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• Research PaperVolume 15, Issue 8pp 3035-3051

  TYRO3 promotes tumorigenesis and drug resistance in colorectal cancer by enhancing the epithelial-mesenchymal transition process

  Relevance score: 0.00

  Xinyu Shao, Yibin Sun, Kaiqiang Zhong, Jinrong Gu, Yang Yu, Tong Hu, Xiaoyi Kuai, Yechen Xing

  Keywords: TYRO3, colorectal cancer, drug-resistance, ENO1, EMT

  Published in Aging on April 14, 2023

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• Research PaperVolume 12, Issue 1pp 156-177

  Over-expression of EGFR regulated by RARA contributes to 5-FU resistance in colon cancer

  Relevance score: 0.00

  Xin-Yue Gu, Yang Jiang, Ming-Qi Li, Peng Han, Yan-Long Liu, Bin-Bin Cui

  Keywords: autophagy, drug sensitivity, EGFR, 5-fluorouracil

  Published in Aging on January 2, 2020

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• Meeting ReportVolume 10, Issue 11pp 3079-3088

  Aging and drug discovery

  Relevance score: 0.00

  Daniela Bakula, Alexander M. Aliper, Polina Mamoshina, Michael A. Petr, Amanuel Teklu, Joseph A. Baur, Judith Campisi, Collin Y. Ewald, Anastasia Georgievskaya, Vadim N. Gladyshev, Olga Kovalchuk, Dudley W. Lamming, Martijn S. Luijsterburg, Alejandro Martín-Montalvo, Stuart Maudsley, Garik V. Mkrtchyan, Alexey Moskalev, S. Jay Olshansky, Ivan V. Ozerov, Alexander Pickett, Michael Ristow, Alex Zhavoronkov, Morten Scheibye-Knudsen

  Keywords: aging, drug discovery

  Published in Aging on November 13, 2018

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