Volume 17, Issue 11

November 30, 2025pp 2655—2876

About the Cover

The cover features Figure 2 "Overview of SAMP-Score model development" from Wallis et al.

Essay

On the intergenerational transfer of ideas in aging and cancer research: from the hypothalamus according to V.M. Dilman to the mTOR protein complex according to M.V. Blagosklonny

Aleksei G. Golubev

https://doi.org/10.18632/aging.206338pp 2655—2663

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Research Papers

Infusion of blood from young and old mice modulates amyloid pathology

Matias Pizarro, Ruben Gomez-Gutierrez, Ariel Caviedes, Catalina Valdes, Ute Woehlbier, Cristian Vargas, Mauricio Hernandez, Claudia Duran-Aniotz, Rodrigo Morales

https://doi.org/10.18632/aging.206319pp 2664—2687

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SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells

Ryan Wallis, Bethany K. Hughes, Madeleine Moore, Emily A. O’Sullivan, Luke C. McIlvenna, Luke Gammon, Anthony Hope, Fiona Bellany, Parul Dixit, Claire Mackenzie, Charlotte Green, David Gray, Cleo L. Bishop

https://doi.org/10.18632/aging.206333pp 2688—2716

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Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence

Parminder Singh, Ravinandan Venkatasubramanian, Sophia A. Mahoney, Mary A. Darrah, Katelyn R. Ludwig, Alice Zhang, Kiyomi Kaneshiro, Lizbeth Enriquez Najera, Lauren Wimer, Muniesh M. Shanmugam, Edgard Morazan, James J. Galligan, Marrisa N. Trujillo, Richmond Sarpong, Douglas R. Seals, Pankaj Kapahi, Zachary S. Clayton

https://doi.org/10.18632/aging.206335pp 2717—2743

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Topography of small vessel cerebrovascular disease differentially impacts cognitive domains across cognitive syndromes

Jia Dong James Wang, Yi Jin Leow, Ashwati Vipin, Gurveen Kaur Sandhu, Chao Dang, Seyed Ehsan Saffari, Nagaendran Kandiah

https://doi.org/10.18632/aging.206336pp 2744—2758

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Epigenetic age predicts depressive symptoms during the COVID-19 pandemic in the Canadian Longitudinal Study on Aging: importance of biological sex

Cindy K. Barha, Teresa Liu-Ambrose, Amy M. Inkster, Ryan S. Falck, Joel S. Burma, Susan Kirkland, Lauren E. Griffith, Mary Thompson, Nicole E. Basta, Jacqueline M. McMillan, Cynthia Balion, Christina Wolfson, Parminder Raina, on behalf of the Canadian Longitudinal Study on Aging (CLSA) Team

https://doi.org/10.18632/aging.206337pp 2759—2777

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A natural language processing–driven map of the aging research landscape

Jose Perez-Maletzki, Jorge Sanz-Ros

https://doi.org/10.18632/aging.206340pp 2778—2808

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Epigenetic aging signatures and age prediction in human skeletal muscle

Soo-Bin Yang, Jeong Min Lee, Moon-Young Kim, Soong Deok Lee, Hwan Young Lee

https://doi.org/10.18632/aging.206341pp 2809—2843

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REVIVE: a computational platform for systematically identifying rejuvenating chemical and genetic perturbations

Sascha Jung, Javier Arcos Hodar, Tejwasi Venkata S. Badam, Antonio del Sol

https://doi.org/10.18632/aging.206342pp 2844—2858

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Correction

Correction for: Sex-specific longitudinal reversal of aging in old frail mice

Cameron Kato, Jessica Zheng, Cindy Quang, Sophia Siopack, Joana Cruz, Zachery R. Robinson, Nicole Fong, Zhixin A. Zhang, Patrick Young, Michael J. Conboy, Irina M. Conboy

https://doi.org/10.18632/aging.206345pp 2875

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Retraction

Retraction of: The microRNA miR-29c-5p inhibits cell proliferation and migration by targeting TMEM98 in head and neck carcinoma

Jingjia Li, Weixiong Chen, Lixia Luo, Lieqiang Liao, Xuequan Deng, Yuejian Wang

https://doi.org/10.18632/aging.206346pp 2876

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