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Meeting Report|Volume 10, Issue 11|pp 3079—3088

Aging and drug discovery

Daniela Bakula1, Alexander M. Aliper2, Polina Mamoshina2, Michael A. Petr1, Amanuel Teklu1, Joseph A. Baur3,4, Judith Campisi5,6, Collin Y. Ewald7, Anastasia Georgievskaya8, Vadim N. Gladyshev9,10, Olga Kovalchuk11,12, Dudley W. Lamming13, Martijn S. Luijsterburg14, Alejandro Martín-Montalvo15, Stuart Maudsley16,17, Garik V. Mkrtchyan1, Alexey Moskalev18,19,20, S. Jay Olshansky21, Ivan V. Ozerov2, Alexander Pickett22, Michael Ristow7, Alex Zhavoronkov2, Morten Scheibye-Knudsen1
  • 1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
  • 2Pharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD 20850, USA
  • 3Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  • 4Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  • 5Buck Institute for Research on Aging, Novato, CA 94945, USA
  • 6Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA 94720, USA
  • 7Institute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute for Technology (ETH) Zürich, Switzerland
  • 8Youth Laboratories, Moscow, Russia
  • 9Division of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA
  • 10Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia
  • 11Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
  • 12Pathway Rx Ltd, Lethbridge, Alberta, Canada
  • 13Department of Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA
  • 14Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
  • 15Pancreatic Islet Development and Regeneration Unit/Laboratory of Aging Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain
  • 16Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
  • 17Translational Neurobiology Group, Center of Molecular Neurology, VIB, Antwerp, Belgium
  • 18Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
  • 19Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia
  • 20Moscow Institute of Physics and Technology, Dolgoprudny, Russia
  • 21Division of Epidemiology and Biostatistics University of Illinois at Chicago School of Public Health, Chicago, IL 60612, USA
  • 22Juvenescence Limited, Douglas, Isle of Man, UK
Received: October 8, 2018Accepted: November 4, 2018Published: November 13, 2018

Copyright: © 2018 Bakula et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.