Volume 16, Issue 11

June 15, 2024pp 9306—10200

About the Cover

The cover features Figure 2 "Assessment of basal mitophagy, using a mitochondrially-targeted red fluorescent protein (mt-Keima-RFP), in doubly-transfected MCF7-BNIP3-GFP and MCF7-BNIP3L-GFP cells" from Mauro-Lizcano et al.

Editorial

Global consensus for sarcopenia

Ben Kirk, Peggy M. Cawthon, Alfonso J. Cruz-Jentoft

https://doi.org/10.18632/aging.205919pp 9306—9308

PDF

Research Papers

Dietary sucrose determines the regulatory activity of lithium on gene expression and lifespan in Drosophila melanogaster

Katharina Jans, Kai Lüersen, Jakob von Frieling, Thomas Roeder, Gerald Rimbach

https://doi.org/10.18632/aging.205933pp 9309—9333

View Abstract PDF Full-Text

Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration

Marta Mauro-Lizcano, Federica Sotgia, Michael P. Lisanti

https://doi.org/10.18632/aging.205939pp 9334—9349

View Abstract PDF Full-Text

Associations of childhood, adolescence, and midlife cognitive function with DNA methylation age acceleration in midlife

Junyu Chen, Leah Moubadder, Elizabeth S. Clausing, Katrina L. Kezios, Karen N. Conneely, Anke Hüls, Andrea Baccarelli, Pam Factor-Litvak, Piera Cirrillo, Rachel C. Shelton, Bruce G. Link, Shakira F. Suglia

https://doi.org/10.18632/aging.205943pp 9350—9368

View Abstract PDF Full-Text

Identification of key genes and biological pathways associated with vascular aging in diabetes based on bioinformatics and machine learning

Sha Wang, Xia Wang, Jing Chen, Min Wang, Chi Zhang

https://doi.org/10.18632/aging.205870pp 9369—9385

View Abstract PDF Full-Text

LASSO regression and WGCNA-based telomerase-associated lncRNA signaling predicts clear cell renal cell carcinoma prognosis and immunotherapy response

Cheng Shen, Kaiyao Jiang, Wei Zhang, Baohui Su, Zhenyu Wang, Xinfeng Chen, Bing Zheng, Tao He

https://doi.org/10.18632/aging.205871pp 9386—9409

View Abstract PDF Full-Text

APOA5 alleviates reactive oxygen species to promote oxaliplatin resistance in PIK3CA-mutated colorectal cancer

Yu-Lin Liu, Zhuo Xiang, Bo-Ya Zhang, Yu-Wei Zou, Gui-Lai Chen, Li Yin, Yan-Long Shi, Li-Li Xu, Jingwang Bi, Qiang Wang

https://doi.org/10.18632/aging.205872pp 9410—9436

View Abstract PDF Full-Text

Machine learning-based identification and immune characterization of ferroptosis-related molecular clusters in osteoarthritis and validation

Xiaocheng Guo, Xinyuan Feng, Yue Yang, Wenying An, Lunhao Bai

https://doi.org/10.18632/aging.205875pp 9437—9459

View Abstract PDF Full-Text

High glucose enhances fibrosis in human annulus fibrosus cells by activating mTOR, PKCδ, and NF-κB signaling pathways

Chun Tseng, Shan-Chi Liu, Xiu-Yuan He, Hsien-Te Chen, Pang-Hsuan Hsiao, Yi-Chin Fong, Chih-Hsin Tang

https://doi.org/10.18632/aging.205876pp 9460—9469

View Abstract PDF Full-Text

Genome-wide association analysis reveals potential genetic correlation and causality between circulating inflammatory proteins and amyotrophic lateral sclerosis

Jing Shen, Xiaochu Gu, Chenxu Xiao, Hanfei Yan, Yu Feng, Xiaowei Li

https://doi.org/10.18632/aging.205878pp 9470—9484

View Abstract PDF Full-Text

circRNA6448-14/miR-455-3p/OTUB2 axis stimulates glycolysis and stemness of esophageal squamous cell carcinoma

Yaowen Zhang, Heming Zhang, Chenyu Wang, Shasha Cao, Xinyu Cheng, Linzhi Jin, Runchuan Ren, Fuyou Zhou

https://doi.org/10.18632/aging.205879pp 9485—9497

View Abstract PDF Full-Text

THY1 is a prognostic-related biomarker via mediating immune infiltration in lung squamous cell carcinoma (LUSC)

Changsheng Yi, Nan Zang, Limin Gao, Fang Ren

https://doi.org/10.18632/aging.205880pp 9498—9517

View Abstract PDF Full-Text

Glutathione metabolism-related gene signature predicts prognosis and treatment response in low-grade glioma

Zaidong Deng, Jing Luo, Jing Ma, Youngnam N. Jin, Yanxun V. Yu

https://doi.org/10.18632/aging.205881pp 9518—9546

View Abstract PDF Full-Text

Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1

Wenhuan Li, Peng Fu, Pengfei Shi, Bo Hu, Hai Li

https://doi.org/10.18632/aging.205882pp 9547—9557

View Abstract PDF Full-Text

The protective effects of orexin-A in alleviating cell senescence against interleukin-1β (IL-1β) in chondrocytes

Lin Shen, Xiantie Zeng, Haiying Zhang

https://doi.org/10.18632/aging.205884pp 9558—9568

View Abstract PDF Full-Text

Attenuating bone loss in osteoporosis: the potential of corylin (CL) as a therapeutic agent

Song Zhou, Junming Huang, Kun Chen, Qixuan Wang, Zheng Liu, Yanli Sun, Feng Yin, Shanjin Wang, Zhiying Pang, Min Ma

https://doi.org/10.18632/aging.205885pp 9569—9583

View Abstract PDF Full-Text

The association between diabetes mellitus and prostate cancer: a meta-analysis and Mendelian randomization

Gui-Chen Ye, Yu-Xuan Yang, Kuang-Di Luo, Shao-Gang Wang, Qi-Dong Xia

https://doi.org/10.18632/aging.205886pp 9584—9598

View Abstract PDF Full-Text

Prognosis and diagnosis of prostate cancer based on hypergraph regularization sparse least partial squares regression algorithm

Ruo-Hui Huang, Zi-Lu Ge, Gang Xu, Qing-Ming Zeng, Bo Jiang, Guan-Cheng Xiao, Wei Xia, Yu-Ting Wu, Yun-Feng Liao

https://doi.org/10.18632/aging.205889pp 9599—9624

View Abstract PDF Full-Text

3D-printed porous zinc scaffold combined with bioactive serum exosomes promotes bone defect repair in rabbit radius

Baoxin Zhang, Zhiwei Pei, Wanxiong He, Wei Feng, Ting Hao, Mingqi Sun, Xiaolong Yang, Xing Wang, Xiangyu Kong, Jiale Chang, Guanghui Liu, Rui Bai, Chang Wang, Feng Zheng

https://doi.org/10.18632/aging.205891pp 9625—9648

View Abstract PDF Full-Text

A novel mitochondrial metabolism-related gene signature for predicting the prognosis of oesophageal squamous cell carcinoma

Wenhao Lin, Changchun Ye, Liangzhang Sun, Zilu Chen, Chao Qu, Minxia Zhu, Jianzhong Li, Ranran Kong, Zhengshui Xu

https://doi.org/10.18632/aging.205892pp 9649—9679

View Abstract PDF Full-Text

Daphnoretin inhibited SCI-induced inflammation and activation of NF-κB pathway in spinal dorsal horn

Jiazhang Wu, Fengfei Lin, Bin Chen

https://doi.org/10.18632/aging.205893pp 9680—9691

View Abstract PDF Full-Text

Prognostic and therapeutic roles of SETD2 in cutaneous melanoma

Jiani Xiong, Liping Zhu, Yunrong Fu, Zhoujie Ye, Cuimin Deng, Xinrui Wang, Yu Chen

https://doi.org/10.18632/aging.205894pp 9692—9708

View Abstract PDF Full-Text

Identification of a unique stress response state of T cells-related gene signature in patients with gastric cancer

Qin Yang, Xin Li, Weiyuan Zhu

https://doi.org/10.18632/aging.205895pp 9709—9726

View Abstract PDF Full-Text

14-3-3σ downregulation sensitizes pancreatic cancer to carbon ions by suppressing the homologous recombination repair pathway

Dandan Wang, Hongtao Luo, Yanliang Chen, Yuhong Ou, Meng Dong, Junru Chen, Ruifeng Liu, Xiaohu Wang, Qiuning Zhang

https://doi.org/10.18632/aging.205896pp 9727—9752

View Abstract PDF Full-Text

Identification of disulfidptosis-associated genes and characterization of immune cell infiltration in thyroid carcinoma

Siyuan Song, Jie Zhou, Li Zhang, Yuqing Sun, Qiling Zhang, Ying Tan, Xiqiao Zhou, Jiangyi Yu

https://doi.org/10.18632/aging.205897pp 9753—9783

View Abstract PDF Full-Text

Overexpression of zinc finger DHHC-type containing 1 is associated with poor prognosis and cancer cell growth and metastasis in uterine corpus endometrial carcinoma

Ni Jiang, Dan Li, Ye Han, Zhi-Guo Luo, Lu-Bin Liu

https://doi.org/10.18632/aging.205899pp 9784—9812

View Abstract PDF Full-Text

Targeting cGAS-STING signaling protects retinal ganglion cells from DNA damage-induced cell loss and promotes visual recovery in glaucoma

Qiuli Zhang, Yinghuan Xiong, Ruizhuang Li, Xiuqin Wang, Xu Lin, Ya’ni Tong

https://doi.org/10.18632/aging.205900pp 9813—9823

View Abstract PDF Full-Text

Age-related nomogram revealed optimal therapeutic option for older patients with primary liver cancer: less is more

Bo Wang, Yongqiang Xiong, Ren Li, Shu Zhang

https://doi.org/10.18632/aging.205901pp 9824—9845

View Abstract PDF Full-Text

LncRNA MIR181A2HG inhibits keratinocytes proliferation through miR-223-3p/SOX6 axis

Mingzhao Li, Mutian Niu, Xiaomei Fan, Fangru Chen, Hui Cao, Qingbo Liu, Shaoqin Gan, Pengpeng Yue, Jintao Gao

https://doi.org/10.18632/aging.205902pp 9846—9858

View Abstract PDF Full-Text

Tsc22d3 promotes morphine tolerance in mice through the GPX4 ferroptosis pathway

Yan Chen, Shan Li, Fenghui Guo

https://doi.org/10.18632/aging.205903pp 9859—9875

View Abstract PDF Full-Text

High estrogen induces trans-differentiation of vascular smooth muscle cells to a macrophage-like phenotype resulting in aortic inflammation via inhibiting VHL/HIF1a/KLF4 axis

Ruijing Zhang, Heng Wang, Xing Cheng, Keyi Fan, Tingting Gao, Xiaotong Qi, Siqi Gao, Guoping Zheng, Honglin Dong

https://doi.org/10.18632/aging.205904pp 9876—9898

View Abstract PDF Full-Text

Construction and validation of a prognostic signature based on anoikis-related lncRNAs in lung adenocarcinoma

Xiaoqi Dong, Chuan Shao, Shuguang Xu, Jinjing Tu, Wenjing Xu, Dahua Chen, Yaodong Tang

https://doi.org/10.18632/aging.205905pp 9899—9917

View Abstract PDF Full-Text

Mechanistic insights into super-enhancer-related genes as prognostic signatures in colon cancer

Yini Tang, Shuliu Sang, Shuang Gao, Weina Xu, Hailun Zhou, Xiaoting Xia

https://doi.org/10.18632/aging.205906pp 9918—9932

View Abstract PDF Full-Text

Ginsenoside Rg3 induces mesangial cells proliferation and attenuates apoptosis by miR-216a-5p/MAPK pathway in diabetic kidney disease

Yuanzhen Chen, Yuhuan Peng, Ping Li, Ying Jiang, Dan Song

https://doi.org/10.18632/aging.205907pp 9933—9943

View Abstract PDF Full-Text

Causal effects for neurodegenerative diseases on the risk of myocardial infarction: a two-sample Mendelian randomization study

Jianing Chi, Jiaman Hu, Ningxia Wu, Hua Cai, Cailong Lin, Yingying Lai, Jianyu Huang, Weihua Li, Peng Su, Min Li, Lin Xu

https://doi.org/10.18632/aging.205909pp 9944—9958

View Abstract PDF Full-Text

Efficacy of bumetanide in animal models of ischemic stroke: a systematic review and meta-analysis

Xiaoyu Sun, Jiadi Hou, Haichun Xu, Huiling Qu

https://doi.org/10.18632/aging.205910pp 9959—9971

View Abstract PDF Full-Text

Disulfidptosis-related lncRNAs signature predicting prognosis and immunotherapy effect in lung adenocarcinoma

Suifeng Hong, Yu Zhang, Dongfeng Wang, Huaying Wang, Huihui Zhang, Jing Jiang, Liping Chen

https://doi.org/10.18632/aging.205911pp 9972—9989

View Abstract PDF Full-Text

Analysis and experimental validation of genes and their transcription factor prediction in contused rat spinal cord at the intermediate phase

Zhongju Shi, Tuo Fang, Baoyou Fan, Jun Ma, Jianhao Wang, Shiqing Feng

https://doi.org/10.18632/aging.205912pp 9990—10003

View Abstract PDF Full-Text

Altered intra- and inter-network connectivity in autism spectrum disorder

Rui Zhou, Chenhao Sun, Mingxiang Sun, Yudi Ruan, Weikai Li, Xin Gao

https://doi.org/10.18632/aging.205913pp 10004—10015

View Abstract PDF Full-Text

Landscape analysis of alternative splicing in kidney renal clear cell carcinoma and their clinical significance

Songtao Cheng, Zili Zhou, Jiannan Liu, Jun Li, Yu Wang, Jiantao Xiao, Yongwen Luo

https://doi.org/10.18632/aging.205915pp 10016—10032

View Abstract PDF Full-Text

A new perspective: deciphering the aberrance and clinical implication of disulfidptosis signatures in clear cell renal cell carcinoma

Bohong Chen, Mingguo Zhou, Li Guo, Xinyue Sun, Haoxiang Huang, Kaijie Wu, Wei Chen, Dapeng Wu

https://doi.org/10.18632/aging.205916pp 10033—10062

View Abstract PDF Full-Text

The causal role of immune cells on lung cancer: a bi-directional Mendelian randomization (MR) study

Hongyu Zhu, Caihua Chen, Haixie Guo, Bo Zhang, Quanteng Hu

https://doi.org/10.18632/aging.205917pp 10063—10073

View Abstract PDF Full-Text

Immunotherapy, prognostic, and tumor biomarker based on pancancer analysis, SMARCD3

Zishun Guo, Bingji Cao, Zhuozheng Hu, Jiajun Wu, Weijun Zhou, Wenxiong Zhang, Zhihua Shi

https://doi.org/10.18632/aging.205921pp 10074—10107

View Abstract PDF Full-Text

Comprehensive evaluation of genes related to basement membrane in hepatocellular carcinoma

Guojing Wu, Fei Li, Danyan Guo, Kaiwen Xi, Dayong Zheng, Ruichao Huang, Xiuqiong Wu, Aimin Li, Xinhui Liu

https://doi.org/10.18632/aging.205923pp 10108—10131

View Abstract PDF Full-Text

Total flavonoids of Chrysanthemum indicum L inhibit colonic barrier injury induced by acute pancreatitis by affecting gut microorganisms

Xiaojuan Yang, Jia Hu, Chao Zhong, Song Xu, Shiyao Hua, Peng Liu, Ling He

https://doi.org/10.18632/aging.205924pp 10132—10141

View Abstract PDF Full-Text

Prognostic implication and immunotherapy response prediction of a novel ubiquitination-related gene signature in liver cancer

Re-Guang Pan, Jingyao Zhou, Xiao-Wu Wang, Xi-Kai Cen, Yu-Ping Zhou, Yang-Yang Guo, Xue-Feng Feng

https://doi.org/10.18632/aging.205926pp 10142—10164

View Abstract PDF Full-Text

Review

Targeting tumor-associated macrophages to reverse antitumor drug resistance

Sheng Li, Jiyao Sheng, Dan Zhang, Hanjiao Qin

https://doi.org/10.18632/aging.205858pp 10165—10196

View Abstract PDF Full-Text

Correction

Correction for: The p53/miR-17/Smurf1 pathway mediates skeletal deformities in an age-related model via inhibiting the function of mesenchymal stem cells

Wenjia Liu, Meng Qi, Anna Konermann, Liqiang Zhang, Fang Jin, Yan Jin

https://doi.org/10.18632/aging.205986pp 10197—10198

PDF Full-Text

Retraction

Retraction: RPN2 promotes metastasis of hepatocellular carcinoma cell and inhibits autophagy via STAT3 and NF-κB pathways

Linsheng Huang, Zhiyuan Jian, Yi Gao, Ping Zhou, Gan Zhang, Bin Jiang, Yi Lv

https://doi.org/10.18632/aging.205555pp 10199—10200

PDF Full-Text